D-type prostanoid receptor enhances the signaling of chemoattractant receptor-homologous molecule expressed on TH2 cells

Our data demonstrate the capacity of DP receptors to amplify the biological response to CRTH2 activation. Therefore the CRTH2/DP heteromer might not only represent a functional signaling unit for PGD2 but also a potential target for the development of heteromer-directed therapies to treat allergic diseases.