دانلود مقالات ISI درباره Cro + ترجمه فارسی

ارزیابی کیفیت و هزینه یک قطعه آنتی بادی نوترکیب تولید شده از سلول های میزبان پستانداران، مخمر و پروکاریوت: مطالعه مورد قبل از توسعه دارویی

Quality and cost assessment of a recombinant antibody fragment produced from mammalian, yeast and prokaryotic host cells: A case study prior to pharmaceutical development

Keywords: CMC; Chemistry, Manufacturing and Controls; CoG; cost of goods; CRO; Contract Research Organization; DTT; dithiothreitol; DSP; downstream process; Fd; heavy chain fragment; GP; glycoprotein; HRP; horseradish peroxidase; IEF; Isoelectrofocusing; Mr; relati

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

فوری برای بهینه سازی و هماهنگی تجزیه و تحلیل هورمون های تیروئید و تفسیر آنها در مطالعات سم شناسی توسعه و تولید مثل

The urgency for optimization and harmonization of thyroid hormone analyses and their interpretation in developmental and reproductive toxicology studies

Keywords: ANSES; Agence nationale de sécurité sanitaire de l'alimentation, de l'environnement et du travail (French Agency for Food, Environmental and Occupational Health & Safety); CRO; contract research organization; CV; coefficient of variation; DART; deve

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

مدل پیش بینی سرعت باد چند مرحله ای بر اساس تجزیه ثانویه، روش گروهی و الگوریتم اصلاح خطا

Big multi-step wind speed forecasting model based on secondary decomposition, ensemble method and error correction algorithm

Keywords: NWP; numerical weather prediction; CS; Cuckoo search; FS; fuzzy system; WRF; weather research and forecasting; KF; Kalman filter; ARIMA; auto-regressive integrated moving average; ARCH; autoregressive conditional heteroskedasticity; ANN; artificial neural

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2018 سفارش ترجمه

خصوصیات نانومواد: انعکاس در زمینه ای که در حال ساخت است مورد نیاز برای موفقیت ترجمه بالینی است

Characterization of nanomedicines: A reflection on a field under construction needed for clinical translation success

Keywords: Characterization; Nanomedicine; Regulatory; Biological systems; Quality control; AFM; Atomic force microscopy; API; Active pharmaceutical ingredient; BSAI; Biological Surface Adsorption Index; CARPA; Complement activation related pseudo allergy; CRO; Cont

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

یک الگوریتم برنامه ریزی نرم افزاری چند منظوره برای الگوریتم تولید ریخته گری عملیات فولادسازی مستمر با الگوبرداری

A preference-inspired multi-objective soft scheduling algorithm for the practical steelmaking-continuous casting production

Keywords: Steelmaking; Uncertain scheduling; Preference; CRO;

دانلود رایگان متن کامل مقاله ISI 60 صفحه سال انتشار : 2018 سفارش ترجمه

آزمایش ثبات میکروسمالی با قدرت بالا هماهنگ شده است

Harmonised high throughput microsomal stability assay

Keywords: ADME; absorption distribution metabolism excretion; AFE; average fold error; CLint; intrinsic metabolic clearance; CRO; contract research organisation; CYP; cytochrome P450; DMPK; drug metabolism and pharmacokinetics; G6P; glucose-6-phosphate; t1/2; half-

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

دیدگاه صنعت در متدولوژی های مرتبط با پروتئین معاصر: ملاحظات مربوط به تعاملات دارویی مدرن و دستورالعمل های مرتبط با داروهای بسیار محدود

Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs

Keywords: plasma protein binding; fraction unbound; drug-drug interaction; AUC; area under the curve; AUCR; area under the curve ratio; AAG; alpha 1-acid glycoprotein; CYP; cytochrome P450; BSA; bovine serum albumin; CRO; contract research organization; CV; coeffic

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

بررسی مقاله بررسی اکسیدیدروکات ها در راه انتقال به تغییرات صنعتی صنعتی

Research review paperOxidoreductases on their way to industrial biotransformations

Keywords: AAD; aryl-alcohol dehydrogenase; AAO; aryl-alcohol oxidase; ABTS; 2,2′-azino-bis(3-ethylbenzothiazoline-6-sulphonic acid); CDH; cellobiose dehydrogenase; CPK; Corey/Pauling/Koltun (atom coloring convention); CRO; copper-radical oxidase; DFF; 2,5-diformy

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

ملاحظات اخلاقی در تحقیقات مهندسی بافت: مطالعات موردی در ترجمه

Ethical considerations in tissue engineering research: Case studies in translation

Keywords: TESM; tissue engineered skeletal muscle; BAP; bioartificial pancreas; TM; therapeutic misconception; TD; translational distance; FIH; first-in-human; CRO; contract research organization; Human research ethics; Animal research ethics; Translational researc

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

سنجش از دور با استفاده از ماهواره زیستگاه آب در حال اجرا در مقیاس بزرگ رودخانه: ابزار برای تجزیه و تحلیل زیستگاه ناهمگونی برای مدیریت اکوسیستم رودخانه

Satellite-based remote sensing of running water habitats at large riverscape scales: Tools to analyze habitat heterogeneity for river ecosystem management

Keywords: 2D; two-dimensional; α; constant depending on the local value of river slope; γ; unit weight of water; y0; river bed roughness constant for vertical velocity profiles; ρw; water volumetric mass density; σ; standard deviation; τ0; shear stress; A; cro

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2016 سفارش ترجمه

ایجاد یک واحد آزمایشگاهی بالینی برای پیشبرد تحقیقات در موسسه علمی

Developing a clinical trial unit to advance research in an academic institution

Keywords: AAHC; Association of Academic Health Centers; CRO; Clinical Research Office; CTSA; Clinical and Translational Science Awards; CTU; clinical trial unit; DOM; Department of Medicine; FDA; Food and Drug Administration; GCP; Good Clinical Practice; IMARC; Inf

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

مطالعات پس از تایید در فرانسه، چالش های مواجهه با دستگاه های پزشکی

Post-approval Studies in France, Challenges Facing Medical Devices

Keywords: medical device; post-approval study; evaluation; CEESP; Commission for Economic Evaluation and Public Health (Commission d'évaluation économique et de santé publique); CEPS; Economic Committee on Health Care Products (Comité économique des produits

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2014 سفارش ترجمه

Nasopharyngeal s. pneumoniae carriage and density in Belgian infants after 9 years of pneumococcal conjugate vaccine programme

Keywords: AOM; acute otitis media; CRO; clinical research organisation; Chi2; Chi-Square test; DCC; day-care centre; GP; general practitioner; IPD; invasive pneumococcal disease; MWU; Mann-Whitney U test; NP; nasopharyngeal; PCV; pneumococcal conjugate vaccine; STG

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Temporal transcriptome analysis of the white-rot fungus Obba rivulosa shows expression of a constitutive set of plant cell wall degradation targeted genes during growth on solid spruce wood

Keywords: AA; auxiliary activity; AAO; aryl alcohol oxidase; AE; acetylesterase; AGL; α-galactosidase; AGU; α-glucuronidase; AOX; alcohol oxidase; BGL; β-1,4-glucosidase; CAZy; CAZyme, carbohydrate-active enzyme; CBH; cellobiohydrolase; CDH; cellobiose dehydroge

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

A lecithin phosphatidylserine and phosphatidic acid complex (PAS) reduces symptoms of the premenstrual syndrome (PMS): Results of a randomized, placebo-controlled, double-blind clinical trial

Keywords: Cortisol; Daily record of severity of problems; Phosphatidic acid; Phosphatidylserine; Premenstrual syndrome; AE; adverse event; AUCg; area under the curve (ground); AUCi; area under the curve (increase); BMI; body mass index; CAR; cortisol awakening resp

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Chuna manual therapy combined with acupuncture and cupping for frozen shoulder (adhesive capsulitis): Study protocol for a multicenter, randomized, patient-assessor blind, clinical trial

Keywords: FS; frozen shoulder; ROM; range of motion; NSAIDs; non-steroidal anti-inflammatory drugs; CMT; chuna manual therapy; CONSORT; consolidated standards of reporting trials; SPIRIT; standard protocol items: recommendations for interventional trials; KMD; Kore

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

In vitro secondary pharmacological profiling: An IQ-DruSafe industry survey on current practices

Keywords: AUC; Area Under the Curve; CRO; Contract Research Organization; CTA; Clinical Trial Authorization; GLP; Good Laboratory Practice; hERG; human ether-a-go-go-related gene; ICH; International Conference on Harmonization; IND; Investigational New Drug; IQ; In

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of Contract Research Organization Bureaucracy in Clinical Trial Management: A Model From Lung Cancer

Keywords: Bureaucratic procedures; Clinical trials; CRO; Patient accrual; Timelines;

دانلود رایگان متن کامل مقاله ISI 24 صفحه سال انتشار : 2018 سفارش ترجمه

Plasma N-glycome composition associates with chronic low back pain

Keywords: Glycan biomarker; Low back pain; Plasma N-glycosylation; Retrospective study; % Area; percentage of total integrated area of the chromatogram; 2-AB; 2-aminobenzamide; 2-PB; 2-picoline borane; AbSur; cohort of patients with acute inflammation that had abdo

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Nanostructured lipid dispersions for topical administration of crocin, a potent antioxidant from saffron (Crocus sativus L.)

Keywords: NLD; nanostructured lipid dispersions; CRO; crocin; cryo-TEM; Cryo-transmission electron microscopy; SCE; Stratum Corneum Epidermis; ORAC; oxygen radical absorbance capacity; Nanotechnology; Materials science; Chemical stability; Formulation; Antioxidant;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

DNA adductomics to study the genotoxic effects of red meat consumption with and without added animal fat in rats

Keywords: O6-CM-G; O6-carboxymethylguanine; O6-Me-G; O6-methylguanine; A; adenine; C; cytosine; CRO; crotonaldehyde; Cro-G; Methylhydroxypropanoguanine, the main CRO adduct with G; DNA; DeoxyriboNucleic Acid; G; guanine; Hep-G; heptenal-G; HNE-C; Hydroxynonenal-C;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Exploring opportunities and risks for RES-E deployment under Cooperation Mechanisms between EU and Western Balkans: A multi-criteria assessment

Keywords: ALB; Albania; BiH; Bosnia & Herzegovina; CDM; Clean Development Mechanism; CRO; Croatia; DM; Decision Maker; FYR; FYROM; GHG; Greenhouse gas; KOS; Kosovo*; MON; Montenegro; MCDA; Multi-criteria decision analysis; MS; Member State; RES; Renewable Energy So

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

HESTAT: Study protocol for a phase II/III, randomized, placebo-controlled, single blind study to evaluate the new hemostatic agent TT-173 in total knee arthroplasty

Keywords: Randomized controlled trial; TT-173; Hemostatic agent; Topical; Total knee arthroplasty; AE; adverse event; AEMPS; Spanish Agency for Medicines and Sanitary Products; ABT; allogenic blood transfusion; CRO; Contract Research Organization; Hb; hemoglobin; r

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Full Length ArticleTissue oxidative stress induced by patulin and protective effect of crocin

Keywords: Patulin; Nephrotoxicity; Hepatotoxicity in vivo; Oxidative stress; Lipid peroxidation; Antioxidant molecule; PAT; patulin; CRO; crocin; DNPH; dinitrophenylhydrazine; MDA; malondialdehyde; HSP70; heat shock proteins; SOD; superoxide dismutase;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Micro-CT imaging: Developing criteria for examining fetal skeletons in regulatory developmental toxicology studies - A workshop report

Keywords: Concordance criteria; Developmental toxicology; Imaging; Micro-CT; Skeletal evaluation; GLP validation; 2-D; two-dimensional; 3-D; three-dimensional; CRO; contract research organization; DART; developmental and reproductive toxicology; EFD; embryo-fetal d

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Validation of a Patient-reported Outcome (PRO) Measure and a Clinician-reported Outcome (CRO) Measure to Assess Satisfaction with Pharmacologic Stress Agents for Single-photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)

Keywords: clinician-reported outcome; CRO; patient-reported outcome; PRO; satisfaction; stress agents;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Development of SYN-004, an oral beta-lactamase treatment to protect the gut microbiome from antibiotic-mediated damage and prevent Clostridium difficile infection

Keywords: Antibiotic risk factors; Beta-lactamase; Clostridium difficile; Healthcare-associated infections; Microbiome; AAD; antibiotic-associated diarrhea; CDI; Clostridium difficile infection; Conc; concentration; Cmax; maximum concentration; CRO; ceftriaxone; FM

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Synthesis of CrO single crystal slices by firing under water vapor atmosphere

Keywords: CrO; Single crystal slice; Crystal growth; Crystal structure;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

The Management of Schizophrenia in Clinical Practice (MOSAIC) Registry: A focus on patients, caregivers, illness severity, functional status, disease burden and healthcare utilization

Keywords: AE; adverse event; B-CATS; Brief Cognitive Assessment Tool for Schizophrenia; BMI; body mass index; CAINS; Clinical Assessment Interview for Negative Symptoms; CGI-SCH; Clinical Global Impression-Schizophrenia; CHMC; Community Mental Health Center; COPD

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Mechanistic studies of anticancer aptamer AS1411 reveal a novel role for nucleolin in regulating Rac1 activation

Keywords: AS1411; Aptamer; Nucleolin; Rac1; Methuosis; Macropinocytosis; CRO; cytosine-rich oligonucleotide (an inactive control sequence); G-LISA; GTPase-linked immunosorbent assay; G-rich; guanosine-rich; MP; macropinocytosis; NCL; nucleolin; NIH; National Instit

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2015 سفارش ترجمه

The Myeloid U937 Skin Sensitization Test (U-SENS) addresses the activation of dendritic cell event in the adverse outcome pathway for skin sensitization

Keywords: ACD; Allergic Contact Dermatitis; BLR; between-laboratory reproducibility; CRO; Contract Research Organisation; DC; dendritic cells; DPRA; Direct Peptide Reactivity Assay; EC3; estimated concentration that produces a stimulation index of 3 in the LLNA; EC

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2015 سفارش ترجمه

Frequent off-label use of fondaparinux in patients with suspected acute heparin-induced thrombocytopenia (HIT) - findings from the GerHIT multi-centre registry study

Keywords: A; argatroban; aPTT; activated partial thromboplastin time; BMI; body-mass index; CRF; case report forms; CRO; Contract Research Organisation; D; danaparoid; DIC; disseminated intravascular coagulation; DTI; direct thrombin inhibitors; DVT; deep vein thro

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2014 سفارش ترجمه

Les études post-inscriptions en France, quels enjeux pour les dispositifs médicaux

Keywords: dispositif médicaux; étude post-inscription; évaluation; ASA; amélioration du service attendu; CEESP; Commission d'évaluation économique et de santé publique; CEPS; Comité économique des produits de santé; CNEDiMTS; Commission nationale d'é

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Lipid peroxidation product 4-hydroxy-2-nonenal modulates base excision repair in human cells

Keywords: 4-Hydroxy-2-nonenal; HNE-DNA adducts; Base excision repair; Ligation, OGG1, TDG, ANPG, APE1; Acr; acrolein; ANPG; alkyl-N-purine glycosylase; AP-site; apurinic/apyrimidinic site; APE1; AP-site endonuclease; BER; base excision repair; BSA; bovine serum a

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

National Observatory on the Therapeutic Management in Ambulatory Care Patients Aged 65 and Over, with Type 2 Diabetes, Chronic Pain or Atrial Fibrillation

Keywords: aged; type 2 diabetes mellitus; atrial fibrillation; chronic pain; pharmacoepidemiology; sujets agés; diabète de type 2; fibrillation auriculaire; douleur chronique; pharmaco épidemiologie; ACE; angiotensin-converting enzyme inhibitor; ADL; activity of

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2013 سفارش ترجمه

Clinical Trials and Contract Research Organizations in India

Keywords: Clinical trials; Research; India; CRO; Research quality; Compliance;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

In vivo antitumor effect of cromolyn in PEGylated liposomes for pancreatic cancer

Keywords: cro; cromolyn; gem; gemcitabine; lipo; liposome; PEG-lipo-cro; PEGylated liposomal cromolyn; PBS; phosphate buffered saline; MTT; 3-[4,5-dimethyl thiazol-2-yl]-2,5-diphenyltetrazolium bromide; TUNEL; terminal deoxynucleotide transferase (TdT)-mediated dUT

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Carbonyls speciation in a typical European automotive diesel engine using bioethanol/butanol-diesel blends

Keywords: MIR; Maximum Incremental Reactivity; SR; specific reactivity; ROP; Relative Ozone Productivity; CCE; Carbonyl Compound Emission; DNPH; dinytrophenylhydrazine; bDOC; before the diesel oxidation catalyst; bDPF; before the diesel particle filter; aDPF; after

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Guide de la Haute autorité de santé (HAS) : les études post-inscription sur les technologies de santé (médicaments, dispositifs médicaux et actes) : principes et méthodes

Keywords: évaluation des technologies de santé; études post-inscription; épidémiologie; méthodologie; conditions réelles d'utilisation; health technology assessment; post-registration studies; epidemiology; methodology; real-life study; Afssaps; Agence fra

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

One-step enzymatic production of fatty acid ethyl ester from high-acidity waste feedstocks in solvent-free media

Keywords: FA; fatty acid; FFA; free fatty acid; FAEE; fatty acid ethyl ester; FAME; fatty acid methyl ester; TAG; triacylglycerol; HAWF; high-acidity waste feedstock; POFA; palm oil fatty acid; CRO; chicken residual oil; TLC; thin layer chromatography; HPLC; high p

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Cross comparison of rapid mycoplasma detection platforms

Keywords: Mycoplasma; Rapid detection; T5000; NAT; cGMP; Current good manufacturing practice; CHO; Chinese Hamster Ovary cells; CRO; Contract Research Organization; CT; Cycle Threshold; EP; European Pharmacopeia; ESI-MS; Electrospray ionization mass spectrometry; F

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2010 سفارش ترجمه

Beneficial impact of crocetin, a carotenoid from saffron, on insulin sensitivity in fructose-fed rats

Keywords: CON; control; CRO; crocetin; CRO(H); high-dose crocetin; CRO(L); low-dose crocetin; FFA; free fatty acids; FRU; fructose; HDL-C; high-density lipoprotein cholesterol; KRBH; Krebs-Ringer bicarbonate HEPES buffer; LDL-C; low-density lipoprotein cholesterol;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Single independent operator sites are involved in the genetic switch of the Lactobacillus delbrueckii bacteriophage mv4

Keywords: Lactobacillus; Bacteriophage; Lysogeny; Genetic switch; CI; Cro; Repressor

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Characterization of the lytic–lysogenic switch of the lactococcal bacteriophage Tuc2009

Keywords: Phage; CI; Cro; DNA binding; DNA looping

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2006 سفارش ترجمه

Equilibrium unfolding of dimeric and engineered monomeric forms of λ Cro (F58W) repressor and the effect of added salts: evidence for the formation of folded monomer induced by sodium perchlorate

Keywords: Cro; Protein folding; Electrostatic interactions; Chaotropic salts; Hofmeister series; NMR;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه