کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
7782231 | 1500563 | 2018 | 33 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
A hyaluronan-based nanosystem enables combined anti-inflammation of mTOR gene silencing and pharmacotherapy
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کلمات کلیدی
TKLDMT-MMHPGPCLPSIL-6TNF-aIL-1βRNA interference - RNA تداخل کنندهRNAi - RNA سرکوبگر،RNA مداخلهگر، RNA خاموش کنندهAutophagy - اتوفاژیHyaluronic acid - اسید هیالورونیکinflammation - التهاب( توروم) interleukin-6 - اینترلوکین ۶Interleukin-1β - اینترلوکین-1βtumor necrosis factor-alpha - تومور نکروز عامل آلفاDexamethasone - دگزامتازونDßH - دیگهlipopolysaccharide - لیپوپلی ساکاریدNanoparticle - نانوذارتHyaluronan - هیالورونانhigh performance gel permeation chromatography - کروماتوگرافی نفوذپذیری ژل عملکرد بالا
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آلی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Accompanied by overproduction of oxidants and reduction of pH, inflammation is closely related to many diseases such as cancer, atherosclerosis, and asthma. Besides chemotherapeutic agents, the potential regulative role of autophagy in inflammation is being actively investigated. RNA interference (RNAi)-based gene therapy is widely explored for clinical therapy but seriously restricted by lack of suitable carriers. In this study, we synthesized a hyaluronan-based ROS-sensitive polymer which was expected to release loaded chemical drugs in inflammatory environment and further developed a stable and nontoxic co-delivery nanosystem of siRNA targeting autophagy suppressive gene and chemotherapeutic agents. The in vitro transfection study of this nanosystem revealed improved intracellular accumulation of siRNA and excellent gene silencing efficacy comparable to that of conventional cationic liposome. Moreover, the mRNA expression of inflammatory cytokines was remarkably decreased by our nanosystem. Considering its biocompatibility, transfection efficacy, and anti-inflammatory capability, this co-delivery nanosystem proclaimed to be a promising combined therapeutic strategy for enhanced anti-inflammatory therapy.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Carbohydrate Polymers - Volume 195, 1 September 2018, Pages 339-348
Journal: Carbohydrate Polymers - Volume 195, 1 September 2018, Pages 339-348
نویسندگان
Chunyan Hou, Hu Bai, Zhaojie Wang, Yuanhao Qiu, Li-Li Kong, Feifei Sun, Dongdong Wang, Hong Yin, Xiaoli Zhang, Haibo Mu, Jinyou Duan,