دانلود مقالات ISI درباره Cyp + ترجمه فارسی

3D engineered In vitro hepatospheroids for studying drug toxicity and metabolism

Keywords: 3D; Three-dimensional; 2D; Two-dimensional; CYP; cytochrome P450; GEVAC; Gelatin-Vinyl Acetate; MSCs; Mesenchymal stem cells; hUC-MSCs; human umbilical cord derived-mesenchymal stem cells; HLCs; Hepatocyte-like cells; DMEM-LG; Dulbecco's Modified Eagle's-

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Acetylated deoxycholic (DCA) and cholic (CA) acids are potent ligands of pregnane X (PXR) receptor

Keywords: BA; bile acid; CA; cholic acid; CDCA; chenodeoxycholic acid; CYP; cytochrome P450; DCA; deoxycholic acid; 6-ECDCA; 6α-ethyl-chenodeoxycholic acid, obeticholic acid; FXR; farnesoid X receptor; LBD; ligand binding domain; LCA; lithocholic acid; PXR; pregna

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Pharmacogenomics: Precision Medicine and Drug Response

Keywords: CYP; cytochrome P450; EHR; electronic health record; eMERGE; Electronic Medical Records and Genomics; GWAS; genome-wide association study; NGS; next-generation sequencing; NIH; National Institutes of Health; ns; nonsynonymous; PGRN; Pharmacogenomics Resea

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

In vitro to in vivo extrapolation of the complex drug-drug interaction of bupropion and its metabolites with CYP2D6; simultaneous reversible inhibition and CYP2D6 downregulation

Keywords: Drug-drug interactions; CYP2D6; Bupropion; Enzyme regulation; In vitro to in vivo extrapolation; AUC; area under plasma concentration time curve; CYP; cytochrome P450; DDI; drug-drug interaction; fm; fraction metabolized; IVIVE; in vitro to in vivo extrap

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Cytochrome P450-2E1 is involved in aging-related kidney damage in mice through increased nitroxidative stress

Keywords: Kidney; Aging; CYP2E1; Apoptosis; Fibrosis; Oxidative stress; APAP; acetaminophen; ATP5B; ATP synthase subunit Beta; CAT; catalase; Cytochrome P450; CYP; DNPH; dinitrophenylhydrazine; GCLC; glutamate-cysteine ligase catalytic subunit; GCLM; glutamate-cyst

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Activation of GR but not PXR by dexamethasone attenuated acetaminophen hepatotoxicities via Fgf21 induction

Keywords: APAP; acetaminophen; bp; base pair; ChIP; chromatin immunoprecipitation; Cyp; cytochrome p450 enzyme; DEX; dexamethasone; Fgf21; fibroblast growth factor 21; GR; glucocorticoid receptor; GRE; glucocorticoid receptor response element; GSH; Glutathione; i.p

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Herbal Medications in Cardiovascular Medicine

Keywords: adverse drug reactions; alternative medicine; cardiovascular disease; CYP; cytochrome; DBP; diastolic blood pressure; FDA; Food and Drug Administration; GSE; grapeseed extract; HbA1c; glycosylated hemoglobin; HDL; high-density lipoprotein; LDL; low-densit

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Development of GC-MS based cytochrome P450 assay for the investigation of multi-herb interaction

Keywords: GC-MS; Human liver microsomes; Cytochrome P450; Cocktail approach; Socheongryong-tang; CAM; Complementary and alternative medicine; CV; Coefficient of variation; CYP; Cytochrome P450; GC-MS; DTE; dithioerythritol; Gas chromatography-mass spectrometry; HDI

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Potential role of CYP1B1 in the development and treatment of metabolic diseases

Keywords: AA; Arachidonic acid; AHR; aryl hydrocarbon receptor; Ang II; angiotensin II; B[a]P; benzo[a]pyrene; CYP; Cytochrome P450; DB[a,l]P; dibenzo[a,l]pyrene; EETs; epoxyeicosatrienoic acids; ER; estrogen receptor; HETE; hydroxyeicosatetraenoic acids; HFD; high

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Steviol, an aglycone of steviol glycoside sweeteners, interacts with the pregnane X (PXR) and aryl hydrocarbon (AHR) receptors in detoxification regulation

Keywords: Food-drug interactions; Drug metabolism; Nuclear receptors; Steviol; Stevioside; ADI; accepted daily intake; AHR; arylhydrocarbon receptor; CAR; constitutive androstane receptor; CYP; cytochrome P450; DDIs; drug-drug interactions; FDIs; food-drug interact

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

B-13 progenitor-derived hepatocytes (B-13/H cells) model lipid dysregulation in response to drugs and chemicals

Keywords: ADFP; adipose differentiation-related protein; B-13; AR42J-B-13; B-13/H; AR42J-B-13 cells following treatment with 10 nM dexamethasone for 14 days; CYP; cytochrome P450; DAPI; 4'6'-diamino-2-phenylindole; DEX; dexamethasone; DTT; dithiothreitol; LAM

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods

Keywords: drug interaction; cytochrome P450s; membrane transport/transporters; regulatory; guidance/guideline; ADME; absorption, distribution, metabolism and excretion; BCRP; breast cancer resistance protein; CYP; cytochrome P-450; d; induction calibration factor;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Efficient substrate screening and inhibitor testing of human CYP4Z1 using permeabilized recombinant fission yeast

Keywords: ADMET; absorption, distribution, metabolism, excretion, and toxicity; API; active pharmaceutical ingredient; CPR; NADPH-cytochrome P450 oxidoreductase; CYP; cytochrome P450; EMM; Edinburgh Minimal Medium; HLMs; human liver microsomes; RLU; relative lumine

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain

Keywords: ACEA; arachidonyl-2′-chloroethylamide; AEA; N-arachidonoylethanolamide, anandamide; APN; aminopeptidase N; BNI; nor-binaltorphimine; CCI; chronic constrictive injury; CYP; cyprodime; DENKI; dual enkephalinase inhibitor; DOR; delta opioid receptor; ENK;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Toxicological evaluation of the flavour ingredient N-(1-((4-amino-2,2-dioxido-1H-benzo[c][1,2,6]thiadiazin-5-yl)oxy)-2-methylpropan-2-yl)-2,6-dimethylisonicotinamide (S2218)

Keywords: amu; atomic mass units; AUC; area under the curve; CBPI; cytokinesis-blocked proliferation index; CL; plasma clearance; Cmax; peak plasma concentration; CYP; cytochrome P450; EIC; extracted ion chromatogram; FDA; Food and Drug Administration; FEMA; Flavou

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Direct comparison of UDP-glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors

Keywords: UDPGA; 5′-diphosphoglucuronic acid; CRMs; chemically reactive metabolites; CYP; cytochrome P450; HLM; human liver microsomes; PHH; primary human hepatocytes; UGTs; UDP-glucuronosyltransferases; β-estradiol (PubChem CID:5757); Chenodeoxycholic acid (Pub

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Cellular retinoid binding-proteins, CRBP, CRABP, FABP5: Effects on retinoid metabolism, function and related diseases

Keywords: 13cRA; 13-cis-retinoic acid; atRA; all-trans-retinoic acid; BP; binding-protein(s); CRABP; cellular retinoic acid BP; CRBP; cellular retinol BP; CYP; cytochrome P-450; FABP; fatty acid BP; LCFA; long-chain fatty acids; LD; lipid droplet(s); LRAT; lecithin

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2017 سفارش ترجمه

Challenges in assignment of allosteric effects in cytochrome P450-catalyzed substrate oxidations to structural dynamics in the hemoprotein architecture

Keywords: Cytochrome P450; Allosteric effects; Cooperativity; Key determinants; Molecular modeling; 1PB; 1-pyrenebutanol; 4MP; 4-methylpyrazole; 7BQ; 7-benzyloxyquinoline; 7EC; 7-ethoxycoumarin; 7EFC; 7-ethoxy-4-trifluoromethylcoumarin; 9AP; 9-aminophenanthrene; 9E

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2017 سفارش ترجمه

Environmental carcinogenesis and pH homeostasis: Not only a matter of dysregulated metabolism

Keywords: AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; CYP; cytochrome P450; EMT; epithelial-to-mesenchymal transition; Cx43; connexin 43; GJIC; gap junction intercellular communication; HMGCoA reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; NHE1; Na

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Impact of chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN) on cancer treatment outcomes: An overview about well-established and recently emerging clinical data

Keywords: ABCC1/MRP; ATP binding cassette subfamily C member 1/ multidrug resistance protein; ABVD; doxorubicine-bleomycin-vinblastine-dacarbazine; AC; doxorubicin-cyclophosphamide; ANC; absolute neutrophil count; ASCO; American Society of Clinical Oncology; AUC; a

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Multiple resistance to pirimiphos-methyl and bifenthrin in Tribolium castaneum involves the activity of lipases, esterases, and laccase2

Keywords: E1; esterase1; LIPs; lipases; LACs; laccases; Pyr; pyrethroid; Org; organophosphate; F1Pyr and F5Pyr; beetles selected throughout one or five generations in the presence of bifenthrin (pyrethroid), respectively; F1Org and F5Org; beetles selected throughou

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Cannabidiol: State of the art and new challenges for therapeutic applications

Keywords: (5-HT)1A; 5-hydroxytryptamine receptor;  ∆9-THC; delta-9-tetrahydrocannabinol; 2-AG; 2-arachidonoylglycerol; A2A; adenosine receptor; AEA; anandamide; ALI; acute lung injury; Aml-1; acute myeloid leukemia; APP; amyloid precursor protein; AR; androgen r

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Comparison of xenobiotic-metabolising human, porcine, rodent, and piscine cytochrome P450

Keywords: Comparison; Detoxification; Drug; Model organism; Pollution; BaP; benzo[a]pyrene; BFCOD; benzyloxy-4-trifluoromethylcoumarin O-debenzylase; CAR; constitutive androstane receptor; CYP; cytochrome P450; EROD-7; ethoxyresorufin dealkylation; GR; glucocortico

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Anti-inflammatory activity of natural stilbenoids: A review

Keywords: AMPK; 5′ adenosine monophosphate-activated protein kinase; AP-1; activator protein 1; CAT; catalase; COX; cyclooxygenase; CRP; C-reactive protein; CSA; cajaninstilbene acid; CYP; cytochrome enzyme; DSS; dextran sulfate sodium; ERK; extracellular signal-

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Aryl hydrocarbon receptor (AHR): “pioneer member” of the basic-helix/loop/helix per-Arnt-sim (bHLH/PAS) family of “sensors” of foreign and endogenous signals

Keywords: AA; arachidonic acid; AHH; aryl hydrocarbon hydoxylase; AHR; aryl hydrocarbon receptor; ARNT; aryl hydrocarbon receptor translocator; B6; C57BL/6J mice; bHLH; basic-helix/loop/helix domain in proteins; Chr; chromosome; CNS; central nervous system; CYP; cy

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2017 سفارش ترجمه

Cloning and identification of a novel steroid 11α-hydroxylase gene from Absidia coerulea

Keywords: Absidia coerulea; 11α-hydroxylase; CYP; Transcriptome sequencing;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Purification and site-directed mutagenesis of linoleate 9S-dioxygenase-allene oxide synthase of Fusarium oxysporum confirms the oxygenation mechanism

Keywords: Cobalt affinity chromatography; Cyclooxygenase; Fusion enzymes; Jasmonic acid; Site-directed mutagenesis; Liquid chromatography-mass spectrometry; AOS; allene oxide synthase(s); COX; cyclooxygenase(s); CYP; cytochrome P450; DOX; dioxygenase(s); EAS; epoxy

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2017 سفارش ترجمه

Charge-tagging liquid chromatography-mass spectrometry methodology targeting oxysterol diastereoisomers

Keywords: ACOX2; acyl-coenzyme A oxidase 2; AMACR; alphamethylacyl-CoA racemase; CTX; cerebrotendinous xanthomatosis; CYP; cytochrome P450; EADSA; enzyme-assisted derivatisation for steroid analysis; ESI; electrospray ionisation; GC; gas chromatography; GP; Girard

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Thermodynamics of interactions between mammalian cytochromes P450 and b5

Keywords: Cytochrome P450; Cytochrome b5; SPR; Optical biosensor; Thermodynamics; Protein-protein interactions; CYP; ≿ytochrome P450; CYB5; ≿ytochrome b5; CYB5A and CYB5B; microsomal and mitochondrial isoforms of b5; SPR; surface plasmon resonance; RU; resonanc

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2017 سفارش ترجمه

Expression of CYP4V2 in human THP1 macrophages and its transcriptional regulation by peroxisome proliferator-activated receptor gamma

Keywords: CYP; CYP4V2; Macrophage; THP1; PPAR gamma; Fatty acid metabolism;

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2017 سفارش ترجمه

Genetic disorders of Vitamin D biosynthesis and degradation

Keywords: CYP; cytochrome P450; ER; endoplasmic reticulum; FAD; flavin adenine dinucleotide; FMN; flavin mononucleotide; POR; P450 oxidoreductase; VDR; vitamin D receptor; Calcium; CYP2R1; CYP27B1; CYP24A1; Neonatal hypercalcemia; Rickets; Secosteroid;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Air particulate matter induced oxidative stress and inflammation in cardiovascular disease and atherosclerosis: The role of Nrf2 and AhR-mediated pathways

Keywords: HDL; high density lipoprotein; apoE; apolipoprotein E; UFP; ultrafine particles; CD40; cluster of differentiation 40; HUVEC; human umbilical vein endothelial cells; HMEC; human microvascular endothelial cells; BAEC; bovine aortic endothelial cells; mRNA;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Mechanisms of Vascular Dysfunction in COPD and Effects of a Novel Soluble Epoxide Hydrolase Inhibitor in Smokers

Keywords: clinical trial; COPD; EETs; endothelial function; smokers; soluble epoxide hydrolase inhibitor; CYP; cytochrome P450; DHET; dihydroxyepoxyeicosatrienoic acid; EC50; half maximal effective concentration; EDHF; endothelium-derived hyperpolarizing factor; EE

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2017 سفارش ترجمه

Modulation of signaling mechanisms in the heart by thioredoxin 1

Keywords: Akt; protein kinase B; AMPK; Adenosine Monophosphate-activated Protein Kinase; Ang-II; Angiotensin-II; AP1; Activator protein 1 (AP-1); ASK1; Apoptosis Signal-regulating kinase; Atg4; Autophagy related-4; ATP; Adenosine Triphosphate; CDDP; cis-diammine-di

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Cellular adaptation to xenobiotics: Interplay between xenosensors, reactive oxygen species and FOXO transcription factors

Keywords: AhR; arylhydrocarbon receptor; AIP; AhR interacting protein; ARE; antioxidant response element; ARNT; AhR nuclear translocator; bHLH; basic helix-loop-helix (DNA binding and dimerisation domain); CAR; constitutive androstane receptor; CBP; CREB-binding pr

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2017 سفارش ترجمه

Ketamine metabolites with antidepressant effects: Fast, economical, and eco-friendly enantioselective separation based on supercritical-fluid chromatography (SFC) and single quadrupole MS detection

Keywords: CYP; cytochrome P450; DHK; dehydronorketamine; KET; ketamine; NK; norketamine; NK-d4; norketamine-d4; HNK; hydroxynorketamine; SFC-MS; supercritical-fluid chromatography single quadrupole mass spectrometry; LLOQ; lower limit of quantification; LOD; limit

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

Obesity is positively associated with arachidonic acid-derived 5- and 11-hydroxyeicosatetraenoic acid (HETE)

Keywords: AEA; arachidonoyl ethanolamide; AG; arachidonoyl glycerol; ALA; alpha-linolenic acid; ARA; arachidonic acid; BHT; butylated hydroxytoluene; BMI; body mass index; COX; cyclooxygenase; CYP; cytochrome P450 enzymes; DGLA; dihomo-gamma-linolenic acid; DHA; do

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2017 سفارش ترجمه

The consequence of regional gradients of P-gp and CYP3A4 for drug-drug interactions by P-gp inhibitors and the P-gp/CYP3A4 interplay in the human intestine ex vivo

Keywords: 3OH-Qi; 3-hydroxy-quinidine; ADME-Tox; absorption, distribution, metabolism, excretion and toxicity; CP100356; N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine; CYP; cytochrome P450; DDI(s); drug

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2017 سفارش ترجمه

Down-regulation of the expression of alcohol dehydrogenase 4 and CYP2E1 by the combination of α-endosulfan and dioxin in HepaRG human cells

Keywords: ADH; Alcohol dehydrogenase; AHR; Aryl hydrocarbon receptor; ALD; Alcohol liver disease; ARNT; AHR nuclear translocator; CAR; Constitutive androstane receptor; CYP; Cytochrome P450; ER; Estrogen receptor; OCP; Organochlorine pesticide; POP; Persistent orga

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2017 سفارش ترجمه

Nutritional modulation of intestinal drug-metabolizing cytochrome P450 by butyrate of different origin in chicken

Keywords: Butyrate; Xenobiotics; CYP; Broiler chicken;

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2017 سفارش ترجمه

In vivo pharmacokinetic interaction by ethanolic extract of Gymnema sylvestre with CYP2C9 (Tolbutamide), CYP3A4 (Amlodipine) and CYP1A2 (Phenacetin) in rats

Keywords: Gymnema sylvestre; Diabetes; Triterpenoids; Steroids; Pharmacokinetic; CYP450-Herb drug interaction; CYP; CytochromeP450; PK; Pharmacokinetics; GS; Gymnema sylvestre; HDI; Herb drug interaction; EL; Ethanolic extract; GA; Gymnemic acid; HRLC-MS; High reso

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Quantitative Analysis of Complex Drug-Drug Interactions Between Repaglinide and Cyclosporin A/Gemfibrozil Using Physiologically Based Pharmacokinetic Models With In Vitro Transporter/Enzyme Inhibition Data

Keywords: clinical trial simulations; drug interactions; pharmacokinetics; physiologically based pharmacokinetic modeling; organic anion-transporting polypeptide transporters; CYP enzymes; AUC; area under the blood concentration-time curve; AUCR; area under the b

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Tetramethylpyrazine suppresses angiotensin II-induced soluble epoxide hydrolase expression in coronary endothelium via anti-ER stress mechanism

Keywords: AUDA; 12-[[(tricyclo[3.3.1.13,7]dec-1ylamino)carbonyl]amino]dodecanoic acid; 4-PBA; 4-phenylbutyric acid; GRP78; 78-kDa glucose-regulated protein; ATF6; Activating transcription factor 6; Ang-II; Angiotensin-II; CYP; Cytochrome P450; ER stress; Endoplasmi

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Quantitative chiral and achiral determination of ketamine and its metabolites by LC-MS/MS in human serum, urine and fecal samples

Keywords: CYP; cytochrome P450; DHNK; dehydronorketamine; D4-n-KET; D4-norketamine; D4-KET; D4-ketamine; HK; hydroxyketamine; HNK; hydroxynorketamine; HPLC; high performance liquid chromatography; KET; ketamine; n-KET; norketamine; LLOQ; lower limit of quantificati

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

Improving the activity of surface displayed cytochrome P450 enzymes by optimizing the outer membrane linker

Keywords: BAM; β-barrel assembly machinery; CPR; Cytochrome P450 reductase; CtxB; Cholera toxine subunit B; CYP; Cytochrome P450 monooxygenase; NADP+;  Nicotinamide adenine dinucleotide phosphate; FAD; flavin adenine dinucleotide; FMN; flavin mononucleotide; ORF;

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of hepatic abcb4 and cyp3a65 gene expression and multidrug/multixenobiotic resistance (MDR/MXR) functional activity in the model teleost, Danio rerio (zebrafish)

Keywords: ABC; ATP-binding cassette; CYP; cytochrome P450; KTC; ketoconazole; MDR/MXR; multidrug/multixenobiotic resistance; P-gp; P-glycoprotein; PCN; pregnenolone 16α-carbonitrile; PXR; pregnane X-receptor; ARmax; maximum accumulation rate; Cmax; maximum concent

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2017 سفارش ترجمه

DHA-derived oxylipins, neuroprostanes and protectins, differentially and dose-dependently modulate the inflammatory response in human macrophages: Putative mechanisms through PPAR activation

Keywords: AP-1; activator protein 1; B94, TNFAIP2; TNF alpha induced protein 2; C/EBP; CCAAT-enhancer-binding protein; CCL; chemokine ligand; CEX-1; chemokine exodus protein 1; COX; cyclooxygenase; CXCL; chemokine (C-X-C motif) ligand; CYP; cytochrome P450 monooxyg

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Current In Vitro Methods to Determine Hepatic Kpuu: A Comparison of Their Usefulness and Limitations

Keywords: active transport; passive diffusion/transport; hepatic metabolism; biliary excretion; distribution; disposition; tissue partition; protein binding; hepatocytes; human liver microsomes; ABT; 1-aminobenzotriazole; AFE; average fold error; CLint; intrinsic c

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Comparison of the Predictability of Human Hepatic Clearance for Organic Anion Transporting Polypeptide Substrate Drugs Between Different In Vitro-In Vivo Extrapolation Approaches

Keywords: active transport; cytochrome P450; glucuronosyltransferase (UGT); hepatic clearance; hepatic transport; hepatocytes; membrane transport/transporters; organic anion transporting polypeptide transporters; transporters; AUC; area under the plasma concentrati

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2017 سفارش ترجمه

RNAi suppression of nuclear receptor genes results in increased susceptibility to sulfoxaflor in brown planthopper, Nilaparvata lugens

Keywords: AHR; aryl hydrocarbon receptor; BLAST; basic local alignment search tool; CAR; constitutive androstane receptor; CYP; cytochrome P450; DBD; DNA-binding domain; ERR; estrogen-related receptor; EST; expressed sequence tag; GR; glucocorticoid receptor; HNF4;

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه