Regulation of IGF-1 but not TGF-β1 by NGF in the smooth muscle of the inflamed urinary bladder
Keywords: NGF; IGF-1; TGF-β1; Urinary bladder; Inflammation;
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Polysaccharides derived from Lycium barbarum suppress IGF-1-induced angiogenesis via PI3K/HIF-1α/VEGF signalling pathways in MCF-7 cells
Keywords: LBPs; Breast cancer; IGF-1; PI3K; HIF-1α; VEGF; Angiogenesis;
Effects of bench step exercise on arterial stiffness in post-menopausal women: Contribution of IGF-1 bioactivity and nitric oxide production
Keywords: IGF-1; Bench step exercise; Elderly women; Pulse wave velocity; Nitric oxide;
The effect of growth factors on both collagen synthesis and tensile strength of engineered human ligaments
Keywords: IGF-1; TGF-beta; Ascorbic acid; EGF; Regenerative medicine; Design of experiments
Research ReportIGF-1 induces hypoxia-inducible factor 1α-mediated GLUT3 expression through PI3K/Akt/mTOR dependent pathways in PC12 cells
Keywords: IGF-1; GLUT3; HIF-1α; (PI3K)/Akt/mTOR pathways; PC12 cells;
Neonatal repetitive maternal separation causes long-lasting alterations in various neurotrophic factor expression in the cerebral cortex of rats
Keywords: Brain; Development; Stress; BDNF; TrkB; IGF-1; IGF-1R;
Effects of lycopene and apigenin on human umbilical vein endothelial cells in vitro under angiogenic stimulation
Keywords: BHT; butylated hydroxytoluene; DMSO; dimethyl sulfoxide; EBM-2; endothelial basal medium; EGM-2; endothelial growth medium; EGF; epidermal growth factor; FBS; fetal bovine serum; FGF; fibroblast growth factor; Hep3B; a human hepatoma cell line; HUVEC; hum
Serum Resistin and Inflammatory and Endothelial Activation Markers in Obese Adolescents
Keywords: BMI; Body mass index; CAM; Cellular adhesion molecule; CCL2; Chemokine ligand 2; CVD; Cardiovascular disease; ET-1; Endothelin-1; ICAM-1; Intercellular adhesion molecule 1; IGF-1; Insulin-like growth factor 1; IL; Interleukin; TNFα; Tumor necrosis factor
Therapeutic potential of PEGylated insulin-like growth factor I for skeletal muscle disease evaluated in two murine models of muscular dystrophy
Keywords: Duchenne MD; Mouse models; IGF-1; PEGylated IGF-1
Human breast carcinoma cells are induced to apoptosis by samsum ant venom through an IGF-1-dependant pathway, PI3K/AKT and ERK signaling
Keywords: CFSE; carboxyfluorescein diacetate succinimidyl ester; ERK; extracellular signal-regulated kinase; IGF-1; insulin-like growth factor-1; PI3K; phosphatidylinositol-3 kinase; PKB or AKT; protein kinase B; SAV; samsum ant venom; Ant; Apoptosis; Breast cancer
Enhancing follicular growth as a prerequisite for GnRH treatment of true anestrum in buffalo
Keywords: Buffalo; Insulin; rbST; Nutritional supplementation; IGF-1;
Effect of triploidy on growth and ionoregulatory performance in ocean-type Chinook salmon: A quantitative genetics approach
Keywords: Triploid; Growth; IGF-1; Gill; Na+, K+-ATPase; Additive genetic variance
Quantitative analysis of exogenous IGF-1 administration of intervertebral disc through intradiscal injection
Keywords: Intervertebral disc; IGF-1; Disc degeneration; Growth factor therapy
Endocrinal disturbances and systemic inflammatiom in chronic obstructive pulmonary disease (COPD)
Keywords: COPD; Sex hormones; IGF-1; C-Reactive protein
Wheel running attenuates microglia proliferation and increases expression of a proneurogenic phenotype in the hippocampus of aged mice
Keywords: Exercise; Proliferation; Hippocampus; Neurogenesis; Insulin-like growth factor; IGF-1; Aging; Microglia;
Growth hormone treatment for sustained pain reduction and improvement in quality of life in severe fibromyalgia
Keywords: Growth hormone; GH; Fibromyalgia; Pain; Fatigue; IGF-1; FIQ; VAS; EQ5D; Adult growth hormone deficiency; Safety;
Downregulation of GPR83 in the hypothalamic preoptic area reduces core body temperature and elevates circulating levels of adiponectin
Keywords: GPR; G protein-coupled receptor; WSN; warm sensitive neurons; POA; preoptic area; CBT; core body temperature; shRNAs; short-hairpin RNAs; GIR; glucocorticoid-induced receptor; Treg; regulatory T cells.; Lentivirus; RNAi; shRNA; Knockdown; Warm sensitive n
Effects of orexin A on proliferation, survival, apoptosis and differentiation of 3T3-L1 preadipocytes into mature adipocytes
Keywords: AKT; protein kinase B (PKB); BrDU; 5-bromo-2â²-deoxyuridine; C/EBPα; CCAAT/enhancer binding protein alpha; cAMP; cyclic adenosine monophosphate; DEXA; dexamethasone; ERK1/2; extracellular signal-regulated kinase 1/2; FCS; fetal calf serum; HPRT; hypoxan
Behavioral and neurobiological characteristics of social stress versus depression in nonhuman primates
Keywords: ACTH; adrenocorticotropic hormone; BP; binding potential; BMI; body mass index; CRH; corticotropin-releasing hormone; CSF; cerebrospinal fluid; Dex; dexamethasone; D2; dopamine receptor D2; HPA; hypothalamic-pituitary-adrenal; HDL-C; high density lipo
Determining skeletal maturation using insulin-like growth factor I (IGF-I) test
Keywords: CVM stages; IGF-1; MP3 stages; Orthodontic therapy; Skeletal maturity;
Progranulin compensates for blocked IGF-1 signaling to promote myotube hypertrophy in C2C12 myoblasts via the PI3K/Akt/mTOR pathway
Keywords: Progranulin; IGF-1; Muscle hypertrophy; C2C12 myoblast; Signaling;
Elevated IGFBP3 Levels in Diabetic Tears: A Negative Regulator of IGF-1 Signaling in the Corneal Epithelium
Keywords: Diabetes; cornea; epithelium; tears; IGFBP3; IGF-1; IGF-1R
Ghrelin improves body weight loss and skeletal muscle catabolism associated with angiotensin II-induced cachexia in mice
Keywords: Ang II; angiotensin II; IGF-1; insulin-like growth factor 1; CHF; chronic heart failure; MuRF1; muscle RING finger protein 1; GHS-R; growth hormone secretagogue receptor; GH; growth hormone; sc; subcutaneous; ip; intraperitoneal; RT-PCR; real-time polymer
Striatal dopamine receptors modulate the expression of insulin receptor, IGF-1 and GLUT-3 in diabetic rats: Effect of pyridoxine treatment
Keywords: Dopamine receptor; Insulin receptor; IGF-1; GLUT-3; Pyridoxine
Cognitive, Behavioral, and Systems NeuroscienceResearch PaperSpatial memory is improved by aerobic and resistance exercise through divergent molecular mechanisms
Keywords: spatial learning; memory; hippocampus; physical exercise; water maze; BDNF; brain-derived neurotrophic factor; CaMKII; calcium/calmodulin-dependent kinase II; IGF-1; insulin-like growth factor 1; IGF-1R; receptor for IGF-1;
Dysbiosis of Gut Microbiota (DOGMA) - A novel theory for the development of Polycystic Ovarian Syndrome
Keywords: PCOS; Polycystic Ovarian Syndrome; LH; Lutenizing Hormone; FSH; Follicle Stimulating Hormone; SHBG; Sex Hormone Binding Globulin; DOGMA; Dysbiosis of Gut Microbiota; LPS; lipopolysaccaride; CFU; colony forming units; SCFA; short chain fatty acids; IBS; Ir
Influence of membrane ion channel in pituitary somatotrophs by hypothalamic regulators
Keywords: GH; growth hormone; GHRH; growth hormone-releasing hormone; GHS; GH secretagogue; SRIF; somatotropin-releasing inhibitory factor; cAMP; cyclic adenosine monophosphate; VGCCs; voltage-gated calcium channels; [Ca2+]i; intracellular free calcium concentratio
Impaired recruitment of neuroprotective microglia and T cells during acute neuronal injury coincides with increased neuronal vulnerability in an amyotrophic lateral sclerosis model
Keywords: ALS; amyotrophic lateral sclerosis; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GDNF; glial cell line-derived neurotrophic factor; Iba1; ionized calcium-binding adaptor molecule 1; IGF-1; insulin-like growth factor 1; iNOS; inducible nitric oxide syn
Response patterns of cytokines/chemokines in two murine strains after irradiation
Keywords: IR; ionizing radiation; TBI; total body irradiation; G-CSF; granulocyte colony-stimulating factor; GM-CSF; granulocyte-macrophage colony stimulating factor; IGF-1; insulin-like growth factor-1; PDGF; platelet-derived growth factor; SCF; stem cell factor
Effects of compound heterozygosity at the Xpd locus on cancer and ageing in mouse models
Keywords: AUC; area under the curve; CH; compound heterozygote; CS; Cockayne syndrome; GG-NER; global genome NER; IGF-1; insulin-like growth factor 1; IGF-1R; insulin-like growth factor receptor; IR; ionizing radiation; MDF; mouse dermal fibroblast; MEF; mouse embr
Research paperMorphological and morphometric characteristics of vestibular hair cells and support cells in long term cultures of rat utricle explants
Keywords: AIC; Akaike's information criterion; ANOVA; analysis of variance; BDNF; brain-derived neurotrophic factor; DIV; days in vitro; FITC; fluorescein isothiocyanate; HC; hair cell; IGF-1; insulin-like growth factor type one; LM; light microscopy; P4; 4-day-
Sequential delivery of BMP-2 and IGF-1 using a chitosan gel with gelatin microspheres enhances early osteoblastic differentiation
Keywords: Chitosan; Gelatin microspheres; Glyoxal; BMP-2; IGF-1
Regenerative Effects of Moxibustion on Skeletal Muscle in Collagen-Induced Arthritic Mice
Keywords: collagen-induced arthritis; direct moxibustion; IGF-1; myostatin; phospho-Erk1/2; skeletal muscle; TGF-β1
Rates of molecular evolution vary in vertebrates for insulin-like growth factor-1 (IGF-1), a pleiotropic locus that regulates life history traits
Keywords: Insulin-like growth factor 1; IGF-1; Reptile; Molecular evolution; Protein structure
Elevated expressions of GH/IGF axis genes in triploid crucian carp
Keywords: GH; GHR; IGF-1; Triploids; Tetraploids; Fast growth
In vitro mechanisms involved in the regulation of cell survival by lithium chloride and IGF-1 in human hormone-dependent breast cancer cells (MCF-7)
Keywords: Lithium chloride; IGF-1; Breast cancer; GSK-3β;
Sodium arsenite represses the expression of myogenin in C2C12 mouse myoblast cells through histone modifications and altered expression of Ezh2, Glp, and Igf-1
Keywords: Arsenite; Myocyte; Myogenin; Histone; Igf-1; Glp
Role of phospholipase Cε in physiological phosphoinositide signaling networks
Keywords: PLC; phosphoinositide-specific phospholipase C; PKC; protein kinase C; LPA; lysophosphatidic acid; S1P; sphingosine-1 phosphate; Epac; Exchange protein directly activated by cAMP; GPCR; G protein-coupled receptor; GEF; guanine nucleotide exchange factor;
PI3K/Akt pathway activation was involved in acute ethanol-induced fatty liver in mice
Keywords: AMPK; AMP-dependent kinase; FAS; fatty acid synthases; GSK-3β; glycogen synthase kinase-3β; IGF-1; insulin-like growth factor-1; PDK1; phosphoinositide-dependent protein kinase 1; PDGF; platelet-derived growth factor; PI3K; phosphatidylinositol 3 kinase
PAPP-A negatively regulates ABCA1, ABCG1 and SR-B1 expression by inhibiting LXRα through the IGF-I-mediated signaling pathway
Keywords: PAPP-A; pregnancy-associated plasma protein-A; IGF-1; insulin-like growth factor 1; IGF-1R; insulin-like growth factor 1 receptor; PI3-K; phosphatidylinositol 3-kinase; Akt; Akt kinase or protein kinase B (PKB); ABCA1; ATP-binding cassette transporter A1;
Internalization and induction of antioxidant messages by microvesicles contribute to the antiapoptotic effects on human endothelial cells
Keywords: Act D; actinomycin D; ATP; adenosine triphosphate; BSA; bovine serum albumin; CMH; 1-hydroxy-3-methoxycarbonyl-2,2,5,5-tetramethylpyrrolidine; Cu/Zn-SOD; copper/zinc superoxide dismutase; CUR61414; N-((3S,5S)-1-(benzo[d][1,3]dioxol-5-ylmethyl)-5-(piperazi
Sp1 is involved in regulation of cystathionine γ-lyase gene expression and biological function by PI3K/Akt pathway in human hepatocellular carcinoma cell lines
Keywords: CSE; cystathionine γ-lyase; PLP; pyridoxal-5â²-phosphate; PI3K; phosphoinositide 3-kinase; Myr-Akt2; myristylated variants of Akt2; IGF-1; insulin-like growth factor-1; PTEN; phosphatase and tensing homolog; CHX; cycloheximide; MEF; mouse embryonic fibr
Effects of voluntary running on plasma levels of neurotrophins, hippocampal cell proliferation and learning and memory in stressed rats
Keywords: BDNF, brain-derived neurotrophic factor; BrdU, bromodeoxyuridine; CORT, corticosterone; DCX, doublecortin; GCL, granular cell layer; IGF-1, insulin-like growth factor; LTP, long-term potentiation; PBS, phosphate-buffered salinecorticosterone; BDNF; IGF-1;
Clinical ScienceFNDC5 and irisin in humans: I. Predictors of circulating concentrations in serum and plasma and II. mRNA expression and circulating concentrations in response to weight loss and exercise
Keywords: BMI; body mass index; GH; growth hormone; IGF-1; insulin-like growth factor 1; IGFBP-3; insulin-like growth factor binding protein 3; PGC1-α; PPARγ coactivator 1 alpha; PPARγ; peroxisome proliferator-activated receptor gamma; UCP1; uncoupling protein 1
Insulin-Like Growth Factor 1 Physiology
Keywords: Insulin-like growth factor 1; Physiology; Mouse models; IGF-1;
Redox-regulating role of insulin: The essence of insulin effect
Keywords: 4-HNE; 4-hydroxynonenal; 8-OHdG; 8-hydroxydeoxyguanosine; 8-OHG; 8-hydroxyguanine; 8-iso-PGF2α; 8-iso-prostaglandin F2α; AD; Alzheimer's disease; AIDS; acquired immunodeficiency syndrome; Akt; protein kinase B; AMI; acute myocardial infarction; APS; a
Specificity of peripheral nerve regeneration: Interactions at the axon level
Keywords: AKT/PKB; protein kinase B; BDNF; brain derived neurotrophic factor; cAMP; cyclic adenosine monophosphate; CAMs; cell adhesion molecules; Cdc42; cell division control protein 42 homolog; cGMP; cyclic guanosine monophosphate; ChAT; choline acetyltransferase
Serum insulin-like growth factor type 1 concentrations in healthy dogs and dogs with spontaneous primary hypothyroidism
Keywords: Dog; IGF-1; Bodyweight; Primary hypothyroidism; Thyroid gland
Adiponectin and IGF-1 are negative acute phase proteins in a dog model of acute endotoxaemia
Keywords: Adiponectin; CRP; Hp; Dog; Endotoxaemia; IGF-1
High fat diet induced insulin resistance and glucose intolerance are gender-specific in IGF-1R heterozygous mice
Keywords: IGF-1; IGF-1R; Igf1r+/−; SGA; HFD; Type 2 diabetes