Behavioral and neurobiological characteristics of social stress versus depression in nonhuman primates

► Social stress and depression have many characteristics in common and promote each other. ► Stress and depression adversely affect social relationships, quality of life, and disease risk. ► However, social stress and depression are not the same constructs. ► The behavior and neurobiology of social stress and depression are different. ► Discrimination between stress and depression is crucial in animal models.