Chromatin-modifying agents in anti-cancer therapy

► Nowadays, many different chromatin-modifying agents (CMAs) have been developed. ► CMAs exert anti-cancer effects through multiple molecular mechanisms. ► A large number of clinical trials are ongoing with CMAs on several cancer types. ► The mechanism by which CMAs provide clinical benefits is not completely understood. ► Combining CMAs to standard therapies is a promising future anti-cancer strategy.