Therapeutic vaccine against IL-1β improved glucose control in a mouse model of type 2 diabetes
Keywords: Type 2 diabetes; Islet inflammation; IL-1β; Therapeutic vaccine;
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MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis
Keywords: ApoB; apolipoprotein B; CBDL; common bile duct ligation; CCl4; carbon tetrachloride; CPT1; peroxisome carnitine palmitoyl transferase 1; CREBH; cAMP responsive element binding protein H; DNL; de novo lipogenesis; ECM; extracellular matrix; ER; endoplasmic
Pudilan xiaoyan oral liquid alleviates LPS-induced respiratory injury through decreasing nitroxidative stress and blocking TLR4 activation along with NF-ÎB phosphorylation in mice
Keywords: PDL; Pudilan xiaoyan oral liquid; LPS; lipopolysaccharide; ELISA; Enzyme-linked immunosorbent assay; IL-6; interleukin-6; IL-1β; interleukin-1β; TNF-α; tumor necrosis factor-α; NO; nitric oxide; HE; Hematoxylin-Eosin staining; WB; Western blotting ana
Oxidized fish oil injury stress in Megalobrama amblycephala: Evaluated by growth, intestinal physiology, and transcriptome-based PI3K-Akt/NF-κB/TCR inflammatory signaling
Keywords: Megalobrama amblycephala; Fish oil; Oxidative stress; PI3K-Akt; NF-κB; TCR; Immunity; TLR2; toll-like receptor 2; PI3K; phosphatidylinositol-4,5-bisphosphate 3-kinase; Akt; RAC serine/threonine-protein kinase; NF-κB; nuclear factor kappa-light-chain-enh
Anti-inflammatory properties of Honokiol in activated primary microglia and astrocytes
Keywords: Neuroinflammation; Microglia; Astrocytes; KLF4; IL-10; IL-1β; Honokiol;
The phosphodiesterase-4 inhibitor, FCPR16, attenuates ischemia-reperfusion injury in rats subjected to middle cerebral artery occlusion and reperfusion
Keywords: Bax; Bcl-2 associated x protein; Bcl-2; B-cell lymphoma-2; cAMP; cyclic adenosine monophosphate; CNS; central nervous system; CREB; cAMP-response element binding protein; GFAP; glial fibrillary acidic protein; H&E; haematoxylin and eosin; Iba-1; ionized c
Ilex asprella aqueous extracts exert in vivo anti-inflammatory effects by regulating the NF-κB, JAK2/STAT3, and MAPK signaling pathways
Keywords: ASA; Acetylsalicylic acid; DAB; tetrahydrochloride dehydrate; Dex; dexamethasone; ELISA; enzyme-linked immunosorbent assay; ERK 1/2; extracellular regulated protein kinases; HE; hematoxylin-eosin; IA; Ilex asprella; IL-6; interleukin-6; IL-1β; interleuki
Piper sarmentosum Roxb. confers neuroprotection on beta-amyloid (Aβ)-induced microglia-mediated neuroinflammation and attenuates tau hyperphosphorylation in SH-SY5Y cells
Keywords: Aβ; Beta amyloid; AD; Alzheimer's disease; ANOVA; Analysis of variance; ATCC; American Tissue Culture Collection; BV-2 cells; Immortalised murine microglial cells; CM; Conditioned media; CNS; Central nervous system; DCM; Dichloromethane; DMEM; Dulbecco's
TLR2/MyD88/NF-κB signaling pathway regulates IL-1β production in DF-1â¯cells exposed to Mycoplasma gallisepticum LAMPs
Keywords: M. gallisepticum-Derived LAMPs; NF-κB; IL-1β;
Developmental expression profiles and thyroidal regulation of cytokines during metamorphosis in the amphibian Xenopus laevis
Keywords: CS; corticosteroids; EF-1α; elongation factor-1α; FETAX; Frog Embryo Teratogenesis Assay-Xenopus; GAPDH; glyceraldehyde 3-phosphate dehydrogenase; hCG; human chorionic gonadotropin; IFN-γ; interferon-γ; IL-1β; interleukin-1β; MS-222; tricaine methan
Immunomodulatory, hemolytic and cytotoxic activity potentials of triterpenoid saponins from eight Cephalaria species
Keywords: Cytotoxic activity; Hemolytic activity; Immunomodulatory activity; Cephalaria; Caprifoliaceae; Triterpene saponin; HeLa; Human Cervix Adenocarcinoma; A549; Human Lung Adenocarcinoma; HEK293; Human Embryonic Kidney Cells; MTT; 3-(4,5-Dimethylthiazol-2-yl)-
Structural characterization and immunomodulatory activity of a pectic polysaccharide (CALB-4) from Fructus aurantii
Keywords: TCM; traditional Chinese medicine; PBMCs; human peripheral blood mononuclear cells; GC-MS; gas chromatography-mass spectrometry; IR; infrared spectroscopy; SEM; scanning electron microscopy; MAPKs; mitogen-activated protein kinases; TNF-α; tumor necr
The regulation of inflammation and oxidative status against lung injury of residue polysaccharides by Lentinula edodes
Keywords: ARPS; acidic-RPS; Ara; arabinose; BALF; bronchoalveolar lavage fluid; CAT; catalase; C3; complement 3; Dex; dexamethasone; DPPH1; 1,1-diphenyl-2-picrylhydrazyl; ERPS; enzymatic-RPS; Gal; galactose; GC; gas chromatography; Glu; glucose; GSH-Px; GSH peroxid
Maternal Consumption of High-fat Diet in Mice Alters Hypothalamic Notch Pathway, NPY Cell Population and Food Intake in Offspring
Keywords: ARC; arcuate nucleus; Ascl1; achaete-scute homolog 1; bHLH; basic helix-loop-helix; BMP; bone morphogenetic protein; BrDU; 5-bromo-2â²-deoxyuridine; BSA; bovine serum albumin; BW; body weight; Ct; comparative threshold cycle; Cy3; cyanine 3; DAB; 3,3â²-
A pivotal role for NF-κB in the macrophage inflammatory response to the myeloperoxidase oxidant hypothiocyanous acid
Keywords: Macrophage; Atherosclerosis; Myeloperoxidase; Oxidative stress; Inflammation; Cytokine; BSA; bovine serum albumin; CCCP; carbonyl cyanide m-chlorophenyl hydrazone; HOCl; hypochlorous acid; HOSCN; hypothiocyanous acid; HUVEC; human umbilical vein endotheli
Reversal of metabolic disorders by pharmacological activation of bile acid receptors TGR5 and FXR
Keywords: Farnesoid X receptor; TGR5; Atherosclerosis; Obesity; NAFLD; α-Sma; alpha smooth muscle actin (α-Sma); BA; bile acid; BAT; brown adipose tissue; CEBPα; CCAAT/enhancer-binding protein α; Col1α1; collagen type 1 α1; DIO; diet-induced obesity; FXR; far
Genetic or pharmacological superoxide-hydrogen peroxide imbalances modulate the in vitro effects of lithium on glycogen synthase kinase-3β
Keywords: GSK-3β; Glycogen synthase kinase 3 beta; TNF-α; Tumor necrosis factor alpha; IL-10; Interleukin 10; Li; Lithium; S; Superoxide; HP; Hydrogen peroxide; SNP; Single nucleotide polymorphism; MnSOD/SOD2; Superoxide dismutase manganese-dependent enzyme; MTS;
Inhibitive Effect of Resveratrol on the Inflammation in Cultured Astrocytes and Microglia Induced by Aβ1-42
Keywords: AD; Alzheimer's disease; Aβ; beta-amyloid; APC; antigen-presenting cell; BACE1; β-site APP cleaving enzyme 1; BBB; blood-brain barrier; CCK; cell-counting kit; CD40; cluster of differentiation 40; CNS; central nervous system; DAPI; 4â²,6-diamidino-
miR-494-3p modulates the progression of in vitro and in vivo Parkinson's disease models by targeting SIRT3
Keywords: PD; Parkinson's disease; SOD; superoxide dismutase; LDH; lactate dehydrogenase; TNF-α; tumor necrosis factor-α; IL-1β; interleukin-1β; ROS; reactive oxygen species; SNpc; substantia nigra pars compacta; DA; dopaminergic; miRNAs; microRNAs; snRNA; sm
Enhanced oral bioavailability and anti-gout activity of [6]-shogaol-loaded solid lipid nanoparticles
Keywords: SLNs; solid lipid nanoparticles; SSLNs; [6]-shogaol-loaded solid lipid nanoparticles; PO; potassium oxonate; TLC; thin layer chromatography; HPLC; high performance liquid chromatography; PDI; polydispersity index; TEM; transmission electron microscopy; IL
Biogenesis and function of ESCRT-dependent extracellular vesicles
Keywords: Aβ; amyloid-β protein; Acb1; acyl CoA binding protein1; ALIX; ALG-2 interacting protein X; APP; amyloid precursor protein; ARRDC1; ARRestin domain-containing protein 1; COPI/II; coat protein complex I/II; CUPS; compartment for unconventional protein sec
SIRT1 regulates inflammation response of macrophages in sepsis mediated by long noncoding RNA
Keywords: lncRNA; long noncoding RNA; SIRT1; silent information regulator2; LPS; lipopolysaccharide; TNF-α; tumor necrosis factor alpha; IL-1β; interleukin 1beta; IL-6; interleukin 6; PM; peritoneal macrophage; BMM; bone marrow-derived monocyte; MCP-1; monocyte c
Cordyceps sinensis: Anti-fibrotic and inflammatory effects of a cultured polysaccharide extract
Keywords: Cordyceps sinensis; Bioactivity; Polysaccharide; Fibrosis; Inflammation; IL-1β; TGF-β1;
Protective effects of dioscin against fructose-induced renal damage via adjusting Sirt3-mediated oxidative stress, fibrosis, lipid metabolism and inflammation
Keywords: BUN; blood urea nitrogen; Cr; creatinine; α-SMA; α-smooth muscle actin; COL1A1; collagen α1 (I); COL3A1; collagen α1 (III); TNF-α; tumor necrosis factor-alpha; IL-1β; interleukin-1β; IL-6; interleukin-6; TG; triglycerides; TC; total cholesterol; FF
Developmental and extrahepatic physiological functions of SREBP pathway genes in mice
Keywords: AAV; adeno-associated virus; ACC; acetyl-CoA carboxylase; AD; Alzheimer's disease; ADD1; adipocyte determination- and differentiation-dependent factor 1; APP; amyloid precursor protein; Api6; apoptosis inhibitor 6; ApoE; apolipoprotein E; ATF6; activati
A hyaluronan-based nanosystem enables combined anti-inflammation of mTOR gene silencing and pharmacotherapy
Keywords: RNAi; RNA interference; HA; Hyaluronic acid; simTOR; siRNA molecules targeting mTOR; LPS; lipopolysaccharide; TKL; thioketal linkages; DMT-MM; 4-(4 6-Dimethoxy-1 3 5-Triazin-2-yl)-4-Methylmorpholinium Chloride; DSH; dexamethasone hemisuccinate; HA-TKL; th
Cardamonin, a natural flavone, alleviates inflammatory bowel disease by the inhibition of NLRP3 inflammasome activation via an AhR/Nrf2/NQO1 pathway
Keywords: AhR; aryl hydrocarbon receptor; ARNT; ah receptor nuclear translocator protein; ATP; adenosine triphosphate; ASC; apoptosis-associated speck-like protein containing CARD; BMDM; bone marrow-derived macrophage; BSA; bovine serum albumin; Caspase-1; cysteiny
Role of p-MKK7 in myricetin-induced protection against intestinal ischemia/reperfusion injury
Keywords: 5281672; I/R; ischemia/reperfusion; H/R; hypoxia/reoxygenation; SMA; superior mesenteric artery; IEC-6; Intestinal epithelial cells; TNF-α; tumor necrosis factor alpha; IL-1β; interleukin-1β; IL-6; interleukin-6; MDA; malondialdehyde; SOD; superoxide d
Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics for the investigation of the effect of Hugan Qingzhi on non-alcoholic fatty liver disease in rats
Keywords: NAFLD; nonalcoholic fatty liver disease; HQT; Hugan Qingzhi tablet; HFD; high fat diet; iTRAQ; isobaric tags for relative and absolute quantification; GO; Gene Ontology; KEGG; Kyoto Encyclopedia of Gene and Genomes; DEPs; differentially expressed proteins
Luteolin-4â²-O-glucoside and its aglycone, two major flavones of Gnaphalium affine D. Don, resist hyperuricemia and acute gouty arthritis activity in animal models
Keywords: Luteolin-4â²-O-glucoside; Luteolin; Hyperuricemia; Acute Gouty Arthritis; Xanthine Oxidase; Renal Organic Ion Transporters; PO; potassium oxonate; XO; xanthine oxidase; MSU; monosodium urate; Sur; serum uric acid; GLUT9; glucose transporter 9; URAT1; ura
Attenuation of high glucose induced apoptotic and inflammatory signaling pathways in RIN-m5F pancreatic β cell lines by Hibiscus rosa sinensis L. petals and its phytoconstituents
Keywords: ROS; reactive oxygen species; EHRS; ethyl acetate fraction of ethanolic extract of Hibiscus; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NRU; Neutral Red uptake; AO/EB; Acridine orange/Ethidium bromide; iNOS; nitric oxide synthase;
Mapping Txnip: Key connexions in progression of diabetic nephropathy
Keywords: ARRB; arrestin beta; ARRDC; arrestin domain containing protein; ASK-1; apoptosis signal-regulating kinase-1; Cys; cysteine; ECM; extracellular matrix; FOXO; forkhead box protein; Gly; glycine; IL-1β; interleukin-1 β; JNK; c-Jun-N-terminal kinase; MAPK;
Hv1 proton channel facilitates production of ROS and pro-inflammatory cytokines in microglia and enhances oligodendrocyte progenitor cells damage from oxygen-glucose deprivation in vitro
Keywords: Voltage-gated proton channel Hv1; Reactive oxygen species (ROS); Pro-inflammatory cytokines; Microglia; Oligodendrocyte; Oxygen-glucose deprivation (OGD); CNS; central nervous system; DCFH-DA; dichlorodihydrofluorescein diacetate; DMEM; Dulbecco's modifie
Heat shock protein B1 is required for the prolactin-induced cytoprotective effects on pancreatic islets
Keywords: Apoptosis; Diabetes; Human islets; Islet transplantation; Prolactin; Survival; Mouse islets; AG490; Tyrphostin AG490; BAX; BCL2-associated X protein; BCL2; B cell CLL/lymphoma 2; BCLxL; BCL extra large; DM1; Type 1 diabetes mellitus; FCS; Fetal calf serun
Dexmedetomidine attenuated early brain injury in rats with subarachnoid haemorrhage by suppressing the inflammatory response: The TLR4/NF-κB pathway and the NLRP3 inflammasome may be involved in the mechanism
Keywords: ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; BBB; bloodbrain barrier; BSA; bovine serum albumin; CCA; common carotid artery; CI; cerebral ischaemia; CNS; central nervous system; DAMPs; damage-associated molecular p
Ginger (Zingiber officinale Roscoe) for the treatment and prevention of necrotizing enterocolitis
Keywords: DAB; Diaminobenzidine tetrahydrochloride; ET-1; Endothelin-1; ETA; Endothelin receptor type A; ETB; Endothelin receptor type B; GSH; Reduced glutathione; GSH-PX; Glutathione peroxidase; IL-1β; Interleukin 1 beta; IL-6; Interleukin 6; IQR; Interquartile r
C-type natriuretic peptide (CNP) in endothelial cells attenuates hepatic fibrosis and inflammation in non-alcoholic steatohepatitis
Keywords: α-SMA; α-smooth muscle actin; ALT; alanine aminotransferase; AST; aspartate transaminase; CNP; C-type natriuretic peptide; CDAA; choline-deficient defined lâamino acid diet; GTT; glucose tolerance test; HFD; high-fat diet; HSC; hepatic stellate cell;
Characterization, antioxidant and antiinflammation of mycelia selenium polysaccharides from Hypsizygus marmoreus SK-03
Keywords: BALF; bronchoalveolar lavage fluid; C3; complement 3; DMSO; dimethyl sulfoxide; FDA; Food and Drug Administration; FT-IR; Fourier transform infrared spectral; GC; gas chromatography; GGT; glutamyl transpeptidase; GSH-Px; glutathione peroxidase; H&E; hemat
Immunometabolic regulation by triterpenes of Eucalyptus tereticornis in adipose tissue cell line models
Keywords: Obesity; Inflammation; Adipose tissue; Natural products; Triterpenes; PPARγ; Peroxisome proliferator-activated receptor gamma; C/EBPα; CCAAT-enhancer-binding proteins; IL-6; Interleukin 6; IL-1β; Interleukin 1β; TNFα; Tumoral necrosis factor alpha; M
The expression of TRPV channels, prostaglandin E2 and pro-inflammatory cytokines during behavioural fever in fish
Keywords: IPNV; Infectious Pancreatic Necrosis Virus; IL-1β; interleukin-1; IL-6; interleukin-6; TNF-α; tumor necrosis factor-α; COX-2; cyclooxygenase-2; PGE2; prostaglandin E2; TRPV1; transient receptor potential cation channel, subfamily V, member 1; TRPV4; tr
The orphan nuclear receptor TLX regulates hippocampal transcriptome changes induced by IL-1β
Keywords: TLX; orphan nuclear receptor tailless homolog; IL-1β; interleukin-1 beta; TNF; tumor necrosis factor; NPCs; neural progenitor cells; DG; dentate gyrus; LTP; long term potentiation; P; post-natal day; KO; knockout; WT; wildtype; PBS; phosphate buffered sa
TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation
Keywords: CEES; 2-chloroethyl ethyl sulfide; CGRP; calcitonin gene-related peptide; ELISA; enzyme-linked immunosorbent assay; p; intraperitoneal; IL-1β; interleukin-1beta; KC/CXCL1; keratinocyte chemoattractant/chemokine (C-X-C motif) ligand 1; MMP-9; matrix metal
An ethnobotanical survey and inhibitory effects on NLRP3 inflammasomes/Caspase-1 of herbal recipes' extracts traditionally used in Rwanda for asthma treatment
Keywords: FETAX; Frog Embryo Teratogenesis Assay - Xenopus; WHO; World Health Organization; COPD; Chronic Obstructive Pulmonary Disease; Th2; T helper 2; Th17; T helper 17; IL-1β; Interleukin one beta; TNF-α; Tumor necrosis factor alpha; NLRP3; NOD-Like Recepto
The NLRP3 inflammasome: Role in metabolic disorders and regulation by metabolic pathways
Keywords: NLRP3 inflammasome; Metabolic disorder; Metabolic pathway; IL-1β; IL-18;
Suppression of NLRP3 attenuates hemorrhagic transformation after delayed rtPA treatment in thromboembolic stroke rats: Involvement of neutrophil recruitment
Keywords: ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; BBB; blood-brain barrier; HT; hemorrhagic transformation; IgG; immunoglobulin G; IL-1β; interleukin-1β; i.p.; intraperitoneally; MPO; myeloperoxidase; NLRP3; Nod-lik
Vitamin D partially reverses the increase in p-NF-κB/p65 immunocontent and interleukin-6 levels, but not in acetylcholinesterase activity in hippocampus of adult female ovariectomized rats
Keywords: Ach; acetylcholine; AChE; acetylcholinesterase; ANOVA; analysis of variance; ChAT; choline acetyltransferase; CNS; central nervous system; HRT; hormone replacement therapy; IL-1β; interleukin-1β; IL-6; interleukin 6; NF-kB; nuclear factor-kappa B; OVX;
Methylated flavonoids as anti-seizure agents: Naringenin 4â²,7-dimethyl ether attenuates epileptic seizures in zebrafish and mouse models
Keywords: Epilepsy; Drug discovery; Methylated flavonoids; Naringenin; Zebrafish; Mouse; AED; anti-epileptogenic drug; ASD; anti-seizure drug; cLogP; calculated LogP; dpf; days post-fertilization; DMSO; dimethyl sulfoxide; GABA; γ-aminobutyric acid; IL-1β; interl
Influences of Chlorella vulgaris dietary supplementation on growth performance, hematology, immune response and disease resistance in Oreochromis niloticus exposed to sub-lethal concentrations of penoxsulam herbicide
Keywords: O. niloticus; Penoxsulam; Chlorella vulgaris; IL-1β and TNF-α; Quantitative real time polymerase chain reaction; ALP; alkaline phosphatase; A. sorbia; Aeromonus sorbia; AST; aspartate aminotransferase; ALT; alanine aminotransferase; CV; C. vulgaris; GSH
Antioxidant and anti-inflammation of enzymatic-hydrolysis residue polysaccharides by Lentinula edodes
Keywords: ALT; alamine aminotransferase; ALP; alkaline phosphatase; AST; aspertate aminotransferase; l-Ara; l-arabinose; BUN; blood urea nitrogen; CAT; catalase; CKMB; creatine kinase isoenzyme; CRE; creatinine; d-Gal; d-galactose; d-Glu; d-glucose; ERPS; enzymolys
Role of hypochlorous acid (HOCl) and other inflammatory mediators in the induction of macrophage extracellular trap formation
Keywords: ABAH; 4-aminobenzoic acid hydrazide; ANCA; anti-neutrophil cytoplasmic antibody; ATP6; mitochondrial membrane ATP synthase; CYTB; cytochrome b; ETs; extracellular traps; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GM-CSF; granulocyte-macrophage colon