کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
5857141 1131994 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An overview of the preclinical toxicity and potential carcinogenicity of sitaxentan (Thelin®), a potent endothelin receptor antagonist developed for pulmonary arterial hypertension
کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری علوم محیط زیست بهداشت، سم شناسی و جهش زایی
پیش نمایش صفحه اول مقاله
An overview of the preclinical toxicity and potential carcinogenicity of sitaxentan (Thelin®), a potent endothelin receptor antagonist developed for pulmonary arterial hypertension
چکیده انگلیسی
► Sitaxentan preclinical safety was assessed in mice, rats, and dogs. ► Coagulopathy, increased serum alkaline phosphatase, hepatic hypertrophy and decreased blood parameters were observed. ► Effects occurred at exposures substantially greater than human therapeutic exposure. ► Sitaxentan showed a low potential for testicular and hepatic toxicity and was not carcinogenic. ► The pattern of sitaxentan toxicity could be characterized as an exaggeration of its pharmacological mechanism of action.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Regulatory Toxicology and Pharmacology - Volume 64, Issue 1, October 2012, Pages 95-103
نویسندگان
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