1,4-Diazepane compounds as potent and selective CB2 agonists: Optimization of metabolic stability
Keywords: Cannabinoid receptor; CB2; 1,4-Diazepane; Metabolic stability
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Dorsal hippocampal NMDA receptors mediate the interactive effects of arachidonylcyclopropylamide and MDMA/ecstasy on memory retrieval in rats
Keywords: ACPA; Arachidonylcyclopropylamide; ANOVA; Analysis of variance; CA1; cornus ammonis; CB1; Cannabinoid receptor type 1; CB2; Cannabinoid receptor type 2; CP-55,940; (â)-cis-3-[2-Hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol;
CXCR4 activation promotes differentiation of human embryonic stem cells to neural stem cells
Keywords: AP; alkaline phosphatase; BDNF; brain-derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CNS; central nervous system; CXCR4; CXC chemokine receptor type 4; CXCR7; CXC chem
Pure Î9-tetrahydrocannabivarin and a Cannabis sativa extract with high content in Î9-tetrahydrocannabivarin inhibit nitrite production in murine peritoneal macrophages
Keywords: BSA; albumin bovine serum; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CBC; cannabichromene; CBD; cannabidiol; CBG; cannabigerol; COX-2; cyclooxygenase-2; DAN; 2,3-diaminonaphthalene; DMSO; dimethyl sulfoxide (DMSO); DTT; 1,4-dithi
Effects of the cannabinoid 1 receptor peptide ligands hemopressin, (m)RVD-hemopressin(α) and (m)VD-hemopressin(α) on memory in novel object and object location recognition tasks in normal young and Aβ1-42-treated mice
Keywords: AD; Alzheimer's disease; CB1; cannabinoid 1; CB2; cannabinoid 2; BLA; basolateral complex of the amygdala; CNS; central nervous system; Hp; hemopressin; RVD; (m)RVD-hemopressin(α); VD; (m)VD-hemopressin(α); NOR; novel object recognition; OLR; object l
Tricyclic pyrazoles. Part 8. Synthesis, biological evaluation and modelling of tricyclic pyrazole carboxamides as potential CB2 receptor ligands with antagonist/inverse agonist properties
Keywords: Tricyclic pyrazoles; Synthesis; Cannabinoid receptors; CB2 antagonism; Molecular modelling; Î9-THC; Î9-Tetrahydrocannabinol; 2-AG; 2-Arachidonoylglycerol; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CNS; Central nervous system; T
Prophylactic treatment with the tricyclic antidepressant desipramine prevents development of paclitaxel-induced neuropathic pain through activation of endogenous analgesic systems
Keywords: ANOVA; analysis of variance; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; CR; cremophor; DMI; desipramine; DMSO; dimethyl sulfoxide; DMEM; Dulbecco's Modified Eagle Medium; DRG; dorsal root ganglion; FBS; Fetal bovine serum; FDA; US Food an
Discovery of a novel small molecule agonist scaffold for the APJ receptor
Keywords: AT1; angiotensin 2 receptor 1; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; NPS; neuropeptide S receptor; NTR-1; neurotensin receptor 1; BOP; benzotriazole-1-yl-oxy-tris-(dimethylamino)-phosphonium hexafluorophosphate; LiOH·H2O; lithium hydr
Microglia activation states and cannabinoid system: Therapeutic implications
Keywords: 2-AG; 2-arachidonoylglycerol; Aβ; amyloid β; ABDH; α/β-hydrolase; AD; Alzheimer's disease; AEA; anandamide; Arg-1; arginase-1; BBB; blood brain barrier; BDNF; brain derived nerve factor; CB; cannabinoid; CB1; cannabinoid receptor 1; CB2; cannabinoid r
Piperidinyl thiazole isoxazolines: A new series of highly potent, slowly reversible FAAH inhibitors with analgesic properties
Keywords: FAAH; fatty acid amide hydrolase; AEA; arachidonyl ethanolamide; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CP; cytoplasmic port; ABP; acyl binding pocket; MAC; membrane access channel; D-AMC; decanoyl 7-amino-4-methyl coumarin; A
Synthesis and pharmacological evaluation of new biphenylic derivatives as CB2 receptor ligands
Keywords: CB2; Cannabinoid receptor; Biphenyl-carboxamides; CB2 agonist; CB2 antagonist; CB2 inverse agonist; Methylhonokiol; Endocannabinoid system;
Selective CB2 receptor agonists. Part 3: The optimization of a piperidine-based series that demonstrated efficacy in an in vivo neuropathic pain model
Keywords: Cannabinoid receptor; CB2; CB1; Piperidine; Metabolic stability; Solubility
Basic nutritional investigationDifferential modulation of endogenous cannabinoid CB1 and CB2 receptors in spontaneous and splice variants of ghrelin-induced food intake in conscious rats
Keywords: AM-251; AM-630; Cannabinoid receptor; CB1; CB2; Des-Gln14-ghrelin; Food intake; Ghrelin;
Research reportCB1 receptors modulate affective behaviour induced by neuropathic pain
Keywords: Endocannabinoid system; CB1 receptor; Neuropathic pain; Partial sciatic nerve ligation; Depression; Anxiety; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; CB1â/â; CB1 receptor knockout mouse; PNL; partial nerve ligation; WT; wild type mous
Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence
Keywords: ECBS; Endocannabinoids; AEA; Anandamide; FAAH; fatty acid amide hydrolase; CB1; Cannabinoid type 1 receptor; CB2; Cannabinoid type 2 receptor; TRPV1; Transient potential vanilloid type 1 receptor; CBD; cannabidiol; PFC; Prefrontal cortex; MPFC; Medial pr
The type 2 cannabinoid receptor regulates susceptibility to osteoarthritis in mice
Keywords: CB2; Cnr2; Cannabinoids; Osteoarthritis; Cartilage; Mouse model;
Best practice guide for cryoballoon ablation in atrial fibrillation: The compilation experience of more than 3000 procedures
Keywords: AE; atrioesophageal; AF; atrial fibrillation; CB; cryoballoon; CB1; first generation cryoballoon (Arctic Front); CB2; second generation cryoballoon (Arctic Front Advance); CMAP; compound motor action potential; ICE; intracardiac echocardiography; LA; left
Whole-cell biosensor for label-free detection of GPCR-mediated drug responses in personal cell lines
Keywords: cAMP; cyclic adenosine 5â²-monophosphate; CB2; Cannabinoid receptor 2; CI; Cell Index; Î CI; Î Cell Index or Delta Cell Index; DMSO; dimethylsulfoxide; EBV; Epstein-Barr Virus; EC50; half maximal effective concentration; EC80; 80% maximal effective c
ReviewReceptome: Interactions between three pain-related receptors or the “Triumvirate” of cannabinoid, opioid and TRPV1 receptors
Keywords: 2-AG; 2-arachidonoylglycerol; 2-AGE; 2-arachidonyl glyceryl ether; AEA; anandamide; AM251; 1-(2,4-dichlorophenyl)-5-(4-iodophenyl)-4-methyl-N-piperidin-1-ylpyrazole-3-carboxamide; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; CNS; ce
Chronic Cannabinoid Receptor 2 Activation Reverses Paclitaxel Neuropathy Without Tolerance or Cannabinoid Receptor 1–Dependent Withdrawal
Keywords: CB2; Chemotherapy-induced neuropathic pain; Knockout mouse; Tolerance; Precipitated withdrawal; Side effect
Analgesic tolerance and cross-tolerance to the cannabinoid receptors ligands hemopressin, VD-hemopressin(α) and WIN55,212-2 at the supraspinal level in mice
Keywords: AM251; N-(piperidin-1-yl)-5-(4-iodophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide; AM630; 6-iodo-2-methyl-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl(4-methoxyphenyl)-methanone; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor t
Synthesis and preliminary evaluation of a new fluorine-18 labelled triazine derivative for PET imaging of cannabinoid CB2 receptor
Keywords: Cannabinoid; CB2; PET; Imaging; Triazine;
Switching cannabinoid response from CB2 agonists to FAAH inhibitors
Keywords: CB2; FAAH; Isoxazoles; Cannabinoid; IBD
MicroRNA-665 is involved in the regulation of the expression of the cardioprotective cannabinoid receptor CB2 in patients with severe heart failure
Keywords: Endocannabinoid system; CB1; CB2; MicroRNA;
CB2 cannabinoid receptor is a novel target for third-generation selective estrogen receptor modulators bazedoxifene and lasofoxifene
Keywords: SERM; selective estrogen receptor modulator; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; GPCR; G protein-coupled receptor; FDA; food and drug administration; HTRF; homogenous time resolved fluorescence; Cannabinoid receptor; Inverse agonist;
Cyclooxygenase metabolism mediates vasorelaxation to 2-arachidonoylglycerol (2-AG) in human mesenteric arteries
Keywords: 2-AG; 2-arachidonoylglcerol; AEA; anandamide; ANOVA; analysis of variance; CB1; cannabinoid receptor one; CB2; cannabinoid receptor two; COX-1; cyclooxygenase one; COX-2; cyclooxygenase two; ECS; endocannabinoid system; FAAH; fatty acid amide hydrolase; K
2-Arachidonoylglycerol modulates human endothelial cell/leukocyte interactions by controlling selectin expression through CB1 and CB2 receptors
Keywords: Endocannabinoids; Endothelium/leucocyte interaction; TNF-α; Kinases; Selectins; ABHD6; α/β-hydrolase domain 6; APC; allophycocyanin; 2-AG; 2-Arachidonoylglycerol; DAPI; 4â²,6-diamidino-2-phenylindole; CB1; type-1 cannabinoid receptor; CB2; type-2 cann
Activation of CB1 inhibits NGF-induced sensitization of TRPV1 in adult mouse afferent neurons
Keywords: ACEA; arachidonyl-2â²-chloroethylamide; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; CGRP; calcitonin-gene-related peptide; DRG; dorsal root ganglion; NGF; nerve growth factor; trkA; tyrosine kinase A; TRPV1; transient receptor potential van
The cannabinoid CB2 receptor-selective phytocannabinoid beta-caryophyllene exerts analgesic effects in mouse models of inflammatory and neuropathic pain
Keywords: Inflammatory pain; Neuropathic pain; CB2; Beta-caryophyllene; Dietary cannabinoid;
The pseudokinase tribbles homologue-3 plays a crucial role in cannabinoid anticancer action
Keywords: ATF-4; activating transcription factor 4; CB1; cannabinoid type-1 receptor; CB2; cannabinoid type-2 receptor; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; MEF; mouse embryonic fibroblast; mTORC1; mammalian target of rapamycin complex 1; mTOR
Functional relevance of the cannabinoid receptor 2 - heme oxygenase pathway: A novel target for the attenuation of portal hypertension
Keywords: BDL; bile duct ligation; b. w; body weight; CB2; cannabinoid receptor 2; Gp 1a; N-(Piperidin-1-yl)-1-(2,4-dichloropÂhenyl)-1,4-dihydro-6-methylindeno[1,2-c]pyrazole-3Â-carboxamide; GW 9662; 2-Chloro-5-nitro-N-phenylbenzamide; HO; heme oxygenase; JWH-133
Novel antiobesity agents: Synthesis and pharmacological evaluation of analogues of Rimonabant and of LH21
Keywords: LH21; 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-3-hexyl-1H-1,2,4-triazole; Rimonabant; 5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; PPARα; perox
Design, synthesis, and binding mode prediction of 2-pyridone-based selective CB2 receptor agonists
Keywords: IPCYPXCGYWGJEK-UHFFFAOYSA-N; cAMP; 3â²,5â²-cyclic adenosine monophosphate; CB; cannabinoid; CHO; Chinese hamster ovary; CNS; central nervous system; DCM; dichloromethane; DMF; N,N-dimethylformamide; DPPA; diphenylphosphonic azide; ECL; extracellular loo
3-Carboxamido-5-aryl-isoxazoles as new CB2 agonists for the treatment of colitis
Keywords: CB2; Cannabinoid; Isoxazoles; IBD;
Expression, surface immobilization, and characterization of functional recombinant cannabinoid receptor CB2
Keywords: CB2; peripheral cannabinoid receptor; GPCR; G protein-coupled receptor; MBP; maltose binding protein; NTA; nitrilotriacetic acid; SPR; surface plasmon resonance; TEV; tobacco etch virus; CHS; cholesteryl hemisuccinate Tris salt; CHAPS; 3[(cholamidopropyl)
Application of HaloTag technology to expression and purification of cannabinoid receptor CB2
Keywords: CB2; G protein-coupled receptor; HaloTag technology; Escherichia coli expression; Purification; Surface immobilization
Mastering tricyclic ring systems for desirable functional cannabinoid activity
Keywords: Cannabinoid; CB2; GPCR; Neuropathic pain; Carbazole; CB1BSA, bovine serum albumin; CB1, cannabinoid receptor 1; CB2, cannabinoid receptor 2; EC50, half maximal effective concentration; EDTA, ethylenediaminetetraacetic acid; GTP, guanosine-5′-triphosphate;
C3-Heteroaroyl cannabinoids as photolabeling ligands for the CB2 cannabinoid receptor
Keywords: CB2; Cannabinoid; Ligand-assisted protein structure; Photolabeling; Photoactivatable group
Emerging drug targets for pain treatment
Keywords: Pain; Drug target; TRPA1; CB2; GABAA; Imidazoline I2 receptor
Behavioral Effects of Pulp Exposure in Mice Lacking Cannabinoid Receptor 2
Keywords: Behavior; cannabinoid; CB2; pulp exposure; open field
CB2 and TRPV1 receptors mediate cannabinoid actions on MDR1 expression in multidrug resistant cells
Keywords: cannabinoids; P-glycoprotein; CB2; TRPV1
Differences in peripheral endocannabinoid modulation of scratching behavior in facial vs. spinally-innervated skin
Keywords: Endocannabinoid; Itch; Scratch; C-fiber; Cannabinoid receptor; CB1; CB2; G-protein-coupled receptor; Serotonin;
Expression of Fatty Acid Amide Hydrolase (FAAH) in Human, Mouse, and Rat Urinary Bladder and Effects of FAAH Inhibition on Bladder Function in Awake Rats
Keywords: Endocannabinoid; Enzyme; mRNA; Protein; CB2; CB1; Mucosa; Intravesical; Cystometry
The anxiolytic-like effect of an essential oil derived from Spiranthera odoratissima A. St. Hil. leaves and its major component, β-caryophyllene, in male mice
Keywords: CNS; central nervous system; EO; essential oil obtained from S. odoratissima leaves; EPM; elevated plus maze test; LDB; light-dark box test; UFG; Universidade Federal de Goiás; NAN-190; 1-(2-Methoxyphenyl)-4-[4-(2-phthalimido) butyl] piperazine hydrobr
CB2 cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons
Keywords: CB2; Cannabinoid receptor; Autaptic neurons; DSE; Endocannabinoid; 2-AG; 2-arachidonoylglycerol; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; CNS; central nervous system; DGL; diacylglycerol lipase; DSE; depolarization induced suppression of
Review articleSpice drugs are more than harmless herbal blends: A review of the pharmacology and toxicology of synthetic cannabinoids
Keywords: CB1; cannabinoid type-1 receptor; CB2; cannabinoid type-2 receptor; CP55,940; (-)-5-(1,1-dimethylheptyl)-2-[5-hydroxy-2-(3-hydroxypropyl)cyclohexyl]-phenol; DEA; Drug Enforcement Administration; Î9-THC; delta-9-tetrahydrocannabinol; DOI; (±)-1-(2,5-dime
Occurrence, biosynthesis and functions of N-acylphosphatidylethanolamines (NAPE): Not just precursors of N-acylethanolamines (NAE)
Keywords: N-acylphosphatidylethanolamine; Lipid mediator; Cellular process regulations; NAPE properties; NAPE metabolism; CB1; cannabinoid receptor 1; CB2; cannabinoid receptor 2; CL; cardiolipin; FAAH; fatty acid amide hydrolase; FFA; free fatty acid; LOX; lipoxyg
The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB1)
Keywords: CB1; cannabinoid receptor 1; NADA; N-arachidonoyldopamine; NMDA; N-methyl-d-aspartate; OHSC; organotypic hippocampal slice cultures; CB2; cannabinoid receptor 2; TRPV1; transient receptor potential channel V1; TRPA1; transient receptor potential channel A
Euphol, a tetracyclic triterpene produces antinociceptive effects in inflammatory and neuropathic pain: The involvement of cannabinoid system
Keywords: Euphol; CB1 and CB2 cannabinoid receptor; Cytokines/chemokines; Inflammatory and neuropathic persistent pain; euphol; eupha-8,24-dien-3β-ol; CB; cannabinoid; CB1; cannabinoid receptor type 1; CB2; cannabinoid receptor type 2; AS; antisense; ODN; oligodeo
WIN55212-2 attenuates amyloid-beta-induced neuroinflammation in rats through activation of cannabinoid receptors and PPAR-γ pathway
Keywords: WIN55212-2; Neuroinflammation; CB1; CB2; PPAR-γ; Beta-amyloid; AD; Alzheirmer's disease; Aβ; Beta-amyloid peptide (1-42); NF-κB; Nuclear Factor-kappa B; PPARs; peroxisome proliferator-activated receptors; TNF-α; Tumor Necrosis Factor-alpha;