Keywords: 17-AAG; 17-(Allylamino)-17-demethoxygeldanamycin; 17-DMAG; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin; AKT; v-akt murine thymoma viral oncogene homolog; APC; antigen presenting cell; ATM; Ataxia telangiectasia mutated; ATR; Ataxia telangiectasia
مقالات ISI (ترجمه نشده)
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Keywords: AKAP; A-Kinase Anchoring Protein; ALL; acute lymphoblastic leukemia; A.S.; activation segment; CDK; cyclin-dependent kinase; CML; chronic myelogenous leukemia; C-spine; catalytic spine; EGFR; epidermal growth factor receptor; FGFR; fibroblast growth facto
Keywords: Cdk; cyclin-dependent kinase; FAM; carboxyfluorescein; FP; fluorescence polarization; FPIA; fluorescence polarization immunoassay; QQ-plot; quantile-quantile-plot; TBS; Tris-buffered saline; TFA; trifluoroacetic acid; Peptide microarray; Myt1 kinase; Ki
Keywords: Diversity-oriented synthesis; Imidazoheterocyclic; Groebke-Blackburn-Bienayme reaction; Fused imidazole; Lewis acid; Ugi type; Ac; acetyl; Aq; aqueous; Ar; aryl; Bn; benzyl; Boc; tert-butoxycarbonyl; BDMS; bromodimethylsulfonium bromide; CDK; cyclin-d
Keywords: Breast cancer; HER-2-negative; Resistance; Biologic targeted agent; Combination therapy; ABC; advanced breast cancer; AE; adverse event; AI; aromatase inhibitor; AKT; protein kinase; BC; breast cancer; CDK; cyclin-dependent kinase; CT; chemotherapy; CTLA;
Keywords: 4-HPR; N-(4-hydroxyphenyl)retinamide; 5â²-UTR; 5â²-untranslated region; 9-cis-RA; 9-cis retinoic acid; 9cUAB30; (2E,4E,6Z,8E)-8-(3â²,4â²-dihydro-1â²(2'H)-naphthalen-1â²-ylidene)-3,7-dimethyl-2,4,6-octatrienoic acid; Acitretin; (2E,4E,6E,8E)-9-(4-met
Keywords: ARF; alternative reading frame; αSMA; alpha smooth muscle actin; CDK; cyclin-dependent kinase; DDR; DNA damage response; ECM; extracellular matrix; EMT; epithelial mesenchymal transition; FGF; fibroblast growth factor; HDAC; histone deacetylase; HIC1; hy
Keywords: AP-1; activator protein-1; BACH1; BTB and CNC homology 1, basic leucine zipper transcription factor 1; CDK; cyclin-dependent kinase; CYP1A1; cytochrome P450, family 1, subfamily A, polypeptide 1; ERK; extracellular signal-regulated kinase; FACS; Fluoresce
Keywords: BA; N6-Benzyladenine; BA9G; N6-Benzyladenine-9-glucoside; BAR; N6- Benzyladenine riboside; BAR5â²MP; N6-Benzyladenosine-5â²-monophosphate; CDK; Cyclin-dependent kinase; CK; Cytokinin; cZ; cis-Zeatin; cZ9G; cis-Zeatin-9-glucoside; cZOG; cis-Zeatin-O-gluc
Keywords: CDK; cyclin-dependent kinase; HP; hyperplastic polyp;
Keywords: AD; Alzheimer's disease; AP site; apurinic/apyrimidinic site; APE1; apurinic/apyrimidinic endonuclease 1; Aβ; amyloid beta; BER; base excision repair; CaMKII; Ca2 +/Calmodulin-Dependent Protein Kinase II; CDK; cyclin-dependent kinase; CREB; cAMP respons
Keywords: ASK1; apoptosis signal-regulating kinase 1; ATF4; activating transcription factor 4; ATF6; activating transcription factor 6; Bcl-2; B-cell lymphoma 2; BiP; binding immunoglobulin protein; bZIP; basic leucine zipper; CDK; cyclin-dependent kinase; CDKI; CD
Keywords: AHR; aryl hydrocarbon receptor; AIP; aryl hydrocarbon receptor interacting protein; BMP-4; bone morphogenetic protein 4; CDK; cyclin-dependent kinases; CDKN1A; cyclin-dependent kinase inhibitor 1A; CDKN1B; cyclin-dependent kinase inhibitor 1B; CDKN2A; cyc
Keywords: B2M; beta 2 microglobulin; CAR; cyclophophamide, alvocidib, rituximab; CDK; cyclin-dependent kinase; CLL; chronic lymphocytic leukemia; CR; complete response; CRS; cytokine release syndrome; DLT; dose limiting toxicity; ECOG; Eastern Cooperative Oncology
Keywords: ATM; ataxia telangiectasia mutated; ATR; ATM and Rad3-related; BMP-2; bone morphogenetic protein-2; Cdk; cyclin-dependent kinase; CESP; cell-type exclusive senescence phenotype; CHK; check point kinase; DDR; DNA damage response; DSBs; double-strand DNA br
Keywords: NCL; neuronal ceroid lipofuscinosis; CDK; cyclin-dependent kinase; S1P; sphingosine-1-phosphate; GlcCer; glucosylceramide; TLC; thin layer chromatography; FA; fact acid; LacCer; lactosylceramide; Sulf; sulfatide; So; sphingosine; Batten disease; Cell cycl
Keywords: BrdU; bromodeoxyuridine; Cdk; cyclin-dependent kinase; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified eagle medium; Myo7a; myosin VIIA; P2; postnatal day 2; Pax2; paired box 2; pRb; retinoblastoma protein; Ptc; patched; Rb1; retinoblas
Keywords: CDK; cyclin; OXPHOS; oxidative phosphorylation; PGC1; peroxisome proliferator-activated receptor-γcoactivator; ROS; reactive oxygen species; PET scan; positron emission tomography; ETC; electron transport chain; PDH; pyruvate dehydrogenase; SV40; simian
Keywords: Colon cancer; Proliferation; Glucagon-like peptide 2; Cancer therapy; (5-FU); 5-Fluorouracil; Akt; protein kinase B; APC; adenomatous polyposis coli; CAFs; carcinoma-associated fibroblasts; CDK; cyclin-dependent kinase; DPP-IV; dipeptidyl peptidase IV; GL
Keywords: APC/C; anaphase-promoting complex/cyclosome; BM; bone marrow; CDK; cyclin-dependent kinase; CKI; cyclin-dependent kinase inhibitor; CXCL12; chemokine (C-X-C motif) ligand 12; HSC; hematopoietic stem cell; Hsc70; heat shock cognate protein 70; LAP; latency
Keywords: IGFs; insulin-like growth factors; SHBG; sex hormone binding globulin; BMI; body mass index; IGFBPs; IGF binding proteins; IGF-1R; insulin-like growth factor-1 receptor; CLS; crown-like structure; NFκB; nuclear factor kappa-B; STAT3; signal transducer an
Keywords: ACD; Anemia in chronic disease; CD; Crohn's disease; CDK; Chronic kidney disease; CHr; Reticulocyte hemoglobin content; ESA; Erythropoiesis stimulating agent; Hb; Hemoglobin; HMWID; High molecular weight iron dextran; IBD; Inflammatory bowel disease; ID;
Keywords: AhR; aryl hydrocarbon receptor; AKT/PKB; protein kinase B; AOM; azoxymethane; AP; Acticoa power; AP-1; activator protein-1; ARE; antioxidant response element; CDK; cyclins-dpendent kinase; CLPr; cacao liquor proanthocyanidins; COX-2; cyclooxygenase-2; CYP
Keywords: Epigenetics; Phytochemicals; DNA-methylation; Histone-modification; miRNA; Carcinogenesis; Akt; v-akt murine thymoma viral oncogene homolog 1; AP-1; Activator Protein-1; Bax; BCL2-associated X protein; Bcl2; B-cell CLL/lymphoma 2; Bcl-xL; B-cell lymphoma-
Development of CDK-targeted scoring functions for prediction of binding affinity
Keywords: Bioinformatics; Machine learning; CDK; Drug design; Docking; Protein;
The ginsenoside metabolite compound K inhibits hormone-independent breast cancer through downregulation of cyclin D1
Keywords: Compound K; Hormone-independent breast cancer; Cyclin D1; CK; compound K; CDK; cyclin-dependent kinase; ERK; extracellular signal-regulated kinase; PPD; 20(S)-protopanaxadiol; CHX; cyclohexamide;
6,7,4â²-Trihydroxyisoflavone suppressed the estrogen receptor negative breast cancer growth via regulating glycogen synthase kinase-3β/β-catenin signaling
Keywords: Breast cancer; β-catenin; Cell cycle; Glycogen synthase kinase-3β; Trihydroxyisoflaovone; CDK; cyclin dependent kinase; CDKI; cyclin dependent kinase inhibitor; ER; estrogen receptor; ERK; extracellular signal-regulated kinase; GSK; glycogen synthase ki
Role of Forkhead Box O (FOXO) transcription factor in aging and diseases
Keywords: FOXO; Forkhead box O; DBD; DNA-binding domain; NLS; Nuclear localization sequence; NES; Nuclear export sequence; IRE; Insulin-responsive element; ARDs; Age-related diseases; RTK; Receptor tyrosine kinase; PI3K; Phosphoinositide 3kinase; SGK; Serum and glu
Threonine 454 phosphorylation in Grainyhead-like 3 is important for its function and regulation by the p38 MAPK pathway
Keywords: ATF-2; activating transcription factor 2; BLNK; B-cell linker; CaMK; calcium/calmodulin-dependent protein kinase; CDK; cyclin-dependent kinase; CHK; checkpoint kinase; CK; casein kinase; DNAPK; DNA-dependent protein kinase; EPHX3; epoxide hydrolase 3; ERK
Analysis of the meiotic transcriptome reveals the genes related to the regulation of pollen abortion in cytoplasmic male-sterile pepper (Capsicum annuum L.)
Keywords: CMS; cytoplasmic male sterility; PMCs; pollen mother cells; PCD; programmed cell death; RNA-seq; RNA sequencing; DEGs; differentially expressed genes; SCAR; sequence-characterized amplified region; TUNEL; terminal deoxynucleotidyl transferase dUTP nick en
Re-evaluating the role of FOXOs in cancer
Keywords: RTK; receptor tyrosine kinase; GF; growth factor; PI3K; Phosphatidylinositol-4,5-bisphosphate 3-kinase; PKB; protein kinase B; AKT; RAC-alpha serine/threonine-protein kinase; FOXO; forkhead box O; GFR; growth factor receptor; PDPK1; Phosphoinositide-depen
Optimization of permeability in a series of pyrrolotriazine inhibitors of IRAK4
Keywords: ABC; Activated B Cell-like; BTK; Bruton's Tyrosine Kinase; CD79; Cluster of Differentiation 79; CDK; Cyclin Dependent Kinase; CLK; CDC-Like Kinase; DCM; dichloromethane; DDQ; 2,3-Dichloro-5,6-DicyanobenzoQuinone; DIPEA; N,N-diisopropylethylamine; DLBCL;
Possible use of Punica granatum (Pomegranate) in cancer therapy
Keywords: 27HC; 27-hydroxycholesterol; 8-OHdG; 8-hydroxy-2â² -deoxyguanosine; 8-oxodG; 8-oxo-7,8-dihydro-2â²-deoxyguanosine; APC; adenomatous polyposis coli; AR; androgen receptors; AOM; azoxymethane; ATP; adenosine triphosphate; B(a)P; benzo(a)pyrene; Bad; Bcl-2
KRAS-Mutant non-small cell lung cancer: From biology to therapy
Keywords: BATTLE; Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination; BET; bromodomains and extra-terminal domain; CDK; cyclin-dependent kinase; Chk1; checkpoint kinase 1; CI; confidence interval; CUSTOM; Molecular Profiling and Targete
Exogenously applied hydrogen peroxide modifies the course of the Chlamydomonas reinhardtii cell cycle
Keywords: ABS/RC; the amount of energy absorbed by single reaction center of photosystem II; APX; ascorbate peroxidase; CAT; catalase; CYC; cycline; CDK; cycline-dependent kinase; Cu/Zn-SOD; copper-zinc superoxide dismutase; DI0/RC; nonphotochemical energy dissipat
Melanoma antigen-D2 controls cell cycle progression and modulates the DNA damage response
Keywords: APC/C; anaphase-promoting complex or cyclosome; ATM; ataxia-telangiectasia mutated protein; ATR; ataxia-telangiectasia- and rad3-related protein; CDC20; cell division cycle protein 20; CDK; cyclin-dependent kinase; CHK1; checkpoint kinase 1; CHK2; checkpo
Galangin's potential as a functional food ingredient
Keywords: Galangin; Propolis; Alpinia officinarum; Functional food ingredient; Polypharmacology; Flavonoid; AChE; acetylcholinesterase; AD; Alzheimer's disease; ADME; Administration, Distribution, Metabolism and Excretion; AHR; airway hyperresponsive; AhR; aryl h
CCRK is a novel signalling hub exploitable in cancer immunotherapy
Keywords: 9G8; serine and arginine rich splicing factor 7; AKT; AKT serine/threonine kinase; AR; androgen receptor; ARE; androgen response element; ARG1; arginase 1; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia and rad3-related protein; BMDC; mous
Identification of Cep169-interacting proteins and the in vivo modification sites of Cep169 via proteomic analysis
Keywords: Cep169; Mass spectrometry analysis; Cdk; Centrosome; Modification;
Andrographolide, a diterpene lactone from Andrographis paniculata and its therapeutic promises in cancer
Keywords: Andrographolide; Andrographis paniculata; Diterpene lactone; Anticancer; Chemotherapy; Bioactive lactone; ACS; American Chemical Society; AKT; activated protein kinase; Andro; Andrographolide derivative or conjugate; AP-1; activator protein-1; Cdk; Cyclin
The role of CDKN2B in cardiovascular risk in ethnic Saudi Arabs: A validation study
Keywords: CAD; coronary artery disease; CDK; cyclin-dependent kinase; CDKN2B; cyclin-dependent kinase 4 inhibitor B; HDL; high-density lipoprotein; HTN; hypertension; LDL; Low density lipoprotein; MI; myocardial infarction; T2DM; type 2 diabetes mellitus; CDKN2B ge
Regulation and biological roles of the multifaceted miRNA-23b (MIR23B)
Keywords: miRNAs; MicroRNAs; C9orf3; Chromosome 9 Open Reading Frame 3; pri-miRNAs; primary miRNA; pre-miRNAs; precursor miRNAs; miRISC; miRNA-induced silencing complex; ECs; endothelial cells; VSMCs; vascular smooth muscle cells; ACTA2; smooth muscle α-actin; MYH
Pharmacokinetics and cytotoxic study of euphol from Euphorbia umbellata (Bruyns) Pax latex
Keywords: Euphol; Cell culture; Cytotoxic activity; UHPLC-MS; Euphorbia; Pharmacokinetics; 1D and 2D NMR; one and two dimension nuclear magnetic resonance spectroscopy; ACN; acetonitrile; ATCC; american type culture collection; CDCl3; deuterated chloroform; CDK; cy
Post-translational modifications at the ATP-positioning G-loop that regulate protein kinase activity
Keywords: cAbl; abelson murine leukemia virus proto-oncogene; BCR; breakpoint cluster region; CDK; cyclin-dependent kinase; CML; chronic myeloid leukemia; IR; insulin receptor; O-GlcNAc; O-linked β-N-acetyl glucosamine; PKA; protein kinase A; PKC; protein kinase C
Bavachalcone from Cullen corylifolium induces apoptosis and autophagy in HepG2 cells
Keywords: C. corylifolium; Bavachalcone; Apoptosis; Cell cycle; Autophagy; CCE; Cullen corylifolium ethanol extract; HCC; hepatocellular carcinoma; NAFLD; Nonalcoholic fatty liver disease; Bax; bcl-2-associated X protein; Bcl-2; b-cell lymphoma 2; Bid; BH3 interact
FOXOs in cancer immunity: Knowns and unknowns
Keywords: 2B4; CD244 molecule; AKT or PKB; protein kinase B; APCs; antigen-presenting cells; ARG1; arginase 1; BEC; blood endothelial cell; BLNK; B cell Linker protein; BMP; bone morphogenetic protein; BTK; Bruton tyrosine kinase; C/EBP; CCAAT/enhancer-binding prot
An appraisal on synthetic and pharmaceutical perspectives of pyrazolo[4,3-d]pyrimidine scaffold
Keywords: A. flavus; Aspergillus flavus; C. albicans; Candida albicans; cAMP; cyclic adenosine monophosphate; CDK; cyclin-dependent kinase; CNS; central nervous system; COX; cyclooxygenase; CRF; corticotropin-releasing hormone; CRK; cdc2-related kinase; CYC6; cycli
Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro
Keywords: 95%CI; 95% confidential interval; AB; apical-to-basolateral; ABC; ATP-binding cassette; Abcb1; canine P-glycoprotein; ABCB1; human P-glycoprotein; ABCC1; multidrug resistance-associated protein 1; ABCG2; breast cancer resistance protein; BA; basolateral-t
Roscovitine and purvalanol A effectively reverse anthracycline resistance mediated by the activity of aldo-keto reductase 1C3 (AKR1C3): A promising therapeutic target for cancer treatment
Keywords: AKR; aldo-keto reductase; CDK; cyclin-dependent kinase; CI; combination index; Dau; daunorubicin; Dau-ol; daunorubicinol; DOX; doxorubicin; DMSO; dimethyl sulfoxide; Fa; fraction affected; HCT116-AKR1C3; cells transfected with pCI_AKR1C3; HCT116-EV; cells
Structure-based design of novel quinoxaline-2-carboxylic acids and analogues as Pim-1 inhibitors
Keywords: Quinoxaline; Pim-1; Kinase inhibitor; Anticancer targeted therapy; IC50; 50% inhibitory concentration; SAR; structure-activity relationships; Pim; proviral integration site of Moloney murine leukemia virus; CML; chronic myeloid leukemia; DYRK1A; dual spec