The impact of endurance exercise on global and AMPK gene-specific DNA methylation
Keywords: Epigenetics; DNA methylation; Physical exercise; AMPK; LINE-1;
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Bridges between mitochondrial oxidative stress, ER stress and mTOR signaling in pancreatic β cells
Keywords: 4E-BP1; 4E binding protein; AMPK; AMP-activated protein kinase; ATF6; activating transcription factor 6; ATP; adenosine triphosphate; DEPTOR; DEP domain containing mTOR-interacting protein; CI; complexes I; CII; complex II; CIII; complex III; CIV; complex
Entada phaseoloides extract suppresses hepatic gluconeogenesis via activation of the AMPK signaling pathway
Keywords: ACC; acetyl coenzyme A carboxylase; AICAR; 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside; AMPK; AMP-activated protein kinase; CCK-8; cell counting kit-8; Dex/cAMP; dexamethasone/cAMP; Entada phaseoloides; Entada phaseoloides (L.) Merr.; G6pase; glu
Telomerase reverse transcriptase induces basal and amino acid starvation-induced autophagy through mTORC1
Keywords: Autophagy; Cell viability; Human telomerase reverse transcriptase (hTERT); Mammalian target of rapamycin complex 1 (mTORC1); Telomerase; AMPK; AMP-activated protein kinase; DMEM; Dulbecco's Modified Eagle's medium; EBSS; Earle's balanced salt solution; ER
The Crabtree and Warburg effects: Do metabolite-induced regulations participate in their induction?
Keywords: 2HG; 2-hydroxyglutarate; 6PGD; 6-phosphogluconate dehydrogenase; ACC; acetyl-CoA carboxylase; ANT; adenine nucleotide translocase; ADP; adenosine diphosphate; AMP; adenosine monophosphate; AMPK; AMPKinase; ATP; adenosine triphosphate; Fru6P; fructose 6 ph
Stabilization of C-RAF:KSR1 complex by DiRas3 reduces availability of C-RAF for dimerization with B-RAF
Keywords: KSR; kinase suppressor of Ras; RBD; Ras binding domain; M2PK; pyruvate kinase type M2; PARP; poly(ADP-ribose) polymerase; AMPK; AMP-activated protein kinase; RAF dimerization; KSR1; Tumour suppressor DiRas3; Ras-induced transformation;
Rapamycin requires AMPK activity and p27 expression for promoting autophagy-dependent Tsc2-null cell survival
Keywords: AMPK; 5â² AMP-activated protein kinase; Atg13; autophagy-related protein 13; CDK; cyclin-dependent kinase; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified eagle's medium; DMSO; dimethyl sulfoxide; FDA; US Food and Drug Administration; GF
Activated protein C prevents methylglyoxal-induced endoplasmic reticulum stress and cardiomyocyte apoptosis via regulation of the AMP-activated protein kinase signaling pathway
Keywords: Methylglyoxal; CHOP; ER stress; APC; AMPK; Cardiomyocyte;
Antidiabetic effect of total saponins from Polygonatum kingianum in streptozotocin-induced daibetic rats
Keywords: AMPK; Adenosine monophosphate activated protein kinase; DM; Diabetes mellitus; FBG; Fasting blood glucose; FBP; Fructose 6 phosphate kinase2; FINS; Fasting insulin; GK; Glucose kinase; GLUT4; Glucose transporter subtype-4; G6P; Glucose-6-phosphatase; HFD;
Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling
Keywords: Endothelial dysfunction; AICAR; Mitochondrial biogenesis; eNOS; Nitric oxide; mTORC1; AMPK; Rapamycin;
Maintenance of cytosolic calcium is crucial to extend l-arginine therapeutic benefits during continuous dosing
Keywords: Endothelial nitric oxide; Calcium channel; l-arginine; Tolerance; Oxidative stress; Therapeutic efficacy; NOS; Nitric oxide synthase; O2â¢-; Superoxide; ONOOâ; Peroxynitrite; AMPK; AMP-activated protein kinase; Ca2+; Calcium; CaMKII; Calmodulin-depen
The role of mitochondrial DNA damage in the development of atherosclerosis
Keywords: AMPK; AMP activated protein kinase; cGAS; cyclic GMP-AMP synthase; DAMP; damage-associated molecular pattern; Drp1; dynamin-related protein 1; FGF21; fibroblast growth factor 21; IFN; interferon; MOMP; mitochondrial outer membrane permeabilisation; MPTP;
AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions
Keywords: ACAT1; acetoacetyl-CoA thiolase; ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ATAC; Ada-two-A-containing; BET; bromodomains and extra-terminal motif; BMAL1; PAS domain-containing pr
Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1
Keywords: Pparγ; peroxisome proliferator activated receptor γ; aP2; adipocyte protein 2; siRNA; small interfering RNA; MSC; mesenchymal stem cells; DMI; Dexamethasone, IBMX, and Insulin; Dnajb1; DnaJ (Hsp40) Homolog, Subfamily B, Member 1; LCA; licochalcone A; TN
Curcumin induces brown fat-like phenotype in 3T3-L1 and primary white adipocytes
Keywords: ACC; acyl-CoA carboxylase; AMPK; AMP-activated protein kinase; Brite; brown in white; BAT; brown adipose tissue; CYT C; cytochrome C; C/EBP/Cebp; CCAAT/enhancer-binding protein/encoding gene; CPT; carnitine palmitoyltransferase; Fgf21; gene encoding fibro
Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics
Keywords: AC; adenylyl cyclase; ACTH; adrenocorticotropic hormone; AKAP; A-kinase anchor protein; AMP; 5â² adenosine monophosphate; AMPK; AMP-activated protein kinase; Arfgap1; ADP-ribosylation factor GTPase-activating protein 1; Arhgef2; Rho guanine nucleotide ex
Resveratrol attenuates monocyte-to-macrophage differentiation and associated inflammation via modulation of intracellular GSH homeostasis: Relevance in atherosclerosis
Keywords: Monocyte differentiation; Inflammation; Atherosclerosis; Resveratrol; GSH; AMPK;
Defects in 15-HETE Production and Control of Epithelial Permeability by Human Enteric Glial Cells From Patients With Crohn's Disease
Keywords: Enteric Nervous System; Inflammatory Bowel Disease; IBD; Arachidonic Acid; AMPK; adenosine monophosphateâactivated kinase; CD; Crohn's disease; DMEM; Dulbecco's modified Eagle medium; EGC; enteric glial cell; ERK; extracellular signal-regulated kina
The role of CD36 in the regulation of myocardial lipid metabolism
Keywords: ACSL; acyl-coenzyme A synthetase; AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ATGL; adipose triglyceride lipase; CPT; carnitine palmitoyltransferase; CVD; cardiovascular disease; FAT (CD36); fatty acid tr
A SIRT3/AMPK/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages
Keywords: AAPH; 2,2â²-azobis (2-amidinopropane) dihydrochloride; AMPK; AMP-activated protein kinase; ComC; compound C; Edar; edaravone; 3-MA; 3-methyladenine; MMP; mitochondrial membrane potential; Rapa; rapamycin; Resv; trans-resveratrol; VitC; vitamin C; Autopha
Paeonol protects against endoplasmic reticulum stress-induced endothelial dysfunction via AMPK/PPARδ signaling pathway
Keywords: PN; paeonol; ER; endoplasmic reticulum; AMPK; 5Ⲡadenosine monophosphate-activated protein kinase; PPARδ; peroxisome proliferator-activated receptor δ; ACh; acetylcholine; DHE; dihydroethidium; EDR; endothelium-dependent relaxation; NO; nitric oxide
Metformin activation of AMPK-dependent pathways is neuroprotective in human neural stem cells against Amyloid-beta-induced mitochondrial dysfunction
Keywords: AMPK; PGC1α; Mitochondrial function; HNSCs; Aβ;
Insulin-like growth factor 1 (IGF-1) therapy: Mitochondrial dysfunction and diseases
Keywords: ÎΨm; membrane potential; AD; Alzheimer's disease; AMPK; adenosine-monophosphate-activated kinase; ATG proteins; autophagy-related proteins; ATP; adenosine triphosphate; CaMKs; calcium-calmodulin-activated kinases; CDKs; cyclin-dependent kinases; CNS;
Bortezomib attenuates palmitic acid-induced ER stress, inflammation and insulin resistance in myotubes via AMPK dependent mechanism
Keywords: Bortezomib; ER stress; AMPK; Myotube; Insulin resistance;
A conjugated fatty acid present at high levels in bitter melon seed favorably affects lipid metabolism in hepatocytes by increasing NAD+/NADH ratio and activating PPARα, AMPK and SIRT1 signaling pathway
Keywords: ACC; acetyl-CoA carboxylase; ACOX; acyl-CoA oxidase; AMPK; AMP-activated protein kinase; BMSO; bitter melon seed oil; c9,t11-CLA; cis-9, trans-11 isomer of conjugated linoleic acid; α-ESA; α-eleostearic acid; FASN; fatty acid synthase; FOXO1; forkhead b
Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1α
Keywords: Akt; protein kinase B; AMPK; AMP-activated protein kinase; AVOs; acidic vesicular organelles; BNIP3; BCL2/adenovirus E1B 19Â kDa interacting protein 3; BNIP3L; BCL2/adenovirus E1B 19Â kDa interacting protein 3-like; CCND1; cyclin D1; CFSE; 5-(6)-carboxyfl
Modulatory influences of estradiol and other anorexigenic hormones on metabotropic, Gi/o-coupled receptor function in the hypothalamic control of energy homeostasis
Keywords: 2-AG; 2-arachidonoylglycerol; AgRP; agouti-related peptide; AMPK; AMP-activated protein kinase; ARC; hypothalamic arcuate nucleus; CRH; corticotropin-releasing hormone; DSI; depolarization-induced suppression of inhibition; ERK; extracellular signal-regul
Mitochondrial redox system, dynamics, and dysfunction in lung inflammaging and COPD
Keywords: AMPK; AMP-activated protein kinase; COPD; chronic obstructive pulmonary disease; COX; cytochrome c oxidase; CS; cigarette smoke; DRP1, DNM1L; dynamin 1-like; ÎÏm; mitochondrial membrane potential; ETC; electron transport chain; FIS1; fission 1; H2O2; hy
Methylisoindigo preferentially kills cancer stem cells by interfering cell metabolism via inhibition of LKB1 and activation of AMPK in PDACs
Keywords: Indirubin; Meisoindigo; Pancreatic cancer stem cell; CSC drug; LKB1 inactivation; AMPK activation; PDAC; CD133; 2-DG; 2-deoxyglucose; ACC; acetyl-CoA carboxylase; AMPK; 5â² AMP-activated protein kinase; CHK2; check point kinase 2; DM; Dorsomorphin; ESA;
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis
Keywords: NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH associated protein 1; TUNEL; terminal deoxynucleotidyl transferase dUTP nick end labeling; MTT; 3-(4,5-di
Natriuretic peptide receptor A inhibition suppresses gastric cancer development through reactive oxygen species-mediated G2/M cell cycle arrest and cell death
Keywords: NPRA; natriuretic peptide receptor A; ANP; atrial natriuretic peptide; AMPK; AMP-activated protein kinase; ATG; autophagy-related genes; TMA; tissue microarray assay; ROS; reactive oxygen species; JNK; c-Jun N-terminal kinase; MAPKs; mitogen-activated pro
Leucine induced dephosphorylation of Sestrin2 promotes mTORC1 activation
Keywords: 4E-BP1; eukaryotic initiation factor 4E binding protein 1; AMPK; AMP-activated protein kinase; Atg13; autophagy-related 13; FIP200; 200Â kilodalton focal adhesion kinase family kinase-interacting protein; GAP; GTPase activator protein; GATOR; GAP activity
Sodium salicylate reduces the level of GABAB receptors in the rat's inferior colliculus
Keywords: AMPK; 5â²-AMP-dependent protein kinase; CB; cerebellum; GABA; γ-aminobutyric acid; GABAB receptor; type-B GABAergic receptor; IHC; immunohistochemistry; IC; inferior colliculus; ICc; central nucleus of the inferior colliculus; ICd; dorsal cortex of the
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
Keywords: AA; Ascorbic acid; AEM1; ARE expression modulator 1; AEG1; Astrocyte elevated gene-1; Akt; Protein kinase B; AMPK; AMP-activated protein kinase; APL; Acute promyelocytic leukemia; ARE; Antioxidant response element; ATO; Arsenic trioxide; Bach; BTB and CNC
ReviewNeuroglobin: From structure to function in health and disease
Keywords: Neuroglobin; Structure; Function; Signaling; Neuroprotection; Neurodegeneration; Cancer; αSyn; α-synuclein; Aβ; amyloid β; AD; Alzheimer's disease; Adgb; androglobin; AIF; apoptotic inducing factor; AMPK; AMP-activated protein kinase; APAF; apoptotic
Role of AMPK in regulation of LC3 lipidation as a marker of autophagy in skeletal muscle
Keywords: AICAR; 5-aminoimidazole-4-carboxamide riboside; AMP; adenosine monophosphate; AMPK; 5â²AMP activated protein kinase; ANOVA; Analysis of Variance; ATG; autophagy related gene; ATP; adenosine triphosphate; BCA; bicinchoninic acid; BSA; bovine serum albumin
Carnitine palmitoyltransferase 1C: From cognition to cancer
Keywords: ACC; acetyl-CoA carboxylase; ACO; aconitase; AICAR; 5-aminoimidazole-4-1-b-d-ribofuranoside; AMPK; AMP-dependent protein kinase; Arc; Arcuate; BSX; brain-specific homeobox; cAMP; cyclic AMP; CNS; central nervous system; COT; carnitine octanoyltransferase;
Molecular and cellular mechanisms linking inflammation to insulin resistance and β-cell dysfunction
Keywords: AMPK; AMP-activated protein kinase; ATM; adipose tissue macrophages; CCL; chemokine (C-C motif) ligand; CCR2; chemokine (C-C motif) receptor 2; CX3CL1; chemokine (C-X3-C motif) ligand 1; CX3CR1; chemokine (C-X3-C motif) receptor; CXCL; CXC chemokine ligan
Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis
Keywords: ACACB; acetyl-CoA carboxylase beta acetyl-CoA carboxylase beta; ACAT1; acetyl-CoA acetyltransferase 1; ACLY; ATP citrate lyase; AMPK; 5â²AMP-activated protein kinase; ASCL1; acyl-CoA synthetase long-chain family member 1; ACSL4; acyl CoA synthetases long
Aquilaria spp. (agarwood) as source of health beneficial compounds: A review of traditional use, phytochemistry and pharmacology
Keywords: CITES; the Convention on International Trade in Endangered Species of Wild Fauna and Flora; IUCN; International Union for Conservation of Nature and Natural Resources; O2â¢â¾; superoxide anion; HOâ¢; hydroxyl radical; ABTS; 2,2â²-azinobis-(3-ethylbenz
Metformin as possible therapy of pulmonary arterio venous malformation in HHT patients
Keywords: ACVRL1; activin type-II-like receptor kinase 1; ALK1; activin receptor like kinase; AMPK; 5â² adenosine monophosphate-activated protein kinase; ANG; Angiopoietin; HHT; hereditary hemorrhagic telangiectasia; PAVMs; pulmonary arteriovenous malformations; S
Inwardly rectifying Kir2.1 currents in human β-cells control electrical activity: Characterisation and mathematical modelling
Keywords: Insulin secretion; Pancreatic beta-cells; Action potential firing; Electrical activity; Ion channels; Mathematical model; K(ATP); ATP-sensitive potassium (channels, current); AP; action potential; V; membrane potential; I-V; current/voltage (relationshi
Fenoterol inhibits LPS-induced AMPK activation and inflammatory cytokine production through β-arrestin-2 in THP-1 cell line
Keywords: β2-adrenergic receptor; Fenoterol; AMPK; β-arrestin-2; Lipopolysaccharide; THP-1 cell line
Re-purposing of histological tissue sections for corroborative western blot analysis of hypothalamic metabolic neuropeptide expression following delineation of transactivated structures by Fos immuno-mapping
Keywords: AMPK; AICAR; Estradiol; Ovariectomy; Western blot; Arcuate hypothalamic nucleus; Pro-opiomelanocortin; Neuropeptide Y; Ventromedial hypothalamic nucleus; SF-1
A SNP in the 3â²-untranslated region of AMPKγ1 may associate with serum ketone body and milk production of Holstein dairy cows
Keywords: ABCI; animal breeding center of Iran; AMPK; adenosine mono phosphate protein kinase; BHBA; beta hydroxyl butyric acid; BCS; body condition score; CDS; coding DNA sequence; miRNA; microRNA; NCBI; National Center of Biotechnology Information; RPM; read per
Targeting respiratory complex I to prevent the Warburg effect
Keywords: OXPHOS; oxidative phosphorylation; CI; complex I; ROS; reactive oxygen species; TCA; tricarboxylic acid; PARP1; poly (ADP ribose) polymerase 1; AMPK; AMP activated kinase; mTORC1; mammalian target of rapamycin complex 1; HIF1α; hypoxia inducible factor 1
Pronuciferine and nuciferine inhibit lipogenesis in 3T3-L1 adipocytes by activating the AMPK signaling pathway
Keywords: 3T3-L1 adipocytes; Pronuciferine; Nuciferine; Lipogenesis; AMPK
Resveratrol ameliorates high glucose-induced oxidative stress injury in human umbilical vein endothelial cells by activating AMPK
Keywords: AMPK; High glucose; HUVEC; Injury; Oxidative stress; Resveratrol
AICAR administration affects glucose metabolism by upregulating the novel glucose transporter, GLUT8, in equine skeletal muscle
Keywords: GLUT; AMPK; Insulin resistance; Equine metabolic syndrome; Horse
Resveratrol-induced SIRT1 activation promotes neuronal differentiation of human bone marrow mesenchymal stem cells
Keywords: Resveratrol; Bone marrow mesenchymal stem cells (BM-MSCs); Neuronal differentiation; Sirtuin1 (SIRT1); AMPK; AMP-activated protein kinase; BHA; butylated hydroxyanisole; BM-MSCs; bone marrow-mesenchymal stem cells; cAMP; cyclic AMP; ctrl-MSCs; control-MSC