MiRNA expression profile of chronic lymphocytic leukemia patients with 13q deletion
Keywords: miRNA; Array; 13q deletion; Expression; CLL;
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Tumor microenvironment (TME)-driven immune suppression in B cell malignancy
Keywords: CLL; chronic lymphocytic leukemia; DLBCL; diffuse large B cell lymphoma; GCB; germinal centre B cell like; ABC; activated B cell-like; NHL; non-Hodgkin lymphoma; HL; Hodgkin lymphoma; FL; follicular lymphoma; PMBCL; primary mediastinal B-cell lymphoma; MS
Necroptosis: an alternative cell death program defending against cancer
Keywords: AIF; apoptosis-inducing factor; ALL; acute lymphoblastic leukemia; cIAP; cellular inhibitor of apoptosis protein; CLL; chronic lymphocytic leukemia; CYLD; cylindromatosis; DAMPs; Damage Associated Molecular Patterns; DCs; dendritic cells; Drp1; dynamin-re
Improving therapy of chronic lymphocytic leukemia with chimeric antigen receptor T cells
Keywords: CAR; CLL; Immunotherapy; T cell; Leukemia;
ER functions of oncogenes and tumor suppressors: Modulators of intracellular Ca2Â + signaling
Keywords: a.a.; amino acid; ATP; adenosine triphosphate; BH domain; Bcl-2-homology domain; BI-1; Bax inhibitor-1; BIRD-2; Bcl-2/IP3R disruptor-2; BRCA1; breast and ovarian cancer susceptibility gene 1; [Ca2Â +]cyt; cytosolic Ca2Â + concentration; CLL; chronic lymph
Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment
Keywords: APRIL; a proliferation-inducing ligand; ATM; ataxia telangiectasia mutated; BAFF; B-cell activating factor; BAFFR; BAFF receptor; BAG6; BCL2-associated athanogene 6; BCMA; B-cell maturation antigen; BCL2; B-cell lymphoma 2; BCR; B cell receptor; bFGF; bas
Ibrutinib inhibition of Bruton protein-tyrosine kinase (BTK) in the treatment of B cell neoplasms
Keywords: AS; activation segment; CLL; chronic lymphocytic leukemia; CS or C-spine; catalytic spine; CL; catalytic loop; HΦ or Φ; hydrophobic; IP3; inositol 1,4,5 trisphosphate; IP6; inositol 1,2,3,4,5,6 hexakisphosphate; MCL; mantle cell lymphoma; MW; molecular
Combination of Mass Cytometry and Imaging Analysis Reveals Origin, Location, and Functional Repopulation of Liver Myeloid Cells in Mice
Keywords: CyTOF; DC; Liver Development; Mouse Model; APAP; acetaminophen; BM; bone marrow; CLL; clodronate-loaded liposomes; CyTOF; time-of-flight mass cytometry; DC; dendritic cell; GFP; green fluorescent protein; HSC; hepatic stellate cell; ICG; indocyanine green
Palmitoylation in Alzheimerâ¿¿s disease and other neurodegenerative diseases
Keywords: ABCA1; ATP-binding cassette transporter A1; AD; Alzheimer⿿s disease; ADAM17; a disintegrin and metalloproteinase 17; AICD; APP intracellular domain; AKAP79; A-kinase anchoring protein 79; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate; APP; amy
Cancer TARGETases: DSB repair as a pharmacological target
Keywords: DSB repair; Genome instability; Cancer; Kinases; Helicases; Nucleases; ALT; alternative telomere lengthening; AML; acute myeloid leukemia; A-T; ataxia-telangiectasia; ATM; ataxia-telangiectasia mutated; ATP; adenosine triphosphate; ATR; ataxia-tel
Pharmacological targeting of PI3K isoforms as a therapeutic strategy in chronic lymphocytic leukaemia
Keywords: CLL; PI3K; Idelalisib; Duvelisib
PTHrP-Induced Refractory Malignant Hypercalcemia in a Patient With Chronic Lymphocytic Leukemia Responding to Denosumab
Keywords: CLL; Denosumab; Humoral hypercalcemia; Hypercalcemia of malignancy; Parathyroid hormone-related protein; PTHrP;
Ofatumumab in Refractory Chronic Lymphocytic Leukemia: Experience Through the French Early Access Program
Keywords: CD20; CLL; Ofatumumab; Relapsed/refractory; Temporary use authorization
Bendamustine in combination with rituximab for elderly patients with previously untreated B-cell chronic lymphocytic leukemia: A retrospective analysis of real-life practice in Italian hematology departments
Keywords: CLL; Bendamustine; Rituximab; Elderly patients; First-line treatment;
Clinical relevance of vascular endothelial growth factor type A (VEGFA) and VEGF receptor type 2 (VEGFR2) gene polymorphism in chronic lymphocytic leukemia
Keywords: Angiogenesis; VEGFA; VEGFR2; Polymorphism; CLL
KLKB1 mRNA overexpression: A novel molecular biomarker for the diagnosis of chronic lymphocytic leukemia
Keywords: AUC; area under the curve; CI; confidence interval; CLL; chronic lymphocytic leukemia; FITC; fluorescein isothiocyanate; GAPDH; glyceraldehyde 3â²-phosphate dehydrogenase; HR; hazard ratio; IGHV; Immunoglobulin heavy chain variable region; KLKB1; kallikr
Arsenic trioxide synergistically potentiates the cytotoxic effect of fludarabine in chronic lymphocytic leukemia cells by further inactivating the Akt and ERK signaling pathways
Keywords: CLL; Arsenic trioxide; Fludarabine; Synergistic effect; Combined therapies; Survival pathways;
Three-fold higher frequency of circulating chronic lymphocytic leukemia-like B-cell clones in patients with Ph-Myeloproliferative neoplasms
Keywords: Myeloproliferative; MBL; CLL;
CD49d and CD26 are independent prognostic markers for disease progression in patients with chronic lymphocytic leukemia
Keywords: CLL; CD 26; CD 49d; Prognosis
Blockage of Wnt/β-catenin signaling by quercetin reduces survival and proliferation of B-1 cells in vitro
Keywords: APC; adenomatous polyposis coli; CLL; chronic lymphocytic leukemia; Fz; frizzled receptor; GSK-3β; glycogen synthase kinase; HSC; hematopoietic stem cells; LDL; low-density lipoprotein; Lef; lymphoid enhancing factor; LRP; LDL receptor-related protein; P
The mystery of chronic lymphocytic leukemia (CLL): Why is it absent in Asians and what does this tell us about etiology, pathogenesis and biology?
Keywords: Chronic lymphocytic leukemia; CLL; Small lymphocytic lymphoma; Asians; IGHV;
Mast cells, basophils and B cell connection network
Keywords: BMMC; bone marrow mast cell; CLL; chronic lymphocytic leukemia; CSR; class switch recombination; DLBCL; diffuse large B cell lymphoma; FcR; Fc receptor; FL; follicular lymphoma; HL; Hodgkin's lymphoma; LPD; lymphoproliferative diseases; MC; mast cell; MGU
Regulation of NAD biosynthetic enzymes modulates NAD-sensing processes to shape mammalian cell physiology under varying biological cues
Keywords: ADPR; ADP ribose; ARTs; ADP ribose transferases; ARTD1; poly-(ADP ribose) polymerase 1; NAADP; nicotinic acid adenine dinucleotide phosphate; CR; calorie restriction; PAR; poly-(ADP ribose); PGC-1; peroxisome proliferator-activated receptor-γ coactivator
Regulation of cell fate by lymphotoxin (LT) receptor signalling: Functional differences and similarities of the LT system to other TNF superfamily (TNFSF) members
Keywords: Lymphotoxin; CD40; Apoptosis; Receptor cross-linking; Cell signalling; AP-1; activator protein-1; APRIL; a proliferation-inducing ligand; BAFF; B-cell activating factor belonging to the TNF family; CLL; chronic lymphocytic leukaemia; DD; death domain; DR;
Extramedullary chronic lymphocytic leukemia: Systematic analysis of cases reported between 1975 and 2012
Keywords: Extra-medullary; Chronic lymphocytic leukemia; CLL; Prognosis
Isolation and identification of acaricidal compounds in Eupatorium adenophorum petroleum ether extract and determination of their acaricidal activity against Psoroptes cuniculi
Keywords: CLL; complementary log-log; NMR; nuclear magnetic resonance; TLC; thin-layer chromatography; Eupatorium adenophorum; Multiple silica gel column chromatography; 1H NMR and 13C NMR; Acaricidal activity;
Fludarabine plus alemtuzumab (FA) front-line treatment in young patients with chronic lymphocytic leukemia (CLL) and an adverse biologic profile
Keywords: Chronic lymphocytic leukemia; CLL; Young; Biology; Fludarabine; Alemtuzumab;
Adhesion of ZAP-70+ chronic lymphocytic leukemia cells to stromal cells is enhanced by cytokines and blocked by inhibitors of the PI3-kinase pathway
Keywords: CLL; ZAP-70; Microenvironment; IL-6; IL-8; CD40L; IL-4; PI3K pathway;
Rituximab-Based Chemoimmunotherapy Prolongs Survival of Patients With Chronic Lymphocytic Leukemia Independently of the Time of Administration
Keywords: Anti-CD20; CLL; OS; Purine analogues; Treatment;
Rola monocytów w patogenezie przewlekÅej biaÅaczki limfocytowej
Keywords: CLL; monocyty; makrofagi; TAM; TEM; CLL; Monocytes; Macrophages; TAMs; TEMs;
Advances in T-cell therapy for ALL
Keywords: acute lymphocytic leukemia; ALL; chronic lymphocytic leukemia; CLL; cytokine release syndrome; macrophage activation syndrome; chimeric antigen receptor; IL-6
A two-step approach (Enzyme-linked immunosorbent assay and confirmation assay) to detect antibodies against von Willebrand factor in patients with Acquired von Willebrand Syndrome
Keywords: ELISA; Enzyme-linked immunosorbent assay; AVWS; acquired von Willebrand Syndrome; FVIII:C; factor VIII coagulant activity; VWF; von Willebrand Factor; VWF:RCo; von Willebrand Factor Ristocetin Cofactor; VWF:Ag; von Willebrand Factor antigen; VWF:CB; von W
CD1d expression is higher in chronic lymphocytic leukemia patients with unfavorable prognosis
Keywords: CLL; CD1d; iNKT; CD3ζ; ZAP-70; CD38;
Signals from activation of B-cell receptor with anti-IgD can override the stimulatory effects of excess BAFF on mature B cells in vivo
Keywords: BAFF; B-cell activating factor; BAFF-receptor; BAFF-R or BR3; BCMA; B cell maturation antigen; BCR; B-cell receptor; CD40L; CD40 ligand; CLL; chronic lymphocytic leukaemia; FcγRβII; Fc gamma receptor beta isoform II; HRP; horseradish peroxidase; mIgM; m
Identification of B-cell lymphoma subsets by plasma protein profiling using recombinant antibody microarrays
Keywords: BCL; B-cell lymphoma; CLL; chronic lymphocytic leukemia; DLBCL; diffuse large B-cell lymphoma; FC; fold change; FL; follicular lymphoma; IGHV; immunoglobulin heavy-chain variable; IHC; immunohistochemistry; MCL; mantle cell lymphoma; N; population control
B-cell activating factor genetic variants in lymphomagenesis associated with primary Sjogren's syndrome
Keywords: B-lymphocyte activator factor (BAFF); Lymphoma; Primary Sjogren's syndrome (SS); Single nucleotide polymorphisms (SNPs); Genetics; BAFF; B-cell activating factor; BLyS; B lymphocyte stimulator; pSS; primary Sjogren's syndrome; SNPs; single nucleotide poly
Personalized medicine in CLL: Current status and future perspectives
Keywords: CLL; Personalized medicine; Targeted therapy;
The microenvironment in chronic lymphocytic leukemia (CLL) and other B cell malignancies: Insight into disease biology and new targeted therapies
Keywords: Chronic lymphocytic leukemia; CLL; Microenvironment; Nurselike cells; Stromal cells; CXCR4; CXCL12; B cell receptor; BCR; SYK; BTK; PI3Kδ; Chemokines; Chemokine receptors; T cells; NK cells;
New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia
Keywords: ADAM; a disintegrin and metalloprotease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AKT; protein kinase B (PKB); ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AMPK; adenosine monophosphate (AMP) activated protein kinase; ANK;
Genomic aberrations deletion 11q and deletion 17p independently predict for worse progression-free and overall survival after allogeneic hematopoietic cell transplantation for chronic lymphocytic leukemia
Keywords: CLL; Allogeneic hematopoietic cell transplant; Outcomes; Genomic aberrations; 17p deletion; 11q deletion;
Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights
Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki
Large changes in NAD levels associated with CD38 expression during HL-60 cell differentiation
Keywords: NAD(P); CD38; HL-60; CLL; CD157; Pyridine nucleotides;
Detection of Merkel cell polyomavirus in chronic lymphocytic leukemia T-cells
Keywords: Chronic lymphocytic leukemia; CLL; Merkel cell; Polyomavirus;
Multiple microRNAs may regulate the DNA repair enzyme uracil-DNA glycosylase
Keywords: 3â²UTR; 3â²untranslated region; AID; activation-induced cytidine deaminase; ATM; mutated in ataxia teleangiectasia; BER; base excision repair; CLL; chronic lymphocytic leukemia; CSR; class-switch recombination; miRNA; microRNA; MMR; mismatch repair; NER
BTK inhibitor ibrutinib is cytotoxic to myeloma and potently enhances bortezomib and lenalidomide activities through NF-κB
Keywords: BAFF; B cell-activating factor; BTK; Bruton's tyrosine kinase; CLL; chronic lymphocytic leukaemia; FLIP; FLICE (caspase-8)-like inhibitory protein; ibrutinib; 1-[(3R)-3-[4-amino-3-(4-phenoxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]prop-2-en-1-o
Combination of bendamustine and entinostat synergistically inhibits proliferation of multiple myeloma cells via induction of apoptosis and DNA damage response
Keywords: MM; Multiple myeloma; CLL; chronic lymphocytic leukemia; HDAC; histone deacetylase; HDACi; Inhibitor of HDAC; HAT; Histone acetyltransferase; PARP; poly(ADP-ribose) polymerase; ELISA; enzyme-linked immunosorbent assay; PAGE; polyacrylamide gel electrophor
Effector mechanisms of anti-CD20 monoclonal antibodies in B cell malignancies
Keywords: CD20; Antibodies; Immunotherapy; Lymphoma; CLL;
False-positive immunogenicity responses are caused by CD20+ B cell membrane fragments in an anti-ofatumumab antibody bridging assay
Keywords: CLL; chronic lymphocytic leukemia; CMFs; cell membrane fragments; ADA; anti-drug antibody; ECL; electrochemiluminescent; RTX; rituximab; Ofa; Ofatumumab; MVs; microvesicles; MSD; Meso-Scale Discovery; NC; negative control; PC; positive control; Immunogeni
Ectodomain shedding of CD200 from the B-CLL cell surface is regulated by ADAM28 expression
Keywords: CLL; ADAMs; Ectodomain shedding; SCD200
First immunochemotherapy outcomes in elderly patients with CLL: A retrospective analysis
Keywords: CLL; Elderly; Chemotherapy; Comorbidity