IL-1 and TNF-α regulation of aryl hydrocarbon receptor (AhR) expression in HSY human salivary cells
Keywords: AhR; IL-1; TNF-α; HSY; Salivary gland
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Aldehyde dehydrogenase 3A1 protects airway epithelial cells from cigarette smoke-induced DNA damage and cytotoxicity
Keywords: AHR; aryl hydrocarbon receptor; ALDH; aldehyde dehydrogenase; CDK; cyclin-dependent kinase; COPD; chronic obstructive pulmonary disease; CS; cigarette smoke; CSE; cigarette smoke extract; DDR; DNA damage response; FA; Fanconi anemia; FANCD2; a member of t
Modulation of telomerase activity, bTERT and c-Myc induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin during Bovine Herpesvirus 1 infection in MDBK cells
Keywords: TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; MDBK cells; Madin-Darby bovine kidney cells; AhR; aryl hydrocarbon receptor; bTERT; bovine telomerase reverse transcriptase; TCDD; BHV-1; AhR; Apoptosis; Telomerase activity; bTERT; c-Myc;
Regulatory crosstalk and interference between the xenobiotic and hypoxia sensing pathways at the AhR-ARNT-HIF1α signaling node
Keywords: AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; B(a)P; benzo(a)pyrene; bHLH/PAS; basic helix-loop-helix/PER-ARNT-SIM; CoCl2; cobalt chloride; CYP1A1; cytochrome P450 1A1; HIF-1α; hypoxia-inducible factor-1α; HRE; hy
Assessment of estrogenic and anti-androgenic activities of the mycotoxin zearalenone and its metabolites using in vitro receptor-specific bioassays
Keywords: E2; 17β-estradiol; MTT; 3-(4,5-Dimethyl-2-thiazolyl)-2,5-diphenyl-tetrazolium bromide; AhR; aryl hydrocarbon receptor; CPP; central precocious puberty; CAR; constitutive androstane receptor; DCC; dextran-coated charcoal; DMSO; dimethyl sulfoxide; ERs; es
Aryl hydrocarbon receptor protein and Cyp1A1 gene induction by LPS and phenanthrene in Atlantic cod (Gadus morhua) head kidney cells
Keywords: Pheneanthrene; AhR; CYP1A1; LPS; poly I:C;
Toxic assessment of urban atmospheric particle-bound PAHs: Relevance of composition and particle size in Barcelona (Spain)
Keywords: PAHs; Air pollution; Particulate matter; Particle size; AhR; Recombinant yeast assay; Zebrafish embryotoxicity; Aquatic environment; Source apportionment;
Effects of BDE-209 contaminated sediments on zebrafish development and potential implications to human health
Keywords: AChE; acetylcholinesterase; AhR; aryl hydrocarbon receptor; AOP; adverse outcome pathway; BDE-209; decabromodiphenyl ether; CPF; chlorpyrifos; Dpf; days post-fertilization; DEGs; differentially expressed genes; GC-NICI-MS; gas chromatography coupled to
Salmeterol attenuates chemotactic responses in rhinovirus-induced exacerbation of allergic airways disease by modulating protein phosphatase 2A
Keywords: Long-acting β2-agonist; salmeterol; formoterol; salbutamol; asthma; allergy; rhinovirus; exacerbation; chemokine; dexamethasone; (S)-2-amino-4-(4-[heptyloxy]phenyl)-2-methylbutan-1-ol; protein phosphatase 2A; nuclear factor κB; AAD; Allergic airways dis
Molecular characterization of gdf9 and bmp15 genes in rare minnow Gobiocypris rarus and their expression upon bisphenol A exposure in adult females
Keywords: actb; actin beta; Af; atretic follicle; AR; androgen receptor; AHR; aryl hydrocarbon receptor; BPA; bisphenol A; Bmp15; bone morphogenetic protein 15; Coc; cortical alveolus oocytes; KL; c-Kit ligand; dpf; days post-fertilization; DMSO; dimethyl sulfoxide
Genotoxicity but not the AhR-mediated activity of PAHs is inhibited by other components of complex mixtures of ambient air pollutants
Keywords: A549; human adenocarcinoma alveolar basal epithelial cells, type II; AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; DB[a,l]P; dibenzo[a,l]pyrene; B[k]F; benzo[k]fluoranthene; BPDE; benzo[a]pyrene diolepoxide; cDNA; complementary DNA; c-PAH; carcin
Effects of individual polychlorinated naphthalene (PCN) components of Halowax 1051 and two defined, artificial PCN mixtures on AHR and CYP1A1 protein expression, steroid secretion and expression of enzymes involved in steroidogenesis (CYP17, 17β-HSD and C
Keywords: Halowax 1051; PCN; Ovary; Steroidogenesis; CYP1A1; AHR
Viral infections in asthma and COPD
Keywords: RSV; respiratory syncytial virus; HRV; human rhinovirus; LAI; lower airway infection; AHR; airway hyperresponsiveness; TLR3; Toll-like receptor 3; RIG-I; retinoic acid-inducible gene I; MDA5; melanoma differentiation-associated gene 5; TRIF; Toll/IL-1R do
Uremic toxin indoxyl 3-sulfate regulates the differentiation of Th2 but not of Th1 cells to lessen allergic asthma
Keywords: Indoxyl 3-sulfate; AhR; Th2; STAT5; STAT6; α-Naphtoflavone; AhR; aryl hydrocarbon receptor; I3S; indoxyl 3-sulfate; Th; helper T cell; STAT; signal transducer and activator of transcription;
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces expression of p27kip1 and FoxO3a in female rat cerebral cortex and PC12 cells
Keywords: TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; AhR; aryl hydrocarbon receptor; CNS; central nervous system; FBS; fetal bovine serum; FoxO3a; forkhead box class O 3a; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GFAP; glial fibrillary acidic protein; NeuN;
Interindividual variation in response to xenobiotic exposure established in precision-cut human liver slices
Keywords: AFB; aflatoxin B1; AhR; aryl hydrocarbon receptor; APAP; acetaminophen; BaP; benzo(α) pyrene; BMD; benchmark dose; BNA; Bayesian network analysis; BPDE; benzo(a) pyrene diolepoxide; CDKN1A; cyclin-dependent kinase inhibitor 1A; cDNA; copy DNA; CES; criti
Hypoxia perturbs aryl hydrocarbon receptor signaling and CYP1A1 expression induced by PCB 126 in human skin and liver-derived cell lines
Keywords: AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; bHLH/PAS; basic helix-loop-helix/PER-ARNT-SIM; ChIP; chromatin immunoprecipitation; CYP1A1; cytochrome P450 1A1; DMSO; dimethyl sulfoxide; EMSA; electrophoretic mobility
The aryl hydrocarbon receptor suppresses osteoblast proliferation and differentiation through the activation of the ERK signaling pathway
Keywords: Ahr; aryl hydrocarbon receptor; AIP; Ahr-interacting protein; ALP; alkaline phosphatase; ARNT; aryl hydrocarbon receptor nuclear translocator; BMD; bone mineral density; CFA; complete Freund's adjuvant; CH-223191; 2-methyl-2H-pyrazole-3-carboxylic acid; C
Transcriptional repression of the Ahr gene by LHCGR signaling in preovulatory granulosa cells is controlled by chromatin accessibility
Keywords: Ahr; aryl hydrocarbon receptor; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; TSA; trichostatin A; CHX; cycloheximide; FSK; forskolin; CHART-PCR; chromatin accessibility by real-time PCR; TSS; transcriptional start site; ActD; acinomycin D; HDAC; histone dea
Green tea diet decreases PCB 126-induced oxidative stress in mice by up-regulating antioxidant enzymes
Keywords: Green tea; Oxidative stress; PCB toxicity; Antioxidant response; AhR; Nrf2
Short-term calorie restriction feminizes the mRNA profiles of drug metabolizing enzymes and transporters in livers of mice
Keywords: Abc; ATP-binding cassette; Adh; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; Aldh; aldehyde dehydrogenase; AL; ad libitum; Bcrp; breast cancer resistant protein; CAR; constitutive androstane receptor; Ces; carboxylesterase; Comt; catechol-O-meth
A novel MDCKII in vitro model for assessing ABCG2-drug interactions and regulation of ABCG2 transport activity in the caprine mammary gland by environmental pollutants and pesticides
Keywords: AhR; aryl hydrocarbon receptor; ABZSO; albendazole sulfoxide; ARNT; aryl hydrocarbon receptor nuclear translocator; CALUX assay; chemical activated luciferase gene expression assay; CYP1A1; cytochrome P450 1A1; DRE; dioxin response element; MDCKII cells;
SPA0355 suppresses T-cell responses and reduces airway inflammation in mice
Keywords: AHR; airway hyperresponsiveness; BAL; bronchoalveolar lavage; BALF; BAL fluid; CD; cluster of differentiation; CFSE; carboxyfluorescein succinimidyl ester; CsA; cyclosporine A; ERK; extracellular signal-regulated kinase; GADPH; glyceraldehyde-3-phosphate
3, 3â²-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance
Keywords: DIM; 3, 3â²-diindolylmethane; MCD; methionine-choline-deficient; NASH; nonalcoholic steatohepatitis; NAFLD; nonalcoholic fatty liver disease; Treg; regulatory T cells; Th17; T helper cell type 17; AhR; aryl hydrocarbon receptor; TLR; toll-like receptor
ReviewPerspectives on host adaptation in response to Mycobacterium tuberculosis: Modulation of inflammation
Keywords: AIDS; acquired immunodeficiency syndrome; AhR; aryl hydrocarbon receptor; ARG1; arginase 1; CARD9; caspase recruitment domain-containing protein 9; CR; complement receptor; CXCR5; C-X-C motif chemokine (CXC) receptor 5; CXCL1; CXC ligand 1; CXCL5; CXC lig
Cooperation of structurally different aryl hydrocarbon receptor agonists and β-catenin in the regulation of CYP1A expression
Keywords: AhR; aryl hydrocarbon receptor; BHA; butylated hydroxyanisole; BNF; β-naphthoflavone; CAR; constitutive androstane receptor; CYP; cytochrome P450; DRE; dioxin response element; GS; glutamine synthetase; GST; glutathione S-transferase; 3MC; 3-methylcholan
Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression
Keywords: AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; CYP; cytochrome P450; ER; estrogen receptor; GR; glucocorticoid receptor; Hsp90; heat shock protein 90; Sp1; specificity protein; TCDD; 2,3,7,8-tetrachlorodibenzo-p-diox
Therapeutic potential of anti-IL-1β IgY in guinea pigs with allergic asthma induced by ovalbumin
Keywords: AHR; airway hyperresponsiveness; BALF; bronchoalveolar lavage fluid; HE; hematoxylin-eosin; IgE; immunoglobulin E; IgY; immunoglobulin yolk; IL-1β; interleukin-1beta; IL-1ra; IL-1 receptor antagonist; IL-4; interleukin-4; IL-8; interleukin-8; IL-13; inte
Asthma and lower airway diseaseCan an airway challenge test predict respiratory diseases? AÂ population-based international study
Keywords: Airway hyperresponsiveness; airflow obstruction; allergic rhinitis; asthma; European Community Respiratory Health Survey; chronic obstructive pulmonary disease; AHR; Airway hyperresponsiveness; BMI; Body mass index; COPD; Chronic obstructive pulmonary dis
Reviews and feature articleBirth cohorts in asthma and allergic diseases: Report of a NIAID/NHLBI/MeDALL joint workshop
Keywords: Allergy; asthma; birth cohorts; National Heart, Lung, and Blood Institute (NHLBI); National Institute of Allergy and Infectious Disease (NIAID); Mechanisms of the Development of Allergy (MeDALL); AHR; Airway hyperresponsiveness; ECA; Environment and Child
Analysis of gene expression changes in A549 cells induced by organic compounds from respirable air particles
Keywords: A549; human adenocarcinoma alveolar basal epithelial cells type II; AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; BMP; bone morphogenetic proteins; cDNA; complementary DNA; c-PAH; carcinogenic polycyclic aromatic hydrocarbon; cRNA; complementary
Periocular Corticosteroid Injections in Uveitis
Keywords: aHR; adjusted hazard ratio; EY; eye-year; IOP; intraocular pressure; ME; macular edema; SITE; Systemic Immunosuppressive Therapy for Eye Diseases; VA; visual acuity;
Hepatic expression patterns of aryl hydrocarbon receptor, pregnane X receptor, two cytochrome P450s and five phase II metabolism genes responsive to 17alpha-methyltestosterone in rare minnow Gobiocypris rarus
Keywords: AHR; aryl hydrocarbon receptor; PXR; pregnane X receptor; CYP; cytochrome P450; SULT; sulfotransferase; UGT; UDP-glucuronosyltransferases; AHR2; PXR; Cytochrome P450; Sulfotransferase; UDP-glucuronosyltransferases; 17Alpha-methyltestosterone;
Transcriptional expression analysis of ABC efflux transporters and xenobiotic-metabolizing enzymes in the Chinese rare minnow
Keywords: CYP; cytochrome P450; GST; glutathione S-transferase; GCLC; glutamate cysteine ligase catalytic; UGT; UDP glucuronosyltransferase; ABC transporter; ATP-binding cassette transporter; AHR; aryl hydrocarbon receptor; Nrf2; nuclear factor erythroid-2 p45-rela
Integrated systems toxicology approaches identified the possible involvement of ABC transporters pathway in erythromycin estolate-induced liver injury in rat
Keywords: AA; arachidonic acid; ABC; ATP-binding cassette; AhR; aryl hydrocarbon receptor; ALT; alanine aminotransferase; AST; aspartate aminotransferase; ALP; alkaline phosphatase; CAR; constitutive androstane receptor; Cyp1a1; P450 family 1 subfamily a, polypepti
Induction of a chloracne phenotype in an epidermal equivalent model by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is dependent on aryl hydrocarbon receptor activation and is not reproduced by aryl hydrocarbon receptor knock down
Keywords: AhR; aryl hydrocarbon receptor; AHRR; aryl hydrocarbon repressor protein; α-NF; α-naphthoflavone; β-NF; β-naphthoflavone; CYP1A1; cytochrome P450 1A1; ITE; 2-(1â²H-indole-3â²-carbonyl)-thiazole-4-carboxylic acid methyl ester; TCDD; 2,3,7,8-tetrachlo
Differential suppression of the aryl hydrocarbon receptor nuclear translocator-dependent function by an aryl hydrocarbon receptor PAS-A-derived inhibitory molecule
Keywords: AhR; Arnt; DRE binding; HIF-1; AhR deletion constructs; αNF; α-naphthoflavone; AhR; aryl hydrocarbon receptor; Arnt; aryl hydrocarbon receptor nuclear translocator; BaP; benzo[a]pyrene; βNF; β-naphthoflavone; CoCl2; cobalt chloride; CYP; cytochrome P4
Apoptotic and neurotoxic actions of 4-para-nonylphenol are accompanied by activation of retinoid X receptor and impairment of classical estrogen receptor signaling
Keywords: ATP; adenosine triphosphate; AhR; aryl hydrocarbon receptor; CAR; constitutive and rostane receptor; DMSO; dimethyl sulfoxide; DPN; highly potent estrogen receptor β agonist; EDCs; endocrine disrupting chemicals; ER; estrogen receptor; GPR30; G-protein-c
ReviewAirway epithelial regulation of pulmonary immune homeostasis and inflammation
Keywords: AAM; alternatively activated macrophage; AEC; airway epithelial cell; AHR; airway hyperresponsiveness; AJ; adherens junction; CARD; caspase recruitment and activation domain; CPA3; carboxypeptidase A3; DAMP; damage associated molecular pattern(s); DC; den
Dendritic cell immunoreceptor: AÂ novel receptor for intravenous immunoglobulin mediates induction of regulatory T cells
Keywords: Intravenous immunoglobulin; dendritic cells; regulatory T cells; immune modulation; asthma; AAD; Allergic airways disease; AHR; Airway hyperresponsiveness; BMDDC; Bone marrow-derived dendritic cell; DC; Dendritic cell; DCIR; Dendritic cell immunorecepto
Isomer-nonspecific action of dichlorodiphenyltrichloroethane on aryl hydrocarbon receptor and G-protein-coupled receptor 30 intracellular signaling in apoptotic neuronal cells
Keywords: Ac-DEVD-pNA; N-acetyl-asp-glu-val-asp p-nitro-anilide; AhR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor nuclear translocator; DDT; dichlorodiphenyltrichloroethane; DIV; day in vitro; DMSO; dimethyl sulfoxide; ELISA; enzyme-linked immunosorb
CD11a polymorphisms regulate TH2 cell homing and TH2-related disease
Keywords: Asthma; allergic disease; CD11a; TH2 cell; homing; polymorphism; allele; congenic; biomarker; AHR; Airway hyperreactivity; CAMP; Childhood Asthma Management Program; LD; Linkage disequilibrium; LFA-1; Leukocyte function-associated antigen 1; MIBD; Metal
Janus kinase 1/3 signaling pathways are key initiators of TH2 differentiation and lung allergic responses
Keywords: Janus kinase 1/3; asthma; TH2; AHR; Airway hyperresponsiveness; BAL; Bronchoalveolar lavage; BFA; Brefeldin A; EGF; Epidermal growth factor; EGFR; Epidermal growth factor receptor; EPO; Erythropoietin; FACS; Fluorescence-activated cell sorting; Foxp3; For
Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms
Keywords: AhR; aryl hydrocarbon receptor; ARE; antioxidant-responsive element; As(III); arsenite; CYP1A1; cytochrome P450 1A1; NQO1; NADP(H):quinone oxidoreductase; Nrf2; nuclear factor-erythroid 2 p45-related factor 2; SUL; sulforaphane; TCDD; 2,3,7,8-tetrachlorod
Critical comments on the WHO-UNEP State of the Science of Endocrine Disrupting Chemicals - 2012
Keywords: ADDM; Autism and Developmental Disabilities Monitoring Network; ADHD; attention deficit hyperactivity disorder; AhR; aryl hydrocarbon receptor; AHS; Agricultural Health Study; ASD; autism spectrum disorder; BPA; bisphenol A; CDC; Centers for Disease Contr
Consequences of psychophysiological stress on cytochrome P450-catalyzed drug metabolism
Keywords: CYP; Cytochrome P450; PAH; polycyclic aromatic hydrocarbon; EROD; ethoxyresorufin 7-dealkylase; PROD; pentoxyresorufin 7-dealkylase; B[α]P; benzo[α]pyrene; PNP; p-nitrophenol hydroxylation; FMO; flavin-containing monoxygenases; EH; epoxide hydrolases; G
Tolerogenic signaling by pulmonary CD1c+ dendritic cells induces regulatory T cells in patients with chronic obstructive pulmonary disease by IL-27/IL-10/inducible costimulator ligand
Keywords: Chronic obstructive pulmonary disease; dendritic cells; regulatory T cells; IL-27; IL-10; inducible costimulator ligand; AHR; Aryl hydrocarbon receptor; APC; Antigen-presenting cell; BAL; Bronchoalveolar lavage; CD1c+DCCOPD; CD1c+ DCs from lung samples ob
Loss of regulator of G protein signaling 5 promotes airway hyperresponsiveness in the absence of allergic inflammation
Keywords: Asthma; airway hyperresponsiveness; G proteins; regulator of G protein signaling proteins; Aspergillus fumigatus; AHR; Airway hyperresponsiveness; ASM; Airway smooth muscle; BALF; Bronchoalveolar lavage fluid; DAPI; 4â²-6-Diamidino-2-phenylindole dihydro
Acinetobacter species in the skin microbiota protect against allergic sensitization and inflammation
Keywords: Atopy; Gammaproteobacteria; Acinetobacter species; PBMC; anti-inflammatory gene expression; dendritic cells; keratinocytes; mouse asthma model; ACTB; β-Actin gene; AHR; Aryl hydrocarbon receptor gene; DC; Dendritic cell; FOXP3; Forkhead box P3 gene; GAPD
Human cytochrome P450 epoxygenases: Variability in expression and role in inflammation-related disorders
Keywords: Inflammation; Cytochrome P450; Epoxygenase; Epoxyeicosatrienoic acids; Variability; AA; arachidonic acid; AhR; aryl hydrocarbon receptor; AP-1; activator protein-1; bZIP; basic leucine zipper; CAR; constitutive androstane receptor; CCRP; cytoplasmic CAR r