Keywords: Thyroid cancer; Human biomonitoring; Biomarkers; B-Raf; Ret;
مقالات ISI (ترجمه نشده)
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Keywords: AKT inhibitor; autoimmune adverse effects; autoimmune dermopathies; B-RAF; dabrafenib; dermatitis; dual inhibitor; dysgeusia; everolimus; hair loss; hedgehog signaling pathway; immunotherapy; immune-related toxicities; ipilimumab; keratoacanthoma; keratos
Keywords: Guanidine; Sorafenib; Protein kinases; RAF-1; MEK-1; Docking; EGFR; Epidermal growth factor receptor; ERK; extracellular signal-regulated kinase; HB; hydrogen bond; MAPK; Mitogen-activated protein kinase; MEK; Mitogen-activated protein/extracellular signa
Keywords: TNNI3K; B-Raf; Quinazoline; Substituent effects; Kinase selectivity
Design, synthesis, and biological evaluation of new B-RafV600E kinase inhibitors
Keywords: B-Raf; Molecular dynamics; Docking; Kinase inhibitor; Drug design;
Design and discovery of thioether and nicotinamide containing sorafenib analogues as multikinase inhibitors targeting B-Raf, B-RafV600E and VEGFR-2
Keywords: Nicotinamide; B-Raf; VEGFR-2; Kinase inhibitor; Antitumor;
Anticancer potential of benzothiazolic derivative (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-4-nitrophenol against melanoma cells
Keywords: AFN01; (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-4-nitrophenol; AO/EB; acridine orange/ethidium bromide; DCB; dacarbazine; DI; damage index; DMEM; Dulbecco's Modified Eagle's Medium; DMSO; dimethylsulfoxide; DNA; deoxyribonucleic acid; DX; doxorub
ER stress and cancer: The FOXO forkhead transcription factor link
Keywords: Endoplasmic reticulum; ER stress; Cancer; FOXO; Forkhead transcription factors; Unfolded protein response; AKT; Protein Kinase B; AKT1; Protein Kinase B Alpha; AMPK; AMP-activated protein kinase; ASK1; Apoptosis Signal Regulated Kinase 1; ATF4; Activating
Design, synthesis and anticancer evaluation of novel spirobenzo[h]chromene and spirochromane derivatives with dual EGFR and B-RAF inhibitory activities
Keywords: Spirobenzo[h]chromene; Spirochromane; B-RAF; EGFR; Docking; Anticancer agents;
EGFR, KRAS, BRAF and HER2 testing in metastatic lung adenocarcinoma: Value of testing on samples with poor specimen adequacy and analysis of discrepancies
Keywords: Genes, erbB-1; Genes, ras; B-raf; Genes, erbB-2; Adenocarcinoma of lung;
Exchange proteins directly activated by cAMP induce the proliferation of rat anterior pituitary GH3 cells via the activation of extracellular signal-regulated kinase
Keywords: Epac; B-Raf; ERK; Proliferation; Pituitary cells;
Enhanced B-Raf-mediated NRF2 gene transcription and HATs-mediated NRF2 protein acetylation contributes to ABCC1-mediated chemoresistance and glutathione-mediated survival in acquired topoisomerase II poison-resistant cancer cells
Keywords: ABC; ATP-binding cassette; ABCC; The ABC subfamily C; ABCC1; ATP-binding cassette subfamily C member 1; AHR; aryl hydrocarbon receptor; AKR1C1; aldo-keto reductase family 1 member C1; AREs; antioxidant-responsive elements; B-Raf; B-Raf proto-oncogene, ser
Optimization of tetrahydronaphthalene inhibitors of Raf with selectivity over hERG
Keywords: B-Raf; B-Raf inhibitor; hERG
BRAF mutations in non-small cell lung cancer: has finally Janus opened the door?
Keywords: B-Raf; NSCLC; Mutation; B-Raf inhibitors; Drug;
Design, biological evaluation and 3D QSAR studies of novel dioxin-containing triaryl pyrazoline derivatives as potential B-Raf inhibitors
Keywords: Break limit; Triaryl pyrazoline; Dioxin; Antitumor activity; B-Raf; Selective; 3D QSAR
Purinylpyridinylamino-based DFG-in/αC-helix-out B-Raf inhibitors: Applying mutant versus wild-type B-Raf selectivity indices for compound profiling
Keywords: B-Raf; Inhibitor; DFG; C-helix; Selectivity; v600e; Wild-type; Sulfonamide
Synthesis, anticancer activity and photostability of novel 3-ethyl-2-mercapto-thieno[2,3-d]pyrimidin-4(3H)-ones
Keywords: Thieno[2,3-d]pyrimidin-4(3H)-ones; DFT; Cytotoxicity; Photo stability; Anticancer activity; B-Raf;
Global gene expression profiling analysis reveals reduction of stemness after B-RAF inhibition in colorectal cancer cell lines
Keywords: Colon cancer; Gene expression; Differentiation; B-RAF; Bioinformatics
Expression of tumor-related Rac1b antagonizes B-Raf-induced senescence in colorectal cells
Keywords: B-Raf; Colorectal cancer; Oncogene-induced senescence; Rac1b; Tumor progression;
Recent progress on MAP kinase pathway inhibitors
Keywords: MAPK; Kinase; B-RAF; MEK; ERK;
Mammalian cell transient expression, non-affinity purification, and characterization of human recombinant IGFBP7, an IGF-1 targeting therapeutic protein
Keywords: BRAF; B-Raf; CAG; chicken β-actin; CHO; Chinese hamster ovary; CV; column volume; EBV; Epstein-Barr virus; Fer L; ferritin composite light chain; GFP; green fluorescent protein; Grp 78; glucose-regulated protein 78; HEK 293E cell; human embryonic kidne
Histopathologic clues for the diagnosis of Wiesner nevus
Keywords: BAP1 protein; B-raf; epithelioid and spindle cell; human; nevus; proto-oncogene proteins; BAP1; BRCA1-associated protein 1; BRAF; v-raf murine sarcoma viral oncogene homolog B1;
Novel pyrazoline derivatives as bi-inhibitor of COX-2 and B-Raf in treating cervical carcinoma
Keywords: IC50, half maximal inhibitory concentration; GI50, the concentration that causes 50% growth inhibition; QSAR, quantitative structure–activity relationshipCelecoxib; Modification; Pyrazoline; Bi-inhibitor; Cervical carcinoma; COX-2; B-Raf; 3D QSAR
Imidazo[4,5-b]pyridine inhibitors of B-Raf kinase
Keywords: B-Raf; Imidazopyridine; Scaffold hopping; DFG-in; αC-helix out;
B-Raf mutation: A key player in molecular biology of cancer
Keywords: B-Raf; BRAF; Mutation; Melanoma; Colorectal cancer; Thyroid cancer
RKIP regulates MAP kinase signaling in cells with defective B-Raf activity
Keywords: RKIP; Raf-1; B-Raf; MAPK
Potent and selective pyrazolo[1,5-a]pyrimidine based inhibitors of B-RafV600E kinase with favorable physicochemical and pharmacokinetic properties
Keywords: B-Raf; Kinase; Drug discovery; Cancer;
The discovery of potent and selective pyridopyrimidin-7-one based inhibitors of B-RafV600E kinase
Keywords: B-Raf; Kinase; Drug discovery; Pyridopyrimidin-7-one; Structure based drug design
B-RAF: A contributor to the melanoma phenotype
Keywords: B-RAF; Melanoma; RAS-RAF-MEK-ERK pathway
Non-oxime inhibitors of B-RafV600E kinase
Keywords: B-Raf; Furopyridine; Indazole
The Discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors
Keywords: B-Raf; Kinase; Cancer therapy
Non-oxime pyrazole based inhibitors of B-Raf kinase
Keywords: B-Raf; Oxime; Pyrazole
Melanoma cells show a heterogeneous range of sensitivity to ionizing radiation and are radiosensitized by inhibition of B-RAF with PLX-4032
Keywords: Melanoma; B-RAF; Radiosensitization; PLX-4032;
A novel class of specific Hsp90 small molecule inhibitors demonstrate in vitro and in vivo anti-tumor activity in human melanoma cells
Keywords: Hsp90; B-Raf; Melanoma; Cancer drug
Melanoma Pathology: Important Issues for Clinicians Involved in the Multidisciplinary Care of Melanoma Patients
Keywords: Diagnosis; Melanoma; Pathology; Prognosis; Sentinel node, Staging; Biopsy; B-RAF; Molecular pathology; Mutation;
Discovery and optimization of pyrazoline compounds as B-Raf inhibitors
Keywords: B-Raf; B-Raf inhibitor; Pyrazoline
The phosphorylation specificity of B-RAFWT, B-RAFD594V, B-RAFV600E and B-RAFK601E kinases: An in silico study
Keywords: B-RAF; B-RAFV600E; GRID; Molecular dynamics; Kinase
Surgical implications of B-RafV600E mutation in fine-needle aspiration of thyroid nodules
Keywords: B-Raf; Fine-needle aspiration biopsy; Thyroid nodules; Papillary thyroid cancer
Application of a novel [3+2] cycloaddition reaction to prepare substituted imidazoles and their use in the design of potent DFG-out allosteric B-Raf inhibitors
Keywords: B-Raf; p38; Type-II; Allosteric; Kinase inhibitor; Structure-base design; de novo
Identification of pyrazolo[1,5-a]pyrimidine-3-carboxylates as B-Raf kinase inhibitors
Keywords: B-Raf; B-Raf Inhibitor; Pyrazolo[1,5-a]pyrimidine-3-carboxylate
Discovery of highly potent and selective type I B-Raf kinase inhibitors
Keywords: B-Raf; Kinase; Inhibitors; RAS; Raf
Novel pyrazolopyrimidines as highly potent B-Raf inhibitors
Keywords: B-Raf; Pyrazolopyrimidines; B-Raf inhibitors; Indazole; Phenol isostere;
Biological effects of hexitol and altritol-modified siRNAs targeting B-Raf
Keywords: siRNA; Hexitol; Altritol; Chemical modification; B-Raf; Stability
A gene marker panel covering the Wnt and the Ras-Raf-MEK-MAPK signalling pathways allows to detect gene mutations in 80% of early (UICC I) colon cancer stages in humans
Keywords: APC; B-RAF; CTNNB1; Colorectal carcinomas; K-RAS; Microsatellite instability; Oncogenes; Tumour suppressor genes
The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase
Keywords: B-Raf; Kinase; Furan; Indanone-oxime; Stroke
Dual binding site inhibitors of B-RAF kinase
Keywords: B-RAF; Kinase inhibitors; Diarylimidazoles
Differential selection for B-raf and Ha-ras mutated liver tumors in mice with high and low susceptibility to hepatocarcinogenesis
Keywords: Mouse hepatocarcinogenesis; Ha-ras; B-raf; Gene mutation; Strain-specific selection
The Effect of Gefitinib on B-RAF Mutant Non-small Cell Lung Cancer and Transfectants
Keywords: Non-small cell lung cancer; B-RAF; Epidermal growth factor receptor; Gefitinib; Epidermal growth factor receptor-tyrosine kinase inhibitors
Enhanced B-Raf protein expression is independent of V600E mutant status in thyroid carcinomas
Keywords: Thyroid carcinoma; B-Raf; Immunohistochemistry; BRAF mutation
Raf-1 and B-Raf promote protein kinase C θ interaction with BAD
Keywords: T-cells; Raf-1; B-Raf; PKCθ; BAD; Phosphorylation; Signal transduction;