Can NF-κB be a target for novel and efficient anti-cancer agents?
Keywords: Cancer; NF-κB; Chemotherapy; Apoptosis; Proteasome; IKK
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The Ectodysplasin and NFκB signalling pathways in odontogenesis
Keywords: Ectodermal dysplasia; Tooth development; NFκB; Ectodysplasin; Edar; Edaradd; Traf; Nemo; IKK; IκB;
NF-κB as a molecular target in adjuvant therapy of gastrointestinal carcinomas
Keywords: NF-κB; Gastrointestinal carcinoma; Therapeutic target; IKK; IκB kinase; IκB; inhibitor of κB; Ub; ubiquitin; P; phosphorylation; Anti-ox; antioxidants; Asp; aspirin; CsA; cyclosporin A; PTEN; tumour suppressor; Omega; omega-3 fatty acid; ASO; antisens
Identification and characterization of Xenopus laevis homologs of mammalian TRAF6 and its binding protein TIFA
Keywords: BLAST; basic local alignment search tool; FHA; forkhead-associated; IKK; IκB kinase; IL-1R; interleukin-1 receptor; IRAK; IL-1R associated kinase; JNK; Jun N-terminal kinase; PCR; polymerase chain reaction; RANK; receptor activator of NFκB; TIFA; TRAF-i
The IκB kinase (IKK) complex as a critical regulator of immune responses
Keywords: NF-κB; IKK; Inflammation; Immunity;
Sensing and signaling during infection in Drosophila
Keywords: DAP; diaminopimelic acid; DD; death domain; DREDD; death-related ced-3/Nedd2-like DD; FADD; Fas-associated DD-containing protein; GNBP; Gram-negative binding protein; IκB; inhibitory NF-κB; IKK; IκB kinase; JNK; Jun amino-terminal kinase; JAK; Janus fa
Down-regulatory effect of quercitrin gallate on nuclear factor-κB-dependent inducible nitric oxide synthase expression in lipopolysaccharide-stimulated macrophages RAW 264.7
Keywords: IκB; inhibitory κB; IKK; inhibitory κB kinase; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; NF-κB; nuclear factor-κB; NO; nitric oxide; PDTC; pyrrolidine dithiocarbamate; QGR; quercetin 3-O-β-(2â³-galloyl)-rhamnopyranoside; SEAP;
Suppression of macrophage responses to bacterial lipopolysaccharide (LPS) by secretory leukocyte protease inhibitor (SLPI) is independent of its anti-protease function
Keywords: IkB; inhibitor for NF-κB; IKK; IkB kinase; IRAK; IL-1 receptor associated kinase; MyD88; myeloid differentiation antigen 88; SLPI; secretory leukocyte protease inhibitor; TIR; toll IL-1 receptor; TIRAP; TIR domain-containing adapter protein; TRAF; TNF re
Inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by phenolic (3E)-4-(2-hydroxyphenyl)but-3-en-2-one in RAW 264.7 macrophages
Keywords: DCFH-DA; 2â²,7â²-dichlorofluorescein diacetate; EMSA; electrophoretic mobility shift assay; ERK; extracellular signal-regulated kinase; HPB; (3E)-4-(2-hydroxyphenyl)but-3-en-2-one; IκB; inhibitory factor-κB; IKK; IκB kinase; iNOS; inducible NO syntha
IL-1β induces IL-8 in bronchial cells via NF-κB and NF-IL6 transcription factors and can be suppressed by glucocorticoids
Keywords: IL-8; NF-κB; Fluticasone propionate; Lung; IL; Interleukin; Th; T helper; RANTES; regulated upon activation, normal T cell expressed and secreted; GM-CSF; granulocyte-macrophage colony stimulating factor; IRAK; IL-1 receptor associated kinase; NF; nuclea
Signalling pathways in the induction of proteasome expression by proteolysis-inducing factor in murine myotubes
Keywords: Protein degradation; Proteasome proteolysis; Proteolysis-inducing factor (PIF); Protein kinase C; Hydroxyeicosatetraenoic acid (15-HETE); PIF; proteolysis-inducing factor; EPA; eicosapentaenoic acid; 15(S)-HETE; 15-hydroxyeicosatetraenoic acid; PKC; prote
Inhibition of cytokine-induced IκB kinase activation as a mechanism contributing to the anti-atherogenic activity of tilianin in hyperlipidemic mice
Keywords: Tilianin; Atherosclerosis; IKK; Cytokine;
Effects of IκB kinase α on the differentiation of squamous carcinoma cells
Keywords: NF-κB; IKK; Head and neck cancer; Involucrin; Epithelial differentiation; Squamous cell carcinoma;
The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4
Keywords: STKs; Src-family tyrosine kinases; TLR; Toll-like receptor; LPS; lipopolysaccharide; iNOS; inducible nitric oxide synthase; NFκB; nuclear factor κB; MyD88; myeloid differential factor 88; TRAF6; TNF receptor associated factor 6; TRIF; TIR domain-contain
Dying a Thousand Deaths: Redundant Pathways From Different Organelles to Apoptosis and Necrosis
Keywords: Akt; proto-oncogene product of the viral oncogene v-akt; AIF; apoptosis inducing factor; Apaf-1; apoptotic protease activating factor-1; ATF6; activating transcription factor 6; Bad; heterodimeric partner for Bcl-xL and Bcl-2; Bak; Bcl2 homologous antagon
Pertussis toxin-sensitive Gi/o proteins are involved in nerve growth factor-induced pro-survival Akt signaling cascade in PC12 cells
Keywords: NGF; nerve growth factor; EGF; epidermal growth factor; PTX; pertussis toxin; RGSZ1; regulator of G protein signaling Z1; GAIP; Gα-interacting protein; PI3K; phosphatidylinositol 3-kinase; IKK; inhibitor κB kinase; NFκB; nuclear factor-κB; Erk; extrac
Interferons (IFNs) are key cytokines in both innate and adaptive antiviral immune responses-and viruses counteract IFN action
Keywords: Interferons; Innate antiviral immunity; Interferon-regulatory factor; Toll-like receptors; AP-1; activating protein 1; CARD; caspase recruitment domain; CpG DNA; unmethylated double-stranded DNA; DC; dendritic cell; dsRNA; double-stranded RNA; GAS; IFN ga
Clinorotation prevents differentiation of rat myoblastic L6 cells in association with reduced NF-κB signaling
Keywords: DMEM; Dulbecco's modified Eagle's medium; IKK; IκB kinase; MHC; myosin heavy chain; JAXA; Japan Aerospace Exploration Agency; PAGE; polyacrylamide gel electrophoresis; PBS; phosphate-buffered saline; RT-PCR; reverse transcription-polymerase chain reactio
Positive and negative regulation of insulin signaling through IRS-1 phosphorylation
Keywords: Insulin resistance; IRS1; Serine phosphorylation; Kinases; PI 3-kinase; phosphoinositide 3-kinase; Gab1; Grb2-associated binder-1; IRS; insulin receptor substrate; ERK; extracellular signal-regulated kinase; APS; adaptor protein containing PH and SH2 doma
Induction of apoptotic cell death by 2â²-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells
Keywords: HCA; 2â²-hydroxycinnamaldehyde; NF-κB; nuclear transcription factor-κB; TNF-α; tumor necrosis factor-α; ERK; intracellular signal regulated kinase; MAPK; mitogen-activated protein kinase; IKK; IκB kinase; EMSA; electro mobility shift assay; JNK; c-j
Reactive oxygen species and the modulation of stroke
Keywords: Cu,Zn-SOD; copper, zinc-superoxide dismutase; EGF; epidermal growth factor; ERK; extracellular signal-regulated kinase; Fe2+; ferrous iron; FKHRL-1; Forkhead rank ligand-1; Gpx1; glutathione peroxidase-1; IAP; inhibitor of apoptosis protein; IKK; IκB-kin
Phorbol 12-myristate 13-acetate upregulates cyclooxygenase-2 expression in human pulmonary epithelial cells via Ras, Raf-1, ERK, and NF-κB, but not p38 MAPK, pathways
Keywords: COX-2; cyclooxygenase-2; DMEM/Ham's F-12; Dulbecco's modified Eagle's medium/Ham's F-12; ECL; enhanced chemiluminescence; EMSA; electrophoretic mobility shift assay; ERK; extracellular signal-regulated kinase; FCS; fetal calf serum; IKK; IκB kinase; LPS;
Distinct IκB kinase regulation in adult T cell leukemia and HTLV-I-transformed cells
Keywords: ATL; HTLV-I; IKK; Proteasome; Arsenite;
Receptor-independent actions of PPAR thiazolidinedione agonists: Is mitochondrial function the key?
Keywords: AICAR; AMPK activator 5-aminoimidazole-4-carboxamide riboside; AMPK; adenosine 5â²-monophosphate-activated protein kinase; AP1; activator protein 1; AUC; area under the curve; CBP; CREB-binding protein; CNS; central nervous system; COX; cyclooxygenase; C
The 5-HT3 receptor antagonist tropisetron inhibits T cell activation by targeting the calcineurin pathway
Keywords: AP-1; activator protein-1; EMSA; electrophoretic mobility shift assay; 5-HT; serotonin; 5-HTR; serotonin receptor; IKK; IκB kinase; IκB; κB inhibitor; JNK; jun kinase; MAPK; mitogen activated kinase; NF-κB; nuclear factor kappa B; NFAT; nuclear factor
Interferon-γ Inhibits Hepatitis B Virus-Induced NF-κB Activation Through Nuclear Localization of NF-κB-Inducing Kinase
Keywords: DAPI; 4â²,6-diamidino-2-phenylindole; EMSA; electrophoretic mobility shift assay; HBV; human hepatitis B virus; HCC; hepatocellular carcinoma; NF-κB; nuclear factor κB; NIK; NF-κB-inducing kinase; IKK; IκB kinase; IFN; interferon; PBS; phosphate-buff
Inhibition of inhibitor of κB kinases stimulates hepatic stellate cell apoptosis and accelerated recovery from rat liver fibrosis
Keywords: HSC; hepatic stellate cells; IκB; inhibitor of κB; IKK; inhibitor of κB kinase; IL; interleukin; JNK; Jun N-terminal kinase; MMP; matrix metalloproteinase; MPT; mitochondrial permeability transition; NBD; NEMO-binding domain; NF-κB; nuclear factor-κB
Regulatory roles and molecular signaling of TNF family members in osteoclasts
Keywords: AP-1; activator protein-1; ASK1; apoptosis signal-regulated kinase-1; CARD; caspase recruiting domain; CFU-GM; colony forming unit-granulocyte/macrophage; CRD; cysteine-rich repeat; CTR; calcitonin receptor; DD; death domain; DED; death effector domain; E
HDAC inhibition prevents NF-κB activation by suppressing proteasome activity: Down-regulation of proteasome subunit expression stabilizes IκBα
Keywords: SCFA; short chain fatty acid; HDAC; histone deacetylase; NF-κB; nuclear factor-κB; IκB; inhibitor-κB; IKK; IκB kinase; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; BA; butyrate; TSA; trichostatin A; CT-L; chymotrypsin-like; T-L; trypsyn
Signal transduction pathways of nitric oxide release in primary microglial culture challenged with gram-positive bacterial constituent, lipoteichoic acid
Keywords: brain macrophage; signaling; exotoxin; Staphylococcus aureus; CR3; complement receptor type 3; DAPI; 4â² 6â²-diamidino-2-phenylindole hydrochloride; EDTA; edtaethylenediaminetetraacetic acid; EGTA; ethyleneglycol-bis(β-aminoethyl)-N,N,Nâ²,Nâ²-tetraac
Modulation of signal transduction by tea catechins and related phytochemicals
Keywords: EGFR; epidermal growth factor receptor; RTK; receptor tyrosine kinase; EGCG; (â)-epigallocatechin-3-gallate; EGC; (â)-epigallocatechin; ECG; (â)-epicatechin-gallate; EC; (â)-epicatechin; TGFα; transforming growth factor α; EGF; epidermal growth
Curcumin (diferuloylmethane) inhibits constitutive NF-κB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma
Keywords: EMSA; electrophoretic mobility shift assay; IKK; IκB kinase; FBS; fetal bovine serum; IκBα; inhibitory subunit of NF-κB; MCL; mantle cell lymphoma; NF-κB; nuclear transcription factor-κB; NEMO; NF-κB essential modifier; NBD; NEMO-binding domain pep
Honokiol inhibits TNF-α-stimulated NF-κB activation and NF-κB-regulated gene expression through suppression of IKK activation
Keywords: CHX; cycloheximide; EMSA; electrophoretic mobility shift assay; GST; glutathione S-transferase; ICAM-1; intercellular adhesion molecule-1; IL-8; interleukin-8; IκB; inhibitor subunit of NF-κB; IKK; IκB kinase; LPS; lipopolysaccharide; MCP-1; monocyte c
Histamine H1 receptor antagonist blocks histamine-induced proinflammatory cytokine production through inhibition of Ca2+-dependent protein kinase C, Raf/MEK/ERK and IKK/IκB/NF-κB signal cascades
Keywords: H1R; histamine H1 receptor; RT-PCR; reverse transcription-polymerase chain reaction; GM-CSF; granulocyte-macrophage-colony stimulating factor; IL; interleukin; olopatadine; olopatadine hydrochloride; PKC; protein kinase C; MEK; mitogen-activated protein/e
Oxidative stress in the brain: Novel cellular targets that govern survival during neurodegenerative disease
Keywords: Aβ; β-amyloid; AD; Alzheimer's disease; AIF; apoptosis-inducing factor; ALS; amyotrophic lateral sclerosis; Apaf-1; apoptotic protease-activating factor; APC; adenomatous polyposis coli; APP; amyloid precursor protein; BrdU; bromodeoxyuridine; CARD; cas