Arsenite induces cell transformation by reactive oxygen species, AKT, ERK1/2, and p70S6K1
Keywords: آکت; Arsenic; Transformation; ROS; AKT; ERK; p70S6K;
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Akt-FOXO3a signaling axis dysregulation in human oral squamous cell carcinoma and potent efficacy of FOXO3a-targeted gene therapy
Keywords: آکت; Oral squamous cell carcinoma (OSCC); Gene therapy; FOXO3a; Akt; Cell cycle; Apoptosis
Polycystic Liver Diseases: Congenital Disorders of Cholangiocyte Signaling
Keywords: آکت; AC; adenyl cyclase; AC6; adenylyl-cyclases-6; ADPKD; autosomal-dominant polycystic kidney disease; AKT; v-akt murine thymoma viral oncogene homolog 1; ARPKD; autosomal-recessive polycystic kidney disease; cAMP; cycle adenosine monophosphate; CD; Caroli di
Mammalian Target of Rapamycin Signaling Pathway Contributes to Glioma Progression and Patients' Prognosis
Keywords: آکت; glioma; mTOR; S6; Akt; PTEN; p27; prognosis
Role of PI3K/Akt in diazoxide preconditioning against rat hippocampal neuronal death in pilocarpine-induced seizures
Keywords: آکت; Diazoxide; Akt; Seizure; Apoptosis-inducing factor; Cytochrome c; Caspase-3DZ, diazoxide; MitoKATP, mitochondrial ATP-sensitive potassium; AIF, apoptosis-inducing factor; CytC, cytochrome c; 5-HD, 5-hydroxydecanoic acid; WTN, wortmannin; PI3K, phosphatidy
Research ReportIL-10 directly protects cortical neurons by activating PI-3 kinase and STAT-3 pathways
Keywords: آکت; IL-10; Neuroprotection; Oxygen-glucose deprivation; Glutamate; STAT-3; AKT;
The effect of low-energy laser irradiation on apoptotic factors following experimentally induced transient cerebral ischemia
Keywords: آکت; laser; stroke; caspase; apoptosis; ischemia; Akt; serine/threonine kinase; ANOVA; analysis of variance; LLI; low-energy laser irradiation; MCAO; occluded right middle cerebral artery; NIHSS; National Institutes of Health Stroke Scale; NOS; nitric oxide sy
Design and synthesis of novel amide AKT1 inhibitors with selectivity over CDK2
Keywords: آکت; PKB; AKT; CDK; Cancer;
Vaspin protects vascular endothelial cells against free fatty acid-induced apoptosis through a phosphatidylinositol 3-kinase/Akt pathway
Keywords: آکت; Vaspin; Endothelial cells; Apoptosis; Phosphatidylinositol 3-kinase; Akt;
Luteolin and chicoric acid synergistically inhibited inflammatory responses via inactivation of PI3K-Akt pathway and impairment of NF-κB translocation in LPS stimulated RAW 264.7 cells
Keywords: آکت; Synergistic activity; Luteolin; Chicoric acid; NF-κB; Akt;
PARP1 inhibitors attenuate AKT phosphorylation via the upregulation of PHLPP1
Keywords: آکت; PARP1 inhibitor; AKT; FOXO3A; PHLPP1;
Akt phosphorylates and regulates the function of Dlx5
Keywords: آکت; Akt; Dlx5; Protein stability; Bone formation;
The Akt/GSK-3β pathway mediates flurbiprofen-induced neuroprotection against focal cerebral ischemia/reperfusion injury in rats
Keywords: آکت; Flurbiprofen; Apoptosis; Akt; GSK-3β;
ROS enhances CXCR4-mediated functions through inactivation of PTEN in prostate cancer cells
Keywords: آکت; Prostate cancer; PTEN; CXCR4; ROS; H2O2; AKT;
Epigallocatechin gallate (EGCG), a major component of green tea, is a dual phosphoinositide-3-kinase/mTOR inhibitor
Keywords: آکت; EGCG; (â)-epigallocatechin-3-gallate; PI3K; phosphoinositide-3-kinase; mTOR; mammalian target of rapamycin; PI(3,4,5)P3; phosphatidylinositol-3,4,5-triphosphate; ATP; adenosine 5â²-triphosphate; mTORC2; mammalian target of rapamycin complex 2; FRAP1; F
Protein kinase C isoforms: Mediators of reactive lipid metabolites in the development of insulin resistance
Keywords: آکت; Insulin; Ceramide; DAG; Protein kinase B; Akt; Obesity;
microRNA-7 increases radiosensitivity of human cancer cells with activated EGFR-associated signaling
Keywords: آکت; miRNA; microRNA; EGFR; epidermal growth factor receptor; PI3K; phosphatidyl inositide 3 kinase; DNA-PKcs; DNA-dependent protein kinase; microRNA-7; EGFR; PI3K; Akt; Radiosensitivity;
Rho-kinase inhibitor upregulates migration by altering focal adhesion formation via the Akt pathway in colon cancer cells
Keywords: آکت; Rho-kinase; Cell migration; Colon cancer; Focal adhesion; Akt
Leptin reduces gentamicin-induced apoptosis in rat renal tubular cells via the PI3K-Akt signaling pathway
Keywords: آکت; Leptin; Gentamicin; Apoptosis; Renal tubular cells; Akt
Chronic treatment with epoxyeicosatrienoic acids modulates insulin signaling and prevents insulin resistance in hepatocytes
Keywords: آکت; EETs, epoxyeicosatrienoic acids; PI3K, phosphatidylinositol 3-kinase; JNK, c-Jun N-terminal kinase; IRS-1, insulin receptor substrate-1; sEH, soluble epoxide hydrolaseInsulin resistance; Epoxyeicosatrienoic acids; Insulin signal; AKT; PI3K; JNK
Increase in CIP2A expression is associated with doxorubicin resistance
Keywords: آکت; Cancerous inhibitor of PP2A; Doxorubicin; Akt; p53
BLT2 phosphorylation at Thr355 by Akt is necessary for BLT2-mediated chemotaxis
Keywords: آکت; LTB4, leukotriene B4; GPCR, G protein-coupled receptor; ROS, reactive oxygen speciesLeukotriene B4 receptor 2 (BLT2); Chemotaxis; Akt; Reactive oxygen species
Cytoprotective roles of ERK and Akt in endoplasmic reticulum stress triggered by subtilase cytotoxin
Keywords: آکت; Subtilase cytotoxin; Apoptosis; Extracellular signal-regulated kinase (ERK); Akt; Endoplasmic reticulum stress; Unfolded protein response (UPR);
Inhibitory effects of GL-V9 on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-2/9
Keywords: آکت; MMP, matrix metalloproteinase; MAPK, mitogen-activated protein kinase; ERK, extracellular signal-regulated kinase; JNK, c-Jun N-terminal kinase; MTT, 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-diphenytetrazoliumromideGL-V9; Invasion; MMP-2; MMP-9; MAPK; AKT
Anti-tumor effects of proteoglycan from Phellinus linteus by immunomodulating and inhibiting Reg IV/EGFR/Akt signaling pathway in colorectal carcinoma
Keywords: آکت; Phellinus linteus; Proteoglycan; Reg IV; EGFR; PIgR; Akt;
PI3K/PTEN/AKT/mTOR pathway genetic variation predicts toxicity and distant progression in lung cancer patients receiving platinum-based chemotherapy
Keywords: آکت; Lung cancer; Chemotherapy; Platinum-agents; AKT; Clinical outcomes
Akt is the downstream target of GRP78 in mediating cisplatin resistance in ER stress-tolerant human lung cancer cells
Keywords: آکت; Akt; GRP78; ER stress; Drug resistance; Lung cancer
Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway
Keywords: آکت; Acacetin; VEGF; Angiogenesis; HIF-1; AKT;
Arsenic oxide targets stem cell marker CD133/prominin-1 in gallbladder carcinoma
Keywords: آکت; Arsenic trioxide; CD133; Apoptosis; Gallbladder carcinoma; AKT
Downregulation of cPLA2γ expression inhibits EGF-induced chemotaxis of human breast cancer cells through Akt pathway
Keywords: آکت; cPLA2γ; Breast cancer; Chemotaxis; EGF; Akt;
Estrogen, tamoxifen, and Akt modulate expression of putative housekeeping genes in breast cancer cells
Keywords: آکت; Akt; Estrogen; MCF-7; Reference gene; RT-qPCR; Tamoxifen
Akt phosphorylation at Thr308 and Ser473 is required for CHIP-mediated ubiquitination of the kinase
Keywords: آکت; Akt; Hsp90; CHIP; Proteasome
Leptin resistance develops spontaneously in mice during adult life in a tissue-specific manner. Consequences for hepatic steatosis
Keywords: آکت; STAT3; Akt; Leptin receptors; Leptin resistance; Liver;
Akt-mediated signaling is induced by cytokines and cyclic adenosine monophosphate and suppresses hepatocyte inducible nitric oxide synthase expression independent of MAPK P44/42
Keywords: آکت; Akt; Nitric oxide synthase; Cyclic adenosine monophosphate; Hepatocyte
Wisp2/CCN5 up-regulated in the central nervous system of GM3-only mice facilitates neurite formation in Neuro2a cells via integrin-Akt signaling
Keywords: آکت; FCS, fetal calf serum; DMEM, Dulbecco’s modified Eagle’s medium; GM3-only mouse, double knockout mouse of GM2/GD2 synthase and GD3 synthase; CNS, central nervous systemWisp2; CCN5; Ganglioside; Knockout; Akt; Neurite
Akt/Nox2/NF-κB signaling pathway is involved in Tat-induced HIV-1 long terminal repeat (LTR) transactivation
Keywords: آکت; Akt; Nox2; Tat; HIV-1; LTR transactivation;
Cafestol, a coffee-specific diterpene, induces apoptosis in renal carcinoma Caki cells through down-regulation of anti-apoptotic proteins and Akt phosphorylation
Keywords: آکت; Cafestol; Apoptosis; Akt; Caki; Bcl-2
Inhibition of vascular endothelial growth factor (VEGF)-induced endothelial proliferation, arterial relaxation, vascular permeability and angiogenesis by dobesilate
Keywords: آکت; VEGF; FGF; Akt; Angiogenesis; Vascular permeability; Endothelium; Proliferation; Dobesilate
Research ReportVisual abnormalities associated with enhanced optic nerve myelination
Keywords: آکت; Visual evoked potential; Electroretinography; Myelination; Optic nerve; Akt;
Antitumor activity of a novel histone deacetylase inhibitor (S)-HDAC42 in oral squamous cell carcinoma
Keywords: آکت; Oral cancer; (S)-HDAC42; Histone deacetylase inhibitor; Akt; NF-κB;
Chronic treatment with PDGF-BB and endothelin-1 synergistically induces vascular hyperplasia and loss of contractility in organ-cultured rat tail artery
Keywords: آکت; Vascular smooth muscle; Endothelin-1; PDGF-BB; ERK1/2; Akt; mTOR; Organ-culture;
Vitamin A (retinol) up-regulates the receptor for advanced glycation endproducts (RAGE) through p38 and Akt oxidant-dependent activation
Keywords: آکت; Retinol; RAGE; Oxidative stress; p38; Akt;
Induction of apoptosis and inhibition of PI3K/Akt pathway in PC-3 and LNCaP prostate cancer cells by ethanolic neem leaf extract
Keywords: آکت; Apoptosis; Akt; Cell cycle; Ethanolic neem leaf extract; Neem; Prostate cancer;
Lipoteichoic acid promotes nuclear accumulation of β-catenin via AKT in human gingival fibroblasts
Keywords: آکت; Lipoteichoic acid; Human gingival fibroblasts; AKT;
Neuroprotective effects of linarin through activation of the PI3K/Akt pathway in amyloid-β-induced neuronal cell death
Keywords: آکت; Linarin; Flavonoid; Aβ; Neuroprotection; Acetylcholinesterase; Akt; PC12
Isoflurane postconditioning induces neuroprotection via Akt activation and attenuation of increased mitochondrial membrane permeability
Keywords: آکت; Akt; glycogen synthase kinase 3β; isoflurane; neuroprotection; mitochondrial membrane permeability; postconditioningFr1, frontal cortex area 1; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GSK-3β, glycogen synthase kinase 3β; LDH, lactate dehydrogenas
Honokiol inhibits H2O2-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways
Keywords: آکت; Honokiol; Apoptosis; Human lens epithelial cells; Mitogen-activated protein kinase; Akt
Glucose deprivation activates AMPK and induces cell death through modulation of Akt in ovarian cancer cells
Keywords: آکت; Ovarian cancer; Glycolysis; AMPK; Akt
Apigenin attenuates dopamine-induced apoptosis in melanocytes via oxidative stress-related p38, c-Jun NH2-terminal kinase and Akt signaling
Keywords: آکت; Apigenin; Dopamine; Vitiligo; p38; c-Jun NH2-terminal kinase; Akt
Erlotinib inhibits T-cell-mediated immune response via down-regulation of the c-Raf/ERK cascade and Akt signaling pathway
Keywords: آکت; Erlotinib; T cells; Immunosuppression; c-Raf/ERK; Akt