Keywords: Dimethylarsinous acid; Dimethylmonothioarsinic acid; Dimethylarsinic acid; CYP; Rhodanese
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The regulation mechanism of AhR activated by benzo[a]pyrene for CYP expression are different between 2D and 3D culture of human lung cancer cells
Keywords: 3D culture; 3D spheroid; 3D; Three dimension; AhR; Aryl hydrocarbon receptor; CYP; Cytochrome P450;
The impact of proton pump inhibitors on the pharmacokinetics of voriconazole in vitro and in vivo
Keywords: VRC; voriconazole; PPIs; proton pump inhibitors; LAN; lansoprazole; ESO; esomeprazol; OME; omeprazole; PAN; pantoprazole; ILA; ilaprazole; DDIs; drug-drug interactions; CYP; cytochrome P450; TDM; therapeutic drug monitoring; HLM; human liver microsomes; N
The crystal structure of P450-TT heme-domain provides the first structural insights into the versatile class VII P450s
Keywords: CYP; Biocatalysis; C-H activation; Crystallography; Hydroxylation;
Is CYP2D6 phenotype predictable from CYP2D6 genotype?
Keywords: CNV; copy number variation; CYP; cytochrome P450; EM; extensive metabolizer; IM; intermediate metabolizer; PCR; polymerase chain reaction; PM; poor metabolizer; SNP; single nucleotide polymorphism; UM; ultra-rapid metabolizer; CYP2D6 genotype; Genetic pol
Polymorphisms of vitamin K-related genes (EPHX1 and VKORC1L1) and stable warfarin doses
Keywords: ACE; angiotensin converting enzyme; ARB; angiotensin II receptor blocker; BMI; body mass index; CYP; cytochrome P 450; EPHX1; epoxide hydrolase 1; GGCX; γ-glutamyl carboxylase; INR; international normalized ratio; KH2; vitamin K hydroxyquinone; KO; vitam
Altered metabolism of synthetic cannabinoid JWH-018 by human cytochrome P450 2C9 and variants
Keywords: CYP450; CYP2C9 variants; Synthetic cannabinoids; Enzyme kinetics; Toxicity; Î9-THC; (â)-Î9-Tetrahydrocannabinol; P450; cytochrome P450; CYP; specific P450; UGTs; uridine diphosphate (UDP)-glucuronosyltransferases; LC-MS/MS; Liquid chromatography-tande
Utility of in vitro clearance in primary hepatocyte model for prediction of in vivo hepatic clearance of psychopharmacons
Keywords: CYP; cytochrome P450; LC-MS/MS; liquid chromatography tandem mass spectrometry; Pharmacokinetic model; Primary hepatocytes; In vitro - in vivo extrapolation; Psychopharmacons; Clearance; Bioavailability;
Application of plasma levels of olanzapine and N-desmethyl-olanzapine to monitor metabolic parameters in patients with schizophrenia
Keywords: AUC; Area under curve; BMI; body mass index; CYP; Cytochrome P450; DMO; N-desmethyl-olanzapine; MS; metabolic syndrome; OLZ; olanzapine; ROC; receiver operator characteristic; TDM; therapeutic drug monitoring; Olanzapine; N-desmethy-olanzapine; Schizophre
Supercritical fluid extraction (SFE) of ketamine metabolites from dried urine and on-line quantification by supercritical fluid chromatography and single mass detection (on-line SFE-SFC-MS)
Keywords: CYP; cytochrome P450; DHK; dehydronorketamine; KET; ketamine; NK; norketamine; KET-d4; ketamine-d4; HNK; hydroxynorketamine; SFE; supercritical fluid extraction; SFC-MS; supercritical fluid chromatography single quadrupole mass spectrometry; LC-MS/MS;
Effect of human pharmaceuticals common to aquatic environments on hepatic CYP1A and CYP3A-like activities in rainbow trout (Oncorhynchus mykiss): An in vitro study
Keywords: Fish microsomes; Cytochrome P450; Inhibition; Mixture of compounds; Antidepressant; Ki; inhibition constant or equilibrium dissociation constant for the enzyme-inhibitor complex; Km; Michaelis-Menten constant; ER; 7-ethoxyresorufin; EROD; 7-ethoxyreso
Food-drug interactions involving multiple mechanisms: A case study with effect of Capsaicin on the pharmacokinetics of Irinotecan and its main metabolites in rat
Keywords: APC; 7-ethyl-10-[4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxy-camptothecin; AUC; Area under the plasma concentration-time curve; CAP; Capsaicin; CES; Carboxylesterase; CPT; Camptothecin; CPT-11; Irinotecan; CYP; cytochrome P450; DMEs; Drug-meta
Reprint of: A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies
Keywords: 2D; two-dimensional; 3D; three-dimensional; AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; BCG; bromocresol green; CBMN; cytokinesis-blocked micronucleus; CBPI; cytokinesis-block proliferation index; CYP; cytochrome P450; DMSO; dimethyl sulfoxide;
In vitro safety pharmacology evaluation of 2-hydroxybenzylamine acetate
Keywords: Salicylamine; Metabolism; Toxicity; Human; Rat; Rabbit; γKA; γ-ketoaldehyde; 2-AA; 2-aminoanthracene; 2-HOBA; 2-hydroxybenzylamine; 4-NOPD; 4-nitro-o-phenylenediamine; CYP; cytochrome p450; hERG; human ether-a-go-go; HPLC; high-performance liquid chroma
Shikonin upregulates the expression of drug-metabolizing enzymes and drug transporters in primary rat hepatocytes
Keywords: AhR; aryl hydrocarbon receptor; AP1; activating protein 1; ARE; antioxidant-response element; CAR; constitutive androstane receptor; CYP; cytochrome P450; DREs; dioxin-responsive elements; EMSA; electromobility gel shift assay; FBS; fetal bovine serum; GS
A three-dimensional in vitro HepG2 cells liver spheroid model for genotoxicity studies
Keywords: 2D; two-dimensional; 3D; three-dimensional; AhR; aryl hydrocarbon receptor; B[a]P; benzo[a]pyrene; BCG; bromocresol green; CBMN; cytokinesis-blocked micronucleus; CBPI; cytokinesis-block proliferation index; CYP; cytochrome P450; DMSO; dimethyl sulfoxide;
LC-MS/MS method for the simultaneous quantification of intestinal CYP and UGT activity
Keywords: 1-OH-MDZ; 1-hydroxymidazolam; 4-OH-DCL; 4-hydroxydiclofenac; 5-OH-OME; 5-hydroxyomeprazole; CYP; cytochrome P450 enzymes; DXP; dextrorphan; ESI; electrospray ionization; EZE-Glc; ezetimibe glucuronide; LC-MS/MS; liquid chromatography tandem mass spectro
Apiaceous vegetable intake modulates expression of DNA damage response genes and microRNA in the rat colon
Keywords: API; apiaceous vegetable supplemented group; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia mutated and Rad3-related; Bcrp; breast cancer resistance protein; CYP; cytochrome P450; HAA; heterocyclic aromatic amines; INMT; imidazole N-methyl
Corn gluten hydrolysate regulates the expressions of antioxidant defense and ROS metabolism relevant genes in H2O2-induced HepG2 cells
Keywords: Corn gluten meal; Peptide; Reactive oxygen species; Antioxidant gene; HepG2 cells; ALOX; arachidonate lipoxygenase; BP; biological process; CC; cellular component; CGH; corn gluten hydrolysate; CGH1; corn gluten hydrolysate with molecular weight <1 kDa; C
Exposure to endocrine disruptors 17alpha-ethinylestradiol and estradiol influences cytochrome P450 1A1-mediated genotoxicity of benzo[a]pyrene and expression of this enzyme in rats
Keywords: AhR; aryl hydrocarbon receptor; BaP; benzo[a]pyrene; BPDE; benzo[a]pyrene-7,8-dihydrodiol-9,10-epoxide; COMT; catechol-O-methyltransferase; CYP; cytochrome P450; EE2; 17α-ethinylestradiol; DMSO; dimethylsulfoxide; ED; endocrine disruptor; dG-N2-BPDE; 10-
Significance of A-to-I RNA editing of transcripts modulating pharmacokinetics and pharmacodynamics
Keywords: ABC; ATP-binding cassette transporter; ADAR; adenosine deaminase acting on RNA; ADH; alcohol dehydrogenase; AhR; aryl hydrocarbon receptor; AKR; aldo-keto reductase; ALS; amyotrophic lateral sclerosis; AZIN1; antizyme inhibitor 1; AMPA; α-amino-3-hydroxy
MicroRNAs and their targets by high-throughput sequencing and differentially expressed analysis in five Miscanthus species
Keywords: MiRNA; microRNA; EST; expressed sequence tag; NCBI; national center for biotechnology information; M. lutarioriparius; Miscanthus lutarioriparius; M. sacchariflorus; Miscanthus sacchariflorus; M. floridulus; Miscanthus floridulus; M. sinensis; Miscanthus
Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes
Keywords: Mouse; Cytochrome P450; Liver microsomes; Liver lobe differences; AhR; aryl hydrocarbon receptor; Alas1; delta-aminolevulinate synthase 1; BCA; bicinchoninic acid; BSA; bovine serum albumin; CAR; constitutive androstane receptor; CPR; cytochrome P450 redu
Study on the developmental toxicity of β-ionone in the rat
Keywords: Embryotoxicity; Food additives; Fragrance chemicals; Reproductive toxicity; Teratogenicity; ADI; acceptable daily intake; BIO; β-ionone; CYP; cytochrome P450; FDA; US Food and Drug Administration; GD; gestation day; γ-GT; γ-glutamyltransferase; GRAS; G
Genotoxicity analysis of five particle matter toxicants from cigarette smoke based on γH2AX assay combined with Hill/Two-component model
Keywords: DSB; double-strand breaks; ELISA; enzyme-linked immunosorbent assay; WB; western blot; FC; flow cytometry; HCS; high content screening; PAHs; polyaromatic hydrocarbons; WHO FCTC; World Health Organization Framework Convention on Tobacco Control; CCK8; cel
Effective phospholipids removing microelution-solid phase extraction LC-MS/MS method for simultaneous plasma quantification of aripiprazole and dehydro-aripiprazole: Application to human pharmacokinetic studies
Keywords: ARI; aripiprazole; AUC; area under curve; CAL; calibration standard; CID; collision-induced dissociation; Cmax; maximum plasma concentration; CV; coefficient of variation; CYP; cytochrome P450; DAD; diode array detection; DARI; dehydro-aripiprazole; EDTA;
Expression and regulation of CYP17A1 and 3β-hydroxysteroid dehydrogenase in cells of the nervous system: Potential effects of vitamin D on brain steroidogenesis
Keywords: Vitamin D; Brain; Metabolism; Neurons; Astrocytes; Neurosteroids; CNS; central nervous system; CYP; cytochrome P450; DHEA; dehydroepiandrosterone; 3β-HSD; 3β-hydroxysteroid dehydrogenase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; TBP; TATA box bi
Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria
Keywords: AUC; area under the curve; BA; bioavailability; CLplasma; plasma clearance; CLint; intrinsic clearance; CYP; cytochrome P450; DCM; dichloromethane; DMF; dimethyl formamide; ED; effective dose; FaSSIF; fasted state simulated intestinal fluid; FeSSIF; fed s
Effects of caveolae depletion and urothelial denudation on purinergic and cholinergic signaling in healthy and cyclophosphamide-induced cystitis in the rat bladder
Keywords: BPS/IC; bladder pain syndrome/interstitial cystitis; BOO; bladder outlet obstruction; DO; detrusor over-activity; LUTS; lower urinary tract symptoms; ATP; adenosine-5â²-triphosphate; CYP; cyclophosphamide; NO; nitric oxide; EFS; Electrical Field Stimulat
Serum derived from ulcerative colitis mouse changes the metabolism of the fluorescent substrate by P450 depending on the degree of disease progression
Keywords: Cytochrome P450; Ulcerative colitis; Fluorescent P450 inhibition assay; BOMCC; 7-benzyloxy-methyloxy-3-cyanocoumarin; CYP; cytochrome P450; DAI; disease activity index; DBOMF; dibenzyl-methyl-fluorescein; DSS; 4,4-dimethyl-4-silapentane-1-sulfonic acid; E
Sulfation disposition of liquiritigenin in SULT1A3 overexpressing HEK293 cells: The role of breast cancer resistance protein (BCRP) and multidrug resistance-associated protein 4 (MRP4) in sulfate efflux of liquiritigenin
Keywords: CLint; intrinsic clearance; CYP; cytochrome P450; HPLC; high performance liquid chromatography; Km; Michaelis-Menten constant; MS; mass spectroscopy; PAPS; 3â²-Phosphoadenosine-5â²-phosphosulfate; QTOF; Quadrupole time-of-flight; shRNA; short hairpin RN
Hexamoll® DINCH: Lack of in vivo evidence for obesogenic properties
Keywords: ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BMI; body mass index; BROD; Benzoxyresorufin-O-debenzylase; CHDA; cyclohexane 1,2-dicarboxylic acid; CYP; Cytochrome P; DEHP; di-(2-ethylhexyl) phthalate; EROD; Eth
Development of a new tool for the long term in vitro ecotoxicity testing of nanomaterials using a rainbow-trout cell line (RTL-W1)
Keywords: Nanomaterial; CuO NPs; Fish cell line; RTL-W1; Cytotoxicity; Long-term; BSA; Bovine serum albumin; CFDA-AM; 5-carboxyfluorescein diacetate, acetoxy methyl ester; CYP; cytochrome P450; DLS; dynamic light scattering; EDTA; ethylenediaminetetraacetic acid; E
Hydrogen peroxide derived from NADPH oxidase 4- and 2 contributes to the endothelium-dependent vasodilatation of intrarenal arteries
Keywords: ACh; acetylcholine; COX; cyclooxygenase; CYP; cytochrome P450; EC; endothelial cell; EDH; endothelium-derived-hyperpolarization; eNOS; endothelial nitric oxide synthase; ER; endoplasmic reticulum; H2O2; hydrogen peroxide; NADPH; nicotinamide adenine dinuc
A human relevance investigation of PPARα-mediated key events in the hepatocarcinogenic mode of action of propaquizafop in rats
Keywords: Propaquizafop; Carcinogenicity; Rodent hepatocarcinogenesis; PPARα; Liver; Peroxisome proliferators; Mode of action; Human relevance framework; Enzyme induction; Rats; ACO; Acyl-CoA oxidase; bw; body weight; BrdU; bromodeoxyuridine; CAT; catalase; CYP; c
Galangin's potential as a functional food ingredient
Keywords: Galangin; Propolis; Alpinia officinarum; Functional food ingredient; Polypharmacology; Flavonoid; AChE; acetylcholinesterase; AD; Alzheimer's disease; ADME; Administration, Distribution, Metabolism and Excretion; AHR; airway hyperresponsive; AhR; aryl h
Impact of vitamin D on pregnancy-related disorders and on offspring outcome
Keywords: 1,25(OH)2D; 1,25-dihydroxy vitamin D2/1,25-dihydroxyvitaminD3; 25OHD; 25-hydroxyvitamin D2/25-hydroxyvitamin D3; Calcitriol; 1,25-dihydroxyvitamin D3; CYP; cytochrome P450 enzyme; CYP24A1; 25-hydroxy vitaminD-24-hydroxylase; CYP27B1; 1α-hydroxylase; FGF-
Association of CYP3A4*1B genotype with Cyclosporin A pharmacokinetics in renal transplant recipients: A meta-analysis
Keywords: CsA; cyclosporine; CYP; cytochrome P-450; Dose; weight-adjusted cyclosporine daily dose; C0; cyclosporine trough concentration; C0/Dose ratio; trough concentration/weight-adjusted cyclosporine daily dose ratio; CYP3A4*1B genotype; CsA; C0; Dose; C0/Dose r
LC-MS/MS procedure for the simultaneous determination of N-acetyl-S-(1-naphthyl)cysteine and N-acetyl-S-(2-napthyl)cysteine in human urine
Keywords: Biomonitoring; Naphthalene; PAH; Polycyclic aromatic hydrocarbons; Mercapturic acids; Glutathione conjugation; IStd; internal standard; 1-NpMA; N-acetyl-S-(1-naphthyl)cysteine; D3-1-NpMA; N-D3-acetyl-S-(1-naphthyl)cysteine; 2-NpMA; N-acetyl-S-(2-naphthyl)
Potato native and wound periderms are differently affected by down-regulation of FHT, a suberin feruloyl transferase
Keywords: GC-MS; FHT: suberin feruloyl transferase; LC-MS; Periderm suberin and wax; Phellem; Solanum tuberosum; Potato skin; Solid-state NMR; Thioacidolysis; 4CL; 4-Hydroxycinnamic acid; PHT; Putrescine hydroxycinnamoyltransferase; FHT; Fatty Ï-hydroxyacid/fatty
Synergistic effect of 1α,25-dihydroxyvitamin D3 and 17β-estradiol on osteoblast differentiation of pediatric MSCs
Keywords: 1α,25(OH)2D; 1α,25-dihydroxy vitamin D; 25(OH)D; 25-hydroxyvitamin D; AR; androgen receptor; BMI; body mass index; CYP; cytochrome P450; DBP; vitamin D binding protein; ER; estrogen receptor; FGF23; fibroblast growth factor 23; hMSC; human marrow stroma
From TCDD-mediated toxicity to searches of physiologic AHR functions
Keywords: AHR; aryl hydrocarbon receptor; CAR; constitutive androstane receptor; PXR; pregnane-X-receptor; CYP; cytochrome P450; IDO1; indoleamine-2,3-dioxygenase; UDP; UDP-glucuronosyltransferase; FICZ; 6-formylindolo[3,2-b]carbazole; ICZ; indolo[3,2-b]carbazole;
Role of cytochrome P450s in the generation and metabolism of reactive oxygen species
Keywords: Cytochrome P450; Reactive oxygen species; Reaction uncoupling; CYP; cytochrome P450; ROS; reactive oxygen species; NAPQI; N-acetyl-p-benzo-quinone-imine; HETE; hydroxyeicosatetraenoic acid; EET; epoxyeicosatrienoic acid;
In vitro evaluation of structural analogs of diallyl sulfide as novel CYP2E1 inhibitors for their protective effect against xenobiotic-induced toxicity and HIV replication
Keywords: CYP; cytochrome P450; APAP; acetaminophen; DAS; diallyl sulfide; AMS; allyl methyl sulfide; AES; allyl ethyl sulfide; DE; diallyl ether; TP; thiophene; PEA; 2-(prop-2-en-1-yloxy) ethan-1-amine; 5,1 HA; 5-hexen-1-amine; PEXA; 2-prop-2-enoxyacetamide; ROS;
Ubiquitination/sumoylation: An alternative pathway to modify gene regulation directed by xenosensors
Keywords: Epigenetic regulation; Post-translational modifications; Nuclear receptors; Xenobiotics metabolism; AHR; aryl hydrocarbon receptor; AHRR; aryl hydrocarbon receptor repressor; ARNT; aryl hydrocarbon receptor nuclear translocator; CAR; constitutive androsta
Effects of Baoyuan decoction, a traditional Chinese medicine formula, on the activities and mRNA expression of seven CYP isozymes in rats
Keywords: BYD; Baoyuan decoction; TCM; traditional Chinese medicine; CYP; cytochrome P450; HDI; herb-drug interaction; IS; internal standard; RT-PCR; real-time reverse transcription-polymerase chain reaction; QC; quality control; ESI; electrospray ionization; RSD;
Umbilical cord-derived mesenchymal stem cells alleviated inflammation and inhibited apoptosis in interstitial cystitis via AKT/mTOR signaling pathway
Keywords: Stem cells; Cystitis; Inflammation; Apoptosis; IC; interstitial cystitis; UC-MSCs; umbilical cord-derived mesenchymal stem cells; CYP; cyclophosphamide; siRNA; small interfering RNA; EGF; epidermal growth factor;
Role of the equine CYP3A94, CYP3A95 and CYP3A97 in ketamine metabolism in presence of medetomidine, diazepam and methadone studied by enantioselective capillary electrophoresis
Keywords: CE; capillary electrophoresis; Clint; intrinsic clearance; CLM; canine liver microsomes; CYP; cytochrome P450 enzymes; D; diazepam; DHNK; 5,6-dehydronorketamine; ELM; equine liver microsomes; HLM; human liver microsomes; HNK; hydroxynorketamine; IST; inte
Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism
Keywords: CYP; cytochrome P450; CYP-reductase; NADPH cytochrome P450 reductase; DCF-AG; diclofenac acyl glucuronide; DCF-SG; diclofenac glutathione conjugate; DILI; drug-induced liver injury; ESI; electrospray ionization; GST; glutathione S-transferase; GWAS; genom
Enhanced liver-targeting via coadministration of 10-Hydroxycamptothecin polymeric micelles with vinegar baked Radix Bupleuri
Keywords: Vinegar baked Radix Bupleuri (VBRB); Glutathione S-transferase (GST); Liver-targeting; Meridian guided drug; Polymeric micelles; VBRB; vinegar baked Radix Bupleuri; GST; glutathione S-transferase; HPCT; 10-Hydroxycamptothecin; Ce; the ratio of Cmax in the