کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9996621 | 1583415 | 2005 | 7 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Comparison of the lipid composition of porcine buccal and esophageal permeability barriers
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کلمات کلیدی
موضوعات مرتبط
علوم پزشکی و سلامت
پزشکی و دندانپزشکی
دندانپزشکی، جراحی دهان و پزشکی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Comparison of the lipid composition of porcine buccal and esophageal permeability barriers Comparison of the lipid composition of porcine buccal and esophageal permeability barriers](/preview/png/9996621.png)
چکیده انگلیسی
The objectives of this work were to characterize the lipid composition of the esophageal mucosa, to compare it to that of the buccal tissue, and to correlate lipid composition with the membranes' permeability to fentanyl. The major lipid classes of buccal and esophageal epithelia were separated and analysed by automated multiple development high-performance thin-layer chromatography (AMD-HPTLC). The two epithelia presented a very similar lipid pattern. In general, there were more polar lipids than non-polar; glycosylceramides were relatively abundant whereas the amount of ceramides present was very small. The flux of fentanyl applied as the citrate in aqueous solution was comparable across the buccal and esophageal barriers. Lipid extraction provoked a significant increase in permeability. In conclusion, this research confirms the suitability of the esophageal mucosa as a model for buccal permeability studies.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Archives of Oral Biology - Volume 50, Issue 12, December 2005, Pages 981-987
Journal: Archives of Oral Biology - Volume 50, Issue 12, December 2005, Pages 981-987
نویسندگان
Isabel Diaz-del Consuelo, Yves Jacques, Gian-Paolo Pizzolato, Richard H. Guy, Françoise Falson,