دانلود مقالات ISI درباره بازدارنده + ترجمه فارسی

A new class of aggregation inhibitor of amyloid-β peptide based on an O-acyl isopeptide

Keywords: بازدارنده; Aβ; amyloid β peptide; AD; Alzheimer's disease; DIC; N,N′-diisopropylcarbodiimide; DMF; N,N-dimethylformamide; DMSO; dimethyl sulfoxide; FAM; carboxyfluorescein; HOBt; N-hydroxybenzotriazole; HPLC; high-performance liquid chromatography; kDa; kiloda

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Improved guanide compounds which bind the CXCR4 co-receptor and inhibit HIV-1 infection

Keywords: بازدارنده; CXCR4; CXC chemokine receptor 4; SDF-1; stromal-derived-factor-1; HIV-1; human immunodeficiency virus type 1; NapG; naphthylguanide; PheG; phenylguanide; ARRRP; AIDS Research and Reference Reagent Program; Human immunodeficiency virus; Co-receptor; CXCR4;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibitors of the aminoglycoside 6′-N-acetyltransferase type Ib [AAC(6′)-Ib] identified by in silico molecular docking

Keywords: بازدارنده; AAC(6′)-Ib; aminoglycoside 6′-N-acetyltransferase type Ib; acetyl CoA; acetyl coenzyme A; DMSO; dimethyl sulfoxide; DTNB; 5,5′-dithiobis(2-nitrobenzoic acid); Vi; initial velocity; Aminoglycoside resistance; Acetyltransferase; Aminoglycoside modifyi

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

[(4-Hydroxyl-benzo[4,5]thieno[3,2-c]pyridine-3-carbonyl)-amino]-acetic acid derivatives; HIF prolyl 4-hydroxylase inhibitors as oral erythropoietin secretagogues

Keywords: بازدارنده; HIF-PH (PHD); Stabilizer; Inhibitor; Erythropoiesis;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014

Keywords: بازدارنده; mTOR; Inhibitor; AZD8055; AZD2014; Kinase;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

The extremo-α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium azorense is highly inhibited by sulfonamides

Keywords: بازدارنده; Carbonic anhydrase; Anion; α-Class enzyme; Inhibitor; Sulfurihydrogenibium azorense; Thermophilic bacteria;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease

Keywords: بازدارنده; Carbonic anhydrase; Anion; Alpha-class enzyme; Inhibitor; Trypanosoma cruzi;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis, functional and structural characterization of an inhibitor of N-acetylneuraminate-9-phosphate phosphatase: Observation of extensive dynamics in an enzyme/inhibitor complex

Keywords: بازدارنده; YWCWXZOCMORFBO-KFRVFMFJSA-N; N-Acetylnuraminate-9-phosphate phosphatase; Inhibitor; Comparative NMR studies; Enzyme/inhibitor complex;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Identification, synthesis and evaluation of substituted benzofurazans as inhibitors of CREB-mediated gene transcription

Keywords: بازدارنده; CREB; CBP; Cancer; Inhibitor; Screening; Selectivity; Structure-activity relationships;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Potency switch between CHK1 and MK2: Discovery of imidazo[1,2-a]pyrazine- and imidazo[1,2-c]pyrimidine-based kinase inhibitors

Keywords: بازدارنده; Potency switch; CHK1; MK2; Kinase; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

N-(Pyridin-2-yl) arylsulfonamide inhibitors of 11β-hydroxysteroid dehydrogenase type 1: Strategies to eliminate reactive metabolites

Keywords: بازدارنده; 11β-Hydroxysteroid dehydrogenase; 11β-HSD; PF-915275; Reactive metabolite; Bioactivation; Glutathione adduct; Diabetes; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

A modular synthesis of novel 4-amino-7,8-dihydro-1,6-naphthyridin-5(6H)-ones as PDE4 inhibitors

Keywords: بازدارنده; PDE4; Inhibitor; Modular synthesis; Tetra-substituted; Dihydronaphthyridinone;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Mammalian galectins bind Galactoseβ1-4Fucose disaccharide, a unique structural component of protostomial N-type glycoproteins

Keywords: بازدارنده; CRD; carbohydrate-recognition domain; Gal; galactose; Fuc; fucose; Glc; glucose; Galectin; Galβ1-4Fuc; Galβ1-4GlcNAc; Frontal affinity chromatography; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition

Keywords: بازدارنده; Carbonic anhydrase (CA); Anion; CA-related protein (CARP); Inhibitor;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of human carboxylesterases hCE1 and hiCE by cholinesterase inhibitors

Keywords: بازدارنده; Carboxylesterase; Cholinesterase; Inhibitor; Carbamate; AChE; acetylcholinesterase; ACMA; 9-amino-6-chloro-2-methoxyacridine; BChE; butyrylcholinesterase; BNPP; bis(4-nitrophenyl)phosphate; CE; carboxylesterase; ChE; cholinesterase; DEA; 5,9-diamino-2-eth

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors

Keywords: بازدارنده; HIV-1; Inhibitor; Triazolothienopyrimidine; Synthesis; Structure-activity relationship (SAR);

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

13C NMR spectroscopies and formation kinetics of gas hydrates in the presence of monoethylene glycol as an inhibitor

Keywords: بازدارنده; Gas hydrate; Inhibitor; Methane; Natural gas; Ethylene glycol;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2013 سفارش ترجمه

Optimization of a novel potent and selective bacterial DNA helicase inhibitor scaffold from a high throughput screening hit

Keywords: بازدارنده; Optimization; DNA helicase; DNA replication; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Exploring the UDP pocket of LpxC through amino acid analogs

Keywords: بازدارنده; LpxC; Inhibitor; Antibiotic; Hydroxamate;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery and optimization of orally active cyclohexane-based prolylcarboxypeptidase (PrCP) inhibitors

Keywords: بازدارنده; PrCP; Prolylcarboxypeptidase; Serine protease; Inhibitor; Obesity;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Carbonic anhydrase inhibitors: Inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides

Keywords: بازدارنده; Carbonic anhydrase; β-Class enzyme; Inhibitor; Sulfonamide; Sulfamate; Sulfamide; Antifungal;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Pseudoperoxidase investigations of hydroperoxides and inhibitors with human lipoxygenases

Keywords: بازدارنده; LOX; lipoxygenase; 15-LOX-2; human epithelial 15-lipoxygenase-2; 15-LOX-1; human reticulocyte 15-lipoxygenase-1; 12-LOX; human platelet 12-lipoxygenase; soybean LOX-1; soybean lipoxygenase-1; 5-LOX; human 5-lipoxygenase; COX; cyclooxygenase; AA; arachidon

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and SAR of 99mTc/Re-labeled small molecule prostate specific membrane antigen inhibitors with novel polar chelates

Keywords: بازدارنده; Inhibitor; PSMA; Structure-activity relationships; Rhenium; Technetium; Polar chelates;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE), Part II: Development of inhibitors with broad spectrum, Gram-negative antibacterial activity

Keywords: بازدارنده; Bacterial topoisomerases; Pyrrolopyrimidine; GyrB; ParE; Gram-negative antibacterial agents; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Neohesperidin dihydrochalcone: Presentation of a small molecule activator of mammalian alpha-amylase as an allosteric effector

Keywords: بازدارنده; Alpha-amylase; Activator; Neohesperidin dihydrochalcone; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of cyclic sulfoxide hydroxyethylamines as potent and selective β-site APP-cleaving enzyme 1 (BACE1) inhibitors: Structure based design and in vivo reduction of amyloid β-peptides

Keywords: بازدارنده; BACE-1; Inhibitor; Alzheimer's disease; Structure based design; Cyclic sulfoxide hydroxyethylamine inhibitors; In vivo reduction of amyloid β-peptides;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Hypoxia mediated expression of stem cell markers in VHL-associated hemangioblastomas

Keywords: بازدارنده; VHL; von Hippele-Lindau; HIF; hypoxia-inducible-factor; HRE; hypoxia response element; PHD; prolyl hydroxylation domain; VEGF; vascular endothelial growth factor; EPO; erythropoietin; PDGF; platelet-derived growth factor; JMJD1A; Jmj-domain containing pro

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Novel quinoline derivatives as inhibitors of bacterial DNA gyrase and topoisomerase IV

Keywords: بازدارنده; Antibacterial; DNA gyrase; Dual-targeting; Inhibitor; Topoisomerase IV;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery of two new inhibitors of Botrytis cinerea chitin synthase by a chemical library screening

Keywords: بازدارنده; Chitin synthase; Botrytis cinerea; Inhibitor; Glycosyltransferase; Antifungal compounds;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Phenylpropanoid glycoside inhibition of pepsin, trypsin and α-chymotrypsin enzyme activity in Kudingcha leaves from Ligustrum purpurascens

Keywords: بازدارنده; Phenylpropanoid glycoside; Inhibitor; Pepsin; Trypsin; α-Chymotrypsin; Interaction;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

New potent and selective polyfluoroalkyl ketone inhibitors of GVIA calcium-independent phospholipase A2

Keywords: بازدارنده; Phospholipase A2; Inhibitor; GVIA iPLA2; Polyfluoroalkyl ketone; Pentafluoroethyl ketones;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibitory effects of tannic acid on fatty acid synthase and 3T3-L1 preadipocyte

Keywords: بازدارنده; Ac-CoA; acetyl CoA; ACP; acyl carrier protein; DH; dehydrase; DMSO; dimethyl sulfoxide; ER; enoyl reductase; FAS; fatty acid synthase; FBS; fetal bovine serum; IC50; half-inhibitory concentration; KR; ketoacyl reductase; KS; ketoacyl synthase; Mal-CoA; ma

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Analysis of the structure of calpain-10 and its interaction with the protease inhibitor SNJ-1715

Keywords: بازدارنده; Calpain-10; Homology modelling; QM/MM; MD; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Pyrrolopyrimidine inhibitors of DNA gyrase B (GyrB) and topoisomerase IV (ParE). Part I: Structure guided discovery and optimization of dual targeting agents with potent, broad-spectrum enzymatic activity

Keywords: بازدارنده; Bacterial topoisomerases; GyrB; ParE; Pyrrolopyrimidine; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Anti-inflammatory effect and selectivity profile of AS1940477, a novel and potent p38 mitogen-activated protein kinase inhibitor

Keywords: بازدارنده; p38; Mitogen-activated protein kinase; Inhibitor; Lipopolysaccharide; Tumor necrosis factor α; Interleukin-6;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Investigations on the metabolic stability of cytosolic phospholipase A2α inhibitors with 1-indolylpropan-2-one structure

Keywords: بازدارنده; cPLA2α; cytosolic phospholipase A2α; CYP450; cytochrome P450; SDR; short-chain dehydrogenase/reductase; AKR; aldo-keto-reductase; HPLC; high performance liquid chromatography; MS; mass spectrometry; ESI; electrospray ionization; NMR; nuclear magnetic

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Effects of protein isolates from black bean and mungbean on proteolysis and gel properties of surimi from sardine (Sardinella albella)

Keywords: بازدارنده; Sardine; Surimi gel; Degradation; Black bean; Mungbean; Protein isolate; Protease; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis of sterically encumbered 11β-aminoprogesterone derivatives and evaluation as 11β-hydroxysteroid dehydrogenase inhibitors and mineralocorticoid receptor antagonists

Keywords: بازدارنده; 11Beta-hydroxysteroid dehydrogenase; Mineralocorticoid receptor; Inhibitor; Antagonist; Amino acid-steroid conjugates; Glucocorticoid;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Design, synthesis and evaluation of 1,2-benzisothiazol-3-one derivatives as potent caspase-3 inhibitors

Keywords: بازدارنده; DMSMPAJRVJJAGA-UHFFFAOYSA-N; RDWXSJCICPOOKO-UHFFFAOYSA-N; RTMDCQYUXWCPQG-UHFFFAOYSA-N; BUQJUCVPPUJQBJ-UHFFFAOYSA-N; KDMQSUUXKLZVNU-UHFFFAOYSA-N; KRXMYBAZKJBJAB-UHFFFAOYSA-N; ROHBTCZGZVBWBB-UHFFFAOYSA-N; GTTHESNNWLOVLD-UHFFFAOYSA-N; BBUMBHPLXMNIMZ-UHFFFAOY

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Bromo-deaza-SAH: A potent and selective DOT1L inhibitor

Keywords: بازدارنده; Protein methyltransferase; DOT1L; Leukemia; Inhibitor; Crystallography;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Pomegranate husk extract, punicalagin and ellagic acid inhibit fatty acid synthase and adipogenesis of 3T3-L1 adipocyte

Keywords: بازدارنده; Fatty acid synthase; Pomegranate husk; Punicalagin; Ellagic acid; Adipocyte; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Discovery and characterization of synthetic 4′-hydroxyflavones-New CK2 inhibitors from flavone family

Keywords: بازدارنده; Protein kinase CK2; 4′-Hydroxyflavone; Inhibitor; Drug design; Docking; Molecular modeling;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Novel 1H-imidazol-2-amine derivatives as potent and orally active vascular adhesion protein-1 (VAP-1) inhibitors for diabetic macular edema treatment

Keywords: بازدارنده; Vascular adhesion protein-1; Inhibitor; Macular edema; Guanidine bioisostere; 1H-Imidazol-2-amine derivative;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

A high-throughput-compatible, fluorescence anisotropy-based assay for ATP-dependent supercoiled DNA relaxation by human topoisomerase IIα

Keywords: بازدارنده; Topoisomerase; DNA relaxation; Fluorescence anisotropy; High-throughput; Inhibitor;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

An insect trypsin-like serine protease as a target of microRNA: Utilization of microRNA mimics and inhibitors by oral feeding

Keywords: بازدارنده; MicroRNA; Mimic; Inhibitor; Trypsin-like serine protease;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Activity-based assay for human mono-ADP-ribosyltransferases ARTD7/PARP15 and ARTD10/PARP10 aimed at screening and profiling inhibitors

Keywords: بازدارنده; Enzyme; Activity assay; Inhibitor; High-throughput screening; Poly(ADP-ribose)polymerase; ADP-ribosyltransferase;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis, molecular docking and kinetic properties of β-hydroxy-β-phenylpropionyl-hydroxamic acids as Helicobacter pylori urease inhibitors

Keywords: بازدارنده; Hydroxamic acid; Helicobacter pylori urease; Inhibitor; A mixture of competitive and uncompetitive mechanism;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis, enzyme kinetics and computational evaluation of N-(β-d-glucopyranosyl) oxadiazolecarboxamides as glycogen phosphorylase inhibitors

Keywords: بازدارنده; 1,2,4-Oxadiazole; 1,3,4-Oxadiazole; β-d-Glucopyranosyl derivatives; Glycogen phosphorylase; Inhibitor; ADMET;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Toward very potent, non-covalent organophosphonate inhibitors of cathepsin C and related enzymes by 2-amino-1-hydroxy-alkanephosphonates dipeptides

Keywords: بازدارنده; Hydroxyphosphonate; Cathepsin; Inhibitor; Cysteine protease;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Inhibition of gingipains by their profragments as the mechanism protecting Porphyromonas gingivalis against premature activation of secreted proteases

Keywords: بازدارنده; PD; N-terminal prodomain; CD; catalytic domain; CTD; C-terminal domain; Pathogen; Periodontitis; Inhibitor; Proteolysis control; Zymogen activation;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه