دانلود مقالات ISI درباره Hdac + ترجمه فارسی

Cell cycle dependent role of HDAC1 for proliferation control through modulating ribosomal DNA transcription

Keywords: HDAC1; rDNA; Chromatin; Cell cycle; Proliferation; NIH3T3; Pol I; HDAC; histone deacetylase;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2008 سفارش ترجمه

Is the focus moving toward a combination of targeted drugs?

Keywords: targeted agents; histone deacetylase inhibitors; HDAC; NF-κB inhibitors; CDK inhibitors; proteasome inhibitors; MEK inhibitors; BCL-2 inhibitors

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

The use of diversity profiling to characterize chemical modulators of the histone deacetylases

Keywords: HDAC; Polyphenol; Microfluidics; Profiling; Hydroxamate

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2008 سفارش ترجمه

Ceramide inhibition of MMP-2 expression and human cancer bronchial cell invasiveness involve decreased histone acetylation

Keywords: MMP; Invasion; HDAC; Ceramide; Lung;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

The pharmokinetic limitations of antioxidant treatment for COPD

Keywords: COPD; chronic obstructive pulmonary disease; FEV1; forced expiratory volume in 1 s; IL-1β; interleukin-1-beta; GM-CSF; granulocyte monocyte colony stimulating factor; NF-κB; nuclear factor kappa B; MAPK; mitogen activated protein kinase; EGCG; epigallo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Modulation of cell cycles and apoptosis by apicidin in estrogen receptor (ER)-positive and-negative human breast cancer cells

Keywords: HDAC; histone deacetylase; HATs; histone acetyltransferases; ER; estrogen receptor; TSA; trichostatin A; SAHA; suberoylanilide hydroxamic acid; Rb; retinoblastoma; DMEM; Dulbecco's Modified Eagle Medium; FBS; fetal bovine serum; PVDF; polyvinylidene diflu

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

Epigenetic regulation of established human type 1 versus type 2 cytokine responses

Keywords: Human; PBMCs; TH1/TH2; cytokine; HAT; Histone acetyltransferase; HDAC; Histone deacetylase; PHA; Phytohemagglutinin; SPHK1; Sphingosine kinase 1; TSA; Trichostatin A; TSST-1; Toxic shock syndrome toxin 1;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2008 سفارش ترجمه

MS-275, a novel histone deacetylase inhibitor with selectivity against HDAC1, induces degradation of FLT3 via inhibition of chaperone function of heat shock protein 90 in AML cells

Keywords: HDACI, histone deacetylase inhibitor; AML, acute myelogenous leukemia; ALL, acute lymphoblastic leukemia; PDGFR, platelet derived growth factor receptor; FLT3, fms-like tyrosine kinase 3AML; FLT3; HSP90; HDAC

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2008 سفارش ترجمه

A quantitative high-throughput screen identifies potential epigenetic modulators of gene expression

Keywords: Epigenetic; Small molecule; GFP; HTS; HDAC; Cell assay; Cancer

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

Additive effects of histone deacetylase inhibitors and amphetamine on histone H4 acetylation, cAMP responsive element binding protein phosphorylation and ΔFosB expression in the striatum and locomotor sensitization in mice

Keywords: histone deacetylase; cAMP responsive element binding protein; chromatin immunoprecipitation; butyric acid; valproic acid; amphetamine; AcH4; acetylated H4; BA; butyric acid; B+S; butyric acid+saline; ChIP; chromatin immunoprecipitation; co-IP; co-immunopr

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2008 سفارش ترجمه

An Inactivating Mutation in HDAC2 Leads to Dysregulation of Apoptosis Mediated by APAF1

Keywords: ChIP; chromatin immunoprecipitation; HDAC; histone deacetylase; MSI; microsatellite instability; MSS; microsatellite stable; PCR; polymerase chain reaction; SAHA; suberoylanilide hydroxamic acid; TSA; trichostatin A; WT; wild type;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Proteomic analysis of peripheral leukocytes in Alzheimer's disease patients treated with divalproex sodium

Keywords: 2D electrophoresis; Alzheimer's disease; Biomarkers; Glycogen synthase kinase-3; GSK-3; Histone deacetylase inhibitor; HDAC; PBMC; Proteomics; qRT-PCR; Valproic acid; VPA

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2008 سفارش ترجمه

Aberrant Transforming Growth Factor β1 Signaling and SMAD4 Nuclear Translocation Confer Epigenetic Repression of ADAM19 in Ovarian Cancer

Keywords: ADAM19; a disintegrin and metalloprotease domain 19; ChIP-chip; chromatin immunoprecipitation in conjunction with microarray chips; DAC; 5-aza-2′deoxycytidine; HDAC; histone deacetylase; OSE; ovarian surface epithelium; RT-PCR; reverse transcription-p

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

Blimp-1Δexon7: A naturally occurring Blimp-1 deletion mutant with auto-regulatory potential

Keywords: Blimp-1, B lymphocyte-induced maturation protein 1; LPS, lipopolysaccharide; HDACs, histone deacetylases; Ig, immunoglobulinBlimp-1; prdm-1; B cell differentiation; Apoptosis; HDAC; Heterochromatin; Auto-regulatory feedback; Homodimerization

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2008 سفارش ترجمه

NF-κB/p65 antagonizes Nrf2-ARE pathway by depriving CBP from Nrf2 and facilitating recruitment of HDAC3 to MafK

Keywords: NF-κB; Nrf2; ARE; MafK; CBP; HDAC; Transrepression

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2008 سفارش ترجمه

Aging and induced senescence as factors in the pathogenesis of lung emphysema

Keywords: p53; HDAC; HAT; Methylation; Acetylation; SIRT1α1-AT, alpha-1-antitrypsin; Akt, serine-threonine-kinase, member of the protein kinase B (PKB) family; ALT, alternative mechanisms of telomere lengthening; Bad, Bcl-2-associated death promoter, member of the

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2008 سفارش ترجمه

Epigenetic Changes Induced by Reactive Oxygen Species in Hepatocellular Carcinoma: Methylation of the E-cadherin Promoter

Keywords: 5-aza-dC; 5-aza-2′-deoxycytidine; BS; bisulfite sequencing; ChIP; chromatin immunoprecipitation; DNMT; DNA methyltransferase; GPx1; glutathione peroxidase 1; HCC; hepatocellular carcinoma; HDAC; histone deacetylase; MAPK; mitogen-activated protein kinas

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2008 سفارش ترجمه

N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors

Keywords: SIRT2; HDAC; Inhibitor

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Synthesis and biological evaluation of the suberoylanilide hydroxamic acid (SAHA) β-glucuronide and β-galactoside for application in selective prodrug chemotherapy

Keywords: Prodrug; Glucuronide; Galactoside; SAHA; HDAC; ADEPT

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2007 سفارش ترجمه

Valproate induces apoptosis by inducing accumulation of neutral lipids which was prevented by disruption of the SIR2 gene in Saccharomyces cerevisiae

Keywords: Budding yeast; Apoptosis; Valproate; Lipid accumulation; SIR2; VPA; valproic acid; HDAC; histone deacetylase; ROS; reactive oxygen species; TAG; triacylglycerol;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Design and synthesis of thiazole-5-hydroxamic acids as novel histone deacetylase inhibitors

Keywords: HDAC; Inhibitors; Synthesis; Antiproliferative

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Modification of cap group in δ-lactam-based histone deacetylase (HDAC) inhibitors

Keywords: Histone deacetylase; HDAC; Anticancer chemotherapy; Enzyme inhibitor; Growth inhibition; In vivo xenograft model; Docking model

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

ω-Alkoxy analogues of SAHA (vorinostat) as inhibitors of HDAC: A study of chain-length and stereochemical dependence

Keywords: Hydroxamic acid; HDAC; Anticancer activity

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors

Keywords: Histone deacetylase inhibitors; HDAC; Benzamides; Cancer cell proliferation

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Sodium butyrate modifies the stabilizing complexes of tyrosine hydroxylase mRNA

Keywords: Tyrosine hydroxylase; PC12; RNA stability; HDAC; Sodium butyrate; TSA; Histone acetylation; Run-on assay; UV crosslinking

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Epigenetic regulation of clusterin/apolipoprotein J expression in retinal pigment epithelial cells

Keywords: 5-Aza-2′-deoxycytidine; HDAC; Histone deacetylase inhibitor; Macular degeneration; Trichostatin A; Valproate

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

The short chain fatty acid, butyrate, stimulates MUC2 mucin production in the human colon cancer cell line, LS174T

Keywords: Butyrate; Mucin; MUC2; LS174T; HDAC

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2007 سفارش ترجمه

Benzo[b]thiophene-based histone deacetylase inhibitors

Keywords: HDAC; Histone deacetylase inhibitor; HDAC inhibitor; Anticancer drug; SAHA; Hydroxamic acids; Benzo[b]thiophene

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Identification and optimisation of a series of substituted 5-(1H-pyrazol-3-yl)-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Keywords: Histone deacetylase inhibitors; HDAC; Hydroxamic acids

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Design, synthesis, and evaluation of isoindolinone-hydroxamic acid derivatives as histone deacetylase (HDAC) inhibitors

Keywords: HDAC; HDAC inhibitor; Isoindoklinone; Hydroxamic acid; Pancreatic cancer; p21

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Castration Resistant, Taxane Naïve Metastatic Prostate Cancer: Current Clinical Approaches and Future Directions

Keywords: prostate; prostatic neoplasms; drug therapy; immunotherapy; receptors; androgen; AR; androgen receptor; CALGB; Cancer and Leukemia Group B; CTLA4; cytotoxic T lymphocyte-associated antigen 4; ET-1; endothelin 1; HDAC; histone deacetylase; Hsp90; heat shoc

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2007 سفارش ترجمه

Identification and optimisation of a series of substituted 5-pyridin-2-yl-thiophene-2-hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Keywords: Histone deacetylase inhibitors; HDAC; Hydroxamic acids

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

CR/periphilin is a transcriptional co-repressor involved in cell cycle progression

Keywords: CR; Cdc7; Cell cycle; Co-repressor; HDAC

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

HAMLET, protein folding, and tumor cell death

Keywords: α-lactalbumin; Oleic acid; HAMLET; Tumor cell death; Amyloid; AFM; atomic force microscopy; ATP; adenosine triphosphate; BAMLET; bovine α-lactalbumin made lethal to tumor cells; CIDNP; chemically induced dynamic nuclear polarization; ER; endoplasmic ret

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Phenylbutyrate Sensitizes Human Glioblastoma Cells Lacking Wild-Type P53 Function to Ionizing Radiation

Keywords: Phenylbutyrate; Radiation; Glioblastoma; HDAC; p53;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2007 سفارش ترجمه

Boric acid inhibits embryonic histone deacetylases: A suggested mechanism to explain boric acid-related teratogenicity

Keywords: Borate; Axial malformations; HDAC; HDACi; Embryo; Fetus; Mechanism; Kinetic analysis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2007 سفارش ترجمه

CD81, a cell cycle regulator, is a novel target for histone deacetylase inhibition in glioma cells

Keywords: Acetylation; Astrocyte; Glioma; HDAC; Proliferation

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

The Expanding Role of Epigenetics in the Development, Diagnosis and Treatment of Prostate Cancer and Benign Prostatic Hyperplasia

Keywords: prostate; prostatic neoplasms; genetics; DNA methylation; chromatin; 5-AC; 5-aza-cytidine; BPH; benign prostatic hyperplasia; DAC; 5-aza-deoxycytidine; EGCG; (-)-epigallocatechin-3-gallate; HAT; histone acetyltransferase; HDAC; histone deacetylase; HDACi;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

c-Myc overexpression sensitizes Bim-mediated Bax activation for apoptosis induced by histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) through regulating Bcl-2/Bcl-xL expression

Keywords: Myc; HDAC; Bim; Apoptosis; Bax

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2007 سفارش ترجمه

The novel histone deacetylase inhibitor 4-Me2N-BAVAH differentially affects cell junctions between primary hepatocytes

Keywords: 4-Me2N-BAVAH; 5-(4-dimethylaminobenzoyl)-aminovaleric acid hydroxamate; Cx; connexin; GJIC; gap junctional intercellular communication; HDAC; histone deacetylase; LDH; lactate dehydrogenase; PBS; phosphate-buffered saline solution; SAHA; suberoylanilide h

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2007 سفارش ترجمه

Disruption of HDAC4/N-CoR complex by histone deacetylase inhibitors leads to inhibition of IL-2 gene expression

Keywords: HDAC; histone deacetylase; N-CoR; nuclear hormone receptor corepressor; MEF2; myocyte enhancer factor 2; RD3; repression domain 3; HAT; histone acetyltransferase; SMRT; silencing mediator for retinoid and thyroid receptors; RPD3; reduced potassium depende

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2007 سفارش ترجمه

A role for epigenetics in hearing: Establishment and maintenance of auditory specific gene expression patterns

Keywords: CpG; the DNA sequence “CG” where DNA methylation occurs; SINES; short interspersed transposable elements; LINES; long interspersed transposable elements; DNMT; DNA methyltransferase; siRNA; small interfering RNA; miRNA; Micro RNA; H; histone; HAT; his

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2007 سفارش ترجمه

Transcriptional regulation by C-terminal binding proteins

Keywords: CtBP; C-terminal binding protein; Ad; adenovirus; HDAC; histone deacetylase; HMTase; histone lysine methyl transferase; LSD1; lysine-specific demethylase 1; HAT; histone acetyl transferase; PcG; Polycomb group; DH; dehydrogenase; CtBP; CoREST; HDAC; HMTas

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2007 سفارش ترجمه

A series of novel, potent, and selective histone deacetylase inhibitors

Keywords: Histone deacetylase inhibitor; HDAC; SAR studies

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Substituted N-(2-aminophenyl)-benzamides, (E)-N-(2-aminophenyl)-acrylamides and their analogues: Novel classes of histone deacetylase inhibitors

Keywords: Histone deacetylase inhibitors; 2-Aminophenyl-benzamides; 2-Aminophenyl-acrylamides; HDAC; HDACI

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2006 سفارش ترجمه

Dicer and positive charge of proteins decrease the stability of RNA containing the AU-rich element of GM-CSF

Keywords: ARE; GM-CSF; Acetylation; HDAC; Dicer

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2006 سفارش ترجمه

Novel valproic acid derivatives with potent differentiation-inducing activity in myeloid leukemia cells

Keywords: VPA; Differentiation; HDAC; Leukemia; K562; HL60; p21Cip/Waf

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2006 سفارش ترجمه

Depletion of DNA methyltransferase 1 and/or DNA methyltransferase 3b mediates growth arrest and apoptosis in lung and esophageal cancer and malignant pleural mesothelioma cells

Keywords: 29; ASO; antisense oligo; DAC; 5 aza 2′ deoxycytidine; DNMT; DNA methyltransferase; HDAC; histone deacetylase; MM; mismatch; MPM; malignant pleural mesothelioma; NHBE cell; Normal human bronchial epithelial cell; RT-PCR; reverse transcription-polymera

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Grow-ING, Age-ING and Die-ING: ING proteins link cancer, senescence and apoptosis

Keywords: ING; HAT; HDAC; Protein interactions; Epigenetic; Cancer; Apoptosis; Senescence;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2006 سفارش ترجمه

Analysis of the 5-lipoxygenase promoter and characterization of a vitamin D receptor binding site

Keywords: ChIP; chromatin immunoprecipitation; 1,25(OH)2D3; 1,25-dihydroxyvitamin D3; EMSA; electrophoretic mobility shift assay; HDAC; histone deacetlyase; 5-HPETE; 5-hydroperoxyeicosatetraenoic acid; 5-LO; 5-lipoxygenase; rANF; rat atrial natriuretic factor; RLU;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2006 سفارش ترجمه