کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
8553873 | 1562695 | 2018 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Anticancer potential of benzothiazolic derivative (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-4-nitrophenol against melanoma cells
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کلمات کلیدی
HCT-8DCBB-RafMDA-MB-435LMPIC50HL-60NaClMelanoma cell lineNaOHNMPFBSDMEMAO/EB - AO / EBDMSO - DMSODNA - DNA یا اسید دزوکسی ریبونوکلئیکDulbecco's modified Eagle's medium - Medal of Eagle اصلاح شده Dulbeccoacridine orange/ethidium bromide - آکاردین نارنجی / اتیدیم برومیدdeoxyribonucleic acid - اسید deoxyribonucleicdacarbazine - داکarbازینDoxorubicin - دوکسوروبیسینDimethylsulfoxide - دیمتیل سولفواکسیدSodium chloride - سدیم کلریدfetal bovine serum - سرم جنین گاوCytotoxicity - سمیت سلولیDamage index - شاخص خسارتCutaneous melanoma - ملانوم جلدیnormal melting point agarose - نقطه ذوب طبیعی آگارزlow melting point agarose - نقطه ذوب پایین آگارزsodium hydroxide - هیدروکسید سدیم
موضوعات مرتبط
علوم زیستی و بیوفناوری
علوم محیط زیست
بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Anticancer potential of benzothiazolic derivative (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-4-nitrophenol against melanoma cells Anticancer potential of benzothiazolic derivative (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-4-nitrophenol against melanoma cells](/preview/png/8553873.png)
چکیده انگلیسی
Malignant melanoma is an important type of cancer worldwide due to its aggressiveness and poor survival rate. Significant efforts to understand the biology of melanoma and approaches to treat the advanced disease are focused on targeted gene inhibitors. Frequently mutated genes, such as NRAS, B-RAF and TP53, significantly exceed the frequency of mutations of other genes, emphasizing their importance for future targeted therapies. Considering the antitumor activity of benzothiazolic derivatives, this study aimed to demonstrate the action of benzothiazolic (E)-2-((2-(benzo[d]thiazol-2-yl)hydrazono)methyl)-4-nitrophenol (AFN01) against three established human melanoma cell lines that recapitulate the molecular landscape of the disease in terms of its genetic alterations and mutations, such as the TP53, NRAS and B-RAF genes. The results presented here indicate that AFN01, as a significant cytostatic and cytotoxic drug due to its induction of DNA fragmentation, causes single and double DNA strand breaks, consequently inhibiting cell proliferation, migration and invasion by promoting apoptosis. Our data suggest that AFN01 might be considered as a future therapeutic option for managing melanoma.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Toxicology in Vitro - Volume 50, August 2018, Pages 225-235
Journal: Toxicology in Vitro - Volume 50, August 2018, Pages 225-235
نویسندگان
Zanair Soares Vasconcelos, Ana Carolina Lima Ralph, Danielle Queiroz Calcagno, Gleyce dos Santos Barbosa, Tatiana do Nascimento Pedrosa, Lucas Pio Antony, MarÃlia de Arruda Cardoso Smith, Eliza de Lucas Chazin, Thatyana Rocha Alves Vasconcelos,