
Novel indolizino[8,7-b]indole hybrids as anti-small cell lung cancer agents: Regioselective modulation of topoisomerase II inhibitory and DNA crosslinking activities
Keywords: Anti-SCLC hybrids; β-carboline; bis(hydroxymethyl)pyrrole; indolizino[8,7-b]indole; DNA cross-linking; Topoisomerase inhibition; Ac2O; acetic anhydride; ACN; acetonitrile; CCRF-CEM; human lymphoblastic leukemia; CCRF-CEM/VBL; vinblastine-resistant CCRF-C