Keywords: پروتئین پیش ماده β-آمیلوئید; Estrogen-related receptor α; APP/PS1 mice; Amyloidogenesis; Tau phosphorylation; Aβ; amyloid protein; AD; Alzheimer's disease; ADAM10; a disintegrin and metalloproteinase 10; AMPK; AMP-activated protein kinase; APP; β-amyloid precursor protein; APP/PS1
مقالات ISI پروتئین پیش ماده β-آمیلوئید (ترجمه نشده)
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Keywords: پروتئین پیش ماده β-آمیلوئید; PS1 or PS2; presenilin-1 or presenilin-2; AD; Alzheimer's disease; APP; β-amyloid precursor protein; Aβ; amyloid beta peptide; IPTG; Isopropyl β-d-1-thiogalactopyranoside; PMSF; phenylmethylsulfonyl fluoride; FC14; Fos-choline-14; CHS; cholesteryl hemi
Keywords: پروتئین پیش ماده β-آمیلوئید; PD; Parkinson's disease; AD; Alzheimer's disease; EGCG; (â)-Epigallocatechin-3-gallate; NRF2; NF-E2-related factor 2; ROS; reactive oxygen species; H2O2; hydrogen peroxide; ER; endoplasmic reticulum; GPX; glutathione-peroxidase; NOX; NADPH oxidases (NOX
Keywords: پروتئین پیش ماده β-آمیلوئید; Traumatic axonal injury; Diffuse axonal injury; Closed head injury; β-amyloid precursor protein;
Keywords: پروتئین پیش ماده β-آمیلوئید; α-Syn; alpha-synuclein; AD; Alzheimer's disease; ALS; Amyotrophic lateral sclerosis; AMD; Age related macular degeneration; APP; β-amyloid precursor protein; Aβ; Amyloid-beta; Cas; CRISPR associated protein; CRISPR; clustered regularly interspaced shor
Keywords: پروتئین پیش ماده β-آمیلوئید; AD; Alzheimer's disease; ADF; alternate day fasting; ALS; amyotrophic lateral sclerosis; APP; β-amyloid precursor protein; BDNF; brain-derived neurotrophic factor; CER; continuous energy restriction; CR; caloric restriction; CREB; cyclic AMP response e
Keywords: پروتئین پیش ماده β-آمیلوئید; 2,4-D; dichlorophenoxyacetic acid; [35S]TBPS; [35S]tertiary-butylbicyclophosphorothionate; 3-NP; 3-nitropropionic acid; 4CL; 4-coumarate: CoA ligase; 4-O-MH; 4-O-methylhonokiol; 6-OHDA; 6-hydroxydopamine; 8-oxo-dG; 8-oxo-2â²-deoxyguanosine; AChE; acetylc
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ; amyloid-β; AβO; Aβ oligomers; βAPP; β-amyloid precursor protein; BDNF; brain-derived neurotrophic factor; CaMKII; calcium/calmodulin-dependent protein kinase II; Cer; cerebellum; ChAT; choline acetyltransferase; Cx; cortex; CxFr; cortex frontal;
Keywords: پروتئین پیش ماده β-آمیلوئید; AD; Alzheimer׳s disease; ALS; amyotrophic lateral sclerosis; ApoE; apolipoprotein E; AP-1; activator protein-1; β-APP; β-amyloid precursor protein; ATF; activating transcription factor; ATP; adenosine triphosphate; BBB; blood brain barrier; BCSFB; bloo
Keywords: پروتئین پیش ماده β-آمیلوئید; β-APP; β-amyloid precursor protein; CST; corticospinal tract; DC; dorsal column; DLWM; dorsolateral white matter; FITC; fluorescein isothiocyanate; IR; immunoreactivity; MAP-2; microtubule associated protein-2; MBP; myelin basic protein; NF-200; neurofi
Keywords: پروتئین پیش ماده β-آمیلوئید; ANOVA; analysis of variance; CC; corpus callosum; LFP; lateral fluid percussion; NF-H; neurofilament heavy-chain; PFR; peak firing rate; PSTH; peristimulus time histograms; PW; principal whisker; SVZ; subventricular zone; TBI; traumatic brain injury; WDIA
Keywords: پروتئین پیش ماده β-آمیلوئید; AAD; acute axonal degeneration; AIS; axon initial segment; AMPA; α-amino-3-hydroxy-5-methylisoxazole-4-propionate; ankG; ankyrinG; β-APP; β-amyloid precursor protein; CAM; cell adhesion molecule; CAP; compound action potential; Caspr; contactin-associa
Functional significance of O-GlcNAc modification in regulating neuronal properties
Keywords: پروتئین پیش ماده β-آمیلوئید; PTM; post-translational modification; OGT; O-GlcNAc transferase; OGA; O-GlcNAcase; O-GlcNAc; O-linked β-N-acetylglucosamine; UDP-GlcNAc; uridine diphosphate N-acetylglucosamine; GalNAc; N-acetylgalactosamine; Gal; galactose; PSD; postsynaptic density; NF
Soluble Gamma-secretase Modulators Attenuate Alzheimer's β-amyloid Pathology and Induce Conformational Changes in Presenilin 1
Keywords: پروتئین پیش ماده β-آمیلوئید; Alzheimer's disease; β-amyloid; β-amyloid precursor protein; γ-secretase; γ-secretase modulator; Notch;
Downregulation of protein phosphatase 2A by apolipoprotein E: Implications for Alzheimer's disease
Keywords: پروتئین پیش ماده β-آمیلوئید; AD; Alzheimer's disease; APP; β-amyloid precursor protein; ApoE; Apolipoprotein E; SirT1; Sirtuin 1; PP2A; Protein phosphatase-2A; PPP2R5E; regulatory Bâ² subunit of protein phosphatase 2A; PP2AC; catalytic C subunit of protein phosphatase 2A; PME-1; Pr
Protective effects of kinetin against aluminum chloride and D-galactose induced cognitive impairment and oxidative damage in mouse
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ1-42; beta-amyloid protein 1-42; ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's disease; AGEs; advanced glycation end products; AlCl3; aluminum trichloride; APP; β-amyloid precursor protein; CAT; catalase; d-gal; d-galactose; 8-is
Alzheimer's disease: How metal ions define β-amyloid function
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ1â40; β-Amyloid, 40-residue isoform; Aβ1â42; β-Amyloid, 42-residue isoform; Aβ1â42/Aβ1â40; Ratio between levels of Aβ1â42 and Aβ1â40; ADAM; A Disintegrin And Metalloprotease, zinc peptidases, some being α-secretases; AICD; APP intra
Dysregulation of a potassium channel, THIK-1, targeted by caspase-8 accelerates cell shrinkage
Keywords: پروتئین پیش ماده β-آمیلوئید; APP; β-amyloid precursor protein; bioFET; biologically coupled field effect transistor; CASP; caspase; CCD; charge-coupled device; CHX; cycloheximide; DMEM; Dulbecco's Modified Eagle's Medium; EEA1; early endosome antigen 1; EGFP; enhanced green fluoresc
ER and Golgi stresses increase ER-Golgi SNARE Syntaxin5: Implications for organelle stress and βAPP processing
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ peptide; amyloid-β peptide; AD; Alzheimer's disease; BFA; brefeldin A; βAPP; β-amyloid precursor protein; DIV; day in vitro; ELISA; enzyme linked immunosorbent assay; ER; endoplasmic reticulum; SERCA; sarco/endoplasmic reticulum Ca2+-ATPase; siRNA;
The role of copper and the copper-related protein CUTA in mediating APP processing and Aβ generation
Keywords: پروتئین پیش ماده β-آمیلوئید; β-amyloid; β-amyloid precursor protein; Alzheimer's disease; Copper; CutA divalent cation tolerance homolog of E. coli;
Asymmetric dimethylarginine exacerbates Aβ-induced toxicity and oxidative stress in human cell and Caenorhabditis elegans models of Alzheimer disease
Keywords: پروتئین پیش ماده β-آمیلوئید; AD; Alzheimer disease; ADMA; asymmetric dimethylarginine; APP; β-amyloid precursor protein; APPsw; Swedish mutant form of human β-amyloid precursor protein; Aβ; β-amyloid; CSF; cerebrospinal fluid; DDAH; dimethylarginine dimethylaminohydrolase; ERK; e
ER stress response in NG108-15 cells involves upregulation of syntaxin 5 expression and reduced amyloid β peptide secretion
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ peptide; amyloid-β peptide; AD; Alzheimer׳s disease; APP-CTF; C-terminal fragment of β-amyloid precursor protein; BFA; brefeldin A; βAPP; β-amyloid precursor protein; COP; coatmer protein; ER; endoplasmic reticulum; CHX; cyloheximide; CPA; cyclop
Chronic systemic IL-1β exacerbates central neuroinflammation independently of the blood-brain barrier integrity
Keywords: پروتئین پیش ماده β-آمیلوئید; (APP); β-amyloid precursor protein; (BBB); blood-brain barrier; (CSF); cerebrospinal fluid; (EAE); experimental autoimmune encephalomyelitis; (GFAP); glial fibrillary acidic protein; (iv); intravenous; (MHC II); major histocompatibility complex class II;
Purification of pre-miR-29 by arginine-affinity chromatography
Keywords: پروتئین پیش ماده β-آمیلوئید; miRNA; microRNA; RNA; ribonucleic acid; mRNA; messenger RNA; RISC; RNA-induced silencing complex; AD; Alzheimer's disease; Aβ; β-amyloid; APP; β-amyloid precursor protein; BACE1; β-site APP-cleaving enzyme 1; SPE; silica-based solid-phase extraction;
Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death
Keywords: پروتئین پیش ماده β-آمیلوئید; (APP); β-amyloid precursor protein; (AD); Alzheimer's disease; (Tl-AMG); thallium autometallography; (TlDDC); thallium diethyl-dithiocarbamate; (QC); glutaminyl cyclase; (CSD); current source density; (LFP); local field potential; (ICMS); intracortical m
Ferritin light chain interacts with PEN-2 and affects γ-secretase activity
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ; β-amyloid; AD; Alzheimer's disease; APP; β-amyloid precursor protein; CTF; carboxyl-terminal fragment; FTH; ferritin heavy chain; FTL; ferritin light chain; HEK293Swe; HEK293 cells stably expressing human APP Swedish mutations; NICD; notch intracel
Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ; amyloid peptide; AD; Alzheimer's disease; APP; β-amyloid precursor protein; COX-2; cyclooxygenase-2; EGCG; (â)-epigallocatechin-3-gallate; GAPDH; glyceraldehydes-3-phosphate dehydrogenase; ICAM-1; intercellular adhesion molecule-1; icv; intracereb
The γ-secretase inhibitor DAPT increases the levels of gangliosides at neuritic terminals of differentiating PC12 cells
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ; amyloidβ-peptide; AD; Alzheimer disease; APP; β-amyloid precursor protein; ESI; electrospray ionization; GAβ; ganglioside-bound Aβ; LC; liquid chromatography; MRM; multiple reaction monitoring; MS; mass spectrometry; MS/MS; tandem mass spectromet
M1 muscarinic acetylcholine receptor interacts with BACE1 and regulates its proteosomal degradation
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ; β-amyloid; AD; Alzheimer's disease; APP; β-amyloid precursor protein; BACE1; β-site APP cleaving protein 1; HEK-APPSwe; HEK cells stably expressing human APP Swedish mutations; M1 mAChR; M1 muscarinic acetylcholine receptor; mAChRs; muscarinic ace
Research ReportIntraperitoneal injection of JNK-specific inhibitor SP600125 inhibits the expression of presenilin-1 and Notch signaling in mouse brain without induction of apoptosis
Keywords: پروتئین پیش ماده β-آمیلوئید; AD; Alzheimer's disease; APP; β-amyloid precursor protein; DAPI; 4â²-6 diamidino 2-phenylindole dihydrochloride; ERK; Extracellular stimulus-regulated kinase; Ets; Avian erythroblastosis virus E26 oncogene homolog; GAPDH; Glyceraldehyde-3-phosphate dehy
Interleukin-6 is an efficacious marker of axonal transport disruption during experimental glaucoma and stimulates neuritogenesis in cultured retinal ganglion cells
Keywords: پروتئین پیش ماده β-آمیلوئید; 2VO; bilateral occlusion of the common carotid arteries; APP; β-amyloid precursor protein; CNTF; ciliary neurotrophic factor; CTB; cholera toxin β-subunit; IL-1β; interleukin-1β; IL-6; interleukin-6; IOP; intraocular pressure; LPS; lipopolysaccharide;
An age-related axon terminal pathology around the first olfactory relay that involves amyloidogenic protein overexpression without plaque formation
Keywords: پروتئین پیش ماده β-آمیلوئید; AD; Alzheimer's disease; APP; β-amyloid precursor protein; Aβ; β-amyloid peptide; EPL; external plexiform layer; FAD; familial AD; GAP43; growth-associated protein 43; GCL; granule cell layer; GL; glomerular layer; MAP2; microtubule-associated protei
New pyrazolyl and thienyl aminohydantoins as potent BACE1 inhibitors: Exploring the S2â² region
Keywords: پروتئین پیش ماده β-آمیلوئید; AD; Alzheimer's disease; Aβ; β-amyloid peptide; APP; β-amyloid precursor protein; BACE; β-site APP cleaving enzyme; FRET; fluorescence resonance energy transfer; ELISA; enzyme-linked immune sandwich assay; CHO; Chinese hamster ovary; Alzheimer's d
In vitro Pb exposure disturbs the balance between Aβ production and elimination: The role of AβPP and neprilysin
Keywords: پروتئین پیش ماده β-آمیلوئید; Alzheimer's; Neprilysin; Pb; Aβ; β-Amyloid precursor protein; SH-SY5Y cells;
Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events
Keywords: پروتئین پیش ماده β-آمیلوئید; APP; β-amyloid precursor protein; CDS; charcoal/dextran-stripped; ChIP; chromatin immunoprecipitation; FBS; fetal bovine serum; H3-Ac; acetylated histone H3; HDAC; histone deacetylase; HKDM; histone lysine demethylase; H3K4; histone H3 lysine 4; H3K4-2me
ER-stress-inducible Herp, facilitates the degradation of immature nicastrin
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ; amyloid β-protein; AD; Alzheimer's disease; APP; β-amyloid precursor protein; ER; endoplasmic reticulum; ERAD; ER-associated degradation; γ-secretase; Presenilin; Nicastrin; E3 ubiquitin ligase;
Phosphorylation of β-amyloid precursor protein (APP) cytoplasmic tail facilitates amyloidogenic processing during apoptosis
Keywords: پروتئین پیش ماده β-آمیلوئید; AD; Alzheimer's disease; Aβ; β-amyloid peptides; APP; β-amyloid precursor protein; P-APP; β-amyloid precursor protein phosphorylated specifically at threonine residue 668 in cytoplasmic tail (APP-695 numbering); ERK/MAPK; extracellular signal-regulate
Potassium channels in hippocampal neurones are absent in a transgenic but not in a chemical model of Alzheimer's disease
Keywords: پروتئین پیش ماده β-آمیلوئید; aCSF; artificial cerebrospinal fluid; 4-AP; 4-aminopyridine; βAPP; β-amyloid precursor protein; βAP; β-amyloid protein; AD; Alzheimer's disease; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulphonic acid; LC; Lister control; LT; Lister test; SD; Sprag
A quantitative method for comparison of expression of alternatively spliced genes using different primer pairs
Keywords: پروتئین پیش ماده β-آمیلوئید; GPI; glycosyl-phosphatidylinositol; DAF; decay accelerating factor; QPCR; quantitative polymerase chain reaction; kPCR; kinetic polymerase chain reaction; APP; β-amyloid precursor protein; EDC; 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide; GAPDH; glyce
Axonal injury in experimental herpes simplex encephalitis
Keywords: پروتئین پیش ماده β-آمیلوئید; Disorders of the nervous system; Infectious diseases; Axonal injury; β-amyloid precursor protein; Herpes simplex virus; Encephalitis; Microglia; Macrophage;
The expression of p75 neurotrophin receptor protects against the neurotoxicity of soluble oligomers of β-amyloid
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ; β-amyloid; AD; Alzheimer's disease; APP; β-amyloid precursor protein; DD; death domain; JICD; juxtamembrane domain; p75NTR; p75 neurotrophin receptor; PI3K; phosphatidylinositide 3-kinase; AO; acridine orange; EB; ethidium bromide; WT; wortmannin;
Presenilin endoproteolysis is an intramolecular cleavage
Keywords: پروتئین پیش ماده β-آمیلوئید; Aβ; amyloid-β peptide; APP; β-amyloid precursor protein; CTF; C-terminal fragment; ELISA; enzyme-linked immunosorbent assay; FL; full-length; HEK; human embryonic kdney 293; IP; immunoprecipitation; MEF; mouse embryonic fibroblasts; NÎE; Notch ÎE; NC
Antibody-bound β-amyloid precursor protein stimulates the production of tumor necrosis factor-α and monocyte chemoattractant protein-1 by cortical neurons
Keywords: پروتئین پیش ماده β-آمیلوئید; Alzheimer's disease; β-amyloid precursor protein; c-Jun N-terminal protein kinase; Monocyte chemoattractant protein-1; Neuronal death; Tumor necrosis factor-α;