Keywords: FBS; fetal bovine serum; PBS; phosphate buffer saline; DPPC; 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; DPPG; 1,2-dipalmitoyl-sn-glycero-3-phospho-(1â²-rac-glycerol); DODAP; 1,2-dioleoyl-3-dimethylammonium-propane; DLCA; diffusion limited cluster aggre
مقالات ISI (ترجمه نشده)
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Keywords: bioequivalence; metabolite; parent drug; pharmacokinetics; pharmacodynamics; losartan potassium; metabolism; bioavailability; oral absorption; ADME;
Keywords: ADME; Absorption Distribution Metabolism Excretion; ANNs; Artificial Neural Networks; log D; octanol/water distribution coefficient; log P; octanol/water partition coefficient; PAPMA; Parallel Artificial Membrane Permeability Assay; PCA; Principal Compo
Keywords: ADME; absorption, distribution, metabolism, elimination; ATUS; American Time Use Survey; BE; biomonitoring equivalent; BEPOD; biomonitoring equivalent corresponding to the point of departure; BW; body weight; CDC; Centers for Disease Control and Preventio
Keywords: ACToR; Aggregated Computational Toxicology Resource; ADME; Absorption, Distribution, Metabolism, and Elimination; CAS-RN; chemical abstracts service registry number; CBI; confidential business information; CGI; common gateway interface; CHAD; Consolidated
Keywords: ADME; absorption, distribution, metabolism and excretion; A(O)EL; Acceptable (Operator) Exposure Level; BMDL; lower 95% confidence limit of the benchmark dose; HLV; Human Limit Value; MoS; Margin of Safety; NOAEL; No-Observed-Adverse-Effect-Level; OEL; Oc
Keywords: DILI; drug induced liver injury; FDA; Food and Drug Administration; NIH; National Institute of Health; LTKB; Liver Toxicity Knowledge Base; QSAR; quantitative structure activity relationship; ADME; absorption, distribution, metabolism and excretion; ALT;
Keywords: ADME; Absorption, distribution, metabolism and elimination; CVD; Cardiovascular diseases; TTD; Therapeutic Target Database; DT network; Drug-target network; TT network; Target-target network; DD network; Drug-drug network; OB; Oral bioavailability;
Keywords: ADME; clinical pharmacokinetics; drug interactions; membrane transporter; drug metabolizing enzymes; cancer chemotherapy;
Keywords: AAN; aristolochic acid nephropathy; ADME; absorption, distribution, metabolism and excretion; CYT P450; cytochrome P450; DPP-IV; dipeptidyl peptidase IV; GLP1; glucagon like peptide 1; GLUT4; glucose transporter 4; GSH; glutathione; GST; glutathione-S-tra
Keywords: Senolytic; an agent that targets senescent cells; ADME; absorption, distribution, metabolism, and excretion of a drug; SASP; senescence-associated secretory phenotype; mTOR; mammalian target of rapamycin; JAK; Janus-activated kinase; GLP; good laboratory
Keywords: MS; mass spectrometry; UPLC; ultraperformance liquid chromatography; UPLC-ESI-QTOFMS; UPLC-electrospray ionization-quadrupole time-of-flight MS; LCMS; liquid chromatography-mass spectrometry; GCMS; gas chromatography-mass spectrometry; NMR; nuclea
Keywords: ADME; absorption, distribution, metabolism and excretion; 3D; three-dimensional; 3T3; “3-day transfer” mouse fibroblast cell line; AGGR; aggregating brain cell cultures; DIV; day in vitro; EU CLP; European regulation on classification, labelling and p
Keywords: ADME; absorption, distribution, metabolism and excretion; AUC; area under the blood/plasma concentration time curve; BMDL; benchmark dose lower limit; NOAEL; no-observed-adverse-effect level; TK; toxicokinetics; C,t-curve; blood/plasma concentration-time
Keywords: ADC; antibody-drug conjugate; ADME; absorption, distribution, metabolism and elimination; EFD; embryofetal development; ELISA; enzyme-linked immunosorbent assay; FIH; first-in-human; GLP; Good Laboratory Practice; hERG; human ether-Ã -go-go related gene;
Keywords: ADME; DMPK; disposition; distribution; partition coefficients; pharmacokinetics; tissue distribution; toxicology; volume of distribution; safety assessment;
Keywords: ADME; absorption, distribution, metabolism and excretion; ADMET; absorption, distribution, metabolism, excretion and toxicity; FDA; USA Food and Drug Administration; GWAS; genome-wide association study; mTOR; mammalian target of rapamycin; NME; new molecu
Keywords: Keto-enol tautomerism; Tellurouracil; DFT; COSMO-RS; ADME;
Keywords: Animal extrapolation; Preclinical studies; Experimental organism; Prediction; Mechanistic thinking; Ab; Antibody; ADCC; Antibody-Dependent Cell-Mediated Cytotoxicity; ADME; Absorption, Distribution, Metabolism, Excretion; CDC; Complement-Dependent Cytotox
Keywords: ADME; absorption distribution metabolism and excretion; AFP; alpha-fetoprotein; BCLC; Barcelona Clinic Liver Cancer; Chk 1; check point 1; HBV; Hepatitis B Virus; HCC; hepatocellular carcinoma; HCV; Hepatitis C Virus; LT; liver transplatation; NAFLD; nona
Synthesis of novel imidazopyridines and their biological evaluation as potent anticancer agents: A promising candidate for glioblastoma
Keywords: Antiproliferative effect; Comet assay; Flow cytometry; Allene; Heterocyclic chemistry; ADME; INRFCXWTOWNWDJ-UHFFFAOYSA-N; ZMLDNJNPCKLPTJ-UHFFFAOYSA-N; LYJGPJYYRQGSMQ-UHFFFAOYSA-N; YJZACXKDSZKXAC-UHFFFAOYSA-N; MCUUOBZJMYTMGY-UHFFFAOYSA-N; CBOZXBCCVAKTNK-UH
Organ/body-on-a-chip based on microfluidic technology for drug discovery
Keywords: Microfluidic device; Organ-on-a-chip; Body-on-a-chip; Drug discovery; Cell-based assay; Animal testing; ADME;
Pharmacokinetics of bisphenol S in humans after single oral administration
Keywords: Bisphenol S; Oral administration; Human pharmacokinetics; ADME; Pharmacokinetic model;
Development of human biotransformation QSARs and application for PBT assessment refinement
Keywords: In vivo biotransformation; Biotransformation half-life; QSAR; Hazard assessment; Refined PBT assessment; 1-CoPK; one-compartment pharmacokinetic model; AD; Applicability Domain; ADME; Absorption, Distribution, Metabolism and Elimination; B; Bioaccumulati
N-Acylhydrazones as drugs
Keywords: ADME; absorption, distribution, metabolism, excretion; BBNH; N-(4-tert-butylbenzoyl)-2-hydroxy-1-naphthaldehyde hydrazone; BISH; boronyl salicylaldehyde isonicotinoyl hydrazone; DB; drug bank; DHBNH; dihydroxy benzoyl naphthyl hydrazone; FDA; food and dru
Assessing the impact of benzo[a]pyrene with the in vitro fish gut model: An integrated approach for eco-genotoxicological studies
Keywords: NF; naphthoflavone; 3Rs; Replace, Reduce, Refine; ADME; Adsorption, Distribution, Metabolism and Excretion; AHR; Aryl hydrocarbon receptor; AOP; Adverse Outcome Pathway; APH; Acid phosphatase; B[a]P; Benzo[a]pyrene; DMSO; Dimethyl sulfoxide; ECVAM; Europe
Acacia nilotica leaf improves insulin resistance and hyperglycemia associated acute hepatic injury and nephrotoxicity by improving systemic antioxidant status in diabetic mice
Keywords: Keap1; (Kelch-like ECH-associated protein 1); Nrf2; (Nuclear factor erythroid 2-related factor 2); ARE; (antioxidant response element); ADME; (Absorption, distribution, Metabolism, excretion); Catechol (PubChem CID: 289); Pyrogallol (PubChem CID: 1057); P
Galangin's potential as a functional food ingredient
Keywords: Galangin; Propolis; Alpinia officinarum; Functional food ingredient; Polypharmacology; Flavonoid; AChE; acetylcholinesterase; AD; Alzheimer's disease; ADME; Administration, Distribution, Metabolism and Excretion; AHR; airway hyperresponsive; AhR; aryl h
Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists
Keywords: BBB; Blood-Brain Barrier; CB1; Cannabinoid Receptor 1; CB2; Cannabinoid Receptor 2; CHO-K1; Chinese Hamster Ovary Cells; CNS; Central Nervous System; EtOH; ethanol; EtOAc; ethyl acetate; Ke; apparent affinity constant, MDCK-mdr1, Madin-Darby canine kidney
The longevity gene INDY (I'm Not Dead Yet) in metabolic control: Potential as pharmacological target
Keywords: Aak2; 5â²AMP-activated protein kinase catalytic subunit alpha-2; ACC; acetyl CoA carboxylase; Acly; ATP citrate lyase; Adipo-IR; adipose tissue insulin resistance index; ADME; absorption, distribution, metabolism, excretion; AGA; appropriate-for-gestatio
A strategy for systemic toxicity assessment based on non-animal approaches: The Cosmetics Europe Long Range Science Strategy programme
Keywords: ADME; absorption, distribution, metabolism, elimination; AOP; adverse outcome pathway; EFSA; European Food and Safety Agency; EURL ECVAM; European Union Reference Laboratory for Alternatives to Animal Testing; FDA; US Food and Drug Administration; IATA; I
Simultaneous determination of columbianetin-β-d-glucopyranoside and columbianetin in a biological sample by high-performance liquid chromatography with fluorescence detection and identification of other columbianetin-β-d-glucopyranoside metabolites by u
Keywords: Columbianetin-β-d-glucopyranoside; Columbianetin; HPLC-FLD; UPLC-Q-TOF; ADME; Angelicae pubescentis radix;
An integrated computational hierarchy for identification of potent inhibitors against Shikimate Kinase enzyme from Shigella sonnei, a major cause of global dysentery
Keywords: ATP; adenosine triphosphate; SK; Shikimate Kinase; PDB; Protein Data Bank; GOLD; Genetic Optimization for Ligand Docking; VMD; Visual Molecular Dynamics; DS; Discovery Studio; PRDOS; Protein DisOrder prediction System; PK; pharmacokinetics; BBB; blood-bra
Dihydroactinidiolide, a natural product against Aβ25-35 induced toxicity in Neuro2a cells: Synthesis, in silico and in vitro studies
Keywords: Dihydroactinidiolide; Acetylcholinesterase; Alzheimer's disease; ADME; Amyloid β25-35; Neuro2a cells; AChE; Acetylcholinesterase; AChEI; Acetylcholinesterase Inhibitors; AD; Alzheimer's disease; ADME; Absorption Distribution Metabolism Excretion; NO; N
In search of selective 11β-HSD type 1 inhibitors without nephrotoxicity: An approach to resolve the metabolic syndrome by virtual based screening
Keywords: 11β-HSD 1; Virtual screening; PASS toxicity; Lipinski's rule; ADME;
Computational insights into β-site amyloid precursor protein enzyme 1 (BACE1) inhibition by tanshinones and salvianolic acids from Salvia miltiorrhiza via molecular docking simulations
Keywords: Aβ; amyloid β; ADME; absorption distribution metabolism and excretion; ADT; AutoDockTool; APP; amyloid precursor protein; AD; Alzheimer's disease; BACE1; β-site amyloid precursor protein cleaving enzyme 1; n-BuOH; n-butanol; CH2Cl2; dichloromethane;
In vitro to in vivo extrapolation for high throughput prioritization and decision making
Keywords: ADME; chemical absorption, distribution, metabolism, and excretion; AOP; adverse outcome pathway; fu; fraction of chemical unbound; HTS; high throughput screening; IVIVE; in vitro to in vivo extrapolation; PBPK; physiologically based pharmacokinetic; QSAR
In vivo efficacy and pharmacokinetics of bi-aryl oxazolidinone RBx 11760 loaded polylactic acid-polyethylene glycol nanoparticles in mouse hematogenous bronchopneumonia and rat groin abscess caused by Staphylococcus aureus
Keywords: Nanoparticles; PLA-PEG; Oxazolidinone; Staphylococcus aureus; Antibacterial; Nanomedicine; ATCC; American type culture collection; ATR-FTIR; attenuated total reflectance-Fourier transforms infrared spectroscopy; ACN; acetonitrile; ADME; absorption, dist
High-performance liquid chromatography coupled to inductively coupled plasma - Mass spectrometry (HPLC-ICP-MS) for quantitative metabolite profiling of non-metal drugs
Keywords: Quantitative drug metabolite profiling; Inductively coupled plasma - (tandem) mass spectrometry coupled to high-performance liquid chromatography; Spectral interference; Chemical resolution; Chemical derivatization for ICP-MS detection; ICP-MS(/MS); ind
Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment
Keywords: 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti
In silico and in vitro analysis of coumarin derivative induced anticancer effects by undergoing intrinsic pathway mediated apoptosis in human stomach cancer
Keywords: SBC; Apoptosis; Docking; ADME; Stomach cancer cell line (AGS); Anti-proliferative; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide; ADME; absorption, distribution, metabolism and excretion; FBS; fetal bovine serum; RPMI; rosewell park m
Combined QSAR, molecular docking and molecular dynamics study on new Acetylcholinesterase and Butyrylcholinesterase inhibitors
Keywords: AChE/BuChE; ADME; Molecular docking; Molecular dynamics; QSAR;
Establishing a systematic framework to characterise in vitro methods for human hepatic metabolic clearance
Keywords: Toxicokinetics; In vitro hepatic metabolic clearance; ADME; New approach methodology; Chemical risk assessment;
Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction
Keywords: Pharmacokinetics; Benzo[a]pyrene; Accelerator mass spectrometry; Dietary polycyclic aromatic hydrocarbons; ADME; absorption distribution metabolism and excretion; AFB1; aflatoxin B1; AMS; accelerator mass spectrometry; ATDSR; Agency for Toxic Substances a
Role of efflux transporters in the absorption, distribution and elimination in rodents of a novel PDE4 inhibitor, CHF6001
Keywords: ADME; absorption, distribution, metabolism and excretion; AUC0-t(last); area under the concentration-time curve up to the last measurable concentration; AUCinf; area under the concentration-time curve up to infinity; AUCÏ; area under the concentration-ti
Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum
Keywords: Physiologically-based kinetic (PBK) modelling; Hazard and risk assessment; Weight-of-evidence (WoE); Threshold of toxicological concern (TTC); In vitro to in vivo extrapolation (IVIVE); Integrated approach for testing and assessment (IATA); Absorption; Di
Imaging techniques to study drug transporter function in vivo
Keywords: ABC; ATP-binding cassette; AD; Alzheimer's disease; ADME; absorption, distribution, metabolism and elimination; ATP; adenosine triphosphate; AUC; area under the curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BPND; non-displaceabl
Evolution of clinical and environmental health applications of exhaled breath research: Review of methods and instrumentation for gas-phase, condensate, and aerosols
Keywords: Breath research; Exhaled breath condensate (EBC); Exhaled breath aerosol (EBA); Volatile organic compounds (VOCs); Analytical techniques; Biomarkers; 1D; one-dimensional; ADME; absorption, distribution, metabolism, and excretion; AOP; adverse outcome path
“The dose makes the poison”: Key implications for mode of action (mechanistic) research in a 21st century toxicology paradigm
Keywords: Kinetically-derived Maximum Dose (KMD); Maximum Tolerated Dose (MTD); Linear-No-Threshold (LNT); ADME; Saturated metabolism; Mode of action;
Automation of plasma protein binding assay using rapid equilibrium dialysis device and Tecan workstation
Keywords: High-throughput plasma protein binding assay; ADME; RED device; Tecan workstation;