کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
5844393 | 1561035 | 2015 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cannabinoid CB1 receptors in the dorsal hippocampus and prelimbic medial prefrontal cortex modulate anxiety-like behavior in rats: Additional evidence
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کلمات کلیدی
AEAVCTeCBsdHIPCB2prelimbicFAAHPAGMPFCCB1CBDTRPV1PFCTHCEPMVogel Conflict Test - آزمون وگول تضادanandamide - آناندامیدAnxiety - اضطرابendocannabinoids - اندوکانبایوئید هاelevated plus maze - بالا به همراه پیچ و خمlateral - جانبیprefrontal cortex - قشر prefrontalmedial prefrontal cortex - قشر غده پروسترولPeriaqueductal gray matter - ماده خاکستری پرایاکوداکتHIP - مفصل ران یا مفصل هیپHippocampus - هیپوکامپ dorsal hippocampus - هیپوکامپ پشتیventral - ونتیلاتورanteroposterior - پیشاپیشCannabidiol - کانابیدیولcannabinoid type 2 receptor - گیرنده 2 نوع کانابینوئیدCB1 receptors - گیرنده CB1cannabinoid type 1 receptor - گیرنده نوع 1 کانابینوئید
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
روانپزشکی بیولوژیکی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Endocannabinoids (ECBs) such as anandamide (AEA) act by activating cannabinoid type 1 (CB1) or 2 (CB2) receptors. The anxiolytic effect of drugs that facilitate ECB effects is associated with increase in AEA levels in several encephalic areas, including the prefrontal cortex (PFC). Activation of CB1 receptors by CB1 agonists injected directly into these areas is usually anxiolytic. However, depending on the encephalic region being investigated and on the stressful experiences, opposite effects were observed, as reported in the ventral HIP. In addition, contradictory results have been reported after CB1 activation in the dorsal HIP (dHIP). Therefore, in the present paper we have attempted to verify if directly interfering with ECB metabolism/reuptake in the prelimbic (PL) portion of the medial PFC (MPFC) and dHIP would produce different effects in two conceptually distinct animal models: the elevated plus maze (EPM) and the Vogel conflict test (VCT). We observed that drugs which interfere with ECB reuptake/metabolism in both the PL and in the dentate gyrus of the dHIP induced anxiolytic-like effect, in both the EPM and in the VCT via CB1 receptors, suggesting that CB1 signaling in these brain regions modulates defensive responses to both innate and learned threatening stimuli. This data further strengthens previous results indicating modulation of hippocampal and MPFC activity via CB1 by ECBs, which could be therapeutically targeted to treat anxiety disorders.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 59, 3 June 2015, Pages 76-83
Journal: Progress in Neuro-Psychopharmacology and Biological Psychiatry - Volume 59, 3 June 2015, Pages 76-83
نویسندگان
Sabrina F. Lisboa, Anna A. Borges, Priscila Nejo, Aline Fassini, Francisco S. Guimarães, Leonardo B. Resstel,