Discovery of novel purine-based heterocyclic P2X7 receptor antagonists
Keywords: Human P2X7R; Antagonists; Ethidium bromide uptake; IL-1β; Metabolic stability;
مقالات ISI (ترجمه نشده)
مقالات زیر هنوز به فارسی ترجمه نشده اند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
Reactive oxygen species activated NLRP3 inflammasomes initiate inflammation in hyperosmolarity stressed human corneal epithelial cells and environment-induced dry eye patients
Keywords: Dry eye; Tear film hyperosmolarity; Reactive oxygen species; NLRP3; Inflammasomes; Inflammation; Caspase-1; IL-1β; APCs; antigen presenting cells; ASC; apoptosis-associated speck-like protein containing CARD domain; DE; dry eye; HCEC; human corneal epith
Clinical significance of tumor-derived IL-1β and IL-18 in localized renal cell carcinoma: Associations with recurrence and survival
Keywords: Clear cell renal cell carcinoma; Prognostic biomarker; IL-1β; IL-18; Recurrence-free survival; Overall survival;
Research ArticleDecreased Tim-3 expression is associated with functional abnormalities of monocytes in decompensated cirrhosis without overt bacterial infection
Keywords: Tim-3; T-cell immunoglobulin and mucin domain-containing molecule-3; DC-LC; decompensated liver cirrhosis; C-LC; compensated liver cirrhosis; HC; healthy controls; LPS; lipopolysaccharide; TNF-α; tumor necrosis factor; IL-1β; interleukin-1β; IL-10; int
Interleukin 6 inhibits HBV entry through NTCP down regulation
Keywords: HBV; Hepatitis B virus; NTCP; Sodium taurocholate co-transporting polypeptide; IL-6; Interleukin 6; IFN γ; Interferon gamma; ALT; Alanine aminotransferase; TNFα; Tumor Necrosis Factor alpha; IL-1β; Interleukin 1 beta; OSM; Oncostatin M; PHH; Primary Hu
Expression analysis of the Atlantic bluefin tuna (Thunnus thynnus) pro-inflammatory cytokines, IL-1β, TNFα1 and TNFα2 in response to parasites Pseudocycnus appendiculatus (Copepoda) and Didymosulcus katsuwonicola (Digenea)
Keywords: Atlantic bluefin tuna; Innate immunity; Interleukin-1β; Tumour necrosis factor α; Digenea; Copepoda; Parasite protein extracts; ABT; Atlantic bluefin tuna; TNFα; Tumour necrosis factor alpha; IL-1β; interleukin 1 beta; HK; head kidney; LPS; lipopolysa
Exercise modulates the expression of IL-1β and IL-10 in the articular cartilage of normal and osteoarthritis-induced rats
Keywords: Cartilage; IL-1β; IL-10; Exercise; Osteoarthritis;
Hepatitis C virus NS3 protein enhances cancer cell invasion by activating matrix metalloproteinase-9 and cyclooxygenase-2 through ERK/p38/NF-κB signal cascade
Keywords: AP-1; activation protein-1; CMA; cell matrix adhesion; COX-2; cyclooxygenase-2; ECM; extracellular matrix; ELISA; enzyme-linked immunosorbent assay; EMSA; electrophoretic mobility shift assay; ERK; extracellular signal-regulated kinase; HBV; hepatitis B v
Hypermethylation in gastric cancer
Keywords: 5-hmC; 5-hydroxymethylcytosine; 5-mC; 5-methylcytosine; ADAM23; ADAM metallopeptidase domain 23; APC; adenomatosis polyposis coli; ATP; adenosine-triphosphate; BCL6B; B-Cell CLL/Lymphoma 6, Member B; BGS; bisulfite genomic sequencing; BMP-2; bone morphoge
Temporal profile of M1 and M2 responses in the hippocampus following early 24Â h of neurotrauma
Keywords: TBI; traumatic brain injury; SIC; secondary injury cascades; CCI; controlled cortical impact; M1; classical activation of microglia/macrophages; M2; alternative activation of microglia/macrophages; qRT-PCR; quantitative real-time reverse transcription-pol
Anti-inflammatory activity of curcumin-loaded solid lipid nanoparticles in IL-1β transgenic mice subjected to the lipopolysaccharide-induced sepsis
Keywords: Sepsis; Curcumin; IL-1β; Solid lipid nanoparticles; Lipopolysaccharide; TLR4;
CHF5074 (CSP-1103) induces microglia alternative activation in plaque-free Tg2576 mice and primary glial cultures exposed to beta-amyloid
Keywords: Aβ; β-amyloid; AD; Alzheimer's Disease; AICD; APP Intracellular Domain; APP; Amyloid Precursor Protein; ARG1; Arginase 1; CHF5074; 1-(3â²,4â²-dichloro-2-fluoro[1,1â²-biphenyl]-4-yl)-cyclopropanecarboxylic acid; FIZZ1; Found in Inflammatory Zone; GS
Research ReportInvolvement of NFκB signaling in mediating the effects of GRK5 on neural stem cells
Keywords: AD; Alzheimer׳s disease; GPCR; G protein-coupled receptor; GRK; G-protein receptor kinase; IL-6; interleukin-6; IL-1β; interleukin-1β; NAC; N-acetyl cysteine; NFκB; nuclear factor κB; NPCs; neural progenitor cells; NSCs; neuron stem cells; PKA; prote
A functional inflammasome activation assay differentiates patients with pathogenic NLRP3 mutations and symptomatic patients with low penetrance variants
Keywords: CAPS; Autoinflammation; NLRP3; Variants; IL-1β; TNF-α;
Fibroblast growth factor 21 (FGF21) ameliorates collagen-induced arthritis through modulating oxidative stress and suppressing nuclear factor-kappa B pathway
Keywords: RA; rheumatoid arthritis; FGF21; fibroblast growth factor 21; CIA; collagen-induced arthritis; IL-1β; interleukin-1β; TNF-α; tumor necrosis factor; IL-6; interleukin-6; IFN-γ; interferon-γ; MMP-3; matrix metalloproteinase-3; IL-10; interleukin-10; DE
Research PaperInfluence of JuA in evoking communication changes between the small intestines and brain tissues of rats and the GABAA and GABAB receptor transcription levels of hippocampal neurons
Keywords: GABA; γ-aminobutyric acid; JuA; jujuboside A; DZP; Diazepam; Real-time PCR; reverse transcription-polymerase chain reaction; IL-1α; interleukin-1α; MIP-1α; macrophage inflammatory protein-1α; IL-1β; interleukin-1β; IL-2; interleukin-2; IFN-γ; inte
In vitro evaluation of the cytotoxicity and modulation of mechanisms associated with inflammation induced by perfluorooctanesulfonate and perfluorooctanoic acid in human colon myofibroblasts CCD-18Co
Keywords: BSA; bovine serum albumin; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; IL-1β; interleukin-1β; IL-6; interleukin-6; LPS; lipopolysaccharide; NOAEL; lowest no-observed-adverse-effect level; PFASs; perfluorinated compounds; PFOS; perfluoroalkyl and
ATP binding by NLRP7 is required for inflammasome activation in response to bacterial lipopeptides
Keywords: acLP; acetylated lipopeptides; ASC; apoptosis-associated speck-like protein containing a CARD; ATPase; adenosine triphosphatases; CARD; caspase recruitment domain; DAMP; damage associated molecular pattern; FLICA; fluorescent labeled inhibitor of caspase-
GABAA currents are decreased by IL-1β in epileptogenic tissue of patients with temporal lobe epilepsy: implications for ictogenesis
Keywords: Gamma-aminobutyric acid; GABA; GABA type A receptor; GABAA-R; Hippocampal sclerosis; HS; Interleukin-1β; IL-1β; IL-1 receptor type 1; IL-1R1; IL-1 receptor antagonist; IL-1Ra; Interleukin-1 receptor-associated kinase1; IRAK1; N-methyl-d-aspartate; NMDA;
Activation of MEK/ERK pathways through NF-κB activation is involved in interleukin-1β-induced cyclooxygenease-2 expression in canine dermal fibroblasts
Keywords: NF-κB; ERK1/2; IL-1β; COX-2; Prostaglandin E2; Canine dermal fibroblasts;
Anti-inflammatory sesquiterpenes from Costus speciosus rhizomes
Keywords: ANOVA; analysis of variance; COX-2; cyclooxygenase-2; CNS; central nervous system; COSY; Correlation Spectroscopy; DMEM; Dulbecco's Modified Eagle's Medium; EDTA; ethylenediaminetetraacetate; FBS; fetal bovine serum; HMBC; heteronuclear multiple bond corr
TRPV1 promotes repetitive febrile seizures by pro-inflammatory cytokines in immature brain
Keywords: Febrile seizures; HMGB1; IL-1β; TRPV1;
PDE5 inhibitors as therapeutics for heart disease, diabetes and cancer
Keywords: A1AR; adenosine A1 receptor; ABC transporters; ATP-binding cassette; ABCB1/P-gp/MDR1; P-glycoprotein; ABCG2/BCRP; breast cancer resistant protein; Ang-1; angiopoietin 1; ASCs; Adipose stem cells; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma extra-lar
Research ReportPaeoniflorin attenuates Aβ1-42-induced inflammation and chemotaxis of microglia in vitro and inhibits NF-κB- and VEGF/Flt-1 signaling pathways
Keywords: Aβ; beta-amyloid; AD; Alzheimer׳s disease; CNS; central nervous system; PF; paeoniflorin; TNF-α; tumor necrosis factor α; IL-1β; interleukin 1β; IL-6; interleukin 6; NF-κB p65; nuclear factor kappa B subunit p65; IκBα; NF-κB inhibitor alpha; CXC
Muscle hyperalgesia induced by peripheral P2X3 receptors is modulated by inflammatory mediators
Keywords: ANOVA; analysis of variance; CINC-1; cytokine-induced neutrophil chemoattractant 1; DALBK; Des-Arg9-[Leu8]-BK; EDTA; ethylenediaminetetraacetic acid; ELISA; enzyme-linked immunosorbent assay; IL-1β; interleukin 1β; IL-6; interleukin 6; MPO; myeloperoxid
Robust increase of microglia proliferation in the fornix of hippocampal axonal pathway after a single LPS stimulation
Keywords: BrdU; bromodeoxyuridine; IFN-γ; interferon-γ; IL-1β; interleukin-1β; LPS; lipopolysaccharide; LSD; dorsal part of lateral septal nucleus; NPCs; neural progenitor cells; PBS; phosphate-buffered saline; PBST; PBS containing 0.3% Triton X-100; PFA; paraf
Reduction of inflammatory responses by l-serine treatment leads to neuroprotection in mice after traumatic brain injury
Keywords: l-serine; Mouse; Traumatic brain injury; Neuroprotection; Inflammatory response; Glycine receptor; ELISA; enzyme-linked immunosorbent assay; GFAP; glial fibrillary acidic protein; Iba-1; ionized calcium binding adapter molecule-1; IL-1β; interleukin-1β;
Mouse lung slices: An ex vivo model for the evaluation of antiviral and anti-inflammatory agents against influenza viruses
Keywords: TNF-α; tumour necrosis factor alpha; IL-6; interleukin 6; RANTES; regulated on activation, normal T cell expressed and secreted; MIP-3α; macrophage inflammatory protein 3 alpha; IP-10; interferon-gamma induced protein 10; IL-10; interleukin 10; IL-1β;
Adrenomedullin attenuates interleukin-1β-induced inflammation and apoptosis in rat Leydig cells via inhibition of NF-κB signaling pathway
Keywords: IL-1β; Interleukin-1β; NF-κB; Nuclear factor-kappa B; ADM; Adrenomedullin; DMEM; Dulbecco's modified Eagle's medium; FBS; Fetal bovine serum; DAPI; 6-Dianidino-2-phenylindole dihydrochlor; PARP; Poly adenosine diphosphate-ribose polymerase; PBS; phosph
The anti-inflammatory peptide stearyl-norleucine-VIP delays disease onset and extends survival in a rat model of inherited amyotrophic lateral sclerosis
Keywords: ALS; amyotrophic lateral sclerosis; SOD1; superoxide dismutase 1; VIP; vasoactive intestinal peptide; PACAP; pituitary adenylate cyclase-activating polypeptide; SNV; stearyl-norleucine-VIP; PBS; phosphate-buffered saline; GFAP; glial fibrillary acidic pro
Identifying panaxynol, a natural activator of nuclear factor erythroid-2 related factor 2 (Nrf2) from American ginseng as a suppressor of inflamed macrophage-induced cardiomyocyte hypertrophy
Keywords: Nrf2; nuclear factor erythroid-2 related factor 2; Am. G; American ginseng; iNOS; inducible nitric oxide synthase; LPS; lipopolysaccharide; MCP-1; monocyte chemotactic protein-1; MIP-1β; macrophage inflammatory protein-1 beta; IL-1β; interleukin-1 beta;
Chronic ethanol exposure combined with high fat diet up-regulates P2X7 receptors that parallels neuroinflammation and neuronal loss in C57BL/6J mice
Keywords: CNS; central nervous system; Hipp; hippocampus; Striat; striatum; MidBr; midbrain; iG; intragastric; EtOH; ethanol; HCFD; high fat diet; ATP; adenosine triphosphate; NO; nitric oxide; iNOS; inducible NO synthase; IL-1β; interleukin 1 beta; IL-6; interleu
Chemerin: A comprehensive review elucidating the need for cardiovascular research
Keywords: AP-4; adaptor protein-4 complex; BMI; body mass index; CRP; C-reactive protein; CPB; carboxypeptidase B; CPN; carboxypeptidase N; CVS; cardiovascular system; C/EBP; CCAAT/enhancer binding protein; CCL; CC chemokine ligands; CSF; cerebrospinal fluid; ChemR
Lead exposure induced microgliosis and astrogliosis in hippocampus of young mice potentially by triggering TLR4-MyD88-NFκB signaling cascades
Keywords: BrdU; bromodeoxyurinine; DCX; doublecortin; DG; dentate gyrus; GFAP; glial fibrillary acidic protein; IL-1β; interleukin-1β; LPS; lipopolysaccharide; LTP; long-term potentiation; TLR4; toll-like receptor-4; TNFα; tumor necrosis factor-alpha; Pb; plumbu
Cyr61 participates in the pathogenesis of rheumatoid arthritis by promoting proIL-1β production by fibroblast-like synoviocytes through an AKT-dependent NF-κB signaling pathway
Keywords: RA; rheumatoid arthritis; OA; osteoarthritis; FLS; fibroblast-like synoviocytes; RT-PCR; real-time PCR; IL-1β; interleukin-1β; proIL-1β; precursor IL-1β; ATP; adenosine triphosphate; CIA; collagen-induced arthritis; ST; synovial tissues; SF; synovial
Fibrillin-1 impairment enhances blood-brain barrier permeability and xanthoma formation in brains of apolipoprotein E-deficient mice
Keywords: ApoE; apolipoprotein E; ApoEâ/â; ApoE deficiency; BBB; blood-brain barrier; BCSFB; blood-cerebrospinal fluid barrier; CSF; cerebrospinal fluid; ECM; extracellular matrix; Gd; gadolinium; IL-1β; interleukin-1 beta; MMP; matrix metalloproteinases;
Neutralizing anti-interleukin-1β antibodies modulate fetal blood-brain barrier function after ischemia
Keywords: BBB; blood-brain barrier; ECoG; electrocorticogram; IC; internal control; IL-1β; interleukin-1β; I/R; ischemia/reperfusion; Ki; blood-to-brain transfer constant; mAb; monoclonal antibody; RBCs; red blood cells; TJ; tight junction protein; Blood-brai
Nanosized TiO2 is internalized by dorsal root ganglion cells and causes damage via apoptosis
Keywords: Titanium dioxide nanoparticles; Dorsal root ganglion; Apoptosis; ROS; IL-1β; Axonal transport;
The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity
Keywords: [Ca2+]i; intracellular calcium concentration; DAB; diaminobenzidine; DG; dentate gyrus; FBS; fetal bovine serum; GFAP; glial fibrillary acidic protein; IB4; isolectin B4; IFNγ; interferon-gamma; IL-1β; interleukin-1β; KW; Kruskal-Wallis; LPS; lipopol
Dopaminergic dysfunction is associated with IL-1β-dependent mood alterations in experimental autoimmune encephalomyelitis
Keywords: EAE; IL-1β; Striatum; Dopamine; Depression;
A combined cumulative threshold spectra and digital reconstruction analysis reveal structural alterations of microglia within the prefrontal cortex following low-dose LPS administration
Keywords: CTS; cumulative threshold spectra; IL; infralimbic; IL-1β; interleukin-1β; LMA; locomotor activity; LPS; lipopolysaccharide; PBH; phosphate-buffered horse serum; PFC; prefrontal cortex; PL; prelimbic; TLR-4; toll-like 4 receptor; TNF-α; tumor-necrosis
Substance P and the neurokinin-1 receptor regulate electroencephalogram non-rapid eye movement sleep slow-wave activity locally
Keywords: EEG; electroencephalogram; EMG; electromyogram; IL-1β; interleukin-1 beta; IL-6; interleukin-6; LPS; lipopolysaccharide; NK-1R; neurokinin-1 receptor; nNOS; neuronal nitric oxide synthase; NO; nitric oxide; NREMS; non rapid-eye movement sleep; P2X7R; pur
Structure-activity relationship studies of pyrimidine-2,4-dione derivatives as potent P2X7 receptor antagonists
Keywords: P2X7 receptor; Antagonists; KN-62; Structure-activity relationships; IL-1β; Inflammation; AcCl; acetyl chloride; ACN; acetonitrile; ATP; adenosine-5â²-triphosphate; BzATP; 2â²(3â²)-O-(4-benzoylbenzoyl)-ATP; DCM; dichloromethane; DMEM; Dulbecco's Mod
Simultaneous release of peptides and phenolics with antioxidant, ACE-inhibitory and anti-inflammatory activities from pinto bean (Phaseolus vulgaris L. var. pinto) proteins by subtilisins
Keywords: Pinto bean; Proteolysis; Bioactive peptides; Phenolic compounds; Biological activity; AAE; Ascorbic acid equivalents; ABTS; 2,2â²-azinobis 3-ethylbenzothiazoline 6-sulphonate; ACE; Angiotensin I converting enzyme; CAE; Catechin equivalents; CV; cyclic vo
Punicalagin improves chorioallantoic and yolk sac vasculogenesis and teratogenesis of embryos induced by nicotine exposure
Keywords: Punicalagin; Nicotine; Teratogenesis; Placenta; Yolk sac; Vascularization; ROS; reactive oxygen species; TBARS; thiobarbituric acid reactive substances; MDA; malondialdehyde; SOD1; cytoplasmic superoxide dismutase; GPx1; cytoplasmic glutathione peroxidase
Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome
Keywords: Arthritis; ES-62; IL-1β; Inflammasome; NRF2; Parasitic worm;
Early single Aspirin-triggered Lipoxin blocked morphine anti-nociception tolerance through inhibiting NALP1 inflammasome: Involvement of PI3k/Akt signaling pathway
Keywords: Morphine tolerance; Anti-nociception; Aspirin-triggered Lipoxin (ATL); IL-1β; Caspase-1; NALP1 inflammasome; PI3k/Akt; Spinal cord;
Astrocytic TLR4 expression and LPS-induced nuclear translocation of STAT3 in the sensory circumventricular organs of adult mouse brain
Keywords: AP; area postrema; BBB; blood-brain barrier; Cox2; cyclooxygenase-2; CVOs; circumventricular organs; GFAP; glial fibrillar acidic protein; icv; intracerebroventricular; IL-1β; interleukin-1β; LPS; lipopolysaccharide; NF-κB; nuclear factor-κB; OVLT;
A review of the neuro- and systemic inflammatory responses in post concussion symptoms: Introduction of the “post-inflammatory brain syndrome” PIBS
Keywords: PCS; post-concussion syndrome; mTBI; mild traumatic brain injury; TBI; traumatic brain injury; RA; rheumatoid arthritis; DSM-IV; Diagnostic and Statistical Manual of Mental Disorders IV; DSM-5; Diagnostic and Statistical Manual of Mental Disorders 5; ICD-
Space experiment “Cellular Responses to Radiation in Space (CellRad)”: Hardware and biological system tests
Keywords: ATM; Ataxia telangiectasia mutated; CellRad; Cellular Responses to Radiation in Space; CMV; cytomegalovirus; d2EGFP; destabilized variant of EGFP; DDR; DNA damage response; DSB; double strand breaks; DLR; German Aerospace Center; DMSO; dimethyl sulfoxide;