دانلود مقالات ISI درباره Hdac + ترجمه فارسی

Protein kinase Cδ negatively regulates Notch1-dependent transcription via a kinase-independent mechanism in vitro

Keywords: ChIP; chromatin immunoprecipitation; DAPI; 4′,6-diamidino-2-phenylindole; DLL; delta-like; DTT; dithiothreitol; ER; estrogen receptor; HDAC; histone deacetylase; NICD; Notch1 intracellular domain; PKCδ; protein kinase Cδ; PKCδ K376R; kinase-dead domi

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Androgen receptor-mediated gene repression

Keywords: AR; androgen receptor; AR wt; wild type androgen receptor; ARE; androgen response element; nARE; negative androgen response element; pARE; positive androgen response element; AP-1; activator protein-1; αBE; α basal element; BrCa; breast cancer; CBP; CRE

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells

Keywords: HDAC; histone deacetylase; MAPK; mitogen-activated protein kinase; MMP; matrix metalloproteinase; TIMP; tissue inhibitor of metalloproteinases; TSA; trichostatin A; Butyrate; Colon adenocarcinoma; Histone-deacetylase inhibitor; MAP kinase; Metalloproteina

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Cyclin D1 is a NF-κB corepressor

Keywords: CD1; Cyclin D1; Cdk; Cyclin-dependent kinase; ER; Estrogen receptor; HAT; Histone acetylase; HDAC; Histone deacetylase; PMA; 12-O-tetraecanoylphorbol-13-acetate; SRC; Steroid receptor coactivator; RAC3; Retinoic acid coactivator; Cyclin D1; NF-κB; RAC3;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Proteases involved in cartilage matrix degradation in osteoarthritis

Keywords: ADAMTS; a disintegrin and metalloproteinase with thrombospondin motifs; APC; activated protein C; CITED2; cAMP-responsive element-binding protein/p300-interacting transactivator with Glu/Asp-rich carboxy-terminal domain 2; ECM; extracellular matrix; ERK;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase expression by endoplasmic reticulum stress

Keywords: ATF6; activating transcription factor 6; BFA; brefeldin A; CaM; calmodulin; 15dPGJ2; 15-deoxy-Δ12,14-prostaglandin J2; eIF2α; eukaryotic translation initial factor 2α; ER; endoplasmic reticulum; GAS; gamma-activated sequence; HAT; histone acetyltransfe

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

Acetylation modulates the STAT signaling code

Keywords: Acetylation; Cytokine; HAT; HDAC; Phosphorylation; SIRT; STAT; Sumoylation

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2012 سفارش ترجمه

The role of endocannabinoids in gonadal function and fertility along the evolutionary axis

Keywords: 2-AG; 2-arachidonoylglycerol; AA; arachidonic acid; ACTH; corticotrophin; AEA; N-arachidonoylethanolamine; ArKO; aromatase-nullmice; cAMP; cyclic adenosine monophosphate; CB1; type-1 cannabinoid receptor; CB2; type-2 cannabinoid receptor; CB3; type-3 cann

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Transcriptional and translational regulation of cytokine signaling in inflammatory β-cell dysfunction and apoptosis

Keywords: IL-1; IFNg; Diabetes; KDAC; microRNA; ROS; HDAC;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape

Keywords: CAN gene; candidate cancer gene; CD; cluster of differentiation; CDK; cyclin-dependent kinase; COPA; cancer outlier profile analysis; DNMT; DNA methyltransferase; GRN; gene regulatory network; HDAC; histone deacetylase; H3K9; Histone H3 lysine 9; ICBP90;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Estrogen Receptor α Represses Transcription of HBV Genes via Interaction With Hepatocyte Nuclear Factor 4α

Keywords: Hormone; Viral Replication; Mouse Model; Sex Differences; ChIP; chromatin immunoprecipitation; DBD; DNA-binding domain; ER; estrogen receptor; ERE; estrogen-responsive element; HDAC; histone deacetylase; HNF; hepatocyte nuclear factor; OVX; ovariectomy; S

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Role of Transcriptional Corepressor CtBP1 in Prostate Cancer Progression

Keywords: PCa; prostate cancer; CtBP1; C-terminal binding protein 1; HDAC; histone deacetylase; siRNA; small interfering RNA;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Nuclear translocation of DJ-1 during oxidative stress-induced neuronal cell death

Keywords: PD; Parkinson disease; DAergic; dopaminergic; DA; dopamine; 6-OHDA; 6-hydroxydopamine; ROS; reactive oxygen species; CM-H2DCFDA; 5-(and-6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate acetyl ester; PML; promyelocytic leukemia; NAC; N-acetyl

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Chromatin-modifying agents in anti-cancer therapy

Keywords: Epigenetic inhibitors; HDAC; DNMT; Anti-cancer therapy; Clinical trials; Combinatory treatments; AML; acute myeloid leukemia; AZA; 5-azacytidine; CMA; chromatin-modifying agent; CML; chronic myeloid leukemia; CMML; chronic myelomonocytic leukemia; CTCL; c

دانلود رایگان متن کامل مقاله ISI 16 صفحه سال انتشار : 2012 سفارش ترجمه

Toward understanding Machado-Joseph disease

Keywords: ATXN3; ataxin-3; bZIP; basic leucine zipper motif; CBPC; REB binding protein; cDNA; complementary DNA; CHIP; C-terminus of Hsc70 interacting protein; CK2; casein kinase 2; CMV; cytomegalovirus; CNS; central nervous system; CREB; cAMP-response element bind

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2012 سفارش ترجمه

HDAC inhibitor-based therapies: Can we interpret the code?

Keywords: HDAC; Drugs epigenetics; Acetylation; Biomarkers; Cancer

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2012 سفارش ترجمه

Pan-Histone Deacetylase Inhibitor Panobinostat Sensitizes Gastric Cancer Cells to Anthracyclines via Induction of CITED2

Keywords: Cancer Treatment; Stomach; Chemotherapeutic Agent; cDNA; complementary DNA; CEA/Tag; transgenic CEA424/SV40 T-antigen mouse line; ChIP; chromatin immunoprecipitation; CITED2; Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxyterminal domain 2;

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2012 سفارش ترجمه

DNA methylation-based biomarkers in serum of patients with breast cancer

Keywords: 5-Aza-CdR; 5-aza-2′-deoxycytidine; 5-Aza-CR; 5-azacytidine; 5mC; 5-methylcytidine; AIMS; amplification of inter-methylated sites; APC; adenomatous polyposis coli; BiMP; bisulfite methylation profiling; BRCA1; breast cancer gene 1; BsPP; bisulfite padloc

دانلود رایگان متن کامل مقاله ISI 22 صفحه سال انتشار : 2012 سفارش ترجمه

On the function of the internal cavity of histone deacetylase protein 8: R37 is a crucial residue for catalysis

Keywords: HDAC; Epigenetic; Chromatin; Histones; Acetylation

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Alkyl piperidine and piperazine hydroxamic acids as HDAC inhibitors

Keywords: HDAC; Cancer; Lead finding

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Structure and property based design, synthesis and biological evaluation of γ-lactam based HDAC inhibitors

Keywords: Histone deacetylase; HDAC; Inhibitor; Isoform; Anticancer; In vitro activity; Docking study; ADME

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

The design, synthesis and structure–activity relationships of novel isoindoline-based histone deacetylase inhibitors

Keywords: HDAC; hERG; Cancer; Histone deacetylase; Isoindoline; SAR

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Ca2+-calmodulin-dependent protein kinase II regulation of cardiac excitation-transcription coupling

Keywords: Ca-Calmodulin dependent protein kinase; histone deacetylase; calcineurin; β-AR; β-adrenergic receptor; Ca-CaM; Ca-bound CaM; CaM; calmodulin; CaMKII; Ca2+-calmodulin-dependent protein kinase II; CaN; calcineurin; E-C; excitation-contraction; ET; endothe

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2011 سفارش ترجمه

Design and synthesis of aryl ether and sulfone hydroxamic acids as potent histone deacetylase (HDAC) inhibitors

Keywords: HDAC; Histone deacetylase; HDAC-inhibitors; Molecular modeling; Hydroxamic acids; Cell-cycle arrest; Anticancer agents;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

GCN5 regulates the activation of PI3K/Akt survival pathway in B cells exposed to oxidative stress via controlling gene expressions of Syk and Btk

Keywords: AKT; acutely transforming retrovirus AKT8 in rodent T cell lymphoma; BCR; B cell receptor; Btk; Bruton's tyrosine kinase; ChIP; chromatin immunoprecipitation; GCN5; general control non-depressible 5; H2O2; hydrogen peroxide; HAT; histone acetyltransfera

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Discovery of histone deacetylase 8 selective inhibitors

Keywords: HDAC; HDAC8; Macrocycle; Inhibitor; Hydroxamic acid

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Differential regulation of the SMN2 gene by individual HDAC proteins

Keywords: Spinal muscular atrophy; RNAi; HDAC; Luciferase;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

The δA isoform of calmodulin kinase II mediates pathological cardiac hypertrophy by interfering with the HDAC4-MEF2 signaling pathway

Keywords: CaMKII; Ca2+/calmodulin-activated kinase II; HDAC; histone deacetylase; MEF2; myocyte enhancer factor-2; CaN; calcineurin; NFAT; nuclear factor of activated T-cell; PKD; protein kinase D; ANF; atrial natriuretic factor; βMHC; β-myosin heavy chain; NRVM;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Increased HDAC1 deposition at hematopoietic promoters in AML and its association with patient survival

Keywords: AML; HDAC; ChIP

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Pharmacodynamics of curcumin as DNA hypomethylation agent in restoring the expression of Nrf2 via promoter CpGs demethylation

Keywords: PCa; prostate cancer; Nrf2; nuclear factor erythroid-2 (NF-E2) related factor-2; CUR; curcumin; BGS; bisulfite genomic sequencing; MeDIP; methylation DNA immunoprecipitation; anti-mecyt; anti-methycytosine; HDAC; histone deacetylases; DNMTs; DNA methyltra

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Modulation of chromatin modifying factors' gene expression in embryonic and induced pluripotent stem cells

Keywords: Embryonic stem cells; Induced pluripotent stem cells; Chromatin modifying factors; Differentiation; ESC; embryonic stem cell; MEF; mouse embryonic fibroblasts; mESC; mouse embryonic stem cell; hESC; human embryonic stem cell; iPSC; induced pluripotent ste

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

The hallmarks of CDKN1C (p57, KIP2) in cancer

Keywords: AML; acute myeloid leukemia; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma-x long; BCR-ABL; breakpoint cluster region-V-abl Abelson murine leukemia viral oncogene homolog 1; bHLH; basic helix-loop-helix; BWS; Beckwith-Wiedemann Syndrome; CDK; cy

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Anti-inflammatory effects of [6]-shogaol: Potential roles of HDAC inhibition and HSP70 induction

Keywords: CNS; central nervous system; COX-2; cyclooxygenase-2; GFAP; glial fibrillary acidic protein; HSP; heat-shock protein; HDAC; histone deacetylase; iNOS; inducible nitric oxide syntheses; LPS; lipopolysaccharide; MEM; minimal essential media; MS; MS-275; TSA

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

p53 deacetylation by SIRT1 decreases during protein kinase CKII downregulation-mediated cellular senescence

Keywords: CKII; protein kinase CKII (also known as casein kinase II); DRB; 5,6-dichloro-1-β-d-ribofuranosylbenzimidazole; HDAC; histone deacetylase; MBP; maltose binding protein; NOX; NADPH oxidase; PBS; phosphate-buffered saline; ROS; reactive oxygen species; SA-

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

A novel protein kinase C target site in protein kinase D is phosphorylated in response to signals for cardiac hypertrophy

Keywords: CHK; checkpoint kinase; CRD; cysteine rich domain; DAG; diacylglycerol; ET-1; endothelin-1; GPCR; G-protein-coupled receptor; GSK-3β; glycogen synthase kinase-3β; HDAC; histone deacetylase; IKK; IκB kinase; ISO; isoproterenol; MARK; microtubule associa

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Foxp3 inhibits HDAC1 activity to modulate gene expression in human T cells

Keywords: Foxp3; HDAC; HIV-1; LTR; Treg

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Inhibitory effects of the HDAC inhibitor valproic acid on prostate cancer growth are enhanced by simultaneous application of the mTOR inhibitor RAD001

Keywords: HDAC; mTOR; Prostate carcinoma; Cyclins; Cell cycle

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Regulation of remyelination in multiple sclerosis

Keywords: Remyelination; Oligodendrocytes; Hyaluronan; Wnt; Notch1; Retinoid X receptor; 15d-PGJ(2); 15-deoxy-Δ12,14-prostaglandin J2; CNP; 2′,3′-cyclic nucleotide 3′-phosphodiesterase; CNS; central nervous system; cKO; conditional knockout; dpl; days post l

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

HDAC3 and the molecular brake pad hypothesis

Keywords: Long-term memory; Epigenetics; HDAC; HAT; NCoR

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Acetylation-mediated epigenetic regulation of glucocorticoid receptor activity: Circadian rhythm-associated alterations of glucocorticoid actions in target tissues

Keywords: ACTH; adrenocorticotropic hormone; Dbp; albumin gene D site-binding protein; AMPK; AMP-activated protein kinase; AR; androgen receptor; AVP; arginine vasopressin; bHLH; basic helix-loop-helix; Bmal1; brain-muscle-arnt-like protein 1; CNS; central nervous

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Histone modifications on the adrenergic induction of type II deiodinase in rat pinealocytes

Keywords: AA-NAT; arylalkylamine-N-acetyltransferase; ChIP; chromatin immunoprecipitation; CRE; cAMP response element; CREB; cAMP response element binding protein; Dio2; type II deiodinase; Fra2; Fos-related antigen 2; GAPDH; glyceraldehyde-3-phosphate-dehydrogenas

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Effect of different exercise protocols on histone acetyltransferases and histone deacetylases activities in rat hippocampus

Keywords: histone acetylation; HAT; HDAC; neuroprotection; exercise; rats; BDNF; brain-derived neurotrophic factor; EXE; exercised group; HAT; histone acetyltransferases; HDAC; histone deacetylases; SED; sedentary group;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Epigenetics in neurodegeneration: A new layer of complexity

Keywords: AD; Alzheimer's disease; PD; Parkinson's disease; Aβ; amyloid-β; SN; substantia nigra; APP; amyloid precursor protein; EOAD; early-onset Alzheimer's disease; LOAD; late-onset Alzheimer's disease; SNP; several single nucleotide polymorphisms; MZ; monozyg

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Methotrexate induces apoptosis through p53/p21-dependent pathway and increases E-cadherin expression through downregulation of HDAC/EZH2

Keywords: Methotrexate; p53; p21; HDAC; EZH2;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Histone deacetylase inhibitor sodium butyrate enhances cellular radiosensitivity by inhibiting both DNA nonhomologous end joining and homologous recombination

Keywords: DSB; double strand break; FACS; fluorescence activated cell sorting; HAT; histone acetyltransferase; HDAC; histone deacetylase; HR; homologous recombination; NHEJ; nonhomologous end joining; Sodium butyrate; γ-Irradiation; Histone acetylation; DNA nonhom

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Epigenetics in the mature mammalian brain: Effects on behavior and synaptic transmission

Keywords: HDAC; DNA methylation; MeCP2; Neurotransmission; Synaptic plasticity

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

The role of histone acetylation in age-associated memory impairment and Alzheimer’s disease

Keywords: Histone acetylation; HDAC; HAT; Learning and memory; Neurodegenerative diseases; Alzheimer’s disease; Aging; Epigenetics

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه

Thyroid hormone suppression of β-amyloid precursor protein gene expression in the brain involves multiple epigenetic regulatory events

Keywords: APP; β-amyloid precursor protein; CDS; charcoal/dextran-stripped; ChIP; chromatin immunoprecipitation; FBS; fetal bovine serum; H3-Ac; acetylated histone H3; HDAC; histone deacetylase; HKDM; histone lysine demethylase; H3K4; histone H3 lysine 4; H3K4-2me

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

Lithium induces c-Ret expression in mouse inner medullary collecting duct cells

Keywords: Li+; lithium; mIMCD; murine inner medullary collecting duct; GSK-3β; glycogen synthase kinase 3β; BIO; 6-bromoindirubin-3′-oxime; TCF/LEF; T cell factor/lymphoid enhancer factor; mTOR; mammalian target of rapamycin; Ret; REarranged during Transfection

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه

14-3-3 proteins in neurodegeneration

Keywords: TH; tyrosine hydroxylase; 3′UTR; three prime untranslated region; CSF; cerebrospinal fluid; 2D-PAGE; two-dimensional polyacrylamide gel electrophoresis; PD; Parkinson disease; AD; Alzheimer disease; CJD; Creutzfeldt-Jakob disease; MSA; multiple system a

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2011 سفارش ترجمه