Pioglitazone inhibits EGFR/MDM2 signaling-mediated PPARγ degradation
Keywords: Pioglitazone; PPARγ; EGFR; Ubiquitination; Degradation;
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The SWI/SNF chromatin remodeling complex exerts both negative and positive control over LET-23/EGFR-dependent vulval induction in Caenorhabditis elegans
Keywords: EGFR; SWI/SNF; C. elegans; Vulva; LET-23; SMARCA4;
Gallic acid induces apoptosis in EGFR-mutant non-small cell lung cancers by accelerating EGFR turnover
Keywords: Gallic acid; Non-small cell lung cancer; EGFR; EGFR turnover;
Extended structure–activity study of thienopyrimidine-based EGFR inhibitors with evaluation of drug-like properties
Keywords: EGFR; Structure–activity relationship (SAR); Thieno[2,3-d]pyrimidine; ADME; Erlotinib; Gefitinib; Zebrafish
Relation of contrast nephropathy to adverse events in pulmonary emboli patients diagnosed with contrast CT
Keywords: APE; Acute pulmonary embolism; CTPA; Computerized tomography pulmonary angiography; CIN; Contrast-induced nephropathy; eGFR; Estimated glomerular filtration rates;
Oncogenic KRAS signaling and YAP1/β-catenin: Similar cell cycle control in tumor initiation
Keywords: YAP1; Yes; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; eIF4E; eukaryotic translation initiation factor 4E; PI3K; phosphatidylinositide-3-kinase; WNT; Wingless-type mouse mammary tumor virus integration site family m
Caveolin-1 protects against hepatic ischemia/reperfusion injury through ameliorating peroxynitrite-mediated cell death
Keywords: I/R; ischemia and reperfusion; RNS; reactive nitrogen species; ROS; reactive oxygen species; O2â¢â; superoxide; ONOOâ; peroxynitrite; SOD; superoxide dismutase; NOS; nitric oxide synthases; iNOS; inducible nitric oxide synthases; NO; nitric oxide; EG
A Phase III Study of Durvalumab (MEDI4736) With or Without Tremelimumab for Previously Treated Patients With Advanced NSCLC: Rationale and Protocol Design of the ARCTIC Study
Keywords: Anti-CTLA-4; Anti-PD-L1; ALK; EGFR; Tumor membrane staining;
EGFR tyrosine kinase inhibitor (TKI) in patients with advanced non-small cell lung cancer (NSCLC) harboring uncommon EGFR mutations: A real-world study in China
Keywords: Lung cancer; Non-small cell lung cancer; EGFR; Mutations; Tyrosine kinase inhibitor;
Novel roles of androgen receptor, epidermal growth factor receptor, TP53, regulatory RNAs, NF-kappa-B, chromosomal translocations, neutrophil associated gelatinase, and matrix metalloproteinase-9 in prostate cancer and prostate cancer stem cells
Keywords: AR; EGFR; TP53; Regulatory RNAs; NGAL; MMP-9;
Effects of DMSO, glycerol, betaine and their combinations in detecting single nucleotide polymorphisms of epidermal growth factor receptor (EGFR) gene promoter sequence in non-small-cell lung cancer (NSCLC) patients
Keywords: EGFR; PCR; Optimization; Additives; DMSO; Glycerol; Betaine;
Beta-2-microglobulin (B2M) expression in the urinary sediment correlates with clinical markers of kidney disease in patients with type 1 diabetes
Keywords: Diabetic kidney disease; Diabetic nephropathy; Urinary sediment; Beta-2-microglobulin; Focal segmental glomerulosclerosis; ACEI; (angiotensin converting enzyme inhibitors); ACR; (albumin-to-creatinine ratio); AGE; (advanced glycation end products); ARB; (
PLGA-based nanoparticles: A new paradigm in biomedical applications
Keywords: Biodegradable; Poly(lactic-co-glycolic acid); Nanoparticles; Targeting; Sustained release; DCC; N,N-Dicyclohexylcarbodiimide; DDS; Drug delivery system; DNA; Deoxyribose nucleic acid; EDC; 1-ethyl-3-(3-dimethylaminopropyl carbodiimide); EGFR; Epidermal gr
Janus kinases and Src family kinases in the regulation of EGF-induced vimentin expression in MDA-MB-468 breast cancer cells
Keywords: EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMT; epithelial-mesenchymal transition; FBS; fetal bovine serum; JAK; Janus kinase; NT; non-targeting; PP2; 4-amino-5-(4-clorophenyl)-7-(t-butyl) pyrazolo[3,4-d] pyrimidine; SFK; Src fa
L-Ascorbic acid can abrogate SVCT-2-dependent cetuximab resistance mediated by mutant KRAS in human colon cancer cells
Keywords: SVCT-2; sodium-dependent vitamin C transporter 2; CRC; colorectal cancer; EGFR; epidermal growth factor receptor; Mutant K-Ras colon cancer; SVCT-2; L-ascorbic acid; Cetuximab; Cell death;
Intracellular LINGO-1 negatively regulates Trk neurotrophin receptor signaling
Keywords: LINGO-1; LRRN6a; TrkA; TrkB; TrkC; Linx; Trk; tropomyosin-related kinase; LINGO; leucine-rich repeat Ig-domain containing Nogo-interacting protein; EGFR; epidermal growth factor receptor; NGF; nerve growth factor; BDNF; brain derived neurotrophic factor;
Optimal medical therapy with or without percutaneous coronary intervention in women with stable coronary disease: A pre-specified subset analysis of the Clinical Outcomes Utilizing Revascularization and Aggressive druG Evaluation (COURAGE) trial
Keywords: SD; standard deviation; IQR; interquartile range; HR; hazard ratio; CI; confidence interval; HF; heart failure; PCI; percutaneous coronary intervention; CABG; coronary artery bypass grafting; ACS; acute coronary syndrome; LVEF; left ventricular ejection f
Type 1 diabetes in older adults: Comparing treatments and chronic complications in the United States T1D Exchange and the German/Austrian DPV registries
Keywords: ACE-I; angiotensin converting enzyme inhibitor; ARB; angiotensin receptor blocker; BMI; body mass index; CGM; glucose monitor; DPV; Diabetes Patienten Verlaufsdokumentation; DKA; diabetic ketoacidosis; eGFR; estimated glomerular filtration rate; HbA1c; he
Unravelling exemestane: From biology to clinical prospects
Keywords: AI(s); aromatase inhibitor (s); AKT; protein kinase B; AREG; amphiregulin; BMD; bone mineral density; CYP; cytochrome P450; DHEAS; dehydroepiandrosterone sulfate; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMA; European Medicine
Functional proteomic analysis revels that the ethanol extract of Annona muricata L. induces liver cancer cell apoptosis through endoplasmic reticulum stress pathway
Keywords: AGE; Annonaceous acetogenin; Bip; Heat shock protein family A member 5; CHOP; DNA damage inducible transcript 3 protein; DMEM; Dulbecco's Modified Eagle's medium; EGFR; Epidermal growth factor receptor; eIF2α; Eukaryotic translation initiation factor 2al
Impact of the HLA-B*58:01 Allele and Renal Impairment on Allopurinol-Induced Cutaneous Adverse Reactions
Keywords: AUC; area under the curve; BSA; body surface area; cADR; cutaneous adverse drug reaction; CI; confidence interval; CKD; chronic kidney disease; DRESS; drug reaction with eosinophilia and systemic symptoms; eGFR; estimated glomerular filtration rate; HLA;
Clinicopathological, Immunohistochemical, and Genetic Features of Primary Lung Adenocarcinoma Occurring in the Setting of Usual Interstitial Pneumonia Pattern
Keywords: UIP; IPF; Pulmonary fibrosis; Adenocarcinoma; EGFR; KRAS;
Thymosin beta4 promotes oligodendrogenesis in the demyelinating central nervous system
Keywords: Tβ4; thymosin beta 4; MS; multiple sclerosis; EAE; experimental autoimmune encephalomyelitis; OPC; oligodendrocyte progenitor cell; EGFR; epidermal growth factor receptor; pEGFR; phosphorylated EGFR; APP; amyloid beta/A4 precursor protein; BrdU; bromodeo
A Randomized, Phase II Trial of Cetuximab With or Without PX-866, an Irreversible Oral Phosphatidylinositol 3-Kinase Inhibitor, in Patients With Metastatic Colorectal Carcinoma
Keywords: Combination therapy; EGFR; KRAS; PI3K; PIK3CA;
EGFR-GRB2 Protein Colocalization Is a Prognostic Factor Unrelated to Overall EGFR Expression or EGFR Mutation in Lung Adenocarcinoma
Keywords: EGFR; GRB2; Proximity ligation assay; NSCLC; Adenocarcinoma; Quantitative immunofluorescence;
Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity
Keywords: Phthalazine; Cytotoxicity; VEGFR-2; EGFR; Docking;
Studying mechanisms of cAMP and cyclic nucleotide phosphodiesterase signaling in Leydig cell function with phosphoproteomics
Keywords: AC; adenylyl cyclase; ACTH; adrenocorticotropic hormone; AKAP; A-kinase anchor protein; AMP; 5â² adenosine monophosphate; AMPK; AMP-activated protein kinase; Arfgap1; ADP-ribosylation factor GTPase-activating protein 1; Arhgef2; Rho guanine nucleotide ex
Long chain n-3 polyunsaturated fatty acids increase the efficacy of docetaxel in mammary cancer cells by downregulating Akt and PKCε/δ-induced ERK pathways
Keywords: CL; Cardiolipin; DAG; Diacylglycerol; DHA; Docosahexaenoic acid; DMSO; Dimethyl sulfoxide; ECL; Enhanced chemiluminescence; EGFR; Epidermal growth factor receptor; EPA; Eicosapentaenoic acid; ERK; Extracellular signal-related kinase; HP-TLC; High performa
Skp1: Implications in cancer and SCF-oriented anti-cancer drug discovery
Keywords: Arf6; ADP-ribosylation factor 6; BIMEL; extra-long isoform of BIM; β-TRCP; β-transducin repeat-containing protein; CDCA3; cell division cycle associated 3; CDK; cyclin-dependent kinase; CENP-E; centrosome-associated protein E; Cks1; cyclin-dependent pro
Epidermal growth factor receptor inhibitor cancer drug gefitinib modulates cell growth and differentiation of acute myeloid leukemia cells via histamine receptors
Keywords: 4-MH; 4-methylhistamine; AML; acute myelogenous leukemia; CML; chronic myelogenous leukemia; cAMP; cyclic adenosine monophosphate; CRE; cAMP response element; EGFR; epidermal growth factor receptor; ER; estrogen receptor alpha; FSK; Forskolin; GPCR; G-pro
Utilising the EGFR interactome to identify mechanisms of drug resistance in non-small cell lung cancer - Proof of concept towards a systems pharmacology approach
Keywords: EGFR; Lung cancer; Drug resistance; Tyrosine kinase inhibitors; Interactome; Systems pharmacology;
Clinical Significance of PD-L1 Protein Expression in Surgically Resected Primary Lung Adenocarcinoma
Keywords: Programmed death ligand 1; Immunohistochemistry; EGFR; Lung adenocarcinoma;
Chiral 6-aryl-furo[2,3-d]pyrimidin-4-amines as EGFR inhibitors
Keywords: Furopyrimidine; EGFR; Erlotinib; Kinase; Chiral drug;
SIAH and EGFR, Two RAS Pathway Biomarkers, are Highly Prognostic in Locally Advanced and Metastatic Breast Cancer
Keywords: AUC; area under the curve; DRFS; distant recurrence-free survival; EGFR; epidermal growth factor receptor; ER; estrogen receptor; H&E; hematoxylin and eosin staining; HER2; human epidermal growth factor receptor 2; IHC; immunohistochemistry; LN; lymph nod
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
Keywords: AA; Ascorbic acid; AEM1; ARE expression modulator 1; AEG1; Astrocyte elevated gene-1; Akt; Protein kinase B; AMPK; AMP-activated protein kinase; APL; Acute promyelocytic leukemia; ARE; Antioxidant response element; ATO; Arsenic trioxide; Bach; BTB and CNC
Brain Metastases from NSCLC: Radiation Therapy in the Era of Targeted Therapies
Keywords: NSCLC; Brain metastases; Radiotherapy; Targeted therapies; EGFR; Anaplastic lymphoma kinase;
5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells
Keywords: Glioblastoma; Apoptosis resistance; Multidrug resistance; Translation inhibition; Lycorine; Haemanthamine; ATCC; American Type Culture Collection; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco's modified Eagle's medium; DMF; dimethylformamide; DMS
Vemurafenib resistance increases melanoma invasiveness and modulates the tumor microenvironment by MMP-2 upregulation
Keywords: BRAF; v-Raf murine sarcoma viral oncogene homolog B; MAPK; mitogen-activated protein kinases; MMP; matrix metalloproteinase; ECM; extracellular matrix; IL-8; interleukin 8; EGFR; epidermal growth factor receptor; TIMP-2; metallopeptidase-2 or tissue inhib
Balancing potency, metabolic stability and permeability in pyrrolopyrimidine-based EGFR inhibitors
Keywords: EGFR; Pyrrolopyrimidine; SAR; ADME; Metabolism; Erlotinib;
Targeting tumor microenvironment with PEG-based amphiphilic nanoparticles to overcome chemoresistance
Keywords: ABCs; ATP-binding cassette superfamily; AUC; area under the curve; BBB; blood brain barrier; BCRP; breast cancer resistance protein; CMC; critical micellar concentration; CT; computed tomography; CUR; curcumin; DOX; doxorubicin; DSPE-PEG; 1,2-distearoyl-s
Polycations and their biomedical applications
Keywords: Ac-aCD; acetalated cyclodextrin; ASC; adipose-derived stromal cell; αSMA; α-smooth muscle actin; BMA; butyl methacylate; BMP; bone morphogenetic protein; BSA; bovine serum albumin; CDP; cyclodextrin-containing polymer; CPLA; cationic polylactide; cRGD;
Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis
Keywords: ACACB; acetyl-CoA carboxylase beta acetyl-CoA carboxylase beta; ACAT1; acetyl-CoA acetyltransferase 1; ACLY; ATP citrate lyase; AMPK; 5â²AMP-activated protein kinase; ASCL1; acyl-CoA synthetase long-chain family member 1; ACSL4; acyl CoA synthetases long
Redox cycling metals: Pedaling their roles in metabolism and their use in the development of novel therapeutics
Keywords: AC; adenylyl cyclase; AI; anemia of inflammation; cdks; cyclin-dependent kinases; bFGF; basic fibroblast growth factor; BpT; 2-benzoylpyridine thiosemicarbazone; Bp4eT; 2-benzoylpyridine 4-ethyl-3-thiosemicarbazone; Bp44mT; 2-benzoylpyridine 4,4-dimethyl-
De novo pulmonary small cell carcinomas and large cell neuroendocrine carcinomas harboring EGFR mutations: Lack of response to EGFR inhibitors
Keywords: Mutation; Small cell lung cancer; Large cell neuroendocrine carcinoma; EGFR; Never-smoker; Erlotinib; Progression; Resistance;
Brain metastases in patients with EGFR-mutated or ALK-rearranged non-small-cell lung cancers
Keywords: Lung cancer; NSCLC; Brain metastases; EGFR; ALK; Mutation; Rearrangement; Central nervous system; CNS;
Anti-tumor effect of LTA combined with 5-FU on H22 tumor bearing mice
Keywords: LTA; 5-FU; Tumor inhibition rate; Caspase-3; EGFR; TGF-α
EGFR T790M resistance mutation in non small-cell lung carcinoma
Keywords: EGFR; T790M; Mutation; Resistance; Non small-cell lung cancer;
131I-Nimotuzumab - A potential radioimmunotherapeutic agent in treatment of tumors expressing EGFR
Keywords: Radioimmunotherapy; 131I-Nimotuzumab; EGFR; Head and neck cancer;
Prospective study of plasma D-dimer and incident venous thromboembolism: The Atherosclerosis Risk in Communities (ARIC) Study
Keywords: ARIC; Atherosclerosis Risk in Communities; BMI; body mass index; DVT; venous thrombosis; eGFR; estimate glomerular filtration rate; HR; hazard ratio; LITE; Longitudinal Investigation of Thromboembolism Etiology; PE; pulmonary embolism; SNPs; single nucleo
Elevated expression of Notch-1 and EGFR induced apoptosis in glioblastoma multiforme patients
Keywords: Glioblastoma multiforme; Notch-1; EGFR; Apoptosis