دانلود مقالات ISI درباره آمیلوئید بتا + ترجمه فارسی

A phase 1 study to evaluate the safety and pharmacokinetics of PQ912, a glutaminyl cyclase inhibitor, in healthy subjects

Keywords: آمیلوئید بتا; Alzheimer's disease; Glutaminyl cyclase; QC inhibitor; Amyloid-beta; Pyroglutamate; pE-Aβ; Cerebrospinal fluid

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

Methods to monitor monocytes-mediated amyloid-beta uptake and phagocytosis in the context of adjuvanted immunotherapies

Keywords: آمیلوئید بتا; Aβ; amyloid-beta; AD; Alzheimer's disease; APP; amyloid precursor protein; AS01B; adjuvant system 01B; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle medium; DPBS; Dulbecco's Phosphate Buffered Saline; EOAD; early-onset AD; Fig.; figure; FMOs

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Hippocampal plasticity during the progression of Alzheimer's disease

Keywords: آمیلوئید بتا; AD; Alzheimer's disease; aMCI; amnestic mild cognitive impairment; APP; amyloid-beta precursor protein; Aβ; amyloid-beta; CBF; cholinergic basal forebrain; ChAT; choline acetyltransferease; DG; dentate gyrus; JNK; c-Jun N-terminal protein kinase; MCI;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2015 سفارش ترجمه

Alterations in synaptic plasticity coincide with deficits in spatial working memory in presymptomatic 3xTg-AD mice

Keywords: آمیلوئید بتا; Alzheimer's disease; Transgenic mouse model; Radial maze; Hippocampal slice; Amyloid-beta; Synaptic plasticity;

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2015 سفارش ترجمه

Role of F3/contactin expression profile in synaptic plasticity and memory in aged mice

Keywords: آمیلوئید بتا; F3/contactin; Aging; Long-term potentiation; Memory; Amyloid-precursor protein cleavage; Amyloid-beta; Apoptosis; Brain-derived neurotrophic factor; cAMP-responsive element binding;

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2015 سفارش ترجمه

Short CommunicationPeripheral administration of poly I:C leads to increased hippocampal amyloid-beta and cognitive deficits in a non-transgenic mouse

Keywords: آمیلوئید بتا; Alzheimer's disease; Amyloid-beta; Poly I:C; Cognition; Cytokines;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Combination of memantine and vitamin D prevents axon degeneration induced by amyloid-beta and glutamate

Keywords: آمیلوئید بتا; Alzheimer's disease; Amyloid-beta; Glutamate; Memantine; Vitamin D; Neuroprotection;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2014 سفارش ترجمه

Novel APP K724M mutation causes Chinese early-onset familial Alzheimer's disease and increases amyloid-β42 to amyloid-β40 ratio

Keywords: آمیلوئید بتا; Early-onset familial Alzheimer's disease; Amyloid-beta; Amyloid precursor protein; K724M; Mutation;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2014 سفارش ترجمه

ReviewAlzheimer's and ABC transporters - new opportunities for diagnostics and treatment

Keywords: آمیلوئید بتا; AD; Alzheimer's disease; Aβ; amyloid-beta; ABC; ATP binding cassette; BBB; blood-brain barrier; BPND; non-displaceable binding potential; CAA; cerebral amyloid angiopathy; CSF; cerebrospinal fluid; CP; choroid plexus; DLB; dementia with Lewy bodies;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Iron increases APP translation and amyloid-beta production in the retina

Keywords: آمیلوئید بتا; Age-related macular degeneration; Iron; Amyloid precursor protein; Amyloid-beta; Aceruloplasminemia;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Valeriana amurensis improves Amyloid-beta 1-42 induced cognitive deficit by enhancing cerebral cholinergic function and protecting the brain neurons from apoptosis in mice

Keywords: آمیلوئید بتا; Valeriana amurensis; Amyloid-beta; Cognitive deficit; Cholinergic function; Alzheimer's disease;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2014 سفارش ترجمه

Antisense oligonucleotide against GSK-3β in brain of SAMP8 mice improves learning and memory and decreases oxidative stress: Involvement of transcription factor Nrf2 and implications for Alzheimer disease

Keywords: آمیلوئید بتا; Aβ; amyloid-beta; AD; Alzheimer's disease; BBB; blood-brain barrier; BSA; bovine serum albumin; GSK-3β; glycogen synthase kinase-3β; GST; glutathione S-transferase; ICV; intracerebroventricularly; NFTs; neurofibrillary tangles; Nrf2; nuclear factor-E

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

A cellular model of amyloid precursor protein processing and amyloid-β peptide production

Keywords: آمیلوئید بتا; Alzheimer's; BE(2)-M17; Amyloid-beta; In vitro; Secretase; TNF

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Featured ArticleIndependent comparison of CogState computerized testing and a standard cognitive battery with neuroimaging

Keywords: آمیلوئید بتا; Preclinical Alzheimer's disease; Neuropsychology; Computerized cognitive battery; Neuroimaging; Amyloid-beta; Hippocampal volume;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

Preconditioning provides neuroprotection in models of CNS disease: Paradigms and clinical significance

Keywords: آمیلوئید بتا; Preconditioning; Neuroprotection; Ischemia; Traumatic brain injury; MCAO; middle cerebral artery occlusion; 2VO; two vessel occlusion; 3-NPA; 3-Nitropropionic acid; 4VO; four vessel occlusion; BCCAO; bilateral common carotid artery occlusion; CSD; cortica

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2014 سفارش ترجمه

Autophagy and apoptosis dysfunction in neurodegenerative disorders

Keywords: آمیلوئید بتا; AMBRA; activating molecule in Beclin-1-regulated autophagy; AD; Alzheimer's diseases; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; Aβ; amyloid-beta; α-syn; alpha-synuclein; ALS; amyotrophic lateral sclerosis; APP; amyloid beta precursor

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2014 سفارش ترجمه

Imatinib methanesulfonate reduces hippocampal amyloid-beta and restores cognitive function following repeated endotoxin exposure

Keywords: آمیلوئید بتا; Lipopolysaccharide; Cytokines; Amyloid-beta; Alzheimer's disease; Memory;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

ABCA7 expression is associated with Alzheimer's disease polymorphism and disease status

Keywords: آمیلوئید بتا; GWAS; genome-wide association studies; SNP; single nucleotide polymorphism; AD; Alzheimer's disease; ABCA7; ATP binding cassette A7; qPCR; quantitative polymerase chain reaction; Aβ; amyloid-beta; EIF4H; eukaryotic translation initiation factor 4H; RPL32

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Short communicationThe role of TLR2/JNK/NF-κB pathway in amyloid β peptide-induced inflammatory response in mouse NG108-15 neural cells

Keywords: آمیلوئید بتا; AD; Alzheimer's disease; Aβ; amyloid-beta; MTT; methylthiazolyldiphenyl-tetrazolium bromide; TNF-α; tumor necrosis factor-α; MCP-1; monocyte chemoattractant protein-1; IL-10; interleukin-10; NF-κB; nuclear factor-κB; TLR2; toll-like receptor-2; JNK;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

S1 pocket of glutamate carboxypeptidase II: A new binding site for amyloid-β degradation

Keywords: آمیلوئید بتا; Alzheimer's diseases; Amyloid-beta; Binding site; GCPII; S1 pocket;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Amyloid beta(1-42) in aqueous environments: Effects of ionic strength and E22Q (Dutch) mutation

Keywords: آمیلوئید بتا; Amyloid-beta; Alzheimer's disease; Amyloidogenesis; Misfolding; Molecular dynamics; Dutch mutation;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Expression and processing of fluorescent fusion proteins of amyloid precursor protein (APP)

Keywords: آمیلوئید بتا; APP106; truncated last 106 amino acids of APP; GappR; GFP-APP106-DsRed; RappG; DsRed-APP106-GFP; sGapp; soluble GFP-APP; sRapp; soluble DsRed-APP; sGappα; soluble GFP-APP alpha; sGappβ; soluble GFP-APP beta; Amyloid precursor protein; Amyloid-beta; Gree

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Synthetic Aβ oligomers (Aβ1-42 globulomer) modulate presynaptic calcium currents: Prevention of Aβ-induced synaptic deficits by calcium channel blockers

Keywords: آمیلوئید بتا; Alzheimer's disease; Amyloid-beta; Oligomers; Calcium channel blockers; P/Q-type calcium channels; N-type calcium channels;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Epigallocatechin-3-gallate prevents systemic inflammation-induced memory deficiency and amyloidogenesis via its anti-neuroinflammatory properties

Keywords: آمیلوئید بتا; Aβ; amyloid peptide; AD; Alzheimer's disease; APP; β-amyloid precursor protein; COX-2; cyclooxygenase-2; EGCG; (−)-epigallocatechin-3-gallate; GAPDH; glyceraldehydes-3-phosphate dehydrogenase; ICAM-1; intercellular adhesion molecule-1; icv; intracereb

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

In silico and in vitro characterization of anti-amyloidogenic activity of vitamin K3 analogues for Alzheimer's disease

Keywords: آمیلوئید بتا; Aβ; amyloid-beta; VK; vitamin K; AD; Alzheimer's disease; IC50; half maximal inhibitory concentration; ApoE; apolipoprotein E; MD; molecular dynamics; MM-PBSA; molecular mechanics-Poisson−Boltzmann surface area; SI; supplemental information; DCFH-DA; d

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Research reportA novel method for the rapid determination of beta-amyloid toxicity on acute hippocampal slices using MTT and LDH assays

Keywords: آمیلوئید بتا; ACSF; artificial cerebrospinal fluid; AD; Alzheimer's disease; Aβ; amyloid-beta; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; LDH; Lactate dehydrogenase; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; OD; optical density

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Research reportMicroRNA-195 downregulates Alzheimer's disease amyloid-β production by targeting BACE1

Keywords: آمیلوئید بتا; AD; Alzheimer's disease; Aβ; amyloid-beta; NFTs; neurofibrillary tangles; APP; amyloid precursor protein; sAPPβ; the secreted beta-form of APP; Aβ; amyloid-beta; BACE1; beta-site APP cleaving enzyme 1; 3′-UTR; 3′-untranslated region; sAPPβ; the se

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Complement receptor 1 (CR1) and Alzheimer's disease

Keywords: آمیلوئید بتا; AD; Alzheimer's disease; Aβ; amyloid-beta; ApoE; apolipoprotein E; BBB; blood-brain barrier; CCP; complement-control proteins; CFH; complement factor H; C3; complement factor 3; CR1; complement receptor 1; CSF; cerebrospinal fluid; E-CR1; erythrocyte c

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex

Keywords: آمیلوئید بتا; Amyloid-beta; Glutamate; Synaptosome; Alzheimer's disease; VGLUT;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Neuroprotective effect of the aminoestrogen prolame against impairment of learning and memory skills in rats injected with amyloid-β-25-35 into the hippocampus

Keywords: آمیلوئید بتا; Alzheimer's disease; Lipoperoxidation; Amyloid-beta; Oxidative stress; Prolame;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

The senescence accelerated mouse (SAMP8) as a model for oxidative stress and Alzheimer's disease

Keywords: آمیلوئید بتا; Senescence accelerated mouse (SAMP8); Oxidative damage; Alzheimer's disease; Blood–brain barrier; Amyloid-beta

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Cognitive and non-cognitive behaviors in the triple transgenic mouse model of Alzheimer's disease expressing mutated APP, PS1, and Mapt (3xTg-AD)

Keywords: آمیلوئید بتا; Alzheimer models; Transgenic; Amyloid-beta; Tau; Anxiety; Sensorimotor systems; Memory; Open-field; Elevated plus-maze; Object recognition; Left-right discrimination; Rotorod; Hot-plate; SHIRPA

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Hourly variability of cerebrospinal fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers

Keywords: آمیلوئید بتا; Alzheimer's disease; Biomarkers; Cerebrospinal fluid; Amyloid-beta; Tau;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

PerspectiveIs Alzheimer's disease amyloidosis the result of a repair mechanism gone astray?

Keywords: آمیلوئید بتا; Alzheimer's disease; Amyloid-beta; Brain microvasculature; Brain microhemorrhages; Brain hypoperfusion;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Mouse models of Alzheimer's disease

Keywords: آمیلوئید بتا; Alzheimer's disease; Amyloid-beta; Presenilin; Tau; Apolipoprotein E (ApoE); Behavior; Transgenic

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Hormetic effect of amyloid-beta peptide in synaptic plasticity and memory

Keywords: آمیلوئید بتا; Amyloid-beta; Hormesis; Alzheimer's disease; Synaptic plasticity; Memory; Hippocampus; Low doses;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Intranasal inoculation with an adenovirus vaccine encoding ten repeats of Aβ3-10 reduces AD-like pathology and cognitive impairment in Tg-APPswe/PSEN1dE9 mice

Keywords: آمیلوئید بتا; Alzheimer's disease; Amyloid-beta; Adenovirus vaccine; Immunotherapy; Astrocytes;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Effects of curcumin and demethoxycurcumin on amyloid-β precursor and tau proteins through the internal ribosome entry sites: A potential therapeutic for Alzheimer's disease

Keywords: آمیلوئید بتا; Alzheimer's disease; amyloid-beta; curcumin; demethoxycurcumin; internal ribosome entry sites; tau protein

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Pyridazine-derived γ-secretase modulators

Keywords: آمیلوئید بتا; SAR; γ-secretase; Modulator; AD; GSI; GSM; Pyridazine; Amyloid-beta

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Disassembly of preformed amyloid beta fibrils by small organofluorine molecules

Keywords: آمیلوئید بتا; Alzheimer’s disease; Amyloid-beta; Fibrils; Disassembly; Organofluorine compounds

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

A partially folded structure of amyloid-beta(1-40) in an aqueous environment

Keywords: آمیلوئید بتا; Aβ; amyloid-β peptide; DSS; 4,4-dimethyl-4-silapentane-1-sulfonic acid; NOE; nuclear overhauser effect; MD; molecular dynamics; TOCSY; total correlation spectroscopy; NOESY; nuclear overhauser effect spectroscopy; NMR; nuclear magnetic resonance; Struct

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Hydrogen-rich saline reduces oxidative stress and inflammation by inhibit of JNK and NF-κB activation in a rat model of amyloid-beta-induced Alzheimer's disease

Keywords: آمیلوئید بتا; Alzheimer's disease; Amyloid-beta; Hydrogen; Oxidative stress; JNK; NF-κB

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Alteration of the sialylation pattern and memory deficits by injection of Aβ(25-35) into the hippocampus of rats

Keywords: آمیلوئید بتا; Sialic acid; Neurodegeneration; Glycosylation; Amyloid-beta; Lectins;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Respiratory and sniffing behaviors throughout adulthood and aging in mice

Keywords: آمیلوئید بتا; Olfaction; Neurodegeneration; Alzheimer's disease; Amyloid-beta; APP; Orienting; Respiration

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Relationship of Amyloid-Beta Burden With Age-At-Onset in Alzheimer Disease

Keywords: آمیلوئید بتا; Alzheimer disease; amyloid-beta; 11C-PIB; early-onset; late-onset;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

High levels of synaptosomal Na+-Ca2+ exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease

Keywords: آمیلوئید بتا; Na+-Ca2+ exchanger (NCX); Alzheimer's disease; Calcium signaling; Amyloid-beta; Synapse;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Roles of p75NTR in the pathogenesis of Alzheimer's disease: A novel therapeutic target

Keywords: آمیلوئید بتا; Alzheimer's disease; Amyloid-beta; p75NTR; Degeneration; Tau; Cell cycle

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

13-Desmethyl spirolide-C is neuroprotective and reduces intracellular Aβ and hyperphosphorylated tau in vitro

Keywords: آمیلوئید بتا; Alzheimer disease; Spirolides; Amyloid-beta; Tau protein; Acetylcholine

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2011 سفارش ترجمه

Design and evaluation of a 6-mer amyloid-beta protein derived phage display library for molecular targeting of amyloid plaques in Alzheimer's disease: Comparison with two cyclic heptapeptides derived from a randomized phage display library

Keywords: آمیلوئید بتا; Alzheimer's disease; Amyloid-beta; Phage display; Amyloid plaques; High-throughput screening

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2011 سفارش ترجمه

Protective effects of bone morphogenetic protein 7 against amyloid-beta induced neurotoxicity in PC12 cells

Keywords: آمیلوئید بتا; BMP7; amyloid-beta; basal forebrain; hippocampus; neurotoxicity; Alzheimer's diseaseACSF, artificial cerebral spinal fluid; AD, Alzheimer's disease; Annexin V/PI, annexin V and propidium iodide; Aβ, amyloid-beta; BMPs, bone morphogenetic proteins; BMP7, b

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه