
P53 tumor suppressor is required for efficient execution of the death program following treatment with a cytotoxic limonoid obtained from Melia azedarach
Keywords: Meliartenin; 12-Hydroxyamoorastatin; Cytotoxicity; Apoptosis; Cell cycle arrest; HCT116; p53; ALL; acute lymphoblastic leukemia; BrdU; 5-bromo-2'-deoxyuridine; CML; chronic myeloid leukemia; DMSO; dimethyl sulfoxide; DOX; doxorubicin; FBS; fetal bovine