Mixed lineage kinase 3 negatively regulates IKK activity and enhances etoposide-induced cell death
Keywords: MLK3; NF-κB; Apoptosis; IKK;
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TRAF6 negatively regulates TNFα-induced NF-κB activation
Keywords: TRAF6; IL-1α; TNFα; NF-κB; IKK
Regenerative pharmacology in the treatment of genetic diseases: The paradigm of muscular dystrophy
Keywords: MD; muscular dystrophies; DMD; duchenne muscular dystrophy; DAPC; dystrophin-associated protein complex; DGC; dystrophin-glycoprotein complex; DG; dystroglycans; SCG; sarcoglycans; nNOS; neuronal nitric oxide synthase; NO; nitric oxide; HDAC; histone deac
Rac1 regulates peptidoglycan-induced nuclear factor-κB activation and cyclooxygenase-2 expression in RAW 264.7 macrophages by activating the phosphatidylinositol 3-kinase/Akt pathway
Keywords: COX; cyclooxygenase; DMEM/F-12; Dulbecco's modified Eagle's medium/Ham's F-12; ECL; enhanced chemiluminescence; ERK; extracellular signal-regulated kinase; FCS; fetal calf serum; GFP; green fluorescence protein; IKK; IκB kinase; IL-1; interleukin-1; ILR;
Decrease in RelA phosphorylation by inhibiting protein kinase A induces cell death in NF-κB-expressing and drug-resistant tumor cells
Keywords: IAP; inhibitor of apoptosis protein; H-7; 1-(5-isoquinolinesulfonyl)-2-methylpiperazine; H-8; (methylamino)ethyl-5-isoquinolinesulfonamide; IKK; IκBα kinase; Kemptide; Leu-Arg-Arg-Ala-Ser-Leu-Gly; MSK; mitogen activated stress kinase; MTT; 3-(4,5-dimeth
Angiotensin II Activates IκB Kinase Phosphorylation of RelA at Ser536 to Promote Myofibroblast Survival and Liver Fibrosis
Keywords: ACE; angiotensin converting enzyme; α-SMA; smooth muscle α-actin; AT1; angiotensin type 1 receptor; IκB; inhibitor of NF-κB; IKK; IκB kinase; NF-κB; nuclear factor-κB; P-Ser536-RelA; RelA phosphorylated on serine 536;
c-Met Confers Protection Against Chronic Liver Tissue Damage and Fibrosis Progression After Bile Duct Ligation in Mice
Keywords: AFP; α-fetoprotein; Alb-Cre; albumin promoter-Cre transgenic animals; Alfp-Cre; albumin/AFP promoter/enhancer; BDL; bile duct ligation; BrdU; bromodeoxyuridine; c-Met; mesenchymal-epithelial transition factor; DAPI; 6-diamidino-2-phenylindole; HGF; hep
Peripheral blood mononuclear cell NF-κB p105 mRNA decreases during asthmatic attacks
Keywords: Bronchial asthma; NF-κB; Peripheral blood mononuclear cell (PBMC); cDNA; complementary DNA; CRP; C-reactive protein; CTR; carboxy-terminal region; EDTA; ethylenediaminetetraacetic acid; GINA; global initiative for asthma; GM-CSF; granulocyte-macrophage
Enhanced binding of TBK1 by an optineurin mutant that causes a familial form of primary open angle glaucoma
Keywords: TBK1; Optineurin; Glaucoma; TNF; NEMO; IKK;
Intermolecular disulfide bond formation in the NEMO dimer requires Cys54 and Cys347
Keywords: NEMO; Disulfide bond; NF-κB; IKK; Hydrogen peroxide; Cysteine; Molecular modeling
The human IKKβ subunit kinase domain displays CK2-like phosphorylation specificity
Keywords: IκB; IKK; NF-κB; Protein kinase; Signal transduction; Transcriptional regulation
IKBKG (nuclear factor-κB essential modulator) mutation can be associated with opportunistic infection without impairing Toll-like receptor function
Keywords: NEMO; Toll-like receptors; IκB; Inhibitor of nuclear factor-κB; IKK; Inhibitor of nuclear factor-κB kinase; NEMO; Nuclear factor-κB essential modulator; NF-κB; Nuclear factor-κB; NK; Natural killer; TCR; T-cell receptor; TLR; Toll-like receptor;
G-protein-dependent and -independent pathways regulate proteinase-activated receptor-2 mediated p65 NFκB serine 536 phosphorylation in human keratinocytes
Keywords: PAR-2; proteinase-activated receptor-2; PAR-2 AP; PAR-2 activating peptide; 2f-LIGKV-OH; 2-furoyl-LIGKV-hydroxyl; NFκB; nuclear factor kappa B; IKK; inhibitory kappa B kinase; PKC; protein kinase C; siRNA; small interfering ribonucleic acid; RNAi; ribonu
Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline
Keywords: Aniline; Spleen; Oxidative stress; NF-κB; AP-1; IKK; MAPK; Cytokines;
Protective effect of Ginkgolids (A + B) is associated with inhibition of NIK/IKK/IκB/NF-κB signaling pathway in a rat model of permanent focal cerebral ischemia
Keywords: GKAB; Ginkgolid A and B, Ginkgolids (A + B); IKK; IκBα kinase; NIK; NF-κB-inducing kinase; NF-κB; nuclear factor kappaB; LPS; lipopolysaccharide; pMCAO; permanent middle cerebral artery occlusion; p-NIK,; phosphorylated NIK; p-IKKα,; phosphorylated
NUMBL interacts with TAB2 and inhibits TNFα and IL-1β-induced NF-κB activation
Keywords: NF-κB; nuclear factor kappa B; IL-1β; interleukin-1β; TNF; tumor necrosis factor; NUMBL; homologous protein of numb like; TAK1; TGF-β activated kinase1; TAB2; TAK1-binding protein 2; TRAF6; TNF receptor-associated factor 6; TRAF2; TNF receptor-associa
NF-κB is a critical regulator of the survival of rodent and human hepatic myofibroblasts
Keywords: Bcl-2; B-cell CLL/lymphoma 2; DNA; deoxyribonucleic acid; EMSA; electrophoretic mobility shift assay; HM; hepatic myofibroblast; HSC; hepatic stellate cell; IKK; IκBα kinase; JNK; Jun N-terminal kinase; LPS; lipopolysaccharide; TIMP-1; tissue inhibitor
PKCθ cooperates with atypical PKCζ and PKCι in NF-κB transactivation of T lymphocytes
Keywords: CA; constitutive active; DN; dominant negative; I-κB; inhibitor of NFκB; IKK; I-κB-kinase; NFκB; nuclear factor of κB; PMA; phorbol myristate acetate; PH; pleckstrin homology domain; (PI)3K; phosphatidylinositol 3-kinase; PKC; protein kinase C; PTEN;
α-MSH inhibits TNF-α-induced matrix metalloproteinase-13 expression by modulating p38 kinase and nuclear factor κB signaling in human chondrosarcoma HTB-94 cells 1
Keywords: HTB-94 cell; α-MSH; TNF-α; MMP-13; p38 MAP kinase; IKK; NF-κB
Kinin B1 and B2 receptor expression in osteoblasts and fibroblasts is enhanced by interleukin-1 and tumour necrosis factor-α. Effects dependent on activation of NF-κB and MAP kinases
Keywords: AP-1; activator protein-1; BCA; bicinchoninic acid; BK; bradykinin; BSA; essentially fatty acid free fetal bovine serum albumin; CASE; Cellular Activation of Signalling ELISA; COX-2; cyclooxygenase-2; CRE; cyclic AMP responsive element; DALBK; des-Arg10-L
Both IKKα and IKKβ are implicated in the arsenite-induced AP-1 transactivation correlating with cell apoptosis through NF-κB activity-independent manner
Keywords: IKK; AP-1; NF-κB; Cell death; Arsenite
Analysis of innate immune signal transduction with autocatalytic expression vectors
Keywords: IL-1; interleukin-1; IL8; interleukin-8; TLR; toll-like receptor; IL-1RI; type 1 interleukin-1 receptor; TIR; Toll/interleukin-1 receptor; miR; micro-ribonucleic acid; LPS; lipopolysaccharide: NF-κB, Nuclear Factor kappa B(see also RelA); RelA; reticuloe
Activation-Induced Cytidine Deaminase Links Between Inflammation and the Development of Colitis-Associated Colorectal Cancers
Keywords: AID; activation-induced cytidine deaminase; IKK; IκB kinase; IL; interleukin; NF-κB; nuclear factor κB; PCR; polymerase chain reaction; siRNA; small interfering RNA; STAT; signal transducers and activators of transcription; TCR; T-cell receptor; TNF; t
Raf Protects Against Colitis by Promoting Mouse Colon Epithelial Cell Survival Through NF-κB
Keywords: DSS; dextran sulfate sodium; ERK; extracellular signal regulated kinase; IκB; inhibitor of nuclear factor-κB; IKK; inhibitor of κB kinase; IL; interleukin; KOIE; intestinal epithelium-specific knockout; MAPK; mitogen activated protein kinase; NF-κB; n
Bioactive lipids in metabolic syndrome
Keywords: ABCA1; ATP-binding cassette transporter A1; ACC; acetyl-CoA carboxylase; ACO; acyl-CoA oxidase; CDHA; conjugated DHA; CEPA; conjugated EPA; CFAs; conjugated fatty acids; CLA; conjugated LA; CLN; conjugated LNA; CPT; carnitine palmitoyltransferase; CYP7A1;
Hypomorphic nuclear factor-κB essential modulator mutation database and reconstitution system identifies phenotypic and immunologic diversity
Keywords: NEMO; immunodeficiency; genetic database; Jurkat reconstitution; NF-κB activation; A20; 7-AAD; 7-Amino actinomycin D; DC; Dendritic cell; EDA; Ectodermal dysplasia and anhidrosis; EMSA; Electrophoretic mobility shift assay; FACS; Fluorescence-activated c
The nerve growth factor and its receptors in airway inflammatory diseases
Keywords: ADAM; a disintegrin and metalloprotease domain; AP-1; activating protein 1; AP-2; clathrin adaptative protein-2; APPL; amyloid precursor protein-like; ARMS; ankyrin repeat-rich membrane spanning; BDNF; brain-derived neurotrophic factor; bFGF; basic fibrob
Inhibitors of NF-κB derived from thalidomide
Keywords: Thalidomide; NF-κB; IKK; Nuclear translocation
Antiinflammatory effects of the cyclopentenone isoprostane 15-A2-IsoP in human gestational tissues
Keywords: TNF; tumor necrosis factor; IL; interleukin; IsoP; isoprostanes; LPS; lipopolysaccharide; NF-κB; nuclear factor-κB; IKK; IκB kinase; 15d-PGJ2; 15-deoxy-12,14 PGJ2; PPAR; peroxisome proliferator-activated receptor; LDH; lactate dehydrogenase; ELISA; enz
The discovery of 2-amino-3,5-diarylbenzamide inhibitors of IKK-α and IKK-β kinases
Keywords: Kinase; IKK; Inhibitor
Synthesis and structure–activity relationship of imidazo(1,2-a)thieno(3,2-e)pyrazines as IKK-β inhibitors
Keywords: IKK; NF-κB; TNF-α; Imidazothienopyrazine
Activation of non-canonical NF-κB pathway mediated by STP-A11, an oncoprotein of Herpesvirus saimiri
Keywords: STP-A11; Herpesvirus saimiri; IKK; NIK; Canonical NF-κB; Non-canonical NF-κB; NF-κB2; p52 protein; p100 processing
Zn2+-induced NF-κB-dependent transcriptional activity involves site-specific p65/RelA phosphorylation
Keywords: Zinc; NF-κB; Airway epithelium; IKK; p65/RelA;
Novel transcriptional regulation of the schlafen-2 gene in macrophages in response to TLR-triggered stimulation
Keywords: PAMP, pathogen-associated molecular pattern; CpG-DNA, DNA containing immunostimulatory CpG motifs; IRAK, IL-1R-associated kinase; TRAF, TNF receptor-associated kinase; IKK; IκB kinase; DEG, differentially expressed gene; ACP, annealing control primer; slf
Transcriptional response of human cells to microbeam irradiation with 2.1 MeV α-particles
Keywords: AT; ataxia telangiectasia; ATM; ataxia telangiectasia mutated; CP; crossing point; DLR; German aerospace center; FBS; fetal bovine serum; GADD; growth arrest and DNA damage inducible; HEK; human embryonic kidney; IκB; inhibitor of κB; IKK; IκB kinase;
Autophagy and NF-κB: Fight for fate
Keywords: Autophagy; Cancer; Hsp90; IKK; NF-κB; Proteasome; Selective degradation; Therapy
Melittin inhibits inflammatory target gene expression and mediator generation via interaction with IκB kinase
Keywords: BV; bee venom; COX; cyclooxygenase; cPLA2; cytosolic phospholipase A2; DTT; dithiothreitol; EMSA; electrophoretic mobility shift assay; GSH; glutathione; IκBs; inhibitors of κB; IKK; IκB kinase; iNOS; inducible nitric oxide synthase; LPS; lipopolysacch
Magnolol suppresses NF-κB activation and NF-κB regulated gene expression through inhibition of IkappaB kinase activation
Keywords: Magnolol; Nuclear factor kappa B; IKK; Anti-inflammation;
15-Deoxy-Î12,14-prostaglandin J2 down-regulates CXCR4 on carcinoma cells through PPARγ- and NFκB-mediated pathways
Keywords: CAY10410; 9,10-dihydro-15-deoxy-Î12,14-prostaglandin J2; COX; cyclooxygenase; DMEM; Dulbecco's modified Eagle's medium; DMSO; dimethyl sulfoxide; GW9662; 2-chloro-5-nitro-N-phenylbenzamide; IKK; inhibitor of κB kinase; MAPK; mitogen-activated protein ki
Interleukin-1 stimulated activation of the COT catalytic subunit through the phosphorylation of Thr290 and Ser62
Keywords: MAP kinase; Interleukin-1; Proinflammatory cytokine; IKK; COT
5-(1H-Benzimidazol-1-yl)-3-alkoxy-2-thiophenecarbonitriles as potent, selective, inhibitors of IKK-ε kinase
Keywords: IKK-ε kinase inhibitors; IKK
NF-κB inhibition: A double-edged sword in cancer?
Keywords: Cancer; Inflammation; Carcinogens; NF-κB; IKK; IκB; TNF; Animal models; Hepatocellular carcinoma; Squamous cell carcinoma
IKKα stabilizes cytosolic β-catenin by inhibiting both canonical and non-canonical degradation pathways
Keywords: IKK; β-catenin; Wnt; NF-κB; Siah-1
NFκB pathway: A good signaling paradigm and therapeutic target
Keywords: IKK; IκB; NFκB; p65; NEMO; TRAF
Phosphorylation of NF-κB1/p105 by oncoprotein kinase Tpl2: Implications for a novel mechanism of Tpl2 regulation
Keywords: Tpl2; Cot; NF-κB1; p105; IKK; MAPK
β-TrCP binding and processing of NF-κB2/p100 involve its phosphorylation at serines 866 and 870
Keywords: NF-κB2/p100 processing; IKK; NIK; Phosphorylation; Proteasome
Human ubiquitin specific protease 31 is a deubiquitinating enzyme implicated in activation of nuclear factor-κB
Keywords: AP1; activator protein 1; DTT; dithiotreitol; DUB; deubiquitinating enzyme; EBV; Epstein-Barr virus; IKK; IκB kinase; JNK; Jun-kinase; LMP1; latent membrane protein 1; LTβR; lymphotoxin β receptor; MAPK; mitogen activated protein kinase; NP-40; Nonidet
The N-terminus of PKR is responsible for the activation of the NF-κB signaling pathway by interacting with the IKK complex
Keywords: PKR; NF-κB; IKK; dsRNA; TLR; Innate immunity
ERK is an anti-inflammatory signal that suppresses expression of NF-κB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells
Keywords: VEGF; vascular endothelial growth factor; HUVECs; human umbilical vein endothelial cells; bFGF; basic fibroblast growth factor; EGF; epidermal growth factor; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; KDR; Flk-1/kinase-insert domain contai
TNFα induces chromosomal abnormalities independent of ROS through IKK, JNK, p38 and caspase pathways
Keywords: TNF; IL-1; IKK; JNK; Chromosomal breaks; Cell cycle; Caspases; IL-1b;