Development of Akt-activated GSK3β inhibitory peptide
Keywords: GSK3β; Akt; Diabete mellitus; Drug discovery;
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Sodium tungstate activates glycogen synthesis through a non-canonical mechanism involving G-proteins
Keywords: CHO; Chinese hamster ovary cells; CHOIR; Chinese hamster ovary (CHO) cells stably transfected with the human wild-type insulin receptor; ERK; extracellular signal-regulated kinases 1 and 2; GS; glycogen synthase; GSK3β; glycogen synthase kinase-3β; IR;
Molecular and cellular pharmacologyMenadione (Vitamin K3) decreases melanin synthesis through ERK activation in Mel-Ab cells
Keywords: GSK3β; glycogen synthase kinase 3β; ERK; extracellular signal-regulated kinase; MITF; microphthalmia-associated transcription factor; PVDF; polyvinylidene fluoride; TRP; tyrosinase-related protein; UV; ultraviolet; Menadione; Melanogenesis; MITF; Tyrosi
Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells
Keywords: AD; Alzheimer's disease; Aβ; amyloid-beta peptide; ADAM-10; A-disintegrin and metalloprotease 10; APP; amyloid precursor protein; CA; caffeic acid; CAPE; caffeic acid phenethyl ester; GSH; glutathione; MAPK; mitogen-activated protein kinase; JNK; c-jun N
Bis(12)-hupyridone, a novel acetylcholinesterase inhibitor, protects against glutamate-induced neuronal excitotoxicity via activating α7 nicotinic acetylcholine receptor/phosphoinositide 3-kinase/Akt cascade
Keywords: AChE; acetylcholinesterase; AD; Alzheimer's disease; B12H; bis(12)-hupyridone; CGNs; cerebellar granule neurons; DHβE; dihydro-β-erythroidine; GSK3β; glycogen synthase kinase 3β; mAChR; muscarinic acetylcholine receptor; MLA; methyllycaconitine; NMD
PI3-kinase/Akt/mTOR signaling: Impaired on/off switches in aging, cognitive decline and Alzheimer's disease
Keywords: AD; Alzheimer's disease; Aβ; amyloid-β; APP; amyloid precursor protein; 4EBP1; eukaryotic translation initiation factor 4E (eIF-4E)-binding protein-1; FOXO; Forkhead box-O class transcription factors; FMRP; Fragile-X mental retardation protein; GSK3β;
RSK2-induced stress tolerance enhances cell survival signals mediated by inhibition of GSK3β activity
Keywords: Apoptosis inhibition; Cell survival; GSK3β; RSK2; Stress tolerance;
Cholesterol induces cardiac hypertrophy by activating the AKT pathway
Keywords: IGF; insulin growth factor; MAPK; mitogen-activated protein kinase; ERK; extracellular signal-regulated kinase; PI3K; phosphatidylinositol-3-kinase; GPCR; G-protein-coupled receptor; mTOR; mammalian target of rapamycin; GSK3β; phospho-glycogen synthase k
Tubulin polymerization promoting protein 1 (TPPP1) increases β-catenin expression through inhibition of HDAC6 activity in U2OS osteosarcoma cells
Keywords: CK1; caesin kinase 1; GSK3β; glycogen synthase kinase 3β; HDAC6; histone deacetylase 6; ROCK; rho-associated coiled-coil kinase; TPPP1; tubulin polymerization promoting protein 1; β-TrCP; β-transducin repeat-containing protein; β-Catenin; TPPP1; ROCK
Research reportGlutamate transporter type 3 mediates isoflurane preconditioning-induced acute phase of neuroprotection in mice
Keywords: ERK1/2; extracellular signal-regulated kinase 1/2; EAAT; excitatory amino acid transporter; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; GSK3β; glycogen synthase kinase 3β; MCAO; middle cerebral arterial occlusion; SpO2; pulse oximeter oxygen satura
Hypercholesterolemia blocked sevoflurane-induced cardioprotection against ischemia-reperfusion injury by alteration of the MG53/RISK/GSK3β signaling
Keywords: Sevoflurane; GSK3β; Preconditioning; Cardioprotection; Hypercholesterolemia;
Research ArticleTGFβ overrides HNF4α tumor suppressing activity through GSK3β inactivation: implication for hepatocellular carcinoma gene therapy
Keywords: TGFβ; transforming growth factor β; EMT; epithelial-to-mesenchymal transition; HCC; hepatocellular carcinoma; HNF4α; hepatocyte nuclear factor 4 alpha; PTM; post-translational modification; GSK3β; glycogen synthase kinase-3 beta; BIO; GSK3β-inhibitor
Reversal of dexamethasone induced insulin resistance in 3T3L1 adipocytes by 3β-taraxerol of Mangifera indica
Keywords: DEX; dexamethasone; DMEM; Dulbecco's modified Eagle's medium; ELISA; enzyme linked immunosorbent assay; FCS; fetal calf serum; GLUT 4; glucose transporter 4; GS; glycogen synthase; GSK3β; glycogen synthase kinase beta; IR β; insulin receptor beta; IRS1;
The DEAD box proteins DDX5 (p68) and DDX17 (p72): Multi-tasking transcriptional regulators
Keywords: ERα; estrogen receptor alpha; CBP; CREB-binding protein; SRC-1; steroid receptor coactivator 1; SRA; steroid receptor RNA activator; RNA Pol II; RNA polymerase II; P/CAF; CBP/p300 associated factor; TFIIA; transcription factor IIA; AR; androgen receptor;
Glycyrrhizic acid and 18β-glycyrrhetinic acid recover glucocorticoid resistance via PI3K-induced AP1, CRE and NFAT activation
Keywords: Glycyrrhizic acid; 18β-Glycyrrhetinic acid; Glucocorticoid receptor; Phosphoinositide 3-kinase; Glucocorticoid resistance; 18βGA; 18β-glycyrrhetinic acid; Akt; protein kinase B; AP1; activator protein 1; COPD; chronic obstructive pulmonary disease; CRE
Wnt signaling in liver fibrosis: Progress, challenges and potential directions
Keywords: Liver fibrosis; Wnt signaling; Canonical Wnt signaling pathway; Hepatic stellate cell; Myofibroblastic transdifferentiation; HSCs; hepatic stellate cells; GFAP; glial fibrillary acidic protein; a-SMA; a-smooth muscle actin; TRAIL; tumor necrosis factor-re
Novel small-molecule AMPK activator orally exerts beneficial effects on diabetic db/db mice
Keywords: AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; CNTF; ciliary neurotrophic factor; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; KD; kinase domain; AID; autoinhibitory domain; GBD; glycogen-binding domain; CaMKKα/β; calmodulin-d
ReviewMolecular links between Alzheimer's disease and diabetes mellitus
Keywords: AD; Alzheimer's disease; APP; amyloid β precursor protein; BACE1; β-site APP-cleaving enzyme 1; Aβ; amyloid β protein; hIAPP; human islet amyloid polypeptide; IDE; insulin-degrading enzyme; IGF; insulin-like growth factor; GSK3β; glycogen synthase
Genetic variability at IMPA2, INPP1 and GSK3β increases the risk of suicidal behavior in bipolar patients
Keywords: Bipolar disorder; Suicidal behavior; Lithium; IMPA2; INPP1; GSK3β;
Inhibition of glycogen synthase kinase 3beta activity with lithium prevents and attenuates paclitaxel-induced neuropathic pain
Keywords: IL-1β; interleukin-1β; EDTA; ethylene diamine tetra acetic acid; GLT-1; glial glutamate transporter 1; GSK3β; glycogen synthase kinase 3beta; LiCl; lithium chloride; SDS; sodium dodecyl sulfate; nociception; glutamate transporter; glial; chemotherapy;
ReviewWnt signaling and hepatocarcinogenesis: Molecular targets for the development of innovative anticancer drugs
Keywords: HCC; hepatocellular carcinoma; FZD; frizzled; CSC; cancer stem cells; PCP; planar cell polarity; TCF/LEF; T-cell factor/lymphoid enhancer factor; TLE-1; transducin like enhancer-1; APC; adenomatous polyposis coli protein; GSK3β; glycogen synthase kinase
Cripto-1 enhances the canonical Wnt/β-catenin signaling pathway by binding to LRP5 and LRP6 co-receptors
Keywords: TDGF-1; teratocarcinoma-derived growth factor-1; CFC; Cripto-1/FRL1/Cryptic; GPI; glycosylphosphatidylinositol; TGF-β; transforming growth factor-β; GDF; growth differentiation factor; Tcf; T-cell factor; Fz; frizzled; LRP; low-density lipoprotein recep
β-N-methylamino-l-alanine causes neurological and pathological phenotypes mimicking Amyotrophic Lateral Sclerosis (ALS): The first step towards an experimental model for sporadic ALS
Keywords: ALS; Amyotrophic Lateral Sclerosis; ALS-PDC; Amyotrophic Lateral Sclerosis/Parkinson-Dementia complex; Cho; choline; Cr; creatine; ER; endoplasmic reticulum; GSK3β; glycogen synthase kinase-3β; NAA; N-acetylaspartate; L-BMAA; β-N-methylamino-l-alanine;
E3 ubiquitin ligase Fbw7 negatively regulates granulocytic differentiation by targeting G-CSFR for degradation
Keywords: Fbw7; G-CSFR; GSK3β; Ubiquitin-proteasome degradation;
Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation
Keywords: Cell commitment; Cell survival; Endocannabinoids; Membrane receptors; Niche cues; Protein kinases; Transcription factors; 2-AG; 2-arachidonoylglycerol; AEA; N-arachidonoylethanolamine; BDNF; brain derived neurotrophic factor; CBD; cannabidiol; CBG; cannab
Distinctive microRNA signature associated of neoplasms with the Wnt/β-catenin signaling pathway
Keywords: FZD; Frizzled; LRP; LDL receptor-related protein; Dvl; Disheveled; APC; Adenomatous polyposis coli; CK1α; Casein kinase 1α; GSK3β; Glycogen synthase kinase 3β; HCC; Hepatocellular carcinoma; EZH2; Zeste homologue 2; sFRPs; Secreted frizzled-related
Wnt signaling pathway in rheumatoid arthritis, with special emphasis on the different roles in synovial inflammation and bone remodeling
Keywords: RA; rheumatoid arthritis; FLS; fibroblast-like synoviocytes; ACPA; anti-citrullinated peptide antibody; DKK1; dickkopf-1; 11β-HSD1; 11beta-hydroxysteroid dehydrogenase type 1; PADI4; peptidylarginine deiminase-4; hTERT; human telomerase reverse transcrip
RNAi screening identifies GSK3β as a regulator of DRP1 and the neuroprotection of lithium chloride against elevated pressure involved in downregulation of DRP1
Keywords: Glaucoma; Elevated hydrostatic pressure; Mitochondrial fission; DRP1; GSK3β;
2-Phenylamino-6-cyano-1H-benzimidazole-based isoform selective casein kinase 1 gamma (CK1γ) inhibitors
Keywords: Wnt pathway; Casein kinase 1; β-Catenin; GSK3β;
Protein levels of β-catenin and activation state of glycogen synthase kinase-3β in major depression. A study with postmortem prefrontal cortex
Keywords: Major depression; Suicide; β-Catenin; GSK3β; ser9-phospho-GSK3β; Postmortem prefrontal cortex;
Design, synthesis and anticancer activity of 1-acyl-3-amino-1,4,5,6-tetrahydropyrrolo[3,4-c]pyrazole derivatives
Keywords: 3-Aminopyrazole; Synthesis; Anticancer activity; CDK5; GSK3β;
Cdk5-mediated phosphorylation of CRMP-2 enhances its interaction with CaV2.2
Keywords: CaV2.2; N-type voltage-gated Ca2+ channel; CBD; Ca2+ channel binding domain; CRMP-2; collapsin response mediator protein 2; Cdk5; cyclin dependent kinase 5; DIV; days in vitro; DsRed; Discosoma sp. red fluorescent protein E19, embryonic day 19; GSK3β; gl
Phosphorylation prevents C/EBPβ from the calpain-dependent degradation
Keywords: cdk2; cyclin-dependent kinase 2; C/EBP; CCAAT/enhancer-binding protein; GSK3β; glycogen synthase kinase-3β; PPAR; peroxisome proliferator-activated receptor; rC/EBPβ; recombinant C/EBPβ; C/EBPβ; Phosphorylation; Degradation; Calpain;
Frizzled7 as an emerging target for cancer therapy
Keywords: ALL; Acute lymphoblastic leukemia; APC; Adenomatous polyposis coli; CamKII; Calmodulin kinase II; Cthrc1; Collagen triple helix repeat containing protein; CK1; Caseine kinase 1; CTNNB1; β-catenin gene; CRD; Cysteine rich domain; CSC; Cancer stem cells; D
Induction of the permeability transition pore in cells depleted of mitochondrial DNA
Keywords: Cs; cyclosporin; CyP-D; cyclophilin D; ÎÏm; mitochondrial membrane potential difference; EGTA; ethylene glycol-bis(2-aminoethyl)-N,N,N',N'-tetraacetic acid; FCCP; carbonylcyanide-p-trifluoromethoxyphenyl hydrazone; HK II; Hexokinase II; PTP; permeab
Involvement of calmodulin and calmodulin kinase II in tumor necrosis factor alpha-induced survival of bone marrow derived macrophages
Keywords: CAM; calmodulin; CAMKII; calmodulin dependent kinase II; GSK3β; glycogen synthase kinase 3 beta; PI3K; phosphatidylinositol-3-kinase; NFκB; nuclear factor kappa B; M-CSF; macrophage-colony stimulating factor; TNFα; tumor necrosis factor alpha; TRPC; tr
Anti-obesity effect of Schisandra chinensis in 3T3-L1 cells and high fat diet-induced obese rats
Keywords: Schisandra chinensis; Adipocyte differentiation; Akt; GSK3β; 3T3-L1 Adipocytes; HFD obese rats;
MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKAy mouse model
Keywords: FFA; Free fatty acids; GLUT4; Glucose transport protein-4; GSK3β; Glycogen synthase kinase 3 beta; HDL-C; High density lipoprotein cholesterol; InsR; Insulin receptor; IRs-1; Insulin receptor substrate 1; LDL-C; low density lipoprotein cholesterol; OGTT;
Involvement of activation of PI3K/Akt pathway in the protective effects of puerarin against MPP+-induced human neuroblastoma SH-SY5Y cell death
Keywords: PD; Parkinson's disease; GSK3β; glycogen synthase kinase-3β; PI3K; phosphoinositide 3-kinase; SN; Substantia Nigra; ROS; reactive oxidative species; MPP+; 1-methyl-4-phenylpyridinium iodide; Puerarin; PI3K/Akt pathway; p53; Caspase-3;
Differentiation and gene expression profile of tumor-associated macrophages
Keywords: TAM; tumor-associated macrophage; M1; classically activated macrophages; M2; alternatively activated macrophages; iNOS; inducible nitric oxide synthetase; RUNX1; runt-related transcription factor 1; NF-κB; nuclear factor kappaB; IRF8; interferon regulato
The selenoproteins GPx2, TrxR2 and TrxR3 are regulated by Wnt signalling in the intestinal epithelium
Keywords: GPx; glutathione peroxidase; TrxR; thioredoxin reductase; Gsk3β; glycogen synthase kinase 3β; APC; adenomatous polyposis coli; Dvl; dishevelled; Lgr5; leucine-rich repeat containing G protein-coupled receptor 5; Lrp; low density lipoprotein receptor-rel
Behavioral Stress-Induced Activation of FoxO3a in the Cerebral Cortex of Mice
Keywords: Akt; FoxO3a; GSK3β; learned helplessness; signal transduction; stress;
Des-acyl ghrelin exhibits pro-anabolic and anti-catabolic effects on C2C12 myotubes exposed to cytokines and reduces burn-induced muscle proteolysis in rats
Keywords: DAG; des-acyl ghrelin; GHS-R1a; growth hormone secretagogue receptor 1a; GHRP-2; growth hormone releasing peptide 2; GSK3β; glycogen synthase kinase-3 beta; IGF-I; insulin-like growth factor 1; IL-6; interleukin-6; MAFbx; muscle atrophy F-box protein/atr
Janus kinase 2 - A novel negative regulator of estrogen receptor α function
Keywords: CA; constitutive active; CDK2; Cyclin dependent kinase 2; CDK7; Cyclin dependent kinase 7; CK2; Casein kinase 2; DCC; dextran-coated charcoal-treated; DNA-PK; DNA-dependent protein kinase; E2; 17β-estradiol; EGFR; Epidermal growth factor receptor; ER; es
DISC1-binding proteins in neural development, signalling and schizophrenia
Keywords: DISC1; Schizophrenia; Neurodevelopment; Signalling; Synapse; Association studies; APP; Amyloid precursor protein; ATF4; Activating transcription factor 4; BACE1; β-site APP-cleaving enzyme-1; BBS4; Bardet-Biedl syndrome 4; CEP290; Centrosomal protein 2
Back to your heart: Ubiquitin proteasome system-regulated signal transduction
Keywords: AF1/2; activation function 1/2 domains; AP-1; activator protein 1; AKT; protein kinase B; ARF-BP1; ARF binding protein 1; ATM; ataxia telangiectasia mutated; CARP1/2; caspase associated ring protein 1/2; CBP; CREB binding protein; CHIP; C-terminus of HSC7
Autophagy and polyglutamine diseases
Keywords: HD; Huntington's disease; SCA; spinocerebellar ataxia; DRPLA; Denatorubral-pallidoluysian atrophy; SBMA; spinal and bulbar muscular atropy; Htt; Huntingtin; UPS; ubiquitin-proteasome system; HDL-2; Huntington's disease-like 2; IBs; inclusion bodies; RNA
Specificity of peripheral nerve regeneration: Interactions at the axon level
Keywords: AKT/PKB; protein kinase B; BDNF; brain derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; CAMs; cell adhesion molecules; Cdc42; cell division control protein 42 homolog; cGMP; cyclic guanosine monophosphate; ChAT; choline acetyltransferase
Association between affective temperaments and brain-derived neurotrophic factor, Glycogen synthase kinase 3β and Wnt signaling pathway gene polymorphisms in healthy subjects
Keywords: ANOVA; one-way analysis of variance; BDNF; Brain-derived neurotrophic factor; EPQ; Eysenck Personality Questionnaire; GSK3β; Glycogen synthase kinase 3β; MINI; Mini International Neuropsychiatric Interview; PCR; polymerase chain reaction; PPARD; peroxis
The impact of glycogen synthase kinase 3β gene on psychotic mania in bipolar disorder patients
Keywords: GSK3β; Glycogen Synthase Kinase 3-beta; YMRS; Young Mania Rating Scale; BPRS; Brief Psychiatric Rating Scale; SNP; Single Nucleotide Polymorphism; DSM-IV; diagnosis criteria of Diagnostic and Statistical Manual of Mental Disorders-IV; SCID-I; Structured