کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9989634 | 1580761 | 2005 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The F(abâ²)2 fragment of an Aβ-specific monoclonal antibody reduces Aβ deposits in the brain
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
عصب شناسی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The F(abâ²)2 fragment of an Aβ-specific monoclonal antibody reduces Aβ deposits in the brain The F(abâ²)2 fragment of an Aβ-specific monoclonal antibody reduces Aβ deposits in the brain](/preview/png/9989634.png)
چکیده انگلیسی
This work examines whether administering the F(ab´)2 fragment of an IgG1 monoclonal antibody (mAb) targeting the N-terminal 1-13 amino acids of the β-amyloid peptide (Aβ mAb) reduces amyloid deposition in Alzheimer's disease (AD). The F(abâ²)2 fragment was injected intraperitoneally or intracranially into Tg2576 mice, a murine model of human AD. Both routes of administration significantly reduced Aβ plaque formation in the brain, as determined immunohistochemically and by monitoring levels of Aβ1-40 and Aβ1-42 peptide. Use of the F(abâ²)2 fragment significantly reduced phagocytic infiltration in the CNS when compared to intact mAb. Since IgG1 Abs do not fix complement, these findings suggest that effective in vivo clearance of amyloid deposits can be achieved without stimulation of FcR-reactive phagocytes or activation of the complement cascade.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neurobiology of Disease - Volume 20, Issue 2, November 2005, Pages 541-549
Journal: Neurobiology of Disease - Volume 20, Issue 2, November 2005, Pages 541-549
نویسندگان
Yuichi Tamura, Kenji Hamajima, Kiyohiko Matsui, Shunsuke Yanoma, Masato Narita, NobuyoshiI Tajima, Ke-Qin Xin, Dennis Klinman, Kenji Okuda,