کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9919000 | 1557566 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Investigation of entrapped pore in the pastilles by a mercury porosimetery technique
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موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
علوم دارویی
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چکیده انگلیسی
The pore in pastilles was investigated which are produced by a pastillation technology. Mercury intrusion porosimeter and scanning electron microscopy (SEM) techniques were used for the investigation. The formation of micro-pores and cracks were in dependence of the manufacturing conditions of the pastilles (final impacting velocity, degree of subcooling and surface roughness of cooled substrate). The total pore is decreased with decreasing degree of subcooling, final impacting velocity and surface roughness of the cooled substrate. In order to design a drug delivery system and to select an optimum manufacturing parameter the relationship between overall growth rate of the pastilles and total pore was experimentally investigated. The total pore increased with increasing the overall growth rate of pastilles.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Pharmaceutics - Volume 288, Issue 2, 20 January 2005, Pages 305-314
Journal: International Journal of Pharmaceutics - Volume 288, Issue 2, 20 January 2005, Pages 305-314
نویسندگان
Jung-Woo Kim, Yang-Ho Cheon, Danail Donchev, Sung-Hyun Kim, Joachim Ulrich,