دانلود مقالات ISI درباره Adme + ترجمه فارسی

Keeping a Critical Eye on the Science and the Regulation of Oral Drug Absorption: A Review

Keywords: gastrointestinal transit; solubility; permeability; oral absorption; bioavailability; bioequivalence; ADME; BCS; BDDCS

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2013 سفارش ترجمه

Computer-assisted assessment of potentially useful non-peptide HIV-1 protease inhibitors

Keywords: HIV-1 protease; Non-peptide inhibitors; MIA-QSAR; ADME; Docking;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Consensus hologram QSAR modeling for the prediction of human intestinal absorption

Keywords: ADME; Consensus prediction; Hologram QSAR; Human intestinal absorption; Virtual screening

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: From in silico screening to cyclodextrin formulation

Keywords: Angiogenesis; Kinase; Zebrafish; ADME;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

In search for new chemical entities as adenosine receptor ligands: Development of agents based on benzo-γ-pyrone skeleton

Keywords: Chromone carboxamides; Adenosine receptor ligands; SAR; ADME;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Pyridonepezils, new dual AChE inhibitors as potential drugs for the treatment of Alzheimer's disease: Synthesis, biological assessment, and molecular modeling

Keywords: Pyridonepezils; hAChE; hBuChE; Dual AChE inhibitors; In vitro blood brain barrier; Molecular modeling; ADME; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Identification and validation of bioactive small molecule target through phenotypic screening

Keywords: ADME; absorption, distribution, metabolism, and excretion; CsA; cyclosporin A; HBC; 4-[3,5-bis-[2-(4-hydroxy-3-methoxy-phenyl)-ethyl]-4,5-dihydro-pyrazol-1-yl]-benzoic acid; HDAC; histone deacetylase; HUVEC; human umbilical vascular endothelial cell; KF;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Determination of n-octanol/water partition coefficients of weak ionizable solutes by RP-HPLC with neutral model compounds

Keywords: Kow; n-Octanol/water partition coefficient; RP-HPLC; Reversed-phase high performance liquid chromatography; kw; P-HPLC retention factor of the solute corresponding to the neat aqueous fraction of mobile phase; Kow″; Apparent n-octanol/water partition co

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Metabolism of the masked mycotoxin deoxynivalenol-3-glucoside in rats

Keywords: D3G; deoxynivalenol-3-β-d-glucoside; DON; deoxynivalenol; JECFA; Joint FAO/WHO Expert Committee on Food Additives; DOM-1; de-epoxy deoxynivalenol; DON-GlcA; deoxynivalenol-glucuronide; DOM-1-GlcA; DOM-1-glucuronide; b.w.; body weight; SPE; solid phase ex

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Use of toxicokinetics to support chemical evaluation: Informing high dose selection and study interpretation

Keywords: ADME; Toxicokinetics; Dose selection; Blood sampling; 3Rs; Risk assessment;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Regulatory Review of Acetaminophen Clinical Pharmacology in Young Pediatric Patients

Keywords: ADME; clinical pharmacokinetics; disposition; metabolism; pediatric; pharamcokinetics; pharmacodynamics; pharmacokinetics/pharmacodynamics;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Approach to Improve Compound Recovery in a High-Throughput Caco-2 Permeability Assay Supported by Liquid Chromatography-Tandem Mass Spectrometry

Keywords: adsorption; Caco-2; high-throughput; permeability; ADME; recovery; nonspecific binding; LC-MS/MS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design

Keywords: Metabolic stability; Human liver microsomes; Human hepatocytes; Intrinsic clearance; Hepatic transporters; Drug discovery; ADME; Absorption, distribution, metabolism, and excretion; AO; Aldehyde oxidase; BCRP; Breast cancer resistance protein; CYP; Cytoch

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Impact of Recovery on Fraction Unbound Using Equilibrium Dialysis

Keywords: plasma protein binding; brain homogenate binding; equilibrium dialysis; recovery; stability; nonspecific binding; simulation; ADME;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

The design, synthesis, in silico ADME profiling, antiplasmodial and antimycobacterial evaluation of new arylamino quinoline derivatives

Keywords: Antiplasmodial; Antimycobacterial; Arylamino quinoline tetrazoles; Physico-chemical properties; LGCCUMAZYNMYQJ-UHFFFAOYSA-N; ASBQKDGGVSELGK-UHFFFAOYSA-N; ULKYZCWFSKRIAW-UHFFFAOYSA-N; AWAMGPBRYIMAJY-UHFFFAOYSA-N; SZMJVGJCALVYFM-UHFFFAOYSA-N; NUXYBKNVYZESNU

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

A structured approach to Exposure Based Waiving of human health endpoints under REACH developed in the OSIRIS project

Keywords: ADME; absorption, distribution, metabolism, excretion; DNEL; Derived no effect level; EBW; Exposure Based Waiving; EBT; Exposure Based Triggering; ITS; Integrated testing strategy; KOW; n-octanol-water partition coefficient; MMAD; Mass median aerodynami

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Metastatic disease: A drug discovery perspective

Keywords: GEMM; genetically engineered mouse models; ADME; absorption, distribution, metabolism and excretion; PK; pharmacodynamics; ECM; extracellular matrix; EMT; epithelial-mesenchymal transition; MET; mesenchymal-epithelial transition; NSCLC; non-small cell

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Compatibility art of traditional Chinese medicine: From the perspective of herb pairs

Keywords: ADME; absorption, distribution, metabolism and excretion; APL; acute promyelocytic leukemia; CHM; Chinese herbal medicine; CYP2E1; Cytochrome P450 2E1; dl-THP; dl-tetrahydropalmatine; HIF1α; hypoxia-inducible factor-1alpha; HUVECs; human umbilical vascul

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Advancing Prediction of Tissue Distribution and Volume of Distribution of Highly Lipophilic Compounds from a Simplified Tissue-Composition-Based Model as a Mechanistic Animal Alternative Method

Keywords: animal alternative; ADME; disposition; distribution; volume of distribution; pharmacokinetics; protein binding; unbound fraction; PBPK; first-time-in-human;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Oral Coadministration of β-Glucuronidase to Increase Exposure of Extensively Glucuronidated Drugs that Undergo Enterohepatic Recirculation

Keywords: β-glucuronidase; enterohepatic circulation; glucuronidation; site-specific delivery; intestinal metabolism; oral absorption; ADME; pharmacokinetics; intestinal absorption; bioavailability;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

In Vitro Measurement of Drug Efficiency Index to Aid Early Lead Optimization

Keywords: ADME; biomimetics; HPLC (high-performance/pressure liquid chromatography); log P; protein binding; phospholipids; tissue partition; drug-like properties;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Administration, distribution, metabolism and elimination of polymer therapeutics

Keywords: Polymer therapeutics; Angiogenesis; ADME; Biodistribution; Angiogenesis-dependent diseases; Cancer

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Application of pharmacokinetics-pharmacodynamics/clinical response modeling and simulation for biologics drug development

Keywords: ADME; pharmacokinetics; pharmacodynamics; pharmacokinetic/pharmacodynamic models; physiological model;

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Impact of the Pharmaceutical Sciences on Health Care: A Reflection over the Past 50 Years

Keywords: drug design; drug formulation; ADME; pharmacokinetics/pharmacodynamics; drug regulatory; drug utilization;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2012 سفارش ترجمه

DEHP: Genotoxicity and potential carcinogenic mechanisms-A review

Keywords: ADME; absorption, distribution, metabolism and elimination; CAR; constitutive androstane receptor; CERHR; NTP Center for the Evaluation of Risks to Human Reproduction; CHO; Chinese hamster ovary; CYP; cytochrome p450; CpG; cytosine guanine dinucleotide; D

دانلود رایگان متن کامل مقاله ISI 76 صفحه سال انتشار : 2012 سفارش ترجمه

Ivermectin Interacts With Human ABCG2

Keywords: BCRP; macrocyclic lactones; ADME; toxicity; ABC transporter

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors

Keywords: Histone deacetylase; HDAC; Inhibitor; Isoform; Anticancer; In vitro activity; Docking study; ADME

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Drug Delivery Trends in Clinical Trials and Translational Medicine: Evaluation of Pharmacokinetic Properties in Special Populations

Keywords: pharmacokinetics; pharmacokinetics/pharmacodynamics; physiological model; population pharmacokinetics/pharmacodynamics; pediatric; elderly; inclusions; ADME; clinical pharmacokinetics

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties

Keywords: Farnesoid X receptor agonist; FXR; Nuclear receptor; Lead optimization; ADME; X-ray structure

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

The use of molecular fluorescent markers to monitor absorption and distribution of xenobiotics in a silkworm model

Keywords: Silk; Xenobiotic; ADME; Tissue engineering

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Absorption, distribution, metabolism, and excretion of [1-14C]-perfluorohexanoate ([14C]-PFHx) in rats and mice

Keywords: Perfluorohexanoate; ADME; Perfluoroalkyl; Tissue distribution

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

An Integrated Pharmacokinetic Model for the Influence of CYP3A4 Expression on the In Vivo Disposition of Lopinavir and Its Modulation by Ritonavir

Keywords: drug metabolizing enzymes; drug interactions; ADME; bioavailability; computational ADME; cytochrome P450;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Identification of novel selective antagonists for cyclin C by homology modeling and virtual screening

Keywords: Cyclin-dependent kinase; Cyclin C; Homology modeling; Virtual screening; ADME

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Structural characterization of inhibitor complexes with checkpoint kinase 2 (Chk2), a drug target for cancer therapy

Keywords: ADME; adsorption, distribution, metabolism, and elimination; ADP; adenosine diphosphatase; ATM; ataxia telangiectasia mutated; ATP; adenosine triphosphate; ATR; ataxia telangiectasia and Rad3 related; BRCA1; breast cancer 1; Cdc25a; cell division cycle 25

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Susceptibility to Amoxicillin-Clavulanate-Induced Liver Injury Is Influenced by Multiple HLA Class I and II Alleles

Keywords: Hepatotoxicity; Genome-Wide Association Study; GWAS; Pharmacogenomics; AC; amoxicillin-clavulanate; AC-DILI; DILI following AC administration; ADME; drug absorption, distribution, metabolism, and excretion; ALP; alkaline phosphatase; ALT; alanine transami

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Structural Features Determining the Intestinal Epithelial Permeability and Efflux of Novel HIV-1 Protease Inhibitors

Keywords: Absorption; ADME; Caco-2 cells; Drug design; Drug transport; HIV/AIDS; Intestinal absorption; Passive diffusion/transport; P-glycoprotein; Permeability

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

The influence of dissolution conditions on the drug ADME phenomena

Keywords: Dissolution; Pharmacokinetic modeling; Enteric coated; ADME

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Extraction of tacit knowledge from large ADME data sets via pairwise analysis

Keywords: Pairwise; ADME; Activity cliff; Switch; HLM; Permeability; MDCK; P-gp; MDR1; Lipophilicity; Log D; SAR

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Development of a new permeability assay using low‐efflux MDCKII cells

Keywords: absorption; P‐glycoprotein; ADME; drug transport; in vitro models; bioavailability; LC-MS; Biopharmaceutics Classification System (BCS); cell culture; MDCK cells; transporters;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

The Permeation of Neutral Molecules, Ions, and Ionic Species Through Membranes: Brain Permeation as an Example

Keywords: absorption; ADME; blood-brain barrier; membrane transport; passive diffusion/transport; permeability; physicochemical properties;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125

Keywords: DPP-4; Dipeptidyl peptidase IV; GLP-1; Glucagon-like peptide 1; SAR; Structure-activity relationship; AcOH; Acetic acid; DIBAL-H; Diisobutylaluminum hydride; Boc; tert-Butoxy carbonyl; TMSCN; Trimethylsilyl cyanide; TBAF; Tetrabutylammonium fluoride; mC

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2011 سفارش ترجمه

Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease

Keywords: Acetylcholinesterase inhibitors; Butyrylcholinesterase inhibitors; Quinolizidine derivatives; Bi- and tricyclic systems derivatives; Single-entity multi-target agents; Aβ; β-amyloid; ACh; acetylcholine; AChE; acetylcholinesterase; AD; Alzheimer's dise

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2011 سفارش ترجمه

Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors

Keywords: ADME; absorption, distribution, metabolism, and excretion; ADI; Acceptable Daily Intake; Colipa; the European Cosmetic Toiletry and Perfumery Association; CYPs; cytochrome P450s; DNEL; Derived No Effect Level; DG; Directorate General; ECHA; EU Chemicals A

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2011 سفارش ترجمه

Lipophilicity study of some non-steroidal anti-inflammatory agents and cephalosporin antibiotics: A review

Keywords: 13C NMR; carbon nuclear magnetic resonance; 1H NMR; proton nuclear magnetic resonance; ADME; absorption distribution metabolism elimination; AID; adjuvant induced disease; AUC; plasma-time curve; BBB; blood-brain barrier; BMC; biopartitioning micellar

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2011 سفارش ترجمه

Influence of Drug Transport Proteins on the Pharmacokinetics and Drug Interactions of Hiv Protease Inhibitors

Keywords: ABC transporters; ADME; drug transport; HIV/AIDS; organic anion-transporting polypeptide transporters; pharmacokinetics/pharmacodynamics

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2011 سفارش ترجمه

Challenges in inhaled product development and opportunities for open innovation

Keywords: Aerosol dosimetry; Deposition; Inhalation toxicology; ADME; Isolated perfused lung; Transporter; Pharmacokinetics; Pharmacodynamics

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2011 سفارش ترجمه

Discovery of novel sphingosine kinase-1 inhibitors. Part 2

Keywords: Sphingosine kinase; SK1; Inhibitors; Enzyme; PK; ADME; Solubility; Heterocycles; 3-Hydroxypyrrolidine-2-carboxamides; Oxadiazole;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2010 سفارش ترجمه

Interstrain Differences of In Vitro Metabolic Stability and Impact on Early Drug Discovery

Keywords: ADME; high-performance/pressure liquid chromatography (HPLC); microsomes; mass spectrometry; in vitro models; metabolic clearance; cytochrome P450; phase I metabolism;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Azaindole N-methyl hydroxamic acids as HIV-1 integrase inhibitors-II. The impact of physicochemical properties on ADME and PK

Keywords: HIV integrase; Azaindole hydroxamates; Antiviral; ADME; PK; Log D; LipE; Physicochemical parameters

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Pharmacokinetic and pharmacodynamic evaluation of the lantibiotic MU1140

Keywords: ADME; antiinfectives; pharmacokinetics; pharmacokinetic/pharmacodynamic models; preclinical pharmacokinetic;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه