Ketamine attenuates sepsis-induced acute lung injury via regulation of HMGB1-RAGE pathways
Keywords: Ketamine; CLP; HMGB1; RAGE; ALI
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SurveySTAT3 signaling in immunity
Keywords: APRF; acute phase response factor; BAC; bacterial artificial chromosome; bHLH; basic helix loop-helix; Breg; B regulatory cells; CDP; common DC progenitor; CLP; common lymphoid progenitor; CMP; common myeloid progenitor; CTLs; cytotoxic CD8+ T lymphocytes
The evaluation of the role of C–H⋯F hydrogen bonds in crystal altering the packing modes in the presence of strong hydrogen bond
Keywords: N-benzylideneanilines; C–H⋯F hydrogen bond; Gaussian09; AIM2000; Weak interactions; Organic fluorine; Benzylideneanilines; CLP
Specific role of cytoplasmic dynein in the mechanism of action of an antitumor molecule, Amblyomin-X
Keywords: BTZ; bortezomib; FDA; Food and Drug Administration; Arf6; ADP-ribosylation factor 6; LR; lipid raft; EE; early endosomes; SE; sorting endosomes; ERC; endocytic recycling compartment; RE; recycling endosome; LE; late endosomes; Rab; Ras superfamily of mono
Reinterpreting the best biomarker of oxidative stress: The 8-iso-prostaglandin F2α/prostaglandin F2α ratio shows complex origins of lipid peroxidation biomarkers in animal models
Keywords: 8-iso-PGF2α; 8-iso-prostaglandin F2α; PGF2α; prostaglandin F2α; PGHS; prostaglandin-endoperoxide synthases, cyclooxygenases; CLP; chemical lipid peroxidation; 8-iso-PGF2α/PGF2α ratio; F2-isoprostanes; Oxidative stress; Inflammation; Biomarkers; Lipi
Constitutive over-expression of rice ClpD1 protein enhances tolerance to salt and desiccation stresses in transgenic Arabidopsis plants
Keywords: AMY; alpha amylase; BMY; beta amylase; Clp; caseinolytic protease; CS; citrate synthase; DAG; days after germination; DAS; days after stress; EE; enzyme extract; GITC; guanidium thiocynate; GST; glutathione S-transferase; IMY; iso amylase; IPTG; isopropyl
Inhibitory effects of three diketopiperazines from marine-derived bacteria on endothelial protein C receptor shedding in human endothelial cells and mice
Keywords: Diketopiperazine; EPCR shedding; Vascular inflammation; CLP;
GHS additivity formula: A true replacement method for acute systemic toxicity testing of agrochemical formulations
Keywords: Acute toxicity; GHS; Theory of additivity; Replacement; Global policy change; 3Rs; ANVISA; Agência Nacional de Vigilância Sanitária (Brazil); AF; Additivity formula; ATE; Acute Toxicity Estimate; EPA; Environmental Protection Agency (US); CLP; Classifi
Considering the antibacterial activity of Zataria multiflora Boiss essential oil treated with gamma-irradiation in vitro and in vivo systems
Keywords: Zataria multiflora; Irradiation; Antibacterial activity; CLP
Variability of magnetic character of S5-1 paleosol (age â¼470Â Ka) along a rainfall transect explains why susceptibility decreased with high rainfall
Keywords: Magnetic characters; Magnetic alteration; S5-1 paleosol; CLP;
Full Length ArticleCilostazol inhibits HMGB1 release in LPS-activated RAW 264.7 cells and increases the survival of septic mice
Keywords: AMPK; 5' adenosine monophosphate-activated protein kinase; ATCC; American Type Culture Collection; CO; Carbon monoxide; CLP; Cecal ligation and puncture; Cilostazol; (6-[4-(1-cyclohexyl-1H-tetrazol-5-yl) butoxy]-3,4-dihydro-2-(1H)-quinolinone); DMEM; Dulb
Shock/Sepsis/Trauma/Critical CareSepsis varies arterial two-pore-domain potassium channel messenger RNA in mice
Keywords: K2P channels; Dopamine receptors; Sepsis; CLP; Mesenteric artery;
Differential alterations of tissue T-cell subsets after sepsis
Keywords: CLP; cecal ligation and puncture; DN; double negative thymocytes; DP; double positive thymocytes; MFI; mean fluorescence intensity; NK; natural killer cells; NKT; natural killer T cells; SP; single positive thymocytes; Tcm; central memory CD4+ T cells; Te
Daidzein pretreatment improves survival in mouse model of sepsis
Keywords: Daidzein; CLP; Sepsis; Glucocorticoid receptor; Bacterial load; Acute lung injury
Bone marrow transcriptome and epigenome profiles of equine common variable immunodeficiency patients unveil block of B lymphocyte differentiation
Keywords: bHLH; transcription factor basic helix-loop-helix motif; CGI; CpG island; CLP; common lymphoid progenitor; CMP; common myeloid progenitor; CpG; cytosine-phosphate-guanine dinucleotide motif; CPM; count per million reads; CVID; Common variable immu
Withaferin A is an inhibitor of endothelial protein C receptor shedding in vitro and in vivo
Keywords: Withaferin A; EPCR shedding; PMA; CLP;
Tityus serrulatus scorpion venom improves survival and lung inflammation in lethal sepsis induced by CLP in mice
Keywords: Tityus serrulatus; Venom; CLP; Sepsis; Inflammation; Cytokines
Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury, involving heme oxygenase-1
Keywords: HO-1; heme oxygenase-1; NLRP3; nucleotide-binding domain (NOD)-like receptor protein 3; ZnPP; zinc protoporphyrin IX; ASC; apoptosis-associated speck-like protein containing caspase-1 activator domain (CARD); CLP; cecal ligation and perforation; MDA; malo
Optimizing the aquatic toxicity assessment under REACH through an integrated testing strategy (ITS)
Keywords: ACR; acute-to-chronic ratios; AF; assessment factor; BCF; bioconcentration factor; BOD5; 5-days biochemical oxygen demand; C&L; classification and labeling; CLP; classification, labeling and packaging; COD; chemical oxygen demand; CSA; chemical safety ass
Combining the European chemicals regulation and an (eco)toxicological screening for a safer membrane development
Keywords: REACH regulation; European chemical policy; (Eco)toxicological assessment; Polymeric membrane; CLP; Classification, Labelling and Packaging; CMR; carcinogenic, mutagenic and toxic for reproduction; DMA; N,N-Dimethylacetamide; DMSO; dimethyl sulfoxide; ECH
Purification and characterization of an antioxidant peptide (GSQ) from Chinese leek (Allium tuberosum Rottler) seeds
Keywords: ABTS; 2, 2â²-Azinobis-3-ethylbenzthiazoline-6-sulphonate; ACN; acetonitrile; CLP; Chinese leek seed peptide; DPPH; 1, 1-Diphenyl-2-picrylhydrazyl; ESI; electrospray ionization; LC-MS/MS; liquid chromatography-mass spectrometer; MTT; methylthiazol tetrazo
Original ResearchFull Report: Basic and Translational-Alimentary TractEndotoxicity of Lipopolysaccharide as a Determinant of T-CellâMediated Colitis Induction in Mice
Keywords: Mouse Model; IBD; Prevention; Bacteria; clp; colonic lamina propria; DC; dendritic cell; DSS; dextran sodium sulfate; IBD; inflammatory bowel disease; IL; interleukin; LPS; lipopolysaccharide; MHC; major histocompatibility complex; MUT; mutant; rDNA; ribo
Integrated testing strategy (ITS) for bioaccumulation assessment under REACH
Keywords: AD; applicability domain; B; bioaccumulative; BAF; bioaccumulation factor; BCF; bioconcentration factor; BMF; biomagnification factor; C&L; classification and labelling; CLP; classification, labelling and packaging regulation; CSA; chemical safety assessm
Rosmarinic acid down-regulates endothelial protein C receptor shedding in vitro and in vivo
Keywords: Rosmarinic acid; EPCR; Shedding; PMA; CLP;
Trefoil factor 2 expression and its significance as a predictor of severity of sepsis in children
Keywords: TFF2; Trefoil Factor 2; SIRS; systemic inflammatory response syndrome; PELOD; Paediatric Logistic Organ Dysfunction; MODS; Multiple Organ Dysfunction Syndrome; ROC; receiver operating characteristic; HRP; horseradish peroxidase; ANOVA; analysis of varianc
In the shadow of the Cosmetic Directive - Inconsistencies in EU environmental hazard classification requirements for UV-filters
Keywords: UV filter; CLP; Risk assessment; Risk characterization; Cosmetic Directive; Cosmetic Products Regulation;
Tooth agenesis patterns in unilateral cleft lip and palate in humans
Keywords: AP-2 alpha; activating enhancer binding protein 2 alpha; BCOR; BCL6 corepressor gene; C; canine; CLP; cleft lip and palate; CBCLP; complete bilateral cleft lip and palate; CUCLP; complete unilateral cleft lip and palate; I1; central incisor; I2; lateral i
Ulinastatin is a novel candidate drug for sepsis and secondary acute lung injury, evidence from an optimized CLP rat model
Keywords: Sepsis; Ulinastatin; CLP; Candidate drug;
Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; BUN; blood nitrogen urea; CLP; cecal ligation and puncture; COX-2; cyclooxygenase 2; EIH; ethanol extract of Inula helenium L.; HO-1; heme oxygenase-1; HMGB1; high mobility group box 1; iNOS;
Dual role of lipoxin A4 in pneumosepsis pathogenesis
Keywords: LXA4; 5(S),6(R)-Lipoxin A4; FPR2/ALX; formyl peptide receptor-2; AhR; aryl hydrocarbon receptor; LO; lipoxygenases; BOC-2; N-t-Boc-Phe-Leu-Phe-Leu-Phe; WRW(4); Trp-Arg-Trp-Trp-Trp-Trp-CONH2; BML-111; 5(S),6(R),7-trihydroxyheptanoic acid methyl ester; BAL;
In vivo detection of free radicals in mouse septic encephalopathy using molecular MRI and immuno-spin trapping
Keywords: anti-DMPO probe; anti-DMPO-biotin-BSA-Gd-DTPA; BBB; blood-brain-barrier; BSA; bovine serum albumin; CLP; cecal ligation and puncture; DMPO; 5,5-dimethyl-1-pyrroline-N-oxide; Gd-DTPA; gadolinium diethylene triamine pentaacetic acid; HNE; 4-hydroxynonenal
Identification, biological characterization and pharmacophoric analysis of a new potent and selective NK1 receptor antagonist clinical candidate
Keywords: NK; neurokinin; SP; substance P; GPCR; G protein-coupled receptor; CNS; central nervous system; SAD; social anxiety disorders; CINV; chemotherapy-induced nausea and vomiting; PoC; prove of concept; SAR; structure-activity relationship; CDI; carbonyldiim
In vivo-in vitro comparison of acute respiratory tract toxicity using human 3D airway epithelial models and human A549 and murine 3T3 monolayer cell systems
Keywords: 3T3-LDH/3T3-WST-1; test using 3T3 mouse fibroblasts and determining LDH release/WST-1 reduction; A549-LDH/A549-WST-1; test using A549 human alveolar epithelial cells and determining LDH release/WST-1 reduction; CLP; Classification Labelling and Packaging;
Assessment of the predictive capacity of the 3T3 Neutral Red Uptake cytotoxicity test method to identify substances not classified for acute oral toxicity (LD50Â >Â 2000Â mg/kg): Results of an ECVAM validation study
Keywords: Acute oral toxicity; Validation; Cytotoxicity; BALB/3T3 Neutral Red Uptake assay; CLP; Industrial chemicals;
The p75NTR signaling cascade mediates mechanical hyperalgesia induced by nerve growth factor injected into the rat hind paw
Keywords: AP; action potential; aPKC; atypical protein-kinase C; C2-ceramide; N-acetyl sphingosine; CLP; contralateral paw; DMSO; dimethyl sulfoxide; DRG; dorsal root ganglia; GSH; glutathione; IgG; immunoglobulin G; i.pl.; intraplantar; IPSI; ipsilateral paw; mPSI
FT-Raman, FT-IR, UV spectroscopic, NBO and DFT quantum chemical study on the molecular structure, vibrational and electronic transitions of clopidogrel hydrogen sulfate form 1: A comparison to form 2
Keywords: CLP; Polymorphism; Raman; Infrared; UV–vis spectroscopy; Quantum mechanical calculations
Survey on methodologies in the risk assessment of chemical exposures in emergency response situations in Europe
Keywords: ACUTEX; ACUTe EXposure (an EU project in 2002-2005); AEGL; acute exposure guideline level; AERV; acute exposure reference value; AETL; acute exposure threshold levels; CLP; regulation on classification, labelling and packing of substances and mixtures;
Peripheral 5-HT7 receptors as a new target for prevention of lung injury and mortality in septic rats
Keywords: Sepsis; 5-HT7 receptor; CLP; Rat; NF-κB
PPAR gamma activation protects the brain against microvascular dysfunction in sepsis
Keywords: PPARγ; peroxisome proliferator-activated receptor gamma; CLP; cecal ligation and puncture; TZD; thiazolidinediones;
An indirect sandwich ELISA for the determination of agkisacutacin in human serum: Application to pharmacokinetic study in Chinese healthy volunteers
Keywords: GPIb-IX-V; glycoprotein Ib-IX-V complex; CLP; C-type lectin-like protein; GPIb-bp; glycoprotein Ib-binding protein; vWF; von Willebrand factor; ACSs; acute coronary syndromes; mAb; monoclonal antibody; pAbs; polyclonal antibody; PBS; phosphate-buffered sa
α-Iso-cubebene, a natural compound isolated from Schisandra chinensis fruit, has therapeutic benefit against polymicrobial sepsis
Keywords: LPS; lipopolysaccharide; TNF-α; tumor necrosis factor-α; CLP; cecal ligation and puncture; ELISA; enzyme-linked immunosorbent assay; Sepsis; α-Iso-cubebene; Inflammation; Organ failure;
Effect of acute ethanol treatment on biochemical and histopathological factors in rat liver in an experimental sepsis model
Keywords: CLP; Alcohol; Sepsis; Inflammation; Liver damage;
Compartment-specific expression of plasminogen activator inhibitor-1 correlates with severity/outcome of murine polymicrobial sepsis
Keywords: PAI-1; plasminogen activator inhibitor type-1; CLP; cecal ligation and puncture; SUR; surviving mice; DIE; dying mice; LCVC; left cranial vena cava; t-PA; tissue-type plasminogen activator; u-PA; urokinase-type plasminogen activator; LPS; lipopolysacchari
HPLC-MS/MS method for the simultaneous determination of clopidogrel, its carboxylic acid metabolite and derivatized isomers of thiol metabolite in clinical samples
Keywords: CLP; clopidogrel; CLPM; carboxylic acid derivative of clopidogrel; CTM; thiol metabolite of clopidogrel; CTMD; derivatized thiol metabolite of clopidogrel; IS; internal standard; MP-H1, MP-H2, MP-H3; 3â²-methoxyacetophenone derivatives of isomers of clop
A regulatory approach to assess the potency of substances toxic to the reproduction
Keywords: GHS; globally harmonised system of classification and labelling of chemicals; CLP; regulation on classification labelling and packaging of substances and mixtures; GCL; generic concentration limit; SCL; specific concentration limit; LOAEL; lowest observed
Decision trees for evaluating skin and respiratory sensitizing potential of chemicals in accordance with European regulations
Keywords: CLP; European Council requirements for Classification, Labeling and Packaging of substances and mixtures; EC; the concentration of chemical required to induce a 3-fold stimulation index in the local lymph node assay; ECHA; European Chemicals Agency; EPA;
ReviewMapping the road to recovery: The ClpB/Hsp104 molecular chaperone
Keywords: AAA; ATPases associated with various cellular activities; Clp; Caseinolytic protease; EClpB; ClpB from Escherichia coli; EM; electron microscopy; Hsp; heat-shock protein; NBD; nucleotide binding domain; NEF; nucleotide exchange factor; RCMLA; reduced-carb
Risk assessment of endocrine active chemicals: Identifying chemicals of regulatory concern
Keywords: ACR; acute-to-chronic ratio; BfR; Bundesinstitut für Risikobewertung (German regulatory body); CLP; Classification, Labelling and Packaging; CRD; Chemicals Regulation Directorate (UK regulatory body); ECETOC; European Centre for Ecotoxicology and Toxicol
A consistent and transparent approach for calculation of Derived No-Effect Levels (DNELs) for petroleum substances
Keywords: ACGIH; American Conference of Governmental Industrial Hygienists; AD; Animal Dose; AF; Assessment Factor; BW; body weight; CLP; Classification, Labelling and Packaging Regulation; CNS; Central Nervous System; CSA; Chemical Safety Assessment; CSR; Chemical
A new approach for investigating protein flexibility based on Constraint Logic Programming. The first application in the case of the estrogen receptor
Keywords: CLP; Protein flexibility; Estrogen receptor; Protein folding