دانلود مقالات ISI درباره Adme + ترجمه فارسی

Pyrazole clubbed triazolo[1,5-a]pyrimidine hybrids as an anti-tubercular agents: Synthesis, in vitro screening and molecular docking study

Keywords: Triazolopyrimidine; Diaryl pyrazole aldehydes; Glide; Enzyme inhibition assay; ADME;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

A physiologically based toxicokinetic (PBTK) model for moderately hydrophobic organic chemicals in the European eel (Anguilla anguilla)

Keywords: ADME; BCF; Bioconcentration; Organic pollutants; PBTK;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

A Paradigm Shift in Pharmacokinetic-Pharmacodynamic (PKPD) Modeling: Rule of Thumb for Estimating Free Drug Level in Tissue Compared with Plasma to Guide Drug Design

Keywords: ADME; unbound fraction; pharmacokinetics; pharmacodynamics; disposition; distribution; partition coefficients; PBPK; PKPD;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Piperlongumine for Enhancing Oral Bioavailability and Cytotoxicity of Docetaxel in Triple-Negative Breast Cancer

Keywords: ADME; absorption enhancer; bioavailability; Caco-2 cells; cytochrome P450; drug interactions; efflux pumps; preclinical pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Preclinical Pharmacokinetics and In Vitro Metabolism of Asunaprevir (BMS-650032), a Potent Hepatitis C Virus NS3 Protease Inhibitor

Keywords: ADME; antiinfectives; in vitro/in vivo correlations (IVIVC); disposition; hepatic clearance; clearance; metabolism; P-glycoprotein; pharmacokinetics; bioavailability

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Utilizing Physiologically Based Pharmacokinetic Modeling to Inform Formulation and Clinical Development for a Compound with pH-Dependent Solubility

Keywords: absorption; disposition; pharmacokinetics; ADME; physiological model;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

New insights into the bioavailability of red raspberry anthocyanins and ellagitannins

Keywords: ADME; absorption, disposition, metabolism and excretion; Cmax; peak plasma concentration; CID; collision-induced dissociation; ESI; electrospray interface; GIT; gastrointestinal tract; PDA; photodiode array; Tmax; time to reach peak plasma concentration;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Use of physiologically based kinetic (PBK) modeling to study interindividual human variation and species differences in plasma concentrations of quercetin and its metabolites

Keywords: PBK; physiologically based kinetic; AUC; area under the curve; ADME; absorption, distribution, metabolism, excretion; Q4′Gly; quercetin-4′-O-glucoside; Q34′diGly; quercetin-3,4′-O-diglucoside; DMSO; dimethyl sulfoxide; Quercetin; Absorption distri

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Towards the evaluation in an animal disease model: Fluorinated 17β-HSD1 inhibitors showing strong activity towards both the human and the rat enzyme

Keywords: 17β-Hydroxysteroid dehydrogenase type 1; Interspecies differences; Estrogen-dependent diseases; Estrogen mimetics; Non-steroidal inhibitors; 17β-HSD1; 17β-hydroxysteroid dehydrogenase type 1; 17β-HSD2; 17β-hydroxysteroid dehydrogenase type 2; E1; est

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

Quantitative in vitro to in vivo extrapolation of tissues toxicity

Keywords: ADME; absorption, distribution, metabolism, and excretion; ARE; antioxidant responses elements; BBB; blood brain barrier; CsA; cyclosporine A; CYP; cytochrome P450; EPA; Environmental Protection Agency; GCL; glutamate cysteine ligase; GCLC; glutamate cyst

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Prediction of Drug Distribution in Subcutaneous Xenografts of Human Tumor Cell Lines and Healthy Tissues in Mouse: Application of the Tissue Composition-Based Model to Antineoplastic Drugs

Keywords: ADME; chemotherapy; oncology; disposition; distribution; partition coefficients; pharmacokinetics; PBPK modeling; tumor; xenograft;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Toxicology of wear particles of cobalt-chromium alloy metal-on-metal hip implants Part II: Importance of physicochemical properties and dose in animal and in vitro studies as a basis for risk assessment

Keywords: MoM; Metal-on-metal; CoCr; Cobalt-chromium-molybdenum alloy; Co; Cobalt; Cr; Chromium; ADME; Absorption, distribution, metabolism, and excretion; ALVAL; Aseptic lymphocyte dominated vasculitis associated lesion; NAS; National Academy of Sciences; LOAEL; L

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2015 سفارش ترجمه

In vivo toxicity studies of fusarium mycotoxins in the last decade: A review

Keywords: ADME; absorption, distribution, metabolism and excretion; AFs; aflatoxins; ALT; alanine aminotransferase; HFB1; aminopentol; AS; aluminosilicate; AST; aspartate aminotransferase; AUC; area under curve; BEA; beauvericin; bw; body weight; CAT; catalase; CYP

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2015 سفارش ترجمه

Recent progresses in the exploration of machine learning methods as in-silico ADME prediction tools

Keywords: ADME; Absorption; Distribution; Metabolism; Excretion; Drug discovery; Machine learning; Molecular descriptors; QSAR;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2015 سفارش ترجمه

Estimation of the chemical-induced eye injury using a weight-of-evidence (WoE) battery of 21 artificial neural network (ANN) c-QSAR models (QSAR-21): Part I: Irritation potential

Keywords: 3Rs; refinement, reduction and replacement; AD; applicability domain; ADME; absorption, distribution, metabolism, and excretion; ANN; artificial neural network; ANNE; artificial neural network ensemble; Architecture; particular combination of neurons and

دانلود رایگان متن کامل مقاله ISI 44 صفحه سال انتشار : 2015 سفارش ترجمه

Optimization of a novel series of N-phenylindoline-5-sulfonamide-based acyl CoA:monoacylglycerol acyltransferase-2 inhibitors: Mitigation of CYP3A4 time-dependent inhibition and phototoxic liabilities

Keywords: ACAT; acyl CoA:cholesterol acyltransferase; ADME; absorption, distribution, metabolism and excretion; APCI; atomospheric pressure chemical ionization; CM; chylomicron; dba; dibenzylideneacetone; CYP; cytochrome P450; DDI; drug-drug interaction; DGAT; ac

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2015 سفارش ترجمه

Deuteration and fluorination of 1,3-bis(2-phenylethyl)pyrimidine-2,4,6(1H,3H,5H)-trione to improve its pharmacokinetic properties

Keywords: ADME; absorption, distribution, metabolism, excretion; ALS; amyotrophic lateral sclerosis; PYT; pyrimidine 2,4,6-trione; Pyrimidine-2,4,6-triones (PYT); Amyotrophic lateral sclerosis (ALS); Fluorination; Deuteration; ADME; Microsome stability; Pharmacokin

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2014 سفارش ترجمه

In silico identification of potent inhibitors of alpha-synuclein aggregation and its in vivo evaluation using MPTP induced Parkinson mice model

Keywords: Parkinson disease; Alpha-synuclein; ADME; Toxicity; Docking; CNB-001; MPTP

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

Comparison of MDCK-MDR1 and Caco-2 cell based permeability assays for anti-malarial drug screening and drug investigations

Keywords: MDCK; Madin-Darby canine kidney; MDR1; multi-drug resistance gene 1; Caco-2; colorectal adenocarcinoma; P-gp; P-glycoprotein; Papp; permeability coefficient; PAPMA; parallel artificial membrane permeability assay; LC-MS; liquid chromatography-mass spe

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in pigs

Keywords: 3-ADON; 3-acetyl-deoxynivalenol; 15-ADON; 15-acetyl-deoxynivalenol; b.w.; body weight; D3G; deoxynivalenol-3-β-d-glucoside; DON; deoxynivalenol; DON-3-GlcA; deoxynivalenol-3-glucuronide; DON-15-GlcA; deoxynivalenol-15-glucuronide; DON-GlcA; deoxynivaleno

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Orally Administered DTPA Penta-Ethyl Ester for the Decorporation of Inhaled 241Am

Keywords: ADME; chelation; oral absorption; pharmacokinetics; prodrugs;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

microRNA-34a is associated with expression of key hepatic transcription factors and cytochromes P450

Keywords: miRNA; microRNA; DME; drug metabolizing enzyme; CYP; cytochrome P450; ADME; absorption, disposition, metabolism and elimination; TF; transcription factor; PCT; probability of conserved targeting for highly conserved miRNA families; microRNA; Hepatic; Cyto

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Straightforward entry to pyrido[2,3-d]pyrimidine-2,4(1H,3H)-diones and their ADME properties

Keywords: Pyridopyrimidines; Pyrimidinediones; Pyrimidines; ADME

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Prenatal xenobiotic exposure and intrauterine hypothalamus-pituitary-adrenal axis programming alteration

Keywords: ADME; absorption distribution, metabolism and excretion; AHH; aryl hydrocarbon hydroxylase; CRH; corticotrophin-releasing hormone; CYP; cytochrome P450; DOHaD; developmental origins of health and disease; ECOD; 7-ethoxycoumarin O-deethylase; EROD; 7-ethox

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Applications of a 7-day Caco-2 cell model in drug discovery and development

Keywords: Caco-2 permeability; Lead optimization (LO); Absorption modeling and prediction; 7-day Caco-2 assay; Prodrug; ADME

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Quantification of biliary excretion and sinusoidal excretion of 5(6)-carboxy-2′,7′-dichlorofluorescein (CDF) in cultured hepatocytes isolated from Sprague Dawley, Wistar and Mrp2-deficient Wistar (TR−) rats

Keywords: BC; bile canaliculae; CDF; 5(6)-carboxy-2′,7′-dichlorofluorescein; CDF-DA; CDF-diacetate; abcc1-6; ATP-binding cassette, sub-family C (CFTR/MRP) member 1-6; Mrp1-6; multidrug resistance associated protein 1-6; BEI; biliary excretion index; Oatp; organ

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Preclinical Pharmacokinetics and In Vitro Metabolism of BMS-605339: A Novel HCV NS3 Protease Inhibitor

Keywords: preclinical pharmacokinetics; oral absorption; metabolism; hepatic clearance; in vitro/in vivo correlations (IVIVC); ADME; protease;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Discovery and optimization of novel small-molecule HIV-1 entry inhibitors using field-based virtual screening and bioisosteric replacement

Keywords: ADME; absorption, distribution, metabolism, and excretion; AMLV; amphotropic murine leukemia virus; BBB; blood-brain barrier; BIF; bioisostere factor; CNS; central nervous system; DCM; dichloromethane; DiEA; diisopropylethylamine; DIPEA; N,N-diisopropyl

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2014 سفارش ترجمه

The Combination of MK-5172, Peginterferon, and Ribavirin Is Effective in Treatment-Naive Patients With Hepatitis C Virus Genotype 1 Infection Without Cirrhosis

Keywords: Response-Guided Therapy; Sustained Virologic Response; Chronic HCV; Protease Inhibitor; ADME; absorption, distribution, metabolism, and excretion; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BOC; boceprevir; cEVR; complete early virolo

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2014 سفارش ترجمه

An antioxidant, N,N′-diphenyl-p-phenylenediamine (DPPD), affects labor and delivery in rats: A 28-day repeated dose test and reproduction/developmental toxicity test

Keywords: ADME; absorption, distribution, metabolism, and excretion; COX; cyclooxygenase; DPPD; N,N′-diphenyl-p-phenylenediamine; HPV; high production volume; NSAID; non-steroidal anti-inflammatory drug; OECD; Organisation for Economic Co-operation and Developmen

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Potential sources of high value chemicals from leaves, stems and flowers of Miscanthus sinensis 'Goliath' and Miscanthus sacchariflorus

Keywords: Miscanthus sinensis; Miscanthus sacchariflorus; hydroxybenzoic acids; hydroxycinnamate esters; high-value chemicals; ADME; absorption, distribution, metabolism, excretion; CADPE; 2-(3,4-dihydroxyphenyl)ethyl caffeate; CAPE; 2-phenylethyl caffeate; 2-CaffH

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Effect of combining in vitro estrogenicity data with kinetic characteristics of estrogenic compounds on the in vivo predictive value

Keywords: ADME; absorption distribution metabolism and excretion; BPA; bisphenol A; EE2; 17α-ethinylestradiol; EE2EF; EE2 equivalence factor based on in vitro determined estrogenic potency; EE2EFcorr; EE2EF corrected for differences in hepatic clearance relative t

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Toxicokinetics as a key to the integrated toxicity risk assessment based primarily on non-animal approaches

Keywords: Physiologically based toxicokinetic modelling; Alternative methods validation; In vitro; In silico; ADME;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Ibuprofen plus isosorbide dinitrate treatment in the mdx mice ameliorates dystrophic heart structure

Keywords: IBU; ibuprofen; ISDN; isosorbide dinitrate; WT; wild type; DMD; Duchenne muscular dystrophy; nNOS; neuronal nitric oxide synthase; NO; nitric oxide; cGMP; Guanosine 3′,5′ cyclic phosphate; NSAID; non steroidal anti-inflammatory drug; PET; positron emi

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Trigger values for investigation of hormonal activity in drinking water and its sources using CALUX bioassays

Keywords: ADI; Acceptable Daily Intake; ADME; Absorption, Distribution, Metabolism, Excretion; AR; Androgen Receptor; BQ; Benchmark Quotient; DEX; Dexamethasone; DHT; Dihydrotestosterone; DMSO; Dimethylsulfoxide; E1; Estrone; E2; 17β-Estradiol; EE2; 17α-Ethinyles

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

A Pulsed Tangential-Flow Ultrafiltration Technique for Studying Protein-Drug Binding

Keywords: albumin; analytical chemistry; protein binding; ADME; analysis; bioavailability; diffusion; transport; analytical biochemistry; drug interactions;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: New set of data for predictive in silico ADME models

Keywords: ADME; absorption distribution metabolism and excretion; AEDs; antiepileptic drugs; AUC; area under the plasma drug concentration-time curve; BBB; blood-brain barrier; CBZ; carbamazepine; CBZ-E; carbamazepine-10,11-epoxide; Cmax; maximum peak concentra

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and SAR studies of 5-(pyridin-4-yl)-1,3,4-thiadiazol-2-amine derivatives as potent inhibitors of Bloom helicase

Keywords: BLM; Bloom helicase; SAR; structure activity relationship; HTS; high throughput screen; ADME; absorption, distribution, metabolism and excretion; MLM; mouse liver microsomes; NADPH; nicotinamide adenine dinucleotide phosphate; PBS; phosphate buffered sali

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2013 سفارش ترجمه

Tetrazole-based deoxyamodiaquines: Synthesis, ADME/PK profiling and pharmacological evaluation as potential antimalarial agents

Keywords: ADME; absorption distribution metabolism excretion; HPLC; High pressure liquid chromatography; LC-MS; Liquid chromatography mass spectrometry; LORA; Low Oxygen Recovery Assay; MABA; Microplate Alamar Blue Assay; TMSN3; trimethylsilyl azide; Antiplasmodi

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2013 سفارش ترجمه

Cytochrome P450 enzymes in drug metabolism: Regulation of gene expression, enzyme activities, and impact of genetic variation

Keywords: Biotransformation; Cytochrome P450 monooxygenase; NADPH:cytochrome P450 reductase; Pharmacogenetics; Polymorphism; Xenobiotic; ADME; absorption, distribution, metabolism, excretion; ADR; adverse drug reaction; AhR; aromatic hydrocarbon receptor; CNV; copy

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2013 سفارش ترجمه

AFN-1252 in vitro absorption studies and pharmacokinetics following microdosing in healthy subjects

Keywords: AFN-1252; Staphylococcus aureus; FabI inhibitor; ADME; Phase 0

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Involvement of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Gastrointestinal Absorption of Metformin

Keywords: oral absorption; organic cation transporter; pharmacokinetics; ADME; drug transport; renal excretion

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Investigation of the role of transporters on the hepatic elimination of an LAT1 selective inhibitor JPH203

Keywords: ADME; biliary excretion; bioavailability; cancer chemotherapy; hepatocytes; transporters

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis, pharmacological assessment, and molecular modeling of 6-chloro-pyridonepezils: New dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease

Keywords: hAChE; hBuChE; Dual AChE inhibitors; 6-Chloro-pyridonepezils; In vitro blood brain barrier; Molecular modeling; ADME; Alzheimer's disease

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Computer-aided identification of EGFR tyrosine kinase inhibitors using ginsenosides from Panax ginseng

Keywords: Panax ginseng; Ginsenosides; EGFR; Pharmacophore; ADME; Insilco

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Qualitative and quantitative mass spectrometry imaging of drugs and metabolites

Keywords: ADME; Spatial distribution; Quantitative mass spectrometry; PK/PD; Molecular imaging; Pharmaceuticals

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Development of a Hybrid Physiologically Based Pharmacokinetic Model with Drug‐Specific Scaling Factors in Rat to Improve Prediction of Human Pharmacokinetics

Keywords: ADME; in vitro‐in vivo extrapolation (IVIVE); metabolic clearance; modeling and simulation; PBPK modeling; pharmacokinetics; physiological model; prediction of human pharmacokinetics; simulations; translational research;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Time-Dependent Interaction of Ritonavir in Chronic Use: The Power Balance Between Inhibition and Induction of P-Glycoprotein and Cytochrome P450 3A

Keywords: ADME; bioavailability; cytochrome P450; disposition; drug interaction; intestinal absorption; P-glycoprotein; pharmacokinetics;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Quantitative Atlas of Blood–Brain Barrier Transporters, Receptors, and Tight Junction Proteins in Rats and Common Marmoset

Keywords: blood–brain barrier; membrane transporter; proteomics; multidrug resistance transporters; P-glycoprotein; receptors; tight junction; permeability; ADME; preclinical pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Correlation of Tissue-Plasma Partition Coefficients Between Normal Tissues and Subcutaneous Xenografts of Human Tumor Cell Lines in Mouse as a Prediction Tool of Drug Penetration in Tumors

Keywords: ADME; chemotherapy; oncology; disposition; distribution; partition coefficients; pharmacokinetics; PBPK modeling; xenograft;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه