کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9933573 | 1568465 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Emerging roles for TGF-β1 in nervous system development
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کلمات کلیدی
PAI-1N-methyl-d-aspartateGDNFNMDAPDGFAPPTGF-β2t-PAFGFTGF-β3IL2GFAPTGF-β1SMADsEGFECMBMPs - BMP هاAstrocyte - آستروسیتneuron–glia interaction - تعامل نورون گلیاShh - خیرCNS - دستگاه عصبی مرکزیDevelopment - رشدcentral nervous system - سیستم عصبی مرکزیsonic hedgehog - صدای جیر جیرepidermal growth factor - عامل رشد اپیدرمیplatelet-derived growth factor - فاکتور رشد حاصل از پلاکتfibroblast growth factor - فاکتور رشد فیبروبلاستGlial cell line-derived neurotrophic factor - فاکتور نوروتروفی مشتق از سلول گلیاییTissue-type plasminogen activator - فعال کننده بافت پلاسمینوژنType-1 plasminogen activator inhibitor - مهار کننده فعال کننده پلاسمینوژن نوع 1Extracellular matrix molecules - مولکول های ماتریکس غیر سلولیGlial fibrillary acidic protein - پروتئین اسیدی فیبریلاسیون گلایالbone morphogenetic proteins - پروتئین های مورفوژنیک استخوانTGF-β receptor - گیرنده TGF-β
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی تکاملی
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چکیده انگلیسی
Transforming growth factor betas (TGF-βs) are known as multifunctional growth factors, which participate in the regulation of key events of development, disease and tissue repair. In central nervous system (CNS), TGF-β1 has been widely recognized as an injury-related cytokine, specially associated with astrocyte scar formation in response to brain injury. TGF-βs family is represented by three isoforms: TGF-β1, -β2 and -β3, all produced by both glial and neuronal cells. They are involved in essential tissue functions, including cell-cycle control, regulation of early development and differentiation, neuron survival and astrocyte differentiation. TGF-β signaling is mediated mainly by two serine threonine kinase receptors, TGFRI and TGFRII, which activate Smad 2/3 and Smad 4 transcription factors. Phosphorylation and activation of these proteins is followed by formation of Smad 2/3-4 complex, which translocates to the nucleus regulating transcriptional responses to TGF-β. Very few data are available concerning the intracellular pathway required for the effect of TGF-β in brain cells. Recently, emerging data on TGF-β1 and its signaling molecules have been suggesting that besides its role in brain injury, TGF-β1 might be a crucial regulator of CNS development. In this review, we will focus on TGF-βs members, specially TGF-β1, in neuron and astrocyte development. We will discuss some advances concerning the emerging scenario of TGF-β1 and its signaling pathways as putative modulators of astrocyte biology and their implications as a novel mediator of cellular interactions in the CNS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: International Journal of Developmental Neuroscience - Volume 23, Issue 5, August 2005, Pages 413-424
Journal: International Journal of Developmental Neuroscience - Volume 23, Issue 5, August 2005, Pages 413-424
نویسندگان
Flávia Carvalho Alcantara Gomes, Vivian de Oliveira Sousa, Luciana Romão,