Cardioprotective Effects of the Novel Selective Endothelin-A Receptor Antagonist BSF 461314 in Ischemia-Reperfusion Injury

Selective endothelin-A receptor antagonism improved microvascular integrity during postischemic reperfusion. Real-time MCE allows visual and quantitative evaluation of dynamics of myocardial ischemia-reperfusion injury and monitoring of cardioprotective effects during pharmacologic interventions.