Histone demethylase PHF8 regulates hypoxia signaling through HIF1α and H3K4me3
Keywords: PHF8; HIF1α; KDM3A; H3K4me3; Hypoxia; Prostate cancer;
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Inhibition of histone/lysine acetyltransferase activity kills CoCl2-treated and hypoxia-exposed gastric cancer cells and reduces their invasiveness
Keywords: Ac; acetylated; BH3; Bcl2 homology 3; CM-H2-DCFDA; 5-(and 6)-chloromethyl-2,7-dichlorodihydrofluorescein diacetate acetyl ester; CoCl2·6H2O; cobalt chloride hexahydrate; Cyt c; cytochrome c; DAPI; (4â²,6-Diamidino-2-phenylindole Dilactate; ERK; extracel
Targeting GPNMB with glembatumumab vedotin: Current developments and future opportunities for the treatment of cancer
Keywords: AE; Adverse Event; α-MSH; alpha-Melanocyte Stimulating Hormone; ADC; Antibody-Drug Conjugate; ASPS; Alveolar Soft Part Sarcoma; ASPSCR1; Alveolar Soft Part Sarcoma Chromosome Region Candidate 1; BMP-2; Bone Morphogenetic Protein-2; BRK; Breast Tumor Kina
Osteogenesis imperfecta: new genes reveal novel mechanisms in bone dysplasia
Keywords: ADAMTS; A disintegrin and metalloprotease with thrombospondin motifs; AR-OI; autosomal recessive osteogenesis imperfecta; ATF6; activating transcription factor 6; ATGL; adipose triglyceride lipase; BiP; binding immunoglobulin protein; BMDD; bone mineraliz
Study on the role of Hsa-miR-31-5p in hypertrophic scar formation and the mechanism
Keywords: HS; Hypertrophic scars; ECM; Extracellular matrix; HIF1α; Hypoxia inducible factor1 α; HSFBs; Hypertrophic scar fibroblasts; VEGF; Vascular endothelial growth factor; TIMP-1; Tissue inhibitors of metalloproteinase; TAD; Transcriptional activation domain
Activation of the Hypoxia Inducible Factor 1α Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones
Keywords: Gallstone; NAFLD; Hypoxia; Aquaporin-8; AQP; aquaporin; CCD; cholesterol and cholate-rich diet; cDNA; complementary DNA; HIF1; hypoxia-inducible factor 1; HIF1α; hypoxia-inducible factor 1 α subunit; Hmox1; heme oxygenase-1; IBDU; isolated bile duct uni
The role of the TOR pathway in mediating the link between nutrition and longevity
Keywords: TOR; target of rapamycin; TSC; tuberous sclerosis complex; Rheb; Ras homologue enriched in brain; 4EBP; 4E binding protein; S6K; S6 kinase; PI3K; phosphatidylinositol-3-kinase; Raptor; regulatory-associated protein of mTOR; Deptor; DEP domain-containing m
Molecular neurobiology of mTOR
Keywords: 4E-BPs; 4E-binding proteins; Atg13; autophagy-related protein 13; BDNF; brain-derived neurotrophic factor; CGG; trinucleotide; EGF; epidermal growth factor; FXS; Fragile X syndrome; Hif1α; hypoxia-inducible factor 1-α; LTD; long-term depression; LTP; lo
Potential of α7 nicotinic acetylcholine receptor PET imaging in atherosclerosis
Keywords: 5-HT3; type of 5-hydroxytryptamine (serotonin) receptor; (125I-)αBTX; (125I-labeled) α-bungarotoxin; α-CT; α-contotoxin, α7 nAChR antagonist; AAA; abdominal aorta aneurysm; ACh; acetylcholine; AChE; acetylcholinesterase; AngII; angiotensin II therapy
Microvascular NADPH oxidase in health and disease
Keywords: ROS; reactive oxygen species; NADPH; nicotinamide-adenine-dinucleotide phosphate; Nox; NADPH oxidase; BBB; blood-brain barrier; Ang II; angiotensin II; TRP channels; transient receptor potential channels; DPI; diphenyleneiodonium; PKC; protein kinase C; M
Hif1α is required for osteoclast activation and bone loss in male osteoporosis
Keywords: Testosterone; Osteoporosis; Hif1α; Male; Osteoclasts; Bone;
Cobalt chloride-mediated protein kinase Cα (PKCα) phosphorylation induces hypoxia-inducible factor 1α (HIF1α) in the nucleus of gastric cancer cell
Keywords: Cobalt chloride; Gastric epithelial cell; HIF1α; Hypoxia; p300; PKC; CoCl2·6H2O; Cobalt chloride hexahydrate; DAG; Diacylglycerol; DAPI; 4â²,6-Diamidino-2-Phenylindole, Dilactate; DN; Dominant negative; GECs; Gastric epithelial cells; HDAC1; Histone-de
Dietary lipid concentration affects liver mitochondrial DNA copy number, gene expression and DNA methylation in large yellow croaker (Larimichthys crocea)
Keywords: ATPase 6; ATP synthase 6; COX; Cytochrome c oxidase; CS; Citrate synthase; CYTB; Cytochrome b; D-loop; Displacement loop; HIF1α; Hypoxia-inducible factor 1α; mtDNA; Mitochondrial DNA; MDA; Malondialdehyde; ND6; NADH dehydrogenase subunit 6; ND2; NADH de
Pomolic acid suppresses HIF1α/VEGF-mediated angiogenesis by targeting p38-MAPK and mTOR signaling cascades
Keywords: Pomolic acid; EGF; Angiogenesis; HIF1α; VEGF; mTOR; EGF; Epidermal growth factor; EGFR; Epidermal growth factor receptor; VEGF; Vascular endothelial growth factor; HIF; hypoxia-inducible factor; HRE; hypoxia-response elements; MAPK; Mitogen-activated pro
Suppression of ERK1/2 and hypoxia pathways by four Phyllanthus species inhibits metastasis of human breast cancer cells
Keywords: ERK1/2; HIF1α; MCF-7; neoplasm metastasis; Phyllanthus species;
mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances
Keywords: mTORC1; Rapamycin; Proteomics; KPNA2; HIF1α; Glycolysis;
DAB2IP regulates EMT and metastasis of prostate cancer through targeting PROX1 transcription and destabilizing HIF1α protein
Keywords: Prostate cancer; EMT; Metastasis; DAB2IP; PROX1; HIF1α;
Genomics of human fatty liver disease reveal mechanistically linked lipid droplet-associated gene regulations in bland steatosis and nonalcoholic steatohepatitis
Keywords: ACACB; acetyl-CoA carboxylase beta acetyl-CoA carboxylase beta; ACAT1; acetyl-CoA acetyltransferase 1; ACLY; ATP citrate lyase; AMPK; 5â²AMP-activated protein kinase; ASCL1; acyl-CoA synthetase long-chain family member 1; ACSL4; acyl CoA synthetases long
Targeting respiratory complex I to prevent the Warburg effect
Keywords: OXPHOS; oxidative phosphorylation; CI; complex I; ROS; reactive oxygen species; TCA; tricarboxylic acid; PARP1; poly (ADP ribose) polymerase 1; AMPK; AMP activated kinase; mTORC1; mammalian target of rapamycin complex 1; HIF1α; hypoxia inducible factor 1
Nuclear EGFR renders cells radio-resistant by binding mRNA species and triggering a metabolic switch to increase lactate production
Keywords: nEGFR; mRNA; Hif1α; PDH; Warburg effect;
NOX1 mediates chemoresistance via HIF1α/MDR1 pathway in gallbladder cancer
Keywords: Gallbladder cancer; NOX1; HIF1α; MDR1; Chemoresistance; Cisplatin;
Hypoxia inducible factor-1α: Its role in colorectal carcinogenesis and metastasis
Keywords: HIF1α; Metastasis; Stemness; Tumor resistance; Colorectal cancer;
The role of hypoxia and HIF1α in the regulation of STAR-mediated steroidogenesis in granulosa cells
Keywords: HIF1α; Steroidogenesis; STAR; KK1 granulosa cells;
Non-coding RNA repertoires in malignant pleural mesothelioma
Keywords: AD; adenocarcinoma; ADARB2; RNA-specific adenosine deaminase, B2; aCGH; array comparative genomic hybridization; BAPE; benign asbestos-related pleural effusion; CCND1; cyclin D1; ceRNA; competing endogenous RNA; CREB; cAMP response element binding protein
Development of Long Noncoding RNA-Based Strategies to Modulate Tissue Vascularization
Keywords: angiogenesis; endothelial cell biology; hypoxia; lncRNA; EC; endothelial cell; EHT; engineered heart tissue; GFP; green fluorescent protein; HIF1α; hypoxia-inducible factor 1α; HUVEC; human umbilical vein endothelial cell; lincRNA; long intergenic nonco
Plasma membrane gp96 enhances invasion and metastatic potential of liver cancer via regulation of uPAR
Keywords: mgp96; uPAR; Liver cancer; MAPK; DFS; ADAMTS9; a disintegrin-like and metalloprotease domain with thrombospondin type 1 motifs 9; AIMP1; aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; AKT; v-akt murine thymoma viral oncogene homo
The loss of NDRG2 expression improves depressive behavior through increased phosphorylation of GSK3β
Keywords: NDRG2; N-myc downstream-regulated gene 2; HIF1α; hypoxia-inducible factor 1 α; HSP90; heart shock protein 90; NDRG2; AKT; GSK3β; HIF1α; HSP90;
MYC and metabolism on the path to cancer
Keywords: 2-DG; 2-deoxyglucose; 4E-BP; eIF4E-binding protein; 5,10-methylene THF; 5,10-methylenetetrahydrofolate; ACC; acetyl-CoA carboxylase; ACLY; ATP-citrate lyase; AMPK; AMP-activated protein kinase; ATP; adenosine triphosphate; ChIP-seq; chromatin immunoprecip
β-Catenin Signaling and Roles in Liver Homeostasis, Injury, and Tumorigenesis
Keywords: WNT; β-Catenin; E-Cadherin; Liver Fibrosis; NASH; HCC; Liver Tumors; AJ; adherens junction; APC; adenomatous polyposis coli gene product; FNH; focal nodular hyperplasia; FOXO; forkhead box protein O; GS; glutathione synthetase; GSK3β; glycogen synthase
Targeting eIF4GI translation initiation factor affords an attractive therapeutic strategy in multiple myeloma
Keywords: c-Myc; myelocytomatosis viral oncogene homolog; eIF4GI; eukaryotic translation initiation factor 4GI; ERα; Estrogen receptor α; HIF1α; hypoxia inducible factor 1α; NQO1; NAD(P)H quinone-oxydoreductase 1; MM; multiple myeloma; VEGF; vascular endothelia
Gemcitabine plus sorafenib versus gemcitabine alone in advanced biliary tract cancer: A double-blind placebo-controlled multicentre phase II AIO study with biomarker and serum programme
Keywords: Advanced biliary tract cancer; BTC; Sorafenib; Hand-foot syndrome; VEGFR-2; VEGFR-3; c-kit; PDGFRβ; Hif1α;
Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-β1-mediated anchorage
Keywords: Angiogenesis; GD3; Integrin-β1; Pancreatic ductal adenocarcinoma; S phase; B-MAA; biotinylated-Maackia amurensis lectin; b-FGF; basic fibroblast growth factor; B-SNA; biotinylated-Sambucus nigra lectin; DAPI; 4â²,6-diamidino-2-phenylindole; ECM; extra-c
The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival
Keywords: AIF; apoptosis inducing factor; Akt; v-Akt murine thymoma viral oncogene; AP-1; activator protein 1; ARE; antioxidant responsive element; ASK1; apoptosis signal-regulated kinase 1; ATM; ataxia telangiectasia mutated; Duox; Dual oxidase enzymes; DUSP3; dua
Zebrafish as a model system for mitochondrial biology and diseases
Keywords: 2,5-DHBA; 2,5-dihydroxybenzoic acid; ALS; amyotrophic lateral sclerosis; ATP; adenosine triphosphate; Bcl-2; B-cell lymphoma 2; CMT2; Charcot-Marie-Tooth 2; CNS; central nervous system; coA; coenzyme A; COX; cytochrome c oxidase; DA; dopaminergic; dpf; da
MicroRNA-dependent cross-talk between VEGF and HIF1α in the diabetic retina
Keywords: CeRNA; competing endogenous RNA; DKK1; Dickkopf-1; DM; diabetes mellitus; DR; diabetic retinopathy; HG; high glucose; HIF1α; hypoxia-inducible factor 1-alpha; ICAM-1; intercellular adhesion molecule-1; miRNA; microRNA; MRE; microRNA response element; mRN
MicroRNA-503 targets FGF2 and VEGFA and inhibits tumor angiogenesis and growth
Keywords: VEGFA; vascular endothelial growth factor A; FGF2; fibroblast growth factor-b; HCC; hepatocellular carcinomas; HIF1α; hypoxia inducible transcription factor 1α; Angiogenesis; miR-503; FGF2; VEGFA; Methylation;
Complex I impairment in mitochondrial diseases and cancer: Parallel roads leading to different outcomes
Keywords: CI; complex I; CIII; complex III; CIV; complex IV; CV; complex V; DB; decyl-benzoquinone; D-loop; displacement loop; HIF1α; hypoxia inducible factor 1α; LDH; lactate dehydrogenase; LHON; Leber's hereditary optic neuropathy; LS; Leigh syndrome; MELAS; mi
Overexpression of LC3A autophagy protein in follicular and diffuse large B-cell lymphomas
Keywords: Autophagy; Follicular lymphomas; Diffuse large B-cell lymphomas; HIF1α; LDH5;
Endothelin-1 induces hypoxia inducible factor 1α expression in pulmonary artery smooth muscle cells
Keywords: Endothelin-1; HIF1α; Proteasome; Calcineurin; RACK1;
Aminoguanidine normalizes ET-1-induced aortic contraction in type 2 diabetic Otsuka Long-Evans Tokushima Fatty (OLETF) rats by suppressing Jab1-mediated increase in ETA-receptor expression
Keywords: AG; aminoguanidine; AGEs; advanced glycation end-products; CML; N epsilon-(carboxymethyl) lysine; ECE1; endothelin converting enzyme; ERK; extracellular signal-regulated kinase; ET-1; endothelin-1; ETA-R; endothelin type A receptor; ETB-R; endothelin type
Regulation and protection of mitochondrial physiology by sirtuins
Keywords: Acetyl-CoA; acetyl-coenzyme A; AceCS2; acetyl-coenzyme A synthethase 2; ACC; Acetyl-CoA carboxylase; ADP; adenosine diphosphate; AIF; apoptosis-inducing factor; AMPK; 5â² adenosine monophosphate-activated protein kinase; ANT; adenine nucleotide transloca
Compatibility art of traditional Chinese medicine: From the perspective of herb pairs
Keywords: ADME; absorption, distribution, metabolism and excretion; APL; acute promyelocytic leukemia; CHM; Chinese herbal medicine; CYP2E1; Cytochrome P450 2E1; dl-THP; dl-tetrahydropalmatine; HIF1α; hypoxia-inducible factor-1alpha; HUVECs; human umbilical vascul
Naringenin and quercetin reverse the effect of hypobaric hypoxia and elicit neuroprotective response in the murine model
Keywords: HIF1α; Hypoxia inducible factor 1α; VEGF; Vascular endothelial growth factor; HSPs; Heat shock proteins; CHIP; C-terminus Hsp70 interacting protein; NGEN; Naringenin; UPS; Ubiquitin proteasome system; QUR; Quercetin; Ub; Ubiquitin; FITC; Fluorescein iso
Stem cells as the root of pancreatic ductal adenocarcinoma
Keywords: ABC; ATP binding cassette; ALDH1; Aldehyde dehydrogenase 1a1; Arx; Aristalless-related homeobox; EMT; Epithelial-to-mesenchymal transition; CAC; Centroacinar cells; CD; Cluster of differentiation; CDKN2A; Cyclin-dependent kinase inhibitor 2A; CSC; Cancer
Hedgehog Controls Hepatic Stellate Cell Fate by Regulating Metabolism
Keywords: Mouse Model; Liver Disease; Signal Transduction; Gene Regulation; α-SMA; α-smooth muscle actin; BDL; bile duct ligation; 2DG; 2-deoxy-glucose; DTG; double-transgenic; FBP; fructose bisphosphatase; GFP; green fluorescent protein; GLI; glioblastoma; Hh;
Upregulation of hypoxia-inducible factor 1 alpha in local vein wall is associated with enhanced venous thrombus resolution
Keywords: HIF1α; hypoxia-inducible factor 1α; VEGF; vascular endothelial growth factor; PLGF; placental growth factor; IVC; inferior vena cava; L-mim; L-mimosine; Hypoxia; Hypoxia-inducible factor; Angiogenesis; Thrombus resolution;
Diverging prognostic impacts of hypoxic markers according to NSCLC histology
Keywords: NSCLC; Prognostic impact; Stroma; HIF1α; HIF2α; CAIX; LDH5; GLUT1;
PPARγ activation induces autophagy in breast cancer cells
Keywords: PPARγ; Autophagy; Breast cancer; HIF1α; BNIP3;
In vivo characterization of a reporter gene system for imaging hypoxia-induced gene expression
Keywords: 18F-FMISO; 18F-fluoromisonidazole; 124I-FIAU; 124I-5-iodo-2â²-fluoro-2â²deoxy-1-beta-d-arabino-furanosyl-uracil; eGFP; enhanced green fluorescent protein; HIF; hypoxia-inducible factor; HIF1α; hypoxia-inducible factor subunit 1 alpha; HRE; hypoxia resp
Protection of retinal cells from ischemia by a novel gap junction inhibitor
Keywords: Ischemia; Cobalt Chloride (CoCl2); Gap junctions; Retinal degeneration; Hypoxia; Caspase-3; HIF1α; PQ1;