دانلود مقالات ISI درباره Cyp + ترجمه فارسی

High hepatic exposure of furanocoumarins in Radix Angelica dahuricae is associated with transporter mediated active uptake

Keywords: ABT; 1-aminobenzotriazole; AUC0-∞; area under the curve; BER; bergapten; Cmax; maximum plasma concentration; CsA; cyclosporine A; CYP; cytochrome P450; DMEM/F-12; Dulbecco's modified Eagle medium nutrient mixture F-12; DMSO; dimethyl sulfoxide; ƒu; unb

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Product specificity of fungal 8R- and 9S-dioxygenases of the peroxidase-cyclooxygenase superfamily with amino acid derivatized polyenoic fatty acids

Keywords: Dioxygenase-cytochrome P450 fusion proteins; Lipidomics; Lipid metabolism; Mass spectrometry; Oxygenation mechanism; Peroxidase-cyclooxygenase superfamily; AOS; allene oxide synthase(s); COX; cyclooxygenase(s); CYP; cytochrome(s) P450; DiHODE; dihydroxyoc

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Comparison of Anticoagulant Therapy for Atrial Fibrillation - Novel Oral Anticoagulants Versus Vitamin K Antagonists

Keywords: ACC; American College of Cardiology; ACS; Acute Coronary Syndrome; ACT; Activated Clotting Time; AF; Atrial Fibrillation; AHA; American Heart Association; aPCC; Activated Prothrombin Complex Concentrate; aPTT; Activated Partial Thromboplastin Time; CAD; C

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2018 سفارش ترجمه

Combination of CYP2C19 genotype with non-genetic factors evoking phenoconversion improves phenotype prediction

Keywords: CAR; constitutive androstane receptor; CI; confidence interval; CYP; cytochrome P450; EM; extensive metabolizer; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GR; glucocorticoid receptor; IM; intermediate metabolizer; PCR; polymerase chain reaction; PM

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury

Keywords: Akr1a; aldehyde reductase; ALT; alanine transaminase; AsA; ascorbic acid; CHOP; CCAAT-enhancer-binding protein homologous protein; CYP; cytochrome P450; ER; endoplasmic reticulum; H&E; hematoxylin and eosin; i.p.; intraperitoneally; JNK; c-Jun N-terminal

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Effect of Tinospora cordifolia aqua-alcoholic extract on pharmacokinetic of Glibenclamide in rat: An herb-drug interaction study

Keywords: TC; Tinospora cordifolia; TCE; Tinospora cordifolia extract; CYP; Cytochrome P450; CAM; complementary and alternative medicine; IS; internal standard; LLOQ-QC; quality control sample at lowest limit of quantification level; LQC; low quality control sample

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Genetics of tailored medicine: Focus on CNS drugs

Keywords: Cytochrome P450; CYP; Pharmacogenetics; Tailored medicine;

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Identification of metabolites of MDR-1339, an inhibitor of β-amyloid protein aggregation, and kinetic characterization of the major metabolites in rats

Keywords: AD; alzheimer's disease; AUCINF; area under the concentration time curve from time zero to the last sampling time plus the extrapolated area (i.e., the last concentration divided by the elimination rate constant); AUClast; area under the concentration t

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2018 سفارش ترجمه

Therapeutic potentials of Houttuynia cordata Thunb. against inflammation and oxidative stress: A review

Keywords: NCBI; National Centre for Biotechnology Information; SARS; Severe acute respiratory syndrome; NO; Nitric Oxide; LPS; Lipopolysaccharide; NF-κB; Nuclear factor kappa B; ROS; Reactive Oxygen Species; TNF-α; Tumor Necrosis Factor-α; IL; Interleukin; MCP-1

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Human cytochrome P450 expression in bacteria: Whole-cell high-throughput activity assay for CYP1A2, 2A6 and 3A4

Keywords: ACN; acetonitrile; C7H; coumarin 7-hydroxylation; CPR; NADPH cytochrome P450 oxidoreductase; CYB5; cytochrome b5; CYP; microsomal cytochrome P450 monooxygenases; DBF; dibenzyl-fluorescein; DBODF; dibenzylfluorescein O-debenzylation; DMSO; dimethyl sulfoxi

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro

Keywords: 95%CI; 95% confidential interval; AB; apical-to-basolateral; ABC; ATP-binding cassette; Abcb1; canine P-glycoprotein; ABCB1; human P-glycoprotein; ABCC1; multidrug resistance-associated protein 1; ABCG2; breast cancer resistance protein; BA; basolateral-t

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

CYP27A1 acts on the pre-vitamin D3 photoproduct, lumisterol, producing biologically active hydroxy-metabolites

Keywords: CYP; cytochrome P450; 7DHC; 7-dehydrocholesterol; 20,22(OH)2L3; 20,22-dihydroxylumisterol3; HP-β-CD; 2-hydroxypropyl-β-cyclodextrin; 25(OH)D3; 25-hydroxyvitamin D3; 22(OH)L3; 22-hydroxylumisterol3; 24(OH)L3; 24-hydroxylumisterol3; 25(OH)L3; 25-hydroxylu

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Peroxisome proliferator activated receptor gamma (PPAR-γ) ligand pioglitazone regulated gene networks in term human primary trophoblast cells

Keywords: BNF; beta-naphthoflavone; CCL; C-C motif chemokine ligand; CT; cytotrophoblast; CXCL; C-C-X-C motif chemokine ligand; CYP; cytochrome P450 enzyme superfamily; ELOVL4; fatty acid elongase 4; EVCT; extravillous cytotrophoblast; GEO; Gene Expression Omnibus;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

Dietary ALA, EPA and DHA have distinct effects on oxylipin profiles in female and male rat kidney, liver and serum

Keywords: AA; arachidonic acid; ALA; alpha-linolenic acid; cooh; carboxy; COX; cyclooxygenase; CYP; cytocrome P450; DGLA; dihomo-gamma-linolenic acid; dh; dihydro; dhk; dihydroketo; DiHDoHE; dihydroxy-docosahexaenoic acid; DiHDPE; dihydroxy-docosapentaenoic acid; D

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Mechanistic Physiologically Based Pharmacokinetic Modeling of the Dissolution and Food Effect of a Biopharmaceutics Classification System IV Compound-The Venetoclax Story

Keywords: amorphous; absorption, distribution, metabolism, and excretion (ADME); bioavailability; food effect; physiologically based pharmacokinetic modeling; clinical pharmacokinetics; intestinal absorption; passive diffusion/transport; drug interaction; ASD; Amor

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Distinct effects of dietary ALA, EPA and DHA on rat adipose oxylipins vary by depot location and sex

Keywords: AA; arachidonic acid; ALA; α-linolenic acid; COX; cyclooxygenase; CYP; cytochrome P450; DGLA; dihomo-gamma-linolenic acid; dh; dihydro; dhk; dihydroketo; DiHDoHE; dihydroxy-docosahexaenoic acid; DiHDPE; dihydroxy-docosapentaenoic acid; DiHETrE; dihydroxy

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Identification of 5-hydroxymethylfurfural in cigarette smoke extract as a new substrate metabolically activated by human cytochrome P450 2A13

Keywords: CYP; cytochrome P450; CYP2A13; cytochrome P450 2A13; CYP2A5; cytochrome P450 2A5; 8-MOP; 8-methoxypsoralen; BEAS-2B; immortalized human bronchial epithelial cells; B-2A13; BEAS-2B cells stably expressing CYP2A13; CSE; cigarette smoke extract; TSNA; tobacc

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Effects of volatile anaesthetics on heme metabolism in a murine genetic model of Acute Intermittent Porphyria. A comparative study with other porphyrinogenic drugs

Keywords: AIA; allylisopropylacetamide; AIP; acute intermittent porphyria; ALA; δ-aminolevulinic acid; ALA-S; δ-aminolevulinic acid synthetase; CYP; cytochrome P-450; PBG-D; porphobilinogen deaminase; HO; heme oxygenase; s.d.; standard deviation; 5-Aminolevulinic

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Properties of purified CYP2R1 in a reconstituted membrane environment and its 25-hydroxylation of 20-hydroxyvitamin D3

Keywords: 1,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 25(OH)D3; 25-hydroxyvitamin D3; 20(OH)D3; 20S-hydroxyvitamin D3; 20,25(OH)2D3; 20S,25-dihydroxyvitamin D3; 20,23(OH)2D3; 20S,23S-dihydroxyvitamin D3; 1,20,25(OH)3D3; 1α,20S,25-trihydroxyvitamin D3; CYP; cytochrome

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

Phototrophic production of heterologous diterpenoids and a hydroxy-functionalized derivative from Chlamydomonas reinhardtii

Keywords: cdm; cell dry mass; IPP; isopentenyl pyrophosphate; DMAPP; dimethylallyl pyrophosphate; FPPs; farnesyl pyrophosphate (synthase); GGPP; geranylgeranyl pyrophosphate; TAP; Tris acetate phosphate medium; YFP; mVenus yellow fluorescent protein; CFP; mCerulean

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2018 سفارش ترجمه

Rewiring FadR regulon for the selective production of ω-hydroxy palmitic acid from glucose in Escherichia coli

Keywords: TE; thioesterase; TR; transcriptional regulator; ACP; acyl carrier protein; CYP; cytochrome P450; FAS; fatty acid synthase; FFA; free fatty acid; SFA; saturated fatty acid; UFA; unsaturated fatty acid; HFA; hydroxy fatty acid; HPA; hydroxy palmitic acid;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Hepatic phase I and II biotransformation responses and contaminant exposure in long-finned pilot whales from the Northeastern Atlantic

Keywords: Marine mammals; OHCs; Liver; Enzyme activity; mRNA expression; CYP;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Toxicokinetic and toxicodynamic studies of carbaryl alone or in binary mixtures with azinphos methyl in the freshwater gastropod Planorbarius corneus

Keywords: AChE; acetylcholinesterase; AcSCh; acetylthiocholine iodide; AZM; azinphos-methyl; BCF; bioconcentration factor; CB; carbaryl; CPF; chlorpyrifos; CES; carboxylesterases; ChE; cholinesterase; CYP; cytochrome P450; DTNB; 5,5′-dithio-2-bis-nitrobenzoate; p

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Design and optimization of the cocktail assay for rapid assessment of the activity of UGT enzymes in human and rat liver microsomes

Keywords: Estradiol (PubChem CID: 5757); Chenodeoxycholic acid (PubChem CID: 10133); Serotonin (PubChem CID: 5202); Propofol (PubChem CID: 4943); Zidovudine (PubChem CID: 35370); CYP; cytochrome P450; UGT; UDP-glucuronosyltransferases; DDI; drug-drug interactions;

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

P-glycoprotein and breast cancer resistance protein restrict brigatinib brain accumulation and toxicity, and, alongside CYP3A, limit its oral availability

Keywords: ABC; ATP-binding cassette; ALK; anaplastic lymphoma kinase; ANOVA; analysis of variance; AUC; area under plasma concentration-time curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BTB; blood-testis barrier; Cbrain; brain concentrat

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Biotechnology Challenges to In Vitro Maturation of Hepatic Stem Cells

Keywords: Liver Development; Differentiation; Hepatocyte; Culture; CRISPR; clustered regularly interspaced short palindromic repeats; CYP; cytochrome P450; 3D; 3-dimensional; DNMTi; DNA methylation inhibitor; ECM; extracellular matrix; ESC; embryonic stem cell; ES-

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Design, synthesis, and structure-activity-relationship of a novel series of CXCR4 antagonists

Keywords: Chemokine; CXCR4; Antagonist; GPCR; Scaffold hybridization; Therapy; APC; allophycocyanin; BPO; benzoyl peroxide; CCD; charge coupled device; CYP; cytochrome P450; DC; dendritic cells; DCE; 1,2-dichloroethane; DIPEA; N,N-diisopropylethylamine; DMEM; Dulbe

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2018 سفارش ترجمه

Vitamin D: Effects on human reproduction, pregnancy, and fetal well-being

Keywords: 25(OH)D; 25 hydroxyvitamin D; 1,25(OH)2D; 1,25 dihydroxy vitamin D; CYP; cytochrome P450 family; VDR; vitamin D receptor; IU; international units; IOM; institute of medicine; ng/mL; nanograms/milliliter; nmol/L; nanomoles/liter; UVB; ultraviolet B; 25(OH)

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Selection of P2Y12 Inhibitor in Percutaneous Coronary Intervention and/or Acute Coronary Syndrome

Keywords: ACS; acute coronary syndrome; ACCOAST trial; Comparison of Prasugrel at the Time of Percutaneous Coronary Intervention or as Pretreatment at the Time of Diagnosis in Patients with Non-ST Elevation Myocardial Infarction trial; ACUITY; acute catheterization

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

The activity of brain and liver cytochrome P450 2D (CYP2D) is differently affected by antidepressants in the chronic mild stress (CMS) model of depression in the rat

Keywords: ACTB; beta-actin; CYP; cytochrome P450; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; CMS; chronic mild stress; HPA; hypothalamic-pituitary-adrenal axis; MD; early-life maternal deprivation; RS; repeated restraint stress; SSRI; serotonin selective reup

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Extra collagen overlay prolongs the differentiated phenotype in sandwich-cultured rat hepatocytes

Keywords: Bile canaliculi; Collagen; Hepatic drug disposition; Methods; Sandwich-cultured rat hepatocytes; AUC; Area Under the Curve; BEI; biliary excretion index; CDF; 5-(6)-carboxy-2-dichlorofluorescein; CDFDA; 5-(6)-carboxy-2-dichlorofluorescein diacetate; Clint

دانلود رایگان متن کامل مقاله ISI 41 صفحه سال انتشار : 2018 سفارش ترجمه

Cross-talk of cannabinoid and endocannabinoid metabolism is mediated via human cardiac CYP2J2

Keywords: Δ8-THC; Δ8-tetrahydracannabinol; Δ9-THC; Δ9-tetrahydracannabinol; AEA; anandamide; AA; arachidonic acid; CBC; cannabichromene; CBD; cannabidiol; CBG; cannabigerol; CBR; cannabinoid receptor; CBN; cannabinol; -COOH; carboxy; CYP; cytochrome P450; CPR;

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2018 سفارش ترجمه

Efficacy of 2-hydroxy-3-phenylsulfanylmethyl-[1,4]-naphthoquinone derivatives against different Trypanosoma cruzi discrete type units: Identification of a promising hit compound

Keywords: Trypanosoma cruzi; Naphthoquinones; Trypanocidal activity; Chemotherapy; CD; Chagas disease; Bz; Benznidazole; Nif; Nifurtimox; ROS; Reactive oxygen species; CC50; Concentration of compound that reduces 50% of mammalian cell viability; IC50; Concentration

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Effects of cytochrome P450 single nucleotide polymorphisms on methadone metabolism and pharmacodynamics

Keywords: ADH; alcohol dehydrogenase; CDC; Centers for Disease Control and Prevention; CYP; cytochrome P450; del; deletion; EDDP; 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine; EM; extensive metabolizer; EMDP; 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline; FDA; Food and

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Nano liquid chromatography-high-resolution mass spectrometry for the identification of metabolites of the two new psychoactive substances N-(ortho-methoxybenzyl)-3,4-dimethoxyamphetamine and N-(ortho-methoxybenzyl)-4-methylmethamphetamine

Keywords: NPS; new psychoactive substances; NBOMe; N-ortho-methoxybenzyl; 25B-NBOMe; 2-(4-bromo-2,5-dimethoxyphenyl)-N-(ortho-methoxybenzyl) ethanamine; 25C-NBOMe; 2-(4-chloro-2,5-dimethoxyphenyl)-N-(ortho-methoxybenzyl) ethanamine; 25I-NBOMe; 2-(4-iodo-2,5-dimetho

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Human-based systems: Mechanistic NASH modelling just around the corner?

Keywords: Elafibranor (PubChem CID: 9864881); Obeticholic acid (PubChem CID: 447715); Pioglitazone (PubChem CID: 4829); Rosiglitazone (PubChem CID: 77999); Fenofibrate (PubChem CID: 3339); Serine (PubChem CID: 5951); ACC1; acetyl-coenzyme A carboxylase 1; AdipoR; a

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

Cell-based assay using glutathione-depleted HepaRG and HepG2 human liver cells for predicting drug-induced liver injury

Keywords: AUC; area under receiver operating characteristic curve; BSO; L-buthionine-S,R-sulfoximine; BW; boxed warning; Cmax; therapeutic maximum plasma concentration; CYP; cytochrome P450; DILI; drug-induced liver injury; DMSO; dimethyl sulfoxide; FBS; fetal bovi

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

Microfluidics contribution to pharmaceutical sciences: From drug discovery to post marketing product management

Keywords: ALS; amyotrophic lateral sclerosis; BBB; blood-brain barrier; CE; capillary electrophoresis; CL; chemiluminescence; CMC; capillary microsampling; CSF; cerebrospinal fluid; CTC; circulating cancer cells; CYP; cytochrome P; DBS; dried blood spots; DDS; drug

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Proteomics and phosphoproteomics analysis of liver in male rats exposed to bisphenol A: Mechanism of hepatotoxicity and biomarker discovery

Keywords: Bisphenol A; Proteomics; Phosphoproteomics; Hepatotoxicity; Oxidative stress; 2-DE; Two-dimensional gel electrophoresis; AKR1D1; Aldo-keto reductase family 1 member D1; BHMT; betaine homocysteine s-methyltransferase; BPA; Bisphenol A; Cat; catalase; CYP;

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Cytochrome P450 4A11 inhibition assays based on characterization of lauric acid metabolites

Keywords: CYP4A11; Reaction phenotyping; HET0016; Plumbagin; Lauric acid metabolism; HLM; human liver microsomes; CYP; cytochrome P450; 20-HETE; 20-hydroxyeicosatetraenoic acids; LC-MS/MS; liquid chromatography-tandem mass spectrometry; IC50; the half maximal inh

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2018 سفارش ترجمه

Strategies to improve the prediction accuracy of hepatic intrinsic clearance of three antidiabetic drugs: Application of the extended clearance concept and consideration of the effect of albumin on CYP2C metabolism and OATP1B-mediated hepatic uptake

Keywords: AUC; area under the plasma concentration-time curve; BSA; bovine serum albumin; CCK-8; cholecystokinin octapeptide-8; CYP; cytochrome P450; E1S; estrone-3 sulfate; FAF; fatty-acid-free; HBSS; Hanks' balanced salt solution; HEK; human embryonic kidney; H

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Adelmidrol + sodium hyaluronate in IC/BPS or conditions associated to chronic urothelial inflammation. A translational study

Keywords: CYP; cyclophosphamide; IC/BPS; interstitial cystitis/painful bladder syndrome; MCs; mast cells; iNOS; nitric oxide synthase; ZO-1; zonula occludens type 1; PEA; palmitoylethanolamide; MPO; Myeloperoxidase; (NF-κB) p65; nuclear factor-κB; (IL)-1β; inter

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Aryl hydrocarbon receptor (AhR) mediated short-term effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on bile acid homeostasis in mice

Keywords: Aryl hydrocarbon receptor; TCDD; Bile acids; Biliary excretion; Taurodeoxycholic acid; Cyp8b1; 1°BAs; Primary bile acids; 2°BAs; Secondary bile acids; 6-OH; 6-hydroxylated (6-OH); 12-OH; 12α-hydroxylated; Abc; ATP-binding cassette; AhR; Aryl hydrocarbo

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Genome-wide transcriptome profiling provides insights into panicle development of rice (Oryza sativa L.)

Keywords: COG; Cluster of Orthologous Groups of proteins; CYP; cytochrome P450 monooxygenase; DEGs; differentially expressed genes; FDR; false discovery rate; FPKM; Fragments Per Kilobase of transcript per Million fragments mapped; GO; gene ontology; KEGG; Kyoto En

دانلود رایگان متن کامل مقاله ISI 49 صفحه سال انتشار : 2018 سفارش ترجمه

Mechanisms involved in the death of steatotic WIF-B9 hepatocytes co-exposed to benzo[a]pyrene and ethanol: a possible key role for xenobiotic metabolism and nitric oxide

Keywords: ADH; alcohol dehydrogenase; AU; arbitrary unit; B[a]P; benzo[a]pyrene; CYP; cytochrome P450; CZX; chlorzoxazone; HFD; high fat diet; MDA; malondialdehyde; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; NCZX; chlorzoxazone N-g

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

BCRP/ABCG2 and high-alert medications: Biochemical, pharmacokinetic, pharmacogenetic, and clinical implications

Keywords: ABC; ATP-binding cassette; AUC; area under the time-concentration curve; BCRP; breast cancer resistance protein; Cmax; maximum concentration; CYP; cytochrome P450; DOAC; direct oral anti-coagulant; GI; gastrointestinal; MRP1; multidrug resistance protei

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Pharmacokinetics of [14C]-Benzo[a]pyrene (BaP) in humans: Impact of Co-Administration of smoked salmon and BaP dietary restriction

Keywords: Pharmacokinetics; Benzo[a]pyrene; Accelerator mass spectrometry; Dietary polycyclic aromatic hydrocarbons; ADME; absorption distribution metabolism and excretion; AFB1; aflatoxin B1; AMS; accelerator mass spectrometry; ATDSR; Agency for Toxic Substances a

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

A transcriptomic analysis of black cohosh: Actein alters cholesterol biosynthesis pathways and synergizes with simvastatin

Keywords: Actein; Black cohosh; Microarrays; Ranunculaceae; Simvastatin; Triterpene glycoside; CI; Combination Index; CYP; Cytochrome P450; DMSO; dimethylsulfoxide; DMEM; Dulbecco's Modified Eagle's medium; ERK; Extracellular signal related kinase; EtOH; ethanol; F

دانلود رایگان متن کامل مقاله ISI 51 صفحه سال انتشار : 2018 سفارش ترجمه

A systematic review of pharmacokinetic studies on herbal drug Fuzi: Implications for Fuzi as personalized medicine

Keywords: Aconitum carmichaeli Debx.; Aconitum alkaloids; Pharmacokinetics; Herb-drug interactions; Toxicology; Personalized medicine; DMEs; drug-metabolizing enzymes; ETs; efflux transporters; BB; bioavailability barrier; DDAs; diester-diterpene alkaloids; MDAs; m

دانلود رایگان متن کامل مقاله ISI 55 صفحه سال انتشار : 2018 سفارش ترجمه

Imaging techniques to study drug transporter function in vivo

Keywords: ABC; ATP-binding cassette; AD; Alzheimer's disease; ADME; absorption, distribution, metabolism and elimination; ATP; adenosine triphosphate; AUC; area under the curve; BBB; blood-brain barrier; BCRP; breast cancer resistance protein; BPND; non-displaceabl

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2018 سفارش ترجمه