دانلود مقالات ISI درباره Crth2 + ترجمه فارسی

Prostaglandin D2 induces apoptosis of human osteoclasts through ERK1/2 and Akt signaling pathways

Keywords: CRTH2; chemoattractant receptor homologous molecule expressed on T-helper type 2 cells; DMSO; dimethyl sulfoxide; DP; d-Type prostanoid; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; GPCR; G protein-coupled receptor; GRK5; GPCR kina

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2014 سفارش ترجمه

Anti-inflammatory actions of Chemoattractant Receptor-homologous molecule expressed on Th2 by the antagonist MK-7246 in a novel rat model of Alternaria alternata elicited pulmonary inflammation

Keywords: A. alternata; Alternaria alternata; OVA; Ovalbumin; Th2; Type 2 helper cells; CRTH2; Chemoattractant Receptor-homologous molecule expressed on Th2 cells; MK-7246; {(7R)-7-[[(4-fluorophenyl)sulfonyl](methyl)amino]-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2014 سفارش ترجمه

The molecular and functional characterization of clonally expanded CD8 + TCR BV T cells in eosinophilic granulomatosis with polyangiitis (EGPA)

Keywords: ANCA; anti-neutrophil cytoplasmic autoantibody; CRTH2; chemoattractant receptor-homologous molecule expressed on Th2 cells; TEM; effector memory T cell; EGPA; eosinophilic granulomatosis with polyangiitis; GV; gamma variable; GPA; granulomatosis with poly

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2014 سفارش ترجمه

Prostaglandin D2 activates group 2 innate lymphoid cells through chemoattractant receptor-homologous molecule expressed on TH2 cells

Keywords: Group 2 innate lymphoid cell; PGD2; chemoattractant receptor-homologous molecule expressed on TH2 cells; IL-25; IL-33; innate type 2 immunity; adaptive type 2 immunity; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; CSF-1; Mac

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2014 سفارش ترجمه

Protein kinase C-dependent activation of CaV1.2 channels selectively controls human TH2-lymphocyte functions

Keywords: Chemoattractant receptor-homologous molecule expressed on TH2 cells; asthma; calcium; voltage-dependent calcium channels; TH2 cytokines; protein kinase C α/β; AS; Antisense; [Ca]i; Intracellular calcium concentration; Cav1; Voltage-dependent calcium cha

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2014 سفارش ترجمه

Setipiprant, a Selective Oral Antagonist of Human CRTH2: Relative Bioavailability of a Capsule and a Tablet Formulation in Healthy Female and Male Subjects

Keywords: CRTH2; human pharmacokinetics; relative bioavailability; setipiprant;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases

Keywords: BAL; bronchoalveolar lavage; BEMP; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; CCR-3; CC chemokine receptor 3; CRTh2; chemoattractant receptor homologous expressed on Th2 cells; DK-PGD2; 13,14-dihydro-15-keto-PGD2; ELSD;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

2-(1H-Pyrazol-4-yl)acetic acids as CRTh2 antagonists

Keywords: CRTh2; Prostaglandin D2; Antagonist; Pyrazole; Plasma protein binding

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Evolution of novel tricyclic CRTh2 receptor antagonists from a (E)-2-cyano-3-(1H-indol-3-yl)acrylamide scaffold

Keywords: CRTh2; DP2; Prostaglandin; Asthma; Rhinitis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Optimization of phenylacetic acid derivatives for CRTH2 and DP selective antagonism

Keywords: CRTH2; DP; PGD2; GPCR; Antagonist; Asthma; Allergic diseases; Lead optimization; SAR;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Optimization of phenylacetic acid derivatives for balanced CRTH2 and DP dual antagonists

Keywords: CRTH2; DP; PGD2; GPCR; Dual Antagonist; SAR; Asthma

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Discovery of novel and potent CRTH2 antagonists

Keywords: CRTH2; DP2; PGD2; Asthma; Inflammation;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2012 سفارش ترجمه

Novel 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids: Discovery and hit-to-lead evolution of a selective CRTh2 receptor antagonist chemotype

Keywords: CRTh2; DP2; Prostaglandin; Asthma; Rhinitis

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Use of libraries to access new chemical space: Applications to CRTH2

Keywords: Prostanoid; Prostaglandin; CRTH2; Antagonist; Libraries

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Original Full Length ArticleProstaglandin D2 induces apoptosis of human osteoclasts by activating the CRTH2 receptor and the intrinsic apoptosis pathway

Keywords: PGD2; prostaglandin D2; PGE2; prostaglandin E2; DP; D-type prostanoid receptor; CRTH2; chemoattractant receptor homologous molecule expressed on T-helper type 2 cells; OC; osteoclast; RANKL; receptor activator for nuclear factor κB ligand; M-CSF; macroph

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2012 سفارش ترجمه

Immune response modifiers in the treatment of asthma: A PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology

Keywords: Immune response modifiers; monoclonal antibodies; asthma; allergic diseases; APC; Antigen-presenting cell; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells (also known as DP2); FDA; US Food and Drug Administration; Feno; Fraction

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Differentiation stage determines pathologic and protective allergen-specific CD4+ T-cell outcomes during specific immunotherapy

Keywords: Immunotherapy; allergy; pollen; T cells; CD4; peptide-MHC class II tetramer; peripheral tolerance; differentiation stage; ex vivo; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 lymphocytes; Foxp3; Forkhead box P3; PE; Phycoeryt

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on TH2 cells

Keywords: Chemoattractant receptor-homologous molecule expressed on TH2 cells; eosinophils; prostaglandin D2; Ca2+ flux; G protein-coupled receptor; D-type prostanoid receptor; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2 cells; DK-PG

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه

N-Arylation of a hindered indoline as a route to 2-(2-methyl-1-(4-oxo-3,4-dihydrophthalazin-1-yl)-1H-indol-3-yl)acetic acid derivatives

Keywords: Indoline; Microwave-assisted; Atropisomer; CRTh2; Indole acetic acid;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Intolérance à l’aspirine et mécanismes de l’hypersensibilité

Keywords: Acide arachidonique; Leucotriène; Prostaglandine; Galectine; CRTH2; ComplémentArachidonic acid; Leucotriene; Prostaglandin; Galectin; CRTH2; Complement

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Azaindoles as potent CRTH2 receptor antagonists

Keywords: CRTH2; Chemoattractant receptor-homologous; PGD2; Prostanoid; Azaindole; Tetrahydropyridoindolizines

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Sodium [2′-[(cyclopropanecarbonyl-ethyl-amino)-methyl]-4′-(6-ethoxy-pyridin-3-yl)-6-methoxy-biphenyl-3-yl]-acetate (AM432): A potent, selective prostaglandin D2 receptor antagonist

Keywords: Prostaglandin D2; CRTH2; Antagonist; DP2 receptor

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Discovery and optimization of a biphenylacetic acid series of prostaglandin D2 receptor DP2 antagonists with efficacy in a murine model of allergic rhinitis

Keywords: CRTH2; DP2; Prostaglandin D2; Allergic rhinitis; Eosinophil shape change; Binding; Antagonist

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Substituted indole-1-acetic acids as potent and selective CRTh2 antagonists—discovery of AZD1981

Keywords: CRTh2; DP2; Prostaglandin; Inflammation; Asthma; Candidate drug; Optimization; SAR

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids

Keywords: CRTh2; DP2; Prostaglandin; Inflammation; Asthma; Phenoxyacetic acid

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

IFN-γ and TNF-α potentiate prostaglandin D2-induced human eosinophil chemotaxis through up-regulation of CRTH2 surface receptor

Keywords: IFN; TNF; CRTH2; Eosinophils; Allergic rhinitis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Ara h 1-reactive T cells in individuals with peanut allergy

Keywords: Food allergy; peanut; Ara h 1; T cells; class II tetramers; CLA; Cutaneous lymphocyte antigen; CRTH2; Chemoattractant receptor-homologous molecule expressed on Th2 cells; ICS; Intracellular cytokine staining; TGEM; Tetramer-guided epitope mapping;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2011 سفارش ترجمه

Effects of prostaglandin D2 on tetrodotoxin-resistant Na+ currents in DRG neurons of adult rat

Keywords: DP1 receptor; DP2 receptor; CRTH2; Sensory neuron; Sodium channel; Excitability;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2011 سفارش ترجمه

3-Indolyl sultams as selective CRTh2 antagonists

Keywords: CRTh2; DP; Ramatroban; Antagonist; Prostaglandin D2; Sultam; Indole;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2010 سفارش ترجمه

The prostaglandin D2 receptor CRTH2 is important for allergic skin inflammation after epicutaneous antigen challenge

Keywords: CRTH2; prostaglandin D2; atopic dermatitisAD, Atopic dermatitis; CRTH2, Chemoattractant receptor–homologous molecule expressed on receptor on TH2 cells; DC, Dendritic cell; DP1, Prostaglandin D2 receptor 1; OVA, Ovalbumin; PG, Prostaglandin; WT, Wild-type

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2010 سفارش ترجمه

Therapeutic efficacy of AM156, a novel prostanoid DP2 receptor antagonist, in murine models of allergic rhinitis and house dust mite-induced pulmonary inflammation

Keywords: DP2; CRTH2; Allergic rhinitis; Asthma; House dust mite; Pulmonary inflammation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Prostaglandin D2 induces the production of human β-defensin-3 in human keratinocytes

Keywords: Prostaglandin D2; CRTH2; Human β-defensin-3; Keratinocyte; c-Fos

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2010 سفارش ترجمه

Characterization of C-terminal tail determinants involved in CRTH2 receptor trafficking: Identification of a recycling motif

Keywords: CRTH2; G protein-coupled receptor; Internalization; GRKs; PKC; Arrestin

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2010 سفارش ترجمه

Tetrahydroquinoline derivatives as CRTH2 antagonists

Keywords: CRTH2; PGD2; Antagonists; GPCR; Allergic diseases; Tetrahydroquinoline; SAR; Lead optimization;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

7-Azaindole-3-acetic acid derivatives: Potent and selective CRTh2 receptor antagonists

Keywords: CRTh2; Prostaglandin D2; Azaindole; Eosinophils; Allergic diseases

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Novel tricyclic antagonists of the prostaglandin D2 receptor DP2 with efficacy in a murine model of allergic rhinitis

Keywords: CRTH2; DP2; Prostaglandin D2; Antagonist; Allergic rhinitis; Mouse sneeze; Binding; Eosinophil; Shape change; Azaindole

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Discovery and optimization of CRTH2 and DP dual antagonists

Keywords: CRTH2; DP; Antagonists; GPCR; Asthma; PGD2

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2009 سفارش ترجمه

Clinical studies of the DP1 antagonist laropiprant in asthma and allergic rhinitis

Keywords: Prostaglandin D receptor gene promoter; asthma susceptibility; airway disease; montelukast; AE; Adverse experience; AR; Allergic rhinitis; CRTH2; Chemoattractant receptor-homologous molecule on T-helper type 2 cells, also known as DP2; DASS; Daytime Asthm

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2009 سفارش ترجمه

Filaggrin deficiency confers a paracellular barrier abnormality that reduces inflammatory thresholds to irritants and haptens

Keywords: Atopic dermatitis; barrier function; contact dermatitis; filaggrin; flaky-tail mouse; lamellar body; AD; Atopic dermatitis; CRTH2; Chemoattractant receptor-homologous molecule expressed on TH2; FLG; Human filaggrin gene; flg; Murine filaggrin gene; ft/ft;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2009 سفارش ترجمه

Pain mechanismDifferent effects of spinally applied prostaglandin D2 on responses of dorsal horn neurons with knee input in normal rats and in rats with acute knee inflammation

Keywords: hyperexcitability; central sensitization; prostanoids; pain; arthritis; electrophysiology; cAMP; cyclic AMP; CGRP; calcitonin gene-related peptide; CRTH2; receptor chemoattractant receptor-homologous molecule expressed on T-helper 2 cells; DP1 receptor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

2-Cycloalkyl phenoxyacetic acid CRTh2 receptor antagonists

Keywords: CRTh2; Prostaglandin D2; Phenoxyacetic acid; Eosinophils; Allergic diseases

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Synthesis and in vitro evaluation of a selective antagonist and the corresponding radioligand for the prostaglandin D2 receptor CRTH2

Keywords: CRTH2; DP2; Prostaglandin D2; 7TM receptor; GPCR; Antagonist; Radioligand

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Characterization of the promoter of human CRTh2, a prostaglandin D2 receptor

Keywords: CRTh2; Th2 lymphocytes; GATA-3; Promoter; Transcription; Allergic inflammation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Differential regulation of the signaling and trafficking of the two prostaglandin D2 receptors, prostanoid DP receptor and CRTH2

Keywords: G protein-coupled receptor; Prostaglandin; DP; CRTH2

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2007 سفارش ترجمه

Discovery of potent CRTh2 (DP2) receptor antagonists

Keywords: CRTh2; DP2; Inflammation; Asthma; Indomethacin; Indole; Quinoline

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2006 سفارش ترجمه

Differential Expression of Genes Involved in Skin Homing, Proliferation, and Apoptosis in CD4+ T Cells of Patients with Atopic Dermatitis

Keywords: allergic asthma; atopic dermatitis; atopy; CCR10; CCR4; CRTH2; microarray; TARC;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2005 سفارش ترجمه

Pharmacological characterization of guinea pig chemoattractant receptor-homologous molecule expressed on Th2 cells (CRTH2)

Keywords: Guinea pig CRTH2; Prostaglandin D2 (PGD2); Δ12-PGJ2; Gene cloning and expression; Allergic inflammation; Pharmacology; CRTH2; chemoattractant receptor-homologous molecule expressed on Th2 cells; DP; prostaglandin D2 receptor; DK-PGD2; 13,14-dihydro-15-ke

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه

Δ12-Prostaglandin D2 is a potent and selective CRTH2 receptor agonist and causes activation of human eosinophils and Th2 lymphocytes

Keywords: CRTH2; chemoattractant receptor-homologous molecule expressed on Th2 cells; Dk-PGD2; 13,14-dihydro-15-keto-PGD2; DP; D prostanoid receptor; GPCR; G protein-coupled receptor; 15d-PGD2; 15-deoxy-Δ12,14PGD2; PGD2; prostaglandin D2; PTX; Bordella pertussis t

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2005 سفارش ترجمه