دانلود مقالات ISI درباره Hdac + ترجمه فارسی

NR4A nuclear receptors are orphans but not lonesome

Keywords: 6-MP; 6-mercaptopurine; 9-cis-RA; 9-cis-retinoic acid; AMP; adenosine monophosphate; AMPK; AMP-activated protein kinase; Cam-kinase; calcium/calmodulin-dependent protein kinase; CREB; cAMP response element binding protein; DBD; DNA-binding domain; DSB; DN

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2014 سفارش ترجمه

Design, synthesis, and biological evaluation of 1, 3-disubstituted-pyrazole derivatives as new class I and IIb histone deacetylase inhibitors

Keywords: HDAC; Isoforms selectivity; Structure–activity relationship; Scaffold-hopping

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Inhibition of p300 suppresses growth of breast cancer. Role of p300 subcellular localization

Keywords: BC; breast cancer; CREB; cAMP responsive element binding protein; DMSO; dimethylsulfoxide; VV56; 2-(3-(3,4-dichlorobenzyloxy)phenoxy)pentadecanoic acid; VV59; 2-(3-(3,4-dichlorobenzyloxy)phenoxy)hexadecanoic acid; DMEM; Dulbecco's modified Eagle's medium;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2014 سفارش ترجمه

Keep-ING balance: Tumor suppression by epigenetic regulation

Keywords: bp; base pair; CDK; cyclin-dependent kinase; DNA; desoxyribonucleic acid; DNMT; DNA methyltransferase; H; histone; HAT; histone acetyltransferase; H3K4me3; histone H3 trimethylated on lysine 4; HDAC; histone deacetylase; ING; Inhibitor of growth; mSin3; m

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2014 سفارش ترجمه

Human cytochrome P450 epoxygenases: Variability in expression and role in inflammation-related disorders

Keywords: Inflammation; Cytochrome P450; Epoxygenase; Epoxyeicosatrienoic acids; Variability; AA; arachidonic acid; AhR; aryl hydrocarbon receptor; AP-1; activator protein-1; bZIP; basic leucine zipper; CAR; constitutive androstane receptor; CCRP; cytoplasmic CAR r

دانلود رایگان متن کامل مقاله ISI 28 صفحه سال انتشار : 2014 سفارش ترجمه

PARP and other prospective targets for poisoning cancer cell metabolism

Keywords: ATP; adenosine 5′-triphosphate; 3-BrPA; 3-bromopyruvate; EGFR; epidermal growth factor receptor; FDA; food and drug administration; GSH; glutathione; GSSG; oxidized GSH; GST; glutathione S-transferase; HDAC; histone deacetylase; HIF1; hypoxia inducible

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2014 سفارش ترجمه

Valproic acid increases NO production via the SH-PTP1-CDK5-eNOS-Ser116 signaling cascade in endothelial cells and mice

Keywords: eNOS; endothelial nitric oxide synthase; CDK5; cyclin-dependent kinase 5; JNK; c-Jun N-terminal kinase; Abl; Abelson kinase; SH-PTP; SH2 domain-containing protein tyrosine phosphatase; VPA; valproic acid; HDAC; histone deacetylase; HUVEC; human umbilical

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2014 سفارش ترجمه

Histone deacetylase inhibitor (HDACI) mechanisms of action: Emerging insights

Keywords: HDAC inhibitor; DNA damage response; DNA repair; Cell cycle checkpoints; Apoptosis; Rational combinations; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; APAF-1; apoptotic protease activating factor 1; ASK1; apoptosis signal-regulating ki

دانلود رایگان متن کامل مقاله ISI 78 صفحه سال انتشار : 2014 سفارش ترجمه

Synthesis and HDAC inhibitory activity of isosteric thiazoline-oxazole largazole analogs

Keywords: Largazole; HDAC; Oxazole; Isostere; Conformation;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and bioevalution of novel benzamides derivatives as HDAC inhibitors

Keywords: Benzamide derivatives; HDAC; Antiproliferative activity; Bioavailability;

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

DNA methylation: New therapeutic implications for hepatic fibrosis

Keywords: HSCs; hepatic stellate cells; ECMs; extracellular matrices; α-SMA; α-smooth muscle actin; TGF-β; transforming growth factor-β; PDGF; platelet-derived growth factor; DNMTs; DNA methyltransferases; DNMT1; DNA methyltransferase 1; 5-Aza-dC; 5-Aza-2′-de

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

The discovery of colchicine-SAHA hybrids as a new class of antitumor agents

Keywords: Colchicine; SAHA; HDAC; Tubulin; Hybrid;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Epigenetic regulation of the metallothionein-1A promoter by PU.1 during differentiation of THP-1 cells

Keywords: MT; metallothionein; ChIP; chromatin immunoprecipitation; AML; acute myeloid leukemia; K562PU.1KD; PU.1-knockdown K562; K562PU.1OE; PU.1-overexpressing K562; HDAC; histone deacetylase; Dnmt; DNA methyltransferase; TPA; 12-O-tetradecanoylphorbol-13-acetate

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Akt1 as a putative regulator of Hox genes

Keywords: Hox; homeobox gene; Akt; v-akt murine thymoma viral oncogene homolog; PKB; protein kinase B; PI3K; phosphatidylinositol 3-kinase; RT-PCR; reverse transcription-polymerase chain reaction; MEF; mouse embryonic fibroblast; GEO; gene expression omnibus; COBRA

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

The role of methyl-CpG binding protein 2 in liver fibrosis

Keywords: HSC; hepatic stellate cell; ECMs; extracellular matrices; α-SMA; α-smooth muscle actin; TGF-β; transforming growth factor-β; TRD; Transcriptional Repression Domain; CTD; C-Terminal Domain; PPARγ; peroxisome proliferator-activated receptor-gamma; PDGF

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

ZBTB38 gene polymorphism associated with body measurement traits in native Chinese cattle breeds

Keywords: ZBTB38; zinc finger and BTB domain containing 38; CtBP; C-terminal binding protein; BTB; broad complex, tramtrack and bric-a-brac; CIBZ; murine CtBP-interacting BTB zinc finger protein; ZENON; zinc finger gene expressed in neurons; HDAC; histone deacetyla

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Mitochondria and ALS: Implications from novel genes and pathways

Keywords: ALS; Amyotrophic Lateral Sclerosis; CFP; Cyan Fluorescent Protein; ER; Endoplasmic Reticulum; FUS/TLS; Fused in Sarcoma/Translocated in Liposarcoma; GSH; Glutathione; HAT; Histone Acetyl Transferase; HDAC; Histone Deacetylase; ROS; Reactive Oxygen Species

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Epigenetic regulation of microRNA expression in renal cell carcinoma

Keywords: ccRCC; clear cell renal cell carcinoma; DNMT; DNA methyltransferase; HDAC; histone deacetylase; miR; microRNA; 5-Aza-2′dC; 5-aza-2′-deoxycytidine; SAHA; suberoylanilide hydroxamic acid; RIN; RNA integrity numbers; SDS-PAGE; sodium dodecyl sulphateâ€

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Zinc finger protein 131 inhibits estrogen signaling by suppressing estrogen receptor α homo-dimerization

Keywords: BTB/POZ; broad-complex, tramtrack, and bric-à-brac/poxvirus and zinc finger; ERα; estrogen receptor α; E2; 17β-estradiol; ERE; estrogen response element; HDAC; histone deacetylase; NLS; nuclear localization signal; SUMO; small ubiquitin-like modifier;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Research reportKetamine and imipramine in the nucleus accumbens regulate histone deacetylation induced by maternal deprivation and are critical for associated behaviors

Keywords: HDAC; histone deacetylase; NMDA; N-methyl-d-asparte; Histone deacetylation; Maternal deprivation; Behavior; Depression;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Identification of a histone acetyltransferase as a novel regulator of Drosophila intestinal stem cells

Keywords: ISC; intestinal stem cell; EB; enteroblast; EC; enterocyte; EE; enteroendocrine; HAT; histone acetyltransferase; HDAC; histone deacetylation complex; ATAC; Ada Two-A containing complex; Atac2; ATAC complex component 2; TSA; Trichostatin A; VDRC; Vienna Dr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

The DNA demethylating agent decitabine activates the TRAIL pathway and induces apoptosis in acute myeloid leukemia

Keywords: DAC; 5-aza-2′ Deoxycytidine or Decitabine; DNMT; DNA methyltransferase; HDAC; Histone deacetylase; Acute myeloid leukemia; PML-RAR; DNA methylation; Decitabine; TRAIL; Apoptosis;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Tuning NF-κB activity: A touch of COMMD proteins

Keywords: CFTR; cystic fibrosis transmembrane conductance regulator; COMMD; copper metabolism gene MURR1 domain-containing protein; CRL; Cullin RING ligase; CRM1; chromosome region maintenance 1/exportin 1; CYLD; cylindromatosis; DUB; deubiquitinating enzyme; ENaC;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

ReviewLipids, LXRs and prostate cancer: Are HDACs a new link?

Keywords: Prostate cancer; LXR; Lipids; HDAC;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Targeting DNA damage response: Threshold, chromatin landscape and beyond

Keywords: DSBs; double strand breaks; γ-H2AX; phosphorylation of histone variant H2AX in Ser139; SUMO; small ubiquitin modifier; ROS; reactive oxygen species; IR; ionizing radiation; Tip60; Tat-interactive 60; HAT; histone acetyltransferase; HDAC; histone deacetyl

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Potentiation of anticancer effect of valproic acid, an antiepileptic agent with histone deacetylase inhibitory activity, by the cyclin-dependent kinase inhibitor P276-00 in human non-small-cell lung cancer cell lines

Keywords: CDK inhibitor; P276-00; Valproic acid; HDAC; Combination studies; Non-small-cell lung cancinoma;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Combination of bendamustine and entinostat synergistically inhibits proliferation of multiple myeloma cells via induction of apoptosis and DNA damage response

Keywords: MM; Multiple myeloma; CLL; chronic lymphocytic leukemia; HDAC; histone deacetylase; HDACi; Inhibitor of HDAC; HAT; Histone acetyltransferase; PARP; poly(ADP-ribose) polymerase; ELISA; enzyme-linked immunosorbent assay; PAGE; polyacrylamide gel electrophor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Therapeutic concentrations of valproate but not amitriptyline increase neuropeptide Y (NPY) expression in the human SH-SY5Y neuroblastoma cell line

Keywords: AMI; amitriptyline; AP-1; activator protein 1; Atoh1; atonal homolog-1; BDNF; brain-derived neurotrophic factor; bp; base pair; CREB; cAMP response element-binding protein; Cp; crossing point; ERK; extracellular signal-regulated kinase; DMEM/F12 Ham; Dulb

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Regulation of the cardiac Na+/H+ exchanger in health and disease

Keywords: CaM; calmodulin; CaMKII; Ca2 +/CaM-dependent protein kinase II; CaN; calcineurin; CHP; calcineurin B homologous protein; DAG; diacylglycerol; IP3; inositol 1,4,5-trisphosphate; HDAC; histone deacetylase; LID; lipid-interacting domain; NCX; Na+/Ca2 + exc

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Induction of the liver cancer-down-regulated long noncoding RNA uc002mbe.2 mediates trichostatin-induced apoptosis of liver cancer cells

Keywords: TSA; Trichostatin A; HCC; hepatocellular carcinoma; lncRNA; long non-coding RNA; qRT-PCR; real-time quantitative reverse transcription PCR; HDAC; histone deacetylases; HDACi; histone deacetylase inhibitors; TUNEL; Terminal deoxynucleotidyltransferasedUTP

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Activation of IL-1β and TNFα genes is mediated by the establishment of permissive chromatin structures during monopoiesis

Keywords: Cytokines; Chromatin remodeling; Gene regulation; Hematology; Inflammation; CHART; chromatin accessibility by real-time PCR; HDAC; histone deacetylase; HPC; hematopoietic progenitor cells; TSA; trichostatin A; VD3; 1α,25-dihydroxyvitamin D3;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Chromatin dynamics at the hTERT promoter during transcriptional activation and repression by c-Myc and Mnt in Xenopus leavis oocytes

Keywords: Ac; acetylation; AU; arbitrary units; bHLHZip; basic helix loop helix leucine zipper; bp; basepair; ChIP; chromatin immunoprecipitation; DMS; dimethylsulfate; DNase I; deoxyribonuclease I; dsDNA; double stranded DNA; EMSA; electrophoretic mobility shift a

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Vitamin D receptor signaling mechanisms: Integrated actions of a well-defined transcription factor

Keywords: 1α,25(OH)2D3; 1α,25-dihydroxyvitamin D3; 25(OH)D3; 25-hydroxyvitamin D3; ALOX5; arachidonate 5-lipoxygenase; AR; androgen receptor; CAMP; cathelicidin anti-microbial peptide; CCNC; cyclin C; CDKN1A; cyclin-dependent kinase inhibitor 1A; CoA; co-activato

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Epigenetic upregulation of Bak by ZBP-89 inhibits the growth of hepatocellular carcinoma

Keywords: 5-Aza-dC; 5-aza-2′-deoxycytidine; ChIP; chromatin immunoprecipitation; Co-IP; co-immunoprecipitation; DNMT; DNA methyltransferase; HCC; hepatocellular carcinoma; HDAC; histone deacetylase; MeCP2; methyl-CpG-binding protein 2; MIHA; immortalized non-tumo

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Differential responses of the right ventricle to abnormal loading conditions in vivo: Possible pathophysiologic mechanisms

Keywords: 17; 20; 29; BNP; brain natriuretic peptide; HAT; histone acetyl transferase; HDAC; histone deacetylase; LV; left ventricle; PA; pulmonary artery; RII; receptor type II; RV; right ventricle; SD; standard deviation; SL2; Schneider's Drosophila line 2; Sp; s

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Resveratrol induces nuclear factor-κB activity in human cardiac cells

Keywords: AMPK; AMP-activated protein kinase; HAT; histone acetyltransferase; HDAC; histone deacetylase; EMSA; electrophoretic mobility shift assay; IKKα; IκBα kinase; ICAM-1; intercellular adhesion molecule-1; IL-6; interleukin 6; MCP-1; monocyte chemoattractan

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and evaluation of N8-acetylspermidine analogues as inhibitors of bacterial acetylpolyamine amidohydrolase

Keywords: APAH; acetylpolyamine amidohydrolase; dppm; bis(diphenylphosphino)methane; 9-BBN; 9-borabicyclo[3.3.1]nonane; DMP; Dess-Martin periodinane; DFMO; α-difluoromethylornithine; Boc2O; di-tert-butyl pyrocarbonate; ESI; electrospray ionization; HRMS; high-re

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

HDAC3 interacts with sumoylated C/EBPα to negatively regulate the LXRα expression in rat hepatocytes

Keywords: CBS; C/EBPα binding site; C/EBPs; CCAAT/enhancer binding proteins; ChIP; chromatin immunoprecipitation assay; Co-IP; co-immunoprecipitation; CYP7A1; cholesterol 7α-hydroxylase; FAS; fatty acid synthase; HDAC; histone deacetylase; HFD-MetS; high-fat-diet

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Downregulation of Ezh2 methyltransferase by FOXP3: New insight of FOXP3 into chromatin remodeling?

Keywords: Ezh2; enhancer of zeste homolog 2; H3K27me3; trimethylation of histone H3 lysine 27; HDAC; histone deacetylase; miR-101; microRNA-101; SATB1; special AT-rich sequence binding protein 1; SKP2; S-phase kinase-associated protein 2; FOXP3; Ezh2; Praja1; Trans

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Trichostatin A protects against cisplatin-induced ototoxicity by regulating expression of genes related to apoptosis and synaptic function

Keywords: CaMK; calcium/calmodulin-dependent protein kinase; HDAC; histone deacetylase; PBS; phosphate-buffered saline; PANTHER; Protein ANalysis THrough Evolutionary Relationships; qPCR; quantitative PCR; SGNs; spiral ganglion neurons; SNAP; synaptosomal-associate

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2013 سفارش ترجمه

Bidirectional regulation of NF-κB by reactive oxygen species: A role of unfolded protein response

Keywords: NF-κB; nuclear factor-κB; UV; ultraviolet; IκB; inhibitor of NF-κB; IKK; IκB kinase; NEMO; NF-κB essential modulator; TNFR; tumor necrosis factor receptor; IL-1R; interleukin-1 receptor; NIK; NF-κB inducing kinase; LPS; lipopolysaccharide; PKD; pro

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-κB activation in neuronal and non-neuronal cells

Keywords: MOR; mu opioid receptor; JNK; c-Jun NH2-terminal kinase; MAPK; mitogen-activated protein kinase; MEK; mitogen-activated protein/extracellular signal-regulated kinase; NF-κB; nuclear factor-kappaB; DP; distal promoter; PP; proximal promoter; Oct-1; octame

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

Targeted acetylation of NF-kappaB/RelA and histones by epigenetic drugs reduces post-ischemic brain injury in mice with an extended therapeutic window

Keywords: CBP; p300/CREB-binding protein; CSF; cerebrospinal fluid; DIV; days in vitro; LDH; lactate dehydrogenase; ip; intraperitoneal; K310; lysine 310; MCAO; middle cerebral artery occlusion; NF-κB; nuclear factor kappa B; OGD; oxygen glucose deprivation; SIRT1

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2013 سفارش ترجمه

The discovery and optimization of novel dual inhibitors of topoisomerase ii and histone deacetylase

Keywords: Podophyllotoxin; HDAC; Topoisomerase II; Cancer; Hybrid; Synergistic effect;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

The sirtuin inhibitor cambinol impairs MAPK signaling, inhibits inflammatory and innate immune responses and protects from septic shock

Keywords: BMDCs; bone marrow-derived dendritic cells; BMDMs; bone marrow-derived macrophages; CpG; CpG motif containing oligonucleotide 1826; DC; dendritic cell; E. coli; Escherichia coli O18; HDAC; histone deacetylase; LPS; lipopolysaccharide; MKP; MAPK phosphatas

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and biological evaluation of indeno[1,2-d]thiazole derivatives as potent histone deacetylase inhibitors

Keywords: Histone deacetylases; HDAC; Hydroxamic acids; Indeno[1,2-d]thiazole; Tricyclic

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2013 سفارش ترجمه

Valproate reduces collagen and osteonectin in cultured bone cells

Keywords: Valproate; Collagen; Osteonectin; Bone; HDAC; hFOB1.19

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

A novel two-step QSAR modeling work flow to predict selectivity and activity of HDAC inhibitors

Keywords: HDAC; Two-step; QSAR; GA-kNN; Predict activity

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Effect of microbial coinfection with HIV-1 and butyric acid-producing anaerobic bacteria on AIDS progression

Keywords: Microbial interaction; Butyrate-producing bacteria; Butyric acid; HDAC

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Histone deacetylase inhibition by trichostatin A mitigates LPS induced TNFα and IL-10 production in human placental explants

Keywords: Cytokine; Epigenetic; HDAC; Placenta; Trichostatin A; TNFα; LPSAZA, 5-aza-2′ deoxycytidine; HAT, histone acetyltransferase; HDAC, histone deacetylase; IUGR, intrauterine growth restriction; LPS, lipopolysaccharide; PBMC, peripheral blood mononuclear cell;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه