دانلود مقالات ISI درباره Hdac + ترجمه فارسی

HDAC inhibitors induce global changes in histone lysine and arginine methylation and alter expression of lysine demethylases

Keywords: HDAC; histone deacetylase; HAT; histone acetyltransferase; HKMT; histone lysine methyltransferase; KDM; lysine demethylase; H3K4Me; histone 3 monomethyllysine 4; H3K4Me2; histone 3 dimethyllysine 4; H3K4Me3; histone 3 trimethyllysine 4; H3K4Ac; histone 3

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

Disruption of ATP-sensitive potassium channel function in skeletal muscles promotes production and secretion of musclin

Keywords: Action potential; Calcium; Natriuretic peptide; Fatty acid; Endurance; AKT; protein kinase B; ANP; atrial natriuretic peptide; ATP; adenosine triphosphate; CaMKII; calcium/calmodulin-dependent protein kinase II; FOXO1; forkhead box O1 transcription factor

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

Long non-coding RNA: A newly deciphered “code” in prostate cancer

Keywords: Androgen receptor; LNCaP; Biomarker; PCa; prostate cancer; ncRNA; non-coding RNAs; lncRNA; long ncRNA; miRNA; microRNA; snRNA; small nuclear RNA; siRNA; small interfering RNA; tRNA; transfer RNA; rRNA; ribosomal RNA; PCA3; PCa antigen 3; PIN; prostatic in

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

The effects of Rpd3 on fly metabolism, health, and longevity

Keywords: HDACs; histone deacetylases; HATs; histone acetyltransferases; SIR2; silent information regulator 2; HDAC; rpd3; dSir2; Drosophila melanogaster; Dietary restriction; Aging; Longevity;

دانلود رایگان متن کامل مقاله ISI 26 صفحه سال انتشار : 2016 سفارش ترجمه

Unravelling exemestane: From biology to clinical prospects

Keywords: AI(s); aromatase inhibitor (s); AKT; protein kinase B; AREG; amphiregulin; BMD; bone mineral density; CYP; cytochrome P450; DHEAS; dehydroepiandrosterone sulfate; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EMA; European Medicine

دانلود رایگان متن کامل مقاله ISI 30 صفحه سال انتشار : 2016 سفارش ترجمه

AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions

Keywords: ACAT1; acetoacetyl-CoA thiolase; ACC; acetyl-CoA carboxylase; AICAR; 5-aminoimidazole-4-carboxamide ribonucleoside; AMPK; AMP-activated protein kinase; ATAC; Ada-two-A-containing; BET; bromodomains and extra-terminal motif; BMAL1; PAS domain-containing pr

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2016 سفارش ترجمه

Epigenetic modifications of triterpenoid ursolic acid in activating Nrf2 and blocking cellular transformation of mouse epidermal cells

Keywords: UA; Nrf2; JB6 P+; DNMT; HDAC; Skin cancer;

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2016 سفارش ترجمه

MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation

Keywords: miR; microRNA; HDAC; histone deacetylase; OA; osteoarthritis; COL2A1; collagen 2; SOX9; SRY (sex-determining region Y)-box 9; RUNX2; Runt-related transcription factor 2; HAT; histone acetyltransferase; TSA; trichostatin A; Mmp13; matrix metalloproteinase

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2016 سفارش ترجمه

Novel histone deacetylase inhibitors derived from Magnolia officinalis significantly enhance TRAIL-induced apoptosis in non-small cell lung cancer

Keywords: NSCLC; non-small cell lung cancer; HDAC; histone deacetylase; HAT; histone acetyltransferase; PM; polyphenol mixture; DMSO; dimethyl sulfoxide; TV; tumor volume; SD; standard deviation; TSA; trichostatin A; Magnolol (PubChem CID: 72300); Honokiol (PubChem

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2016 سفارش ترجمه

Expression of microRNA-195 is transactivated by Sp1 but inhibited by histone deacetylase 3 in hepatocellular carcinoma cells

Keywords: ChIP; chromatin immunoprecipitation; EMSA; electrophoretic mobility shift assay; EST; expression sequence tag; miRNA; microRNA; HAT; histone acetyltransferase; HCC; hepatocellular carcinoma; HDAC; histone deacetylase; qPCR; real-time quantitative RT-PCR

دانلود رایگان متن کامل مقاله ISI 39 صفحه سال انتشار : 2016 سفارش ترجمه

Epigenetic reactivation of RASSF1A by phenethyl isothiocyanate (PEITC) and promotion of apoptosis in LNCaP cells

Keywords: PEITC; phenethyl isothiocyanate; RASSF1A; RAS superfamily protein isoform 1A; DNMT; DNA methyl transferases; HDAC; histone deacetylases; MSP; methylation specific PCR; BGS; bisulfite genomic sequencing; PCa; prostate cancer; RASSF1A; Epigenetics; Demethyl

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2016 سفارش ترجمه

Simvastatin enhances NMDA receptor GluN2B expression and phosphorylation of GluN2B and GluN2A through increased histone acetylation and Src signaling in hippocampal CA1 neurons

Keywords: Simvastatin; Hippocampus; NMDA receptors; Farnesyl-pyrophosphate (FPP); Histone acetylation of GluN2B; Src; α7nAChR; α7 nicotinic acetylcholine receptor; AD; Alzheimer's disease; Aβ; β-amyloid peptides; ACSF; artificial cerebral spinal fluid; AHP; aft

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2016 سفارش ترجمه

Multifaceted plasma membrane Ca2 + pumps: From structure to intracellular Ca2 + handling and cancer

Keywords: CaM; calmodulin; CBS; calmodulin-binding sequence; ER; endoplasmic reticulum; ERK; extracellular signal-regulated kinase; HDAC; histone deacetylase; HUVEC; human umbilical vein endothelial cells; IP3; inositol-1,4,5-trisphosphate; MLEC; mouse lung endothe

دانلود رایگان متن کامل مقاله ISI 46 صفحه سال انتشار : 2016 سفارش ترجمه

Pharmacological modulation of HDAC1 and HDAC6 in vivo in a zebrafish model: Therapeutic implications for Parkinson's disease

Keywords: Abdil solution; antibody dilution solution; A.U.; arbitrary units; BBB; blood brain barrier; BSA; bovine serum albumin; DCPIP; 2,6-dichlorophenolindophenol; DD; deacetylase domain; dpf; days post fertilization; DMB; dynein motor binding; HAD; HDAC associa

دانلود رایگان متن کامل مقاله ISI 47 صفحه سال انتشار : 2016 سفارش ترجمه

Toll-like receptor-3 mediates HIV-1 transactivation via NFκB and JNK pathways and histone acetylation, but prolonged activation suppresses Tat and HIV-1 replication

Keywords: TLR3; HIV; Viral transactivation; LTR; NFκB; JNK; STAT1; Histone acetylation; Epigenetics; Human monocyte-derived macrophages; TZM-bl; U38 cells; AP-1; activator protein-1; B2M; beta-2-microglobulin; BCA; bicinchoninic acid; CAT; chloramphenicol acetyltr

دانلود رایگان متن کامل مقاله ISI 56 صفحه سال انتشار : 2016 سفارش ترجمه

Redox biology and the interface between bioenergetics, autophagy and circadian control of metabolism

Keywords: ARE; antioxidant response element; ATP; adenosine triphosphate; 5-hmC; hydroxymethylcytosine; ATG; AuTophaGy related; BNIP; Bcl-2/adenovirus E18 19-kDa-interacting protein; Drp1; dynamin related protein 1; EpRE; electrophile response element; eNOS; endoth

دانلود رایگان متن کامل مقاله ISI 57 صفحه سال انتشار : 2016 سفارش ترجمه

Quantitative proteomics in Giardia duodenalis—Achievements and challenges

Keywords: 2-DE; two-dimensional gel electrophoresis; ADI; arginine deiminase; AUC; area under the curve; CW; cyst wall; CWP; cyst wall protein; DDA; data-dependent acquisition; DIA; data-independent acquisition; ERIF; environmentally resistant infective form; ESV;

دانلود رایگان متن کامل مقاله ISI 66 صفحه سال انتشار : 2016 سفارش ترجمه

OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors

Keywords: Mouse Model; Colon Cancer; Signal Transduction; Tumor Suppression; co-IP; co-immunoprecipitation; CRC; colorectal cancer; EMT; epithelial-to-mesenchymal transition; HDAC; histone deacetylase; IB; immunoblotting; mRNA; messenger RNA; TBE; T-cell factor 4 b

دانلود رایگان متن کامل مقاله ISI 69 صفحه سال انتشار : 2016 سفارش ترجمه

Benzofused hydroxamic acids: Useful fragments for the preparation of histone deacetylase inhibitors. Part 2: 7-Fluorobenzothiophenes and benzofurans

Keywords: HDAC; Hydroxamic acids; Fragment approach

دانلود رایگان متن کامل مقاله ISI 4 صفحه سال انتشار : 2015 سفارش ترجمه

Histone acetyltransferase PCAF is involved in transactivation of Bcl-6 and Pax5 genes in immature B cells

Keywords: B cell development; DT40; Epigenetics; Gene targeting; Histone acetyltransferase; Bach2; BTB and CNC homology 2; Bcl-6; B cell lymphoma-6; Blimp-1; B lymphocyte-induced maturation protein-1; ChIP; chromatin immunoprecipitation; EBF1; early B cell factor 1

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Lacosamide reduces HDAC levels in the brain and improves memory: Potential for treatment of Alzheimer's disease

Keywords: Lacosamide; HDAC; Object recognition; Radial arm maze; Acetylcholinesterase;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2015 سفارش ترجمه

Hybrids from 4-anilinoquinazoline and hydroxamic acid as dual inhibitors of vascular endothelial growth factor receptor-2 and histone deacetylase

Keywords: Hybrid; 4-Anilinoquinazoline; Hydroxamic acid; VEGFR-2; HDAC;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Discovery of 1-hydroxypyridine-2-thiones as selective histone deacetylase inhibitors and their potential application for treating leukemia

Keywords: Drug resistance; HDAC; Pyrithione; Thiohydroxamic acid; Leukemia;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Interaction of autophagy with microRNAs and their potential therapeutic implications in human cancers

Keywords: AAV; adeno-associated viruses; AML; acute myeloid leukemia; ARC; apoptosis repressor with caspase recruit domain; ATG; autophagy-related gene; ATRA; all trans-retinoic acid; BECN 1; Beclin-1; BIF-1; Bax-interacting factor-1; CMA; chaperone-mediated autoph

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Design, synthesis and antiproliferative activities of novel benzamides derivatives as HDAC inhibitors

Keywords: HDAC; Acrylamide; Benzamides derivatives; Synthesis; Antiproliferative; Pharmacokinetic

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Histone deacetylases (HDACs) and brain function

Keywords: Histone; HDAC; HAT; Brain function; Epigenetics; Neuroepigenetics

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Ginsenoside 20(s)-Rh2 as potent natural histone deacetylase inhibitors suppressing the growth of human leukemia cells

Keywords: Leukemia; HDAC; Ginsenoside; Apoptotic

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Pituitary adenylate cyclase-activating polypeptide is regulated by alternative splicing of transcriptional repressor REST/NRSF in nerve injury

Keywords: NP; neuropathic pain; DRG; dorsal root ganglion; PACAP; pituitary adenylate cyclase-activating polypeptide; REST; repressor element 1-silencing transcription factor; RE1; repressor element 1; RT; reverse transcription; L5-SNT; L5-spinal nerve transection;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

SALL4: An emerging cancer biomarker and target

Keywords: ESCs; embryonic stem cells; AML; acute myeloid leukemia; CSCs; cancer stem cells; iPS; induced pluripotent stem cell; HSCs/HPCs; hematopoietic stem/progenitor cells; MDS; myelodysplastic syndrome; LSCs; leukemic stem cells; CML; chronic myeloid leukemia;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

The thioacetate-ω(γ-lactam carboxamide) HDAC inhibitor ST7612AA1 as HIV-1 latency reactivation agent

Keywords: HIV; Reactivation; Latency; HDAC; Shock-and-kill

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Turtle anoxia tolerance: Biochemistry and gene regulation

Keywords: Heat shock response; NF-kappaB; Unfolded protein response; FoxO; p53; HDAC;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers

Keywords: Cytokine; Estrogen; Sex hormone; SIAH1; SIAH2; ACK1/TNK2; activated CDC42-associated kinase 1; AR; androgen receptor; ATM; ataxia telangiectasia mutated; ATR; ataxia telangiectasia mutated related; BF; biochemical failure; DCC; deleted in colorectal cance

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Haloperidol metabolite II prodrug: Asymmetric synthesis and biological evaluation on rat C6 glioma cells

Keywords: Glioma; HDAC; Sigma receptors; Inhibitors; Medicinal chemistry

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

The role of chromatin repressive marks in cognition and disease: A focus on the repressive complex GLP/G9a

Keywords: AAV-Cre; adeno-associated virus with Cre recombinase; AMPA; alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; BDNF; brain-derived neurotrophic factor; BIX-01924; G9a inhibitor; CA1; cornu ammonis 1; DNA; deoxyribonucleic acid; Drd1; dopamine recep

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Research ArticleDefeating EpCAM+ liver cancer stem cells by targeting chromatin remodeling enzyme CHD4 in human hepatocellular carcinoma

Keywords: AFP; alpha-fetoprotein; CHD; chromodomain-helicase-DNA-binding proteins; CSC; cancer stem cell; DSBs; double strand breaks; EpCAM; epithelial cell adhesion molecule; HCC; hepatocellular carcinoma; HDAC; histone deacetylase; HpSC; hepatic stem cell-like; N

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

HDAC expression and activity is upregulated in diseased lupus-prone mice

Keywords: SLE; HDAC; B cells; T cells; Glomerular cells;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Interplay between histone acetylation/deacetylation and poly(ADP-ribosyl)ation in the development of ischemic tolerance in vitro

Keywords: Ischemia tolerance; Preconditioning; NMDA; Histone acetylation/deacetylation; Poly(ADPribosyl)ation; HDAC inhibitors; HAT; histone acetyl transferase; HDAC; histone deacetylase; OGD; oxygen-glucose deprivation; SAHA; suberoylanilide hydroxamic acid; PARP;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

GSK3β-activation is a point of convergence for HIV-1 and opiate-mediated interactive neurotoxicity

Keywords: CNS; central nervous system; HIV-1; human immunodeficiency virus-1; HAND; HIV-1-associated neurocognitive disorders; cART; combination antiretroviral therapy; Tat; trans-activator of transcription; gp120; glycoprotein 120; GSK3β; glycogen synthase kinase

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts

Keywords: AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; BAX; Bcl-2-associated X protein; DNMT; DNA methyltransferase; Dox; doxorubicin; DRAM; damage-regulated autophagy modulator; HDAC; histone deacetylase; LC3; microtubule-associated protein 1 l

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Original Full Length ArticleWnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma

Keywords: Osteosarcoma; WIF1; HDAC; Methylation; Osteoblast; Osteoporosis;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Apelin protects against acute renal injury by inhibiting TGF-β1

Keywords: AKI; Acute kidney injury; ATN; Acute tubular necrosis; TGF-β1; Transforming growth factor- β1; HAT; Histone acetyltransferase; HDAC; Histone deacetylase; HMTs; Histone methyltransferases; HDMs; Histone demethyltransferases; H/R; Hypoxia/reperfusion; I/R

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

PAX transcription factors in neural crest development

Keywords: BMP; bone morphogenetic protein; CDH syndrome; Craniofacial-Deafness-Hand syndrome; Cdx; gene of the caudal homeobox gene family; E n; mouse embryonic day n (e.g. E16); FGF; fibroblast growth factor; GFAP; glial fibrillary acidic protein; GRN; gene regula

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Silencing Daxx increases the anti-tumor activity of a TRAIL/shRNA Bcl-xL-expressing oncolytic adenovirus through enhanced viral replication and cellular arrest

Keywords: TRAIL; tumor necrosis factor-related apoptosis-inducing ligand; Daxx; death domain-associated protein; STAT; signal transducer and activator of transcription; PI; propidium iodide; FACS; fluorescence-activated cell sorter; MTS; 3-(4,5-dimethylthiazol-2-yl

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Acetylation mediates Cx43 reduction caused by electrical stimulation

Keywords: GJ; gap junctions; Cx43; connexin43; HAT; histone acetylase; HDAC; histone deacetylase; CM; cardiomyocyte; NRCM; neonatal rat cardiomyocyte; hCStC; human cardiac stromal cell; Electrical field stimulation; Gap junctions; Acetylation; Connexin43;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

The histone deacetylase inhibitor cambinol prevents acidic pHe-induced anterograde lysosome trafficking independently of sirtuin activity

Keywords: SIRT; sirtuin; NHE; sodium proton exchanger; Tro; troglitazone; JLA; juxtanuclear lysosome aggregation; EIPA; ethyl-isopropyl amiloride; LAMP-1; lysosome associated membrane protein 1; HDAC; histone deacetylase; pHe; extracellular pH; MTOC; microtubule or

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2015 سفارش ترجمه

Incidence and risk of xerosis with targeted anticancer therapies

Keywords: Bcr-Abl; CD20; CD52; dry skin; EGFR; HDAC; HER2; incidence; MEK; mTOR; Raf; risk; xerosis; VEGFRADL, activities of daily living; AE, adverse event; CI, confidence interval; CTCAE, Common Terminology Criteria for Adverse Events; dAE, dermatologic adverse e

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Phosphodiesterase inhibitor, pentoxifylline enhances anticancer activity of histone deacetylase inhibitor, MS-275 in human breast cancer in vitro and in vivo

Keywords: HDAC; MS-275; PDE; Pentoxifylline; Apoptosis; Xenograft

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

Antagonistic role of natural compounds in mTOR-mediated metabolic reprogramming

Keywords: AMPK; AMP-activated protein kinase; EGCG; epigallocatechin-3-gallate; CG; cardiac glycoside; 4E-BP; eukaryotic initiation factor 4E (eIF4E)-binding protein; FAS; fatty acid synthase; FoxO; forkhead box O; GLUT; glucose transporter; HK2; hexokinase-2; HIF-

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2015 سفارش ترجمه

ReviewTranscriptional dysregulation in Huntington's disease: The role of histone deacetylases

Keywords: AD; Alzheimer's disease; BDNF; brain derived neurotrophic factor; CBP; CREB binding protein; CREB; cAMP response element binding protein; GDNF; glial-cell derived neurotrophic factor; HD; Huntington's disease; HDAC; histone deacetylases; HDACI; histon

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه

GCDCA down-regulates gene expression by increasing Sp1 binding to the NOS-3 promoter in an oxidative stress dependent manner

Keywords: Cholestatic liver disease; Endothelial nitric oxide synthase; Oxidative stress; Transcription factor Sp1; Glycochenodeoxycholic acid; ADHP; 0-acetyl-3, 7-dihydroxyphenoxazine; ALT; alanine aminotransferase; AST; aspartate aminotransferase; BDL; bile duct

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2015 سفارش ترجمه