Bortezomib induces autophagy in head and neck squamous cell carcinoma cells via JNK activation
Keywords: Bortezomib; Autophagy; HNSCC; JNK; Bcl-2;
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Rice protein hydrolysate attenuates hydrogen peroxide induced apoptosis of myocardiocytes H9c2 through the Bcl-2/Bax pathway
Keywords: Rice protein hydrolysate; Myocardiocytes; Apoptosis; Bcl-2; Bax;
dl-3-n-Butylphthalide protects rat bone marrow stem cells against hydrogen peroxide-induced cell death through antioxidation and activation of PI3K-Akt pathway
Keywords: ANOVA; analysis of variance; (r)BMSCs; (rat)bone marrow stem cells; Bax; Bcl-2-associated x protein; Bcl-2; B cell lymphoma-2; Caspase; cysteinyl aspartate-specific protease; CRT; cell replacement therapy; DCFH-DA; fluorescent probe 2â²,7â²-dichlorofluo
Corneal endothelial autocrine trophic factor VIP in a mechanism-based strategy to enhance human donor cornea preservation for transplantation
Keywords: corneal endothelium; corneal preservation for transplantation; CNTF; VIP; N-cadherin; connexin-43; Bcl-2; oxidative stress
Molecular basis for the interplay of apoptosis and proliferation mediated by Bcl-xL:Bim interactions in pancreatic cancer cells
Keywords: Bcl-2; B-cell lymphoma 2; BH; Bcl-2 homology; siRNA; small interfering RNA; Bcl-2 family; Mutagenesis; Apoptosis; Proliferation; Computational biochemistry;
The role of survivin and Bcl-2 in zinc-induced apoptosis in prostate cancer cells
Keywords: Prostate cancer; Zinc; Bcl-2; Survivin; Apoptosis;
Targeting C/EBP homologous protein with siRNA attenuates cerebral vasospasm after experimental subarachnoid hemorrhage
Keywords: BA; basilar artery; bcl-2; B-cell lymphoma-2; bim; B cell lymphoma-2 interacting mediator of cell death; CHOP; C/EBP homologous protein; CVS; cerebral vasospasm; ER; endoplasmic reticulum; SAH; subarachnoid hemorrhage; siRNA; small interfering ribonucleic
Smad2 is involved in the apoptosis of murine gingival junctional epithelium associated with inhibition of Bcl-2
Keywords: Smad2; Apoptosis; Gingival junctional epithelium; Bcl-2;
Euphol from Euphorbia tirucalli selectively inhibits human gastric cancer cell growth through the induction of ERK1/2-mediated apoptosis
Keywords: BAX; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; ERK1/2; extra-cellular signal-regulated kinase 1/2; IC50; 50% inhibitory concentration; FITC; fluorescein isothiocyanate; MAPK; mitogen-activated protein kinase; PBS; phosphate buffered saline; p-
Mood stabilizers commonly restore staurosporine-induced increase of p53 expression and following decrease of Bcl-2 expression in SH-SY5Y cells
Keywords: BD; bipolar disorder; Li; lithium; VPA; valproate; CBZ; carbamazepine; LTG; lamotrigine; DG; dentate gyrus; STS; staurosporine; ADP; adult rat dentate gyrus-derived neural precursor cell; Apoptosis; Hippocampus; Dentate gyrus; Adult neurogenesis; Bcl-2;
Research reportInvolvement of GPR12 in the induction of neurite outgrowth in PC12 cells
Keywords: FGF; fibroblast growth factor; NGF; nerve growth factor; cAMP; cyclic AMP; PKA; protein kinase A; GPCR; G protein-coupled receptor; SYP; synaptophysin; MAP-2; microtubule-associated protein-2; GPR12; Phosphor-Erk1/2; Synaptophysin; Bcl-xL; Bcl-2;
Decreased Beclin-1 expression is correlated with the growth of the primary tumor in patients with squamous cell carcinoma and adenocarcinoma of the lung
Keywords: Lung; Squamous cell carcinoma; Adenocarcinoma; Beclin-1; Bcl-2
MicroRNA-125b Induces Cancer Cell Apoptosis Through Suppression of Bcl-2 Expression
Keywords: miR-125b; Bcl-2; Apoptosis; Proliferation
Oxytocin protects cardiomyocytes from apoptosis induced by ischemia-reperfusion in rat heart: Role of mitochondrial ATP-dependent potassium channel and permeability transition pore
Keywords: Oxytocin; Cardioprotection; 5HD; Atractyloside; Apoptosis; Bcl-2;
miR-181 targets multiple Bcl-2 family members and influences apoptosis and mitochondrial function in astrocytes
Keywords: Bcl-2; Mcl-1; Bim; Astrocyte; miR-181; Mitochondria;
Structure-based design of rhodanine-based acylsulfonamide derivatives as antagonists of the anti-apoptotic Bcl-2 protein
Keywords: Bcl-2; Apoptosis; Antagonist; Structure-based design; Acylsulfonamide
The administration of olanzapine and fluoxetine has synergistic effects on intracellular survival pathways in the rat brain
Keywords: Akt; BDNF; CREB; Bcl-2; BAD; Fluoxetine; Olanzapine
Antitumor effects of emodin on LS1034 human colon cancer cells in vitro and in vivo: Roles of apoptotic cell death and LS1034 tumor xenografts model
Keywords: ÎΨm; mitochondrial membrane potential; AIF; apoptosis-inducing factor; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; DAPI; 4,6-diamidino-2-phenylindole dihydrochloride; DMSO; dimethyl sulfoxide; Endo G; endonuclease G; DCFH-DA; 2â²,7â²-di
The antiapoptotic OPA1/Parl couple participates in mitochondrial adaptation to heat shock
Keywords: BAK; Bcl-2 associated killer; BAX; Bcl-2 associated protein X; BCL-2; B-cell lymphoma 2; DRP1; dynamin related protein 1; FCCP; cyanide m-fluorophenylhydrazone; FIS1; fission 1; HSP; heat shock protein; IMM; inner mitochondrial membrane; IMS; intermembran
The use of Bcl-2 over-expression to stabilize hybridomas specific to the HERG potassium channel
Keywords: Hybridoma; Apoptosis; Bcl-2; HERG; Potassium channel;
Bcl-rambo induces apoptosis via interaction with the adenine nucleotide translocator
Keywords: ANT; adenine nucleotide translocator; BA; bonkrekic acid; BH; Bcl-2 homology; CsA; cyclosporin A; MMP; mitochondrial membrane potential; MPT; mitochondrial permeability transition; VDAC; voltage-dependent anion channel; Bcl-rambo; Bcl-2; Permeability tran
Ubiquitination and phosphorylation of Beclin 1 and its binding partners: Tuning class III phosphatidylinositol 3-kinase activity and tumor suppression
Keywords: Beclin 1; Phosphatidylinositol 3-kinase (PI3K); VPS34; VPS15; Ubiquitination; Ubiquitin-protein ligase (E3); Cancer; NEDD4; TRAF6; BCL-2;
Molecular and immunohistochemical characterization of B-cell lymphoma-2-negative follicular lymphomas
Keywords: BCL-2; BCL-2 isoforms; Follicular lymphoma; Immunohistochemistry; Caspase 3;
Odontoblast-targeted Bcl-2 overexpression promotes dentine damage repair
Keywords: α-MEM; alpha-minimum essential medium; BCA; bicinchoninic acid assay; Bcl-2; B-cell lymphoma-2; hBcl-2; human Bcl-2; mBcl-2; mouse Bcl-2; mBax; mouse Bcl-2-associated X protein; βGP; beta-glycerophosphate; BMP; bone morphogenetic protein; BSA; bovine se
Mitochondrial carrier homolog 2 (MTCH2): The recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis
Keywords: Apoptosis; Mitochondrial carriers; MTCH2; BID; BCL-2;
Mitochondrial Ca2+ signals in autophagy
Keywords: mTOR; mammalian target of rapamycin; InsP3R; inositol 1,4,5-trisphosphate receptor; AMPK; adenosine monophosphate activated protein kinase; mTORC1; mammalian target of rapamycin complex 1; GAP; GTPase activating protein; TSC1/TSC2; tuberous sclerosis comp
Inhibition of GSK-3β reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells
Keywords: A; AR-A014418, GSK-3β inhibitor; ANOVA; analysis of variance; ATF3; activating transcription factor 3; Bax; Bcl-2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-XL; B-cell lymphoma-extra large; DMSO; dimethyl sulfoxide; DOC-Na; sodium deoxycholate;
Lipopolysaccharide induces endothelial cell apoptosis via activation of Na+/H+ exchanger 1 and calpain-dependent degradation of Bcl-2
Keywords: Apoptosis; Bcl-2; Endothelial cell; Lipopolysaccharide; Na+/H+ exchanger
Differential induction of autophagy in caspase-3/7 down-regulating and Bcl-2 overexpressing recombinant CHO cells subjected to sodium butyrate treatment
Keywords: Autophagy; Caspase-3/7; Bcl-2; Sodium butyrate; CHO cells; Beclin-1
Anti-inflammatory and anti-apoptotic effects of strawberry and mulberry fruit polysaccharides on lipopolysaccharide-stimulated macrophages through modulating pro-/anti-inflammatory cytokines secretion and Bcl-2/Bak protein ratio
Keywords: Anti-apoptotic effect; Bak; Bcl-2; Mulberry fruit polysaccharide; Strawberry fruit polysaccharide; Pro-/anti-inflammatory cytokines;
Role of JNK and p38 MAPK in Taiwanin A-induced cell death
Keywords: Taiwanin A; Apoptosis; p53; Bcl-2; p38; JNK;
Beta-eleostearic acid induce apoptosis in T24 human bladder cancer cells through reactive oxygen species (ROS)-mediated pathway
Keywords: β-ESA; beta-eleostearic acid; ROS; reactive oxygen species; PPARγ; peroxisome proliferator-activated receptor; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; GSH; glutathione; Bcl-2; B cell lymphoma/leukemia-2; β-Eleostearic acid; A
Anti-oxidative, anti-glycative and anti-apoptotic effects of oleanolic acid in brain of mice treated by d-galactose
Keywords: Aging; Oleanolic acid; Glycation; Aldose reductase; NF-κB; Bcl-2;
STRUCTURE-FUNCTION OF THE TUMOR SUPPRESSOR BRCA1
Keywords: Apoptosis; Bcl-2; Bax; BH3 domain; Apaf-1; Apoptosome
The BH3 mimetic S1 induces autophagy through ER stress and disruption of Bcl-2/Beclin 1 interaction in human glioma U251 cells
Keywords: Autophagy; ER stress; BH3 mimetic; Bcl-2
Prognostic significance of Bcl-2 in invasive mammary carcinomas: a comparative clinicopathologic study between “triple-negative” and non–“triple-negative” tumors
Keywords: Invasive breast carcinoma; Triple-negative breast carcinoma; Bcl-2; Immunohistochemistry; Survival
Memantine prevents cognitive impairment and reduces Bcl-2 and caspase 8 immunoreactivity in rats injected with amyloid β1–40
Keywords: Memantine; Amyloid; Neurodegeneration; Apoptosis; Caspase 8; Bcl-2
Ghrelin regulates Bax and PCNA but not Bcl-2 expressions following scrotal hyperthermia in the rat
Keywords: Ghrelin; Bax; Bcl-2; PCNA; Testis
Mcl-1 regulates the survival of adult neural precursor cells
Keywords: Bcl-2; B cell lymphoma 2; Bcl-xL; B cell lymphoma X large fragment; CKO; conditional knockout; BrdU; Bromodeoxyuridine; Cre; Cre recombinase; CMV; cytomegalovirus; Dcx; Doublecortin; DIV; days in vitro; FGF-2; fibroblast growth factor 2; GFAP; glial fibri
Hydrogen sulfide prevents formaldehyde-induced neurotoxicity to PC12 cells by attenuation of mitochondrial dysfunction and pro-apoptotic potential
Keywords: Hydrogen sulfide; Formaldehyde; Neuroprotection; Mitochondria; Reactive oxygen species; Bcl-2
Bcl-2 increases stroke-induced striatal neurogenesis in adult brains by inhibiting BMP-4 function via activation of β-catenin signaling
Keywords: Adult neurogenesis; Wnt/β-catenin signaling; Bcl-2; Regeneration; Stroke; Neural repair
FMRFamide-related peptides: Anti-opiate transmitters acting in apoptosis
Keywords: ERK-1/2; extracellular signal-regulated protein kinase 1/2; Bcl-2; B-cell lymphoma 2; FADD; Fas-associated death domain; KOP; kappa (κ) opioid receptor; MEIS; homeobox protein Meis1; MOP; mu (μ) opioid receptor; Oct-1; octamer-binding protein 1; p38 MAP
Ruthenium methylimidazole complexes induced apoptosis in lung cancer A549 cells through intrinsic mitochondrial pathway
Keywords: Ruthenium; Apoptosis; Caspase; Bcl-2; Mitochondria;
miR-15b and miR-16 induce the apoptosis of rat activated pancreatic stellate cells by targeting Bcl-2 in vitro
Keywords: Pancreatic stellate cells; miR-15b; miR-16; Bcl-2; Apoptosis;
Research ReportResveratrol attenuates brain damage in a rat model of focal cerebral ischemia via up-regulation of hippocampal Bcl-2
Keywords: Resveratrol; Middle cerebral artery occlusion; Long-term potentiation; Neuroprotection; Bcl-2; Bax;
Standardized flavonoid-rich fraction of Artemisia princeps Pampanini cv. Sajabal induces apoptosis via mitochondrial pathway in human cervical cancer HeLa cells
Keywords: Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma-extra large; Bax; Bcl-2 associated X protein; ÎΨm; mitochondria membrane potential; Caspase; cystein aspartyl-specific protease; PARP; poly (ADP-ribose) polymerase; GAPDH; glyceraldehyde 3-phosphate dehy
Enriching the human apoptosis pathway by predicting the structures of protein-protein complexes
Keywords: AIF; apoptosis-inducing factor, mitochondrion-associated, 1; Apaf-1; apoptotic peptidase activating factor 1; Bax; BCL2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-XL; Bcl-extra large; Bid; BH3 interacting domain death agonist; CASP3; caspase-3; C
Anti-cancer properties of glucosamine-hydrochloride in YD-8 human oral cancer cells: Induction of the caspase-dependent apoptosis and down-regulation of HIF-1α
Keywords: Apaf-1; apoptotic protease activating factor-1; Bcl-2; B cell lymphoma-2; Bcl-xL; B cell lymphoma-extra large; DCFH-DA; 2â²,7â²-dichlorofluorescein-diacetate; ECL; enzyme-linked chemiluminescence; FBS; fetal bovine serum; GAPDH; glyceraldehyde-3-phospha
Akt2 inhibits the activation of NFAT in lymphocytes by modulating calcium release from intracellular stores
Keywords: Akt; NFAT; Bcl-2; IP3 receptor; Calcium mobilization; B cell signaling;
Inhibition of Bcl-2 improves effect of LCL161, a SMAC mimetic, in hepatocellular carcinoma cells
Keywords: HCC; hepatocellular carcinoma; IAP; inhibitor of apoptosis; SMAC; second mitochondrial activator of caspases; TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; PARP; polypolymerase; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine