BCL-2 family proteins as regulators of mitochondria metabolism
Keywords: پیشنهاد; Mitochondria metabolism; Stem cells; Apoptosis; BCL-2; BID; MTCH2;
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Autophagic down-regulation in motor neurons remarkably prolongs the survival of ALS mice
Keywords: پیشنهاد; LC3; microtubule-associated protein 1 light chain 3; SOD1G93A; mutant human Cu/Zn superoxide dismutase; n-BP; n-butylidenephthalide; bid; two times a day; qd; one times a day;
Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye
Keywords: پیشنهاد; alkali injury; corticoid; dexamethasone; doxycycline; dry eye; neutrophils; MMPs; ocular perforation; AB; Alkali burn; BID; Bis in die, i.e., twice a day; BSS; Balanced salt solution; CM; Combined model (AB+DS); D; Days; Dex; Dexamethasone; Doxy; Doxycycl
Sevoflurane post-conditioning protects primary rat cortical neurons against oxygen-glucose deprivation/resuscitation via down-regulation in mitochondrial apoptosis axis of Bid, Bim, Puma-Bax and Bak mediated by Erk1/2
Keywords: پیشنهاد; Sevoflurane; Neuroprotection; Extracellular signal-related kinases 1/2; Bid; Bim; Puma; Bak; Bax;
Hepatocyte autophagy is linked to C/EBP-homologous protein, Bcl2-interacting mediator of cell death, and BH3-interacting domain death agonist gene expression
Keywords: پیشنهاد; Autophagy; Endoplasmic reticulum stress; BIM; BID; CHOP; Hepatocyte
Efficacy of BI 671800, an oral CRTH2 antagonist, in poorly controlled asthma as sole controller and in the presence of inhaled corticosteroid treatment
Keywords: پیشنهاد; CRTH2 antagonist; Asthma; Inhaled corticosteroid; ACQ; Asthma Control Questionnaire; AQLQ; Asthma Quality of Life Questionnaire; AUC; area under the curve; bid; twice daily; CI; confidence interval; CRTH2; chemoattractant receptor homologous molecule on T
Research ArticleRandomized study of danoprevir/ritonavir-based therapy for HCV genotype 1 patients with prior partial or null responses to peginterferon/ribavirin
Keywords: پیشنهاد; HCV; hepatitis C virus; PegIFN; peginterferon; danoprevir/r; ritonavir-boosted danoprevir; IFN; interferon; RNA; ribonucleic acid; SVR24; sustained virological response 24Â weeks after end-of-treatment; G; genotype; bid; twice daily; ACTG; AIDS Clinical T
Research ArticleSTARTVerso1: A randomized trial of faldaprevir plus pegylated interferon/ribavirin for chronic HCV genotype-1 infection
Keywords: پیشنهاد; HCV; hepatitis C virus; PI; protease inhibitor; PegIFN; peginterferon; RBV; ribavirin; SVR; sustained virologic response; DDI; drug-drug interaction; BID; twice daily; ETS; early treatment success; TD; target detected; TND; target not detected; EVR; ear
A randomised, double-blind, four-way, crossover trial comparing the 24-h FEV1 profile for once-daily versus twice-daily treatment with olodaterol, a novel long-acting β2-agonist, in patients with chronic obstructive pulmonary disease
Keywords: پیشنهاد; Olodaterol; Long-acting beta-2-agonist; COPD; AE; adverse event; AUC0-12; area under the curve from 0 to 12Â h; AUC0-24; area under the curve from 0 to 24Â h; AUC12-24; area under the curve from 12 to 24Â h; BID; twice daily; CI; confidence interval
Retinoids induce Nur77-dependent apoptosis in mouse thymocytes
Keywords: پیشنهاد; ATRA; all-trans retinoic acid; Bcl-2; B cell lymphoma 2; Bid; BH3 interacting domain death agonist; DP; double positive; 9cRA; 9-cis retinoic acid; FasL; Fas ligand; NDG-1; Nur77 dependent gene-1 coded protein; RALDH; retinaldehyde dehydrogenase; RAR; ret
Angiotensin II-induced mouse hippocampal neuronal HT22 cell apoptosis was inhibited by propofol: Role of neuronal nitric oxide synthase and metallothinonein-3
Keywords: پیشنهاد; Ang II; angiotensin II; APAF-1; apoptotic protease activating factor-1; AT1R; angiotensin type 1 receptor; AT2R; angiotensin type 2 receptor; Bcl-2; B-cell lymphoma-2; BID; BH3-interacting domain; cIAP-1; cellular inhibitor of apoptosis protein-1; c-FLIP;
A randomized, three-period crossover study of umeclidinium as monotherapy in adult patients with asthma
Keywords: پیشنهاد; Asthma; Fixed-dose combination; Muscarinic antagonist; Inhaled corticosteroid; Trough FEV1; Ae; amount of dose excreted unchanged in urine; AE; adverse event; ALT; alanine aminotransferase; AUC; area under the curve; BID; twice daily; bpm; beats per minut
Sp1 transcription factor: A long-standing target in cancer chemotherapy
Keywords: پیشنهاد; Anticancer drugs; Prognosis; Sp1; Sp3; Transcription factors; Targeted therapy; AMPKα; AMP-activated protein kinase alpha catalytic subunit; Bcl-2; B cell/lymphoma 2; Bcl-w; member of the Bcl-2 family; Bid; BH3 interacting domain death agonist; CDK; cycl
Clinical trials of N-acetylcysteine in psychiatry and neurology: A systematic review
Keywords: پیشنهاد; ABC; Aberrant Behavior Checklist; AD; Alzheimer's disease; ADCS-ADL; Alzheimer's Disease Cooperative Study - Activities of Daily Living; ADHD; attention deficit hyperactivity disorder; ADL; Activities of Daily Living; ADP; adenosine diphosphate; AE; adv
Dexamethasone differentially regulates Bcl-2 family proteins in human proliferative chondrocytes: Role of pro-apoptotic Bid
Keywords: پیشنهاد; Dexamethasone; Human growth plate; Chondrocytes; Apoptosis; Bcl-2 family proteins; Bid; GCs; glucocorticoids; Dexa; dexamethasone; Cont; control;
Treatment of venous thrombosis with an oral direct factor Xa inhibitor edoxaban by single and multiple administrations in rats
Keywords: پیشنهاد; APTT; activated partial thromboplastin time; BID; twice daily; DVT; deep vein thrombosis; factor Xa; activated factor X; HE; hematoxylin and eosin; PE; pulmonary embolism; PT; prothrombin time; PTAH; phosphotungstic acid hematoxylin; QD; once daily; S.E.M
A case series of LMWH use in pregnancy: Should trough anti-Xa levels guide dosing?
Keywords: پیشنهاد; AMS; Anticoagulation Management Service; BID; twice daily; CrCl; creatinine clearance; CVA; cerebrovascular accident; IV; intravenous; LMWH; low molecular weight heparin; MHV; mechanical heart valves; NA; not applicable; OAC; oral anticoagulant; OMC; Obst
Research ArticleA randomized, double-blind, multiple-dose study of the pan-genotypic NS5A inhibitor samatasvir in patients infected with hepatitis C virus genotype 1, 2, 3 or 4
Keywords: پیشنهاد; HCV; hepatitis C virus; NS5A; nonstructural protein 5A; DAA; direct-acting antiviral agent; EC50; 50% effective concentration; CYP; cytochrome P450; HBV; hepatitis B virus; HIV; human immunodeficiency virus; QD; once daily; BID; twice daily; AE; adverse e
Research ArticleRandomized trial of asunaprevir plus peginterferon alfa and ribavirin for previously untreated genotype 1 or 4 chronic hepatitis C
Keywords: پیشنهاد; HCV; hepatitis C virus; PegIFNα; peginterferon alfa; RBV; ribavirin; DAA; direct-acting antiviral; BID; twice daily; SVR24; sustained virologic response 24 weeks posttreatment; PDR; protocol-defined response; LLOQ; lower limit of quantification; EVR; ea
In vitro metabolism, disposition, preclinical pharmacokinetics and prediction of human pharmacokinetics of DNDI-VL-2098, a potential oral treatment for Visceral Leishmaniasis
Keywords: پیشنهاد; AUC; area under the concentration-time curve; BCRP; breast cancer resistant protein; BID; twice a day dosing; Caco-2; human epithelial colorectal adenocarcinoma cells; Cb; concentration in blood; Cp; concentration in plasma; CC; calibration curve; CYP;
Inhibition of protein kinase C (PKC) response of voltage-gated calcium (Cav)2.2 channels expressed in Xenopus oocytes by Cavβ subunits
Keywords: پیشنهاد; Ala; alanine; Asp; aspartate; BID; β interaction domain; Cav; high voltage-gated calcium channels; [Ca2+]i; intracellular Ca2+; Hepes; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; IBa; basal barium current; IP3; inositol triphosphate; MAGUK; membr
Research ArticleSafety and efficacy of protease inhibitors to treat hepatitis C after liver transplantation: A multicenter experience
Keywords: پیشنهاد; ALT; alanine aminotransferase; AFEF; French Association for the Study of the Liver; AUC; area under the curve; BID; twice daily (bis in die); BOC; boceprevir; cEVR; complete early virological response; CNI; calcineurin inhibitors; CYP; cytochrome P450; EP
Reversal of New, Factor-specific Oral Anticoagulants by rFVIIa, Prothrombin Complex Concentrate and Activated Prothrombin Complex Concentrate: A Review of Animal and Human Studies
Keywords: پیشنهاد; AF; atrial fibrillation; aPCC; activated prothrombin complex concentrates; BID; twice daily; Cmax; maximal plasma concentration; F; coagulation factor; FEIBA; factor eight inhibitor bypass activity; PCC; prothrombin complex concentrates; rFVIIa; activated
Trimodality Therapy for Superior Sulcus Non-Small Cell Lung Cancer: Southwest Oncology Group-Intergroup Trial S0220
Keywords: پیشنهاد; ARDS; adult respiratory distress syndrome; BID; twice per day; CDDP; cisplatin; Chem Rx; chemotherapy; CI; confidence interval; csf; cerebrospinal fluid; CT; computed tomography; CTCAE; Common Terminology Criteria for Adverse Events; DFS; disease-free sur
The BCL-2 family protein Bid is critical for pro-inflammatory signaling in astrocytes
Keywords: پیشنهاد; ALS; Amyotrophic Lateral Sclerosis; APAF1; Apoptotic protease activating factor 1; BH3-only protein; Bcl-2 homology domain 3-only protein; bid; BH3 interacting domain death agonist; GFAP; glial fibrillary acidic protein; Iba-1; ionized calcium-binding ada
Comparative profile of cutaneous adverse events: BRAF/MEK inhibitor combination therapy versus BRAF monotherapy in melanoma
Keywords: پیشنهاد; cutaneous adverse event; histology; inflammation; rash; squamous cell carcinoma; therapy; AK; actinic keratosis; bid; twice a day; BRAFi; BRAF inhibitor; CI; confidence interval; FDA; Food and Drug Administration; KA; keratoacanthoma; MAPK; mitogen-activa
Pharmacokinetic interactions between topiramate and pioglitazone and metformin
Keywords: پیشنهاد; ANOVA; analysis of variance; AUC12; area under concentration-time curve over dosing interval of 12Â h; AUC24; area under concentration-time curve over dosing interval of 24Â h; BID; twice daily dosing; CI; confidence interval; CL/F; oral clearance; Cm
Tetramerization-defects of p53 result in aberrant ubiquitylation and transcriptional activity
Keywords: پیشنهاد; p53; Ubiquitylation; Oligomerization; Transcription; Proteasome; OD; Oligomerization Domain; Bax; Bcl2-associated X protein; Bcl-XL; B-cell lymphoma-extralarge; PUMA; p5pregulated Modulator of Apoptosis; Noxa; Noxious stress induced protein; Bid; BH3 inte
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: پیشنهاد; HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
Research ArticleVirologic response and characterisation of HCV genotype 2-6 in patients receiving TMC435 monotherapy (study TMC435-C202)
Keywords: پیشنهاد; HCV; hepatitis C virus; PegIFN; pegylated interferon; RBV; ribavirin; SVR; sustained virologic response; DAAs; direct-acting antiviral agents; PIs; protease inhibitors; BID; twice daily; QD; once daily; LLOQ; lower limit of quantification; RT-PCR; reverse
ReviewClinical management of drug-drug interactions in HCV therapy: Challenges and solutions
Keywords: پیشنهاد; HCV; hepatitis C virus; DAAs; direct-acting antivirals; HIV; human immunodeficiency virus; SPCs; summary of product characteristics; Peg; polyethylene glycol; BID; twice daily; AKR; aldo-ketoreductases; P-gp; P-glycoprotein; AUC; area under the plasma con
Pooled analysis of two large randomised phase III inhaled mannitol studies in cystic fibrosis
Keywords: پیشنهاد; AE; adverse event; ASL; airway surface liquid; BID; twice a day; BMI; body mass index; CF; cystic fibrosis; CFTR; CF transmembrane conductance regulator; CI; confidence interval; DPI; dry powder inhaler; FEV1; forced expiratory volume in 1Â second; FVC; f
FRET-based evaluation of Bid cleavage in a single primary cultured neuron
Keywords: پیشنهاد; Apoptosis; FRET; Mitochondria; Bid; Primary cell culture; Caspase;
A ROS rheostat for cell fate regulation
Keywords: پیشنهاد; reactive oxygen species; stem cell biology; mitochondria; ATM; BID; cell cycle regulation; hematopoietic lineage
Synergistic induction of TRAIL-mediated apoptosis by anisomycin in human hepatoma cells via the BH3-only protein Bid and c-Jun/AP-1 signaling pathway
Keywords: پیشنهاد; Anisomycin; TRAIL; Apoptosis; Bid; C-Jun/AP-1
Signal flow and pathways in response to early Wallerian degeneration after rat sciatic nerve injury
Keywords: پیشنهاد; ACVR1v; activin A receptor, type 1v; BID; BH3 interacting domain death agonist; BIRC3; baculoviral IAP repeat-containing 3; CCL; chemokine (C-C motif) ligand; CCR; chemokine (C-C motif) receptor; CEACAM; carcinoembryonic antigen-related cell adhesion mole
On competitive bidding: Scoring and position probability graphs
Keywords: پیشنهاد; Bid; Tender; Auction; Construction; Score; Forecast
Concomitant use of medication with antiplatelet effects in patients receiving either rivaroxaban or enoxaparin after total hip or knee arthroplasty
Keywords: پیشنهاد; ASA; acetylsalicylic acid; ATC; Anatomical Therapeutic Chemical Classification; bid; twice daily; CI; confidence interval; CrCl; creatinine clearance; NMCR; non-major clinically relevant; NSAIDs; non-steroidal anti-inflammatory drugs; od; once daily; PFIs
Rivastigmine reduces “likely to use methamphetamine” in methamphetamine-dependent volunteers
Keywords: پیشنهاد; ACh; acetylcholine; AChE; acetylcholinesterase; ANOVA; analysis of variance; BCM; Baylor College of Medicine; BID; twice daily dosing; DA; dopamine; DSM; Diagnostic and Statistical Manual; IV; intravenous; MEDVAMC; Michael E. DeBakey Veteran Affairs Medic
Expression, purification, and characterization of recombinant NOD1 (NLRC1): A NLR family member
Keywords: پیشنهاد; NOD1; Protein expression; FPA; NLR; Nucleotide binding; Bid;
Mitochondrial carrier homolog 2 (MTCH2): The recruitment and evolution of a mitochondrial carrier protein to a critical player in apoptosis
Keywords: پیشنهاد; Apoptosis; Mitochondrial carriers; MTCH2; BID; BCL-2;
An overview of the preclinical toxicity and potential carcinogenicity of sitaxentan (Thelin®), a potent endothelin receptor antagonist developed for pulmonary arterial hypertension
Keywords: پیشنهاد; ALP; alkaline phosphatase; ALT; alanaine aminotransferase; APTT; activated partial thromboplastin time; AST; aspartate aminotransferase; AUC; area under the curve; BID; twice daily; BSEP; bile salt export pump; CMC; carboxymethylcellulose; DILI; drug-indu
Enriching the human apoptosis pathway by predicting the structures of protein-protein complexes
Keywords: پیشنهاد; AIF; apoptosis-inducing factor, mitochondrion-associated, 1; Apaf-1; apoptotic peptidase activating factor 1; Bax; BCL2-associated X protein; Bcl-2; B-cell lymphoma 2; Bcl-XL; Bcl-extra large; Bid; BH3 interacting domain death agonist; CASP3; caspase-3; C
The iso-Score Curve Graph. A new tool for competitive bidding
Keywords: پیشنهاد; Bid; Tender; Auction; Construction; Score; Graph
Fondaparinux - data on efficacy and safety in special situations
Keywords: پیشنهاد; ACS; acute coronary syndrome; anti-Xa; anti-factor Xa activity; APS; antiphospholipid syndrome; BID; twice a day; BMI; body mass index; DVT; deep vein thrombosis; EMA; European Medicines Agency; FDA; U.S. Food and Drug Administration; FEIBA; factor eight
Mathematical relationships between scoring parameters in capped tendering
Keywords: پیشنهاد; Bid; Tender; Auction; Construction; Scoring system
How to win a bid for major sporting events? A stakeholder analysis of the 2018 Olympic Winter Games French bid
Keywords: پیشنهاد; Major sporting events; Stakeholder; Olympic Games; Bid
The molecular mechanism of apoptosis upon caspase-8 activation: Quantitative experimental validation of a mathematical model
Keywords: پیشنهاد; ARK5; AMPK-related protein kinase 5; Bid; BH3-interacting domain death agonist; CARP; caspases-8- and -10-associated RING protein; CASP; caspase; CHX; cycloheximide; DED; death effector domain; DISC; death-inducing signaling complex; EGFP; enhanced green
Plasma levels of vascular endothelial growth factor during and after radiotherapy in combination with celecoxib in patients with advanced head and neck cancer
Keywords: پیشنهاد; COX-2; cyclooxygenase type 2; H&N; head and neck; VEGF; vascular endothelial growth factor; BID; bis in die, twice daily; Gy; Gray; GTV; gross target volume; CTV; clinical target volume; PTV; planned target volume; RTOG; Radiation Therapy Oncology Group;
Caspase-8 and Bid: Caught in the act between death receptors and mitochondria
Keywords: پیشنهاد; Caspase-8; Mitochondria; Bid; Type II cells; Death inducing signalling complex; XIAP;