کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9001768 | 1118554 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Induction of apoptotic cell death by 2â²-hydroxycinnamaldehyde is involved with ERK-dependent inactivation of NF-κB in TNF-α-treated SW620 colon cancer cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
NF-κBJnkERKHCAIKKc-Jun NH2-terminal kinaseEMSAIκB kinase - IkB kinaseMAPK - MAPKtumor necrosis factor-α - تومور نکروز عامل αColon cancer - سرطان کولونNuclear transcription factor-κB - فاکتور رونویسی هسته ای κBTNF-α - فاکتور نکروز توموری آلفاApoptotic cell death - مرگ سلولی آپوپتوزmitogen-activated protein kinase - پروتئین کیناز فعال با mitogen
موضوعات مرتبط
علوم پزشکی و سلامت
داروسازی، سم شناسی و علوم دارویی
داروشناسی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
2â²-Hydroxycinnamaldehyde (HCA) inhibits cell growth of several human cancer cells with unknown mechanisms. We investigated the inhibitory effect of HCA on TNF-α-induced cell growth and possible signal pathway in SW620 colon cancer cells. HCA inhibited TNF-α-induced SW620 colon cell growth in time- and dose-dependent manner through induction of apoptotic cell death. Parallel with inhibitory effect on cell growth, HCA dose dependency inhibited TNF-α-induced activation of NF-κB accompanied with inhibition of the translocation of p50. HCA also induced expression of caspase-3 and Bax, but decreased Bcl-2. HCA furthermore activated ERK pathway, and ERK inhibitor reversed inhibitory effect of HCA on cell growth and transcriptional activation of NF-κB. These results demonstrate that HCA inhibits cell growth through induction of apoptotic cell death by ERK pathway-dependent NF-κB inactivation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical Pharmacology - Volume 70, Issue 8, 15 October 2005, Pages 1147-1157
Journal: Biochemical Pharmacology - Volume 70, Issue 8, 15 October 2005, Pages 1147-1157
نویسندگان
Seung Ho Lee, Chung Woo Lee, Jae Woong Lee, Myoung Suk Choi, Dong Ju Son, Youn Bok Chung, Chong Kil Lee, Ki Wan Oh, Dong Chul Moon, Byoung Mog Kwon, Jin Tae Hong,