دانلود مقالات ISI ADME: 346 مقاله انگلیسی + ترجمه فارسی

ADME

در این صفحه تعداد 346 مقاله تخصصی درباره که در نشریه های معتبر علمی و پایگاه ساینس دایرکت (Science Direct) منتشر شده، نمایش داده شده است. برخی از این مقالات، پیش تر به زبان فارسی ترجمه شده اند که با مراجعه به هر یک از آنها، می توانید متن کامل مقاله انگلیسی همراه با ترجمه فارسی آن را دریافت فرمایید.
در صورتی که مقاله مورد نظر شما هنوز به فارسی ترجمه نشده باشد، مترجمان با تجربه ما آمادگی دارند آن را در اسرع وقت برای شما ترجمه نمایند.

مقالات ISI (ترجمه نشده)

مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.

Highly potent and selective NaV1.7 inhibitors for use as intravenous agents and chemical probes

Keywords: ADME; absorption, distribution, metabolism and excretion; Clint; intrinsic clearance; Clp; plasma clearance; Clu; unbound clearance; DCM; dichloromethane; DHEP; dog hepatocytes; DLM; dog liver microsomes; DMAc; dimethylacetamide; DMF; dimethylformamide; D

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and biological evaluation of 2-acetyl-5-O-(amino-alkyl)phenol derivatives as multifunctional agents for the treatment of Alzheimer's disease

Keywords: AD; Alzheimer's disease; AChEIs; acetylcholinesterase inhibitors; NMDA; N-methyl-d-aspartate; AÎ²; Î²-amyloid; Ï; tau protein; ACh; acetylcholine; MTDLs; multi-target-directed ligands; MAO-B; monoamine oxidase B; MAO-A; monoamine oxidase A; BuChE; buty

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Whole blood microsampling for the quantitation of estetrol without derivatization by liquid chromatography-tandem mass spectrometry

Keywords: ACN; acetonitrile; ADME; administration distribution elimination metabolization; DBS; dried blood spot; E1; estrone; E2; estradiol; E3; estriol; E4; estetrol; E4-d4; deuterated estetrol; EDTA; ethylenediaminetetraacetic acid; ESI; electrospray ionization;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Drug-likeness prediction of chemical constituents isolated from Chineseâmateriaâmedica Ciwujia

Keywords: ADME; absorption, distribution, metabolism, and excretion; AS; Acanthopanax senticosus harms; BBB; blood-brain barrier; CMM; Chinese materia medica; CNS; central nervous system; CWJ; Ciwujia; ERK; extracellular signal-regulated kinase; HIA; human intestin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Use of read-across to simplify the toxicological assessment of a complex mixture of lysimeter leachate metabolites on the basis of chemical similarity and ADME behavior

Keywords: Lysimeter; S-metolachlor; ADME; Relevance; Read-across;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacokinetics, pharmacodynamics and safety profiling of IS01957, a preclinical candidate possessing dual activity against inflammation and nociception

Keywords: Pharmacokinetics; Inflammation; Nociception; Safety pharmacology; IS01957; Para-coumaric acid derivative; p-CA; Para coumaric acid; ADME; Absorption, distribution, metabolism and excretion; CH; Chlorpromazine hydrochloride; PS; Pentobarbital sodium; PBS;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Discovery of Novel and Potent Stearoyl Coenzyme A Desaturase 1 (SCD1) Inhibitors as Anticancer Agents

Keywords: Ac; acetyl; ADME; absorption, distribution, metabolism, and excretion; aq.; aqueous; AUC; total area under the blood concentration-time curve; bid; bis in die (twice per day); Boc; (tert-butoxy)carbonyl; Bu; butyl; Bz; benzoyl; cLogP; calculate logarith

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Small molecule metalloprotease inhibitor with inÂ vitro, exÂ vivo and inÂ vivo efficacy against botulinum neurotoxin serotype A

Keywords: Botulism; Botulinum toxin; Botulinum neurotoxin; Mercaptoacetamide; Metalloprotease inhibitor; SNAP-25; SNARE protein; X-ray crystallography; ADME; absorption, distribution, metabolism and excretion; BAT®; heptavalent botulism antitoxin; BHSAI; Biotechno

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of the hypoglycemic potential of a black bean hydrolyzed protein isolate and its pure peptides using in silico, in vitro and in vivo approaches

Keywords: Black bean; Hydrolyzed protein isolate; Diabetes; Glucose absorption; Glucose transporters; Hyperglycemic rats; Glibenclamide: PubChem CID: 3488.; Glucose: PubChem CID: 10954115.; Metformin: PubChem CID: 4091.; Phloretin: PubChem CID: 4788.; Streptozotoci

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

InÂ Vitro-InÂ Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods

Keywords: drug interaction; cytochrome P450s; membrane transport/transporters; regulatory; guidance/guideline; ADME; absorption, distribution, metabolism and excretion; BCRP; breast cancer resistance protein; CYP; cytochrome P-450; d; induction calibration factor;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Acute toxicity, 28-day repeated-dose toxicity and toxicokinetic study of timosaponin BII in rats

Keywords: Timosaponin BII; Toxicity; Toxicokinetics; NOAEL; Rats; 1H NMR; 1H nuclear magnetic resonance; AD; Alzheimer's disease; ADME; absorption, distribution, metabolism, and excretion; ADP; adenosine diphosphate; ALB; albumin; ALP; alkaline phosphatase; ALT; al

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Treatment of estrogen-dependent diseases: Design, synthesis and profiling of a selective 17Î²-HSD1 inhibitor with sub-nanomolar IC50 for a proof-of-principle study

Keywords: 17Î²-Hydroxysteroid dehydrogenase type 1; Enzyme inhibitor; Steroidogenic enzymes; Estrogen-dependent disease; Intracrinology; (h)17Î²-HSD1; (human) 17Î²-hydroxysteroid dehydrogenase type 1; (h)17Î²-HSD2; (human) 17Î²-hydroxysteroid dehydrogenase type 2;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

The silymarin compositionâ¦ and why does it matter???

Keywords: ADME; absorption, distribution, metabolism, and excretion; ASTM; American Society for Testing and Materials; NHDF; normal human dermal fibroblasts; NHEK; normal human epidermal keratinocytes; PE; petroleum ether; LC-MS; liquid chromatography-mass spectr

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Identification of small molecular ligands as potent inhibitors of fatty acid metabolism in Mycobacterium tuberculosis

Keywords: Mycobacterium tuberculosis; Fatty acid metabolism; Virtual screening; Docking; Homology modeling; ADME;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Î³-Cyclodextrin

Keywords: Î³-Cyclodextrin; ADME; Complexing agent; Inclusion complex; Solubilization; Aggregation;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential

Keywords: ADME; absorption, distribution, metabolism, and excretion; AML; acute myelogenous leukemia; AUC; area under the blood concentration time curve; b.i.d.; twice a day; CDK; Cyclin-dependent kinase; CLtotal; clearance; Cmax; maximum drug concentration; CRC; c

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Mining the topography and dynamics of the 4D Nucleome to identify novel CNS drug pathways

Keywords: AE; adverse event (drug); ADLD; autosomal dominant adult-onset demyelinating leukodystrophy; ADME; absorption, distribution, metabolism, excretion (drug); ADRA2A; Adrenoceptor Alpha 2A; ADRA2B; Adrenoceptor Alpha 2B; ARNTL; Aryl Hydrocarbon Receptor Nucle

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Selective ATP competitive leads of CDK4: Discovery by 3D-QSAR pharmacophore mapping and molecular docking approach

Keywords: CDK4; ATP competitive inhibitors; 3D-QSAR pharmacophore; Virtual screening; Docking; ADME;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Structure based virtual screening for identification of potential quorum sensing inhibitors against LasR master regulator in Pseudomonas aeruginosa

Keywords: P.Â aeruginosa; Molecular docking; Quorum sensing inhibitors; ADME; Virtual screening; Lipinski rule;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2017 سفارش ترجمه

Imaging the pharmacology of nanomaterials by intravital microscopy: Toward understanding their biological behavior

Keywords: ADME; absorption distribution metabolism excretion; BODIPY; borondipyrromethene; BTK; Bruton's tyrosine kinase; CIW; cranial imaging window; DCE-MRI; dynamic contrast enhanced magnetic resonance imaging; DiO/DiI/DiD/DiR; dialkylcarbocyanine dyes; ECM; e

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Interaction between the zebrafish (Danio rerio) organic cation transporter 1 (Oct1) and endo- and xenobiotics

Keywords: ADME; absorption, distribution, metabolism and excretion; ASP+; 4-(4-(dimethylamino)styryl)-N-methylpyridinium iodide; DAPI; 4â²,6-diamidino-2-phenylindole; DBT; dibutyltin chloride; DMEM; Dulbecco's modified eagle's medium; HEK239; human embryonic kid

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2017 سفارش ترجمه

Integrating RNA sequencing into neuro-oncology practice

Keywords: CNS; central nervous system; RNA-seq; RNA sequencing; qRT-PCR; quantitative reverse transcription polymerase chain reaction; NGS; next-generation sequencing; GBM; glioblastoma; SNPs; single nucleotide polymorphisms; exRNAs; extracellular RNAs; lncRNAs; lo

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

A Critical View on InÂ Vitro Analysis of P-glycoprotein (P-gp) Transport Kinetics

Keywords: drug transport; ABC transporters; P-glycoprotein; Michaelis-Menten kinetics; drug interactions; ADME; inÂ vitro models;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Synthesis and structure-activity relationship study of novel 3-heteroarylcoumarins based on pyridazine scaffold as selective MAO-B inhibitors

Keywords: Coumarin; Pyridazine; MAO-B; Neurodegenerative disorders; Molecular modeling; ADME;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

ADME properties evaluation in drug discovery: Prediction of plasma protein binding using NSGA-II combining PLS and consensus modeling

Keywords: Plasma protein binding; ADME; QSAR; NSGA-II; Consensus model;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

Detection of ECG effects of (2R,4R)-monatin, a sweet flavored isomer of a component first identified in the root bark of the Sclerochitin ilicifolius plant

Keywords: (2R,4R)-Monatin; QT prolongation; QTc; TQT study; Food ingredient; ADME; absorption, distribution, metabolism, and elimination; AE; adverse event; Ae; amounts excreted; AUC0-inf; area under the plasma concentration-time curve to infinite time; AUC0-t; a

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

5-Benzylidene-hydantoin is a new scaffold for SIRT inhibition: From virtual screening to activity assays

Keywords: Sirtuins; 5-Benzylidene-hydantoin; Virtual screening; Molecular dynamics; Enzymology; PAMPA; p53 acetylation; ADP; Adenosine ribose diphosphate; ADME; Absorption distribution metabolism excretion; BBB; Blood-brain barrier; CNS; Central nervous system; G

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Absorption, distribution, metabolism, excretion, and kinetics of 2,3,3,3-tetrafluoro-2-(heptafluoropropoxy)propanoic acid ammonium salt following a single dose in rat, mouse, and cynomolgus monkey

Keywords: Fluoropolymer; ADME; Rodent; Monkey; Pharmacokinetics; Toxicokinetics;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Comprehensive QSRR modeling as a starting point in characterization and further development of anticancer drugs based on 17Î±-picolyl and 17(E)-picolinylidene androstane structures

Keywords: ADME; absorption, distribution, metabolism, excretion; ANN; artificial neural networks; AR; androgen receptor negative; BP; boiling point; CP; critical pressure; CRRN; comparison of ranks by random numbers; CT; critical temperature; DE; Dreiding energy; E

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacokinetics, tissue distribution, excretion, and metabolite profiling of PEGylated rFIX (nonacog beta pegol, N9-GP) in rats

Keywords: ADME; absorption, distribution, metabolism, and excretion; AMS; accelerator mass spectrometry; AUC; area under the plasma concentration-time curve from zero to infinity; AUC[0-t]; area under the plasma concentration-time curves from zero to time t;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

In vitro and in silico characterisation of Tacrolimus released under biorelevant conditions

Keywords: Tacrolimus (PubChem CID: 5282315); ACAT; advanced compartmental and transit; ADME; absorption, distribution, metabolism and excretion; ANOVA; analysis of variance; API; active pharmaceutical ingredient; BCS; biopharmaceutics classification system; CL; cle

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, characterization and in silico designing of diethyl-3-methyl-5-(6-methyl-2-thioxo-4-phenyl-1,2,3,4-tetrahydropyrimidine-5-carboxamido) thiophene-2,4-dicarboxylate derivative as anti-proliferative and anti-microbial agents

Keywords: Docking; Pyrimidine; ADME; Anti-proliferative; Anti-microbial;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

A two-year dietary carcinogenicity study of (2R,4R)-monatin salt in mice

Keywords: Carcinogenicity; R,R-Monatin; Mice; Safety; Dietary; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; ADME; absorption, distribution, metabolism and excretion; ALT; alanine aminotransferase; FDA; US Food and Drug Administrat

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Heterocyclic replacements for benzene: Maximising ADME benefits by considering individual ring isomers

Keywords: Benzene; Heteroaromatic; Heteroaliphatic; Regioisomer; ADME;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

The Role of Extracellular Binding Proteins in the Cellular Uptake of Drugs: Impact on Quantitative InÂ Vitro-to-InÂ Vivo Extrapolations of Toxicity and Efficacy in Physiologically Based Pharmacokinetic-Pharmacodynamic Research

Keywords: ADME; clearance; disposition; distribution; hepatocytes; IVIVE; partition coefficients; pharmacokinetics; pharmacodynamics; PKPD;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

A combined dietary chronic toxicity and two-year carcinogenicity study of (2R,4R)-monatin salt in Sprague-Dawley rats

Keywords: Carcinogenicity; Chronic; Rat; Safety; Dietary; (2R,4R)-Monatin; AAALAC; Association for Assessment and Accreditation of Laboratory Animal Care; ADME; absorption, distribution, metabolism and excretion; FDA; US Food and Drug Administration; GLP; Good Labo

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2016 سفارش ترجمه

ReviewIn silico pharmacology: Drug membrane partitioning and crossing

Keywords: ABC; ATP-binding cassette; ADME; absorption, distribution, metabolism and excretion; AMP; antimicrobial peptide; CG; coarse-grained; COX; cyclooxygenase; CYP; cytochrome P450; DLiPC; dilinoeyl-phosphatidylcholine; DOPC; 1,2-dioleoyl-sn-glycero-3-phosphoch

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

A systems pharmacology approach to decipher the mechanism of danggui-shaoyao-san decoction for the treatment of neurodegenerative diseases

Keywords: DSS; danggui-shaoyao-san; NDs; neurodegenerative diseases; TCM; traditional Chinese medicine; AD; Alzheimer's disease; PD; Parkinson's disease; HD; Huntington's disease; ALS; amyotrophic lateral sclerosis; AIA; aspirin-intolerant asthma; PRA; Paeoniae Rad

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2016 سفارش ترجمه

New agents for the treatment of drug-resistant Mycobacterium tuberculosis

Keywords: Mtb; Mycobacterium tuberculosis; TB; Tuberculosis; MDR-TB; Multidrug-resistant tuberculosis; RIF; Rifampicin; INH; Isoniazid; PZA; Pyrazinamide; ETH; Ethambutol; WHO; World Health Organization; CYP; Cytochrome P450; ADME; Absorption, distribution, metabol

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2016 سفارش ترجمه

Extended structure–activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties

Keywords: EGFR; Structure–activity relationship (SAR); Thieno[2,3-d]pyrimidine; ADME; Erlotinib; Gefitinib; Zebrafish

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Tolerability, exposure and pharmacokinetics in healthy subjects of a Chinese herbal medicine MaZiRenWan (MZRW): Study protocol for a randomized open-labelled, three-arm phase 0/1 clinical trial

Keywords: MZRW; MaZiRenWan; AUC; the area under the plasma concentration-time curve; Cmax; the peak plasma concentration of an ingredient after administration; tmax; the time to reach Cmax; t1/2; the elimination half-life; CL; clearance; ADME; the absorption, distr

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Beyond PM2.5: The role of ultrafine particles on adverse health effects of air pollution

Keywords: PM2.5; Ultrafine particles; PM0.1; Toxicology; Air pollution; Nanotoxicology; ADME; absorption distribution metabolism and excretion; ARE; antioxidant response; AOP; adverse outcome pathways; CFD; computational fluid dynamics; CMD; count median diameter;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2016 سفارش ترجمه

Novel non-peptide small molecules preventing IKKÎ²/NEMO association inhibit NF-ÎºB activation in LPS-stimulated J774 macrophages

Keywords: ADME; absorption, distribution, metabolism, and excretion; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; EMSA; Electrophoretic Mobility Shift Assay; Erk; extracellular-signal-related kinase; FBS; foetal bovine serum; GAPDH; glyce

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors

Keywords: Coumarins; Factor XIIa; Factor XII; FXII; Antithrombotic agents; Benzopyrans; ADME; absorption, distribution, metabolism and excretion; FXIIa; activated coagulation factor XII; FXa; activated coagulation factor X; THR; thrombin; FVIIa; activated factor VI

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2016 سفارش ترجمه

Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors

Keywords: EGFR; Pyrrolopyrimidine; SAR; ADME; Metabolism; Erlotinib;

دانلود رایگان متن کامل مقاله ISI 61 صفحه سال انتشار : 2016 سفارش ترجمه

In Vitro Metabolism and Stability of the Actinide Chelating Agent 3,4,3-LI(1,2-HOPO)

Keywords: Chelation therapy; stability; microsomes; ADME; protein binding; cytochrome P450; intestinal absorption;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of orally administered fumonisin B1 (FB1), partially hydrolysed FB1, hydrolysed FB1 and N-(1-deoxy-D-fructos-1-yl) FB1 on the sphingolipid metabolism in rats

Keywords: Mycotoxins; Rodents; Biomarkers; ADME; Fumonisin metabolism; LC-MS/MS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Relative Contributions of Presystemic and Systemic Peptidases to Oral Exposure of a Novel Metabotropic Glutamate 2/3 Receptor Agonist (LY404039) After Oral Administration of Prodrug Pomaglumetad Methionil (LY2140023)

Keywords: prodrug activation; bioavailability; accelerator mass spectrometry; pharmacokinetics; ADME;