Furanodien-6-one from Commiphora erythraea inhibits the NF-κB signalling and attenuates LPS-induced neuroinflammation
Keywords: Microglia; In vivo model; SIRT1; iNOS; COX-2
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Dietary quercetin ameliorates nonalcoholic steatohepatitis induced by a high-fat diet in gerbils
Keywords: Lipid profiles; Inflammation; Sirt1; NF-κB; iNOS
Synthesis and anti-inflammatory evaluations of β-lapachone derivatives
Keywords: β-Lapachone (β-LAPA); Anti-inflammatory activity; iNOS; COX-2, NO; TNF-α
Postmortem and ex vivo carbon monoxide ventilation reduces injury in rat lungs transplanted from non-heart-beating donors
Keywords: cGMP; cyclic guanosine monophosphate; CO; carbon monoxide; DCD; donation-after-cardiac-death donor; ERK; extracellular signal-regulated kinase; EVLP; ex vivo lung perfusion; HO; heme oxidase; IL; interleukin; IκBα; nuclear factor of kappa light polypep
Protective effect of tetrahydrocoptisine against ethanol-induced gastric ulcer in mice
Keywords: THC; tetrahydrocoptisine; NO; nitric oxide; TNF-α; tumor necrosis factor-alpha; IL-6; interleukin-6; MPO; myeloperoxidase; NF-κB; nuclear factor kappa B; cNOS; constitutive NO synthase; iNOS; inducible NO synthase; TNF; tumor necrosis factor; IL-1; inte
Anti-inflammatory and antitumoural effects of Uncaria guianensis bark
Keywords: TNF-α, tumour necrosis factor alpha; IL, interleukin; PGE2, prostaglandin E2; NO, nitric oxide; LPS, lipopolysaccharide; COX-2, cyclooxygenase 2; iNOS, inducible nitric oxide synthase; IκB, inhibitor of κBTNF-α; Il-6; iNOS; COX-2; NF-κB
Different regulatory mechanisms in protozoan parasitic infections
Keywords: Leishmania; Trypanosoma; Plasmodium; Regulatory T cells; Alternatively activated macrophages; iNOS; Arginase 1
TNF-alpha decreases infection-induced lung injury in burn through negative regulation of TLR4/iNOS
Keywords: Tumor necrosis factor; Burn; iNOS; TLR4; IL-1β
Effect of iNOS inhibitor S-methylisothiourea in monosodium iodoacetate-induced osteoathritic pain: Implication for osteoarthritis therapy
Keywords: S-methylisothiourea; Osteoarthritis; Pain; iNOS; Monosodium iodoacetate;
Pharmacological inhibition of inducible nitric oxide synthase (iNOS) and nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, convalesce behavior and biochemistry of hypertension induced vascular dementia in rats
Keywords: Aminoguanidine; 4′-hydroxy-3′-methoxyacetophenone; DOCA salt; Mean arterial blood pressure; Morris water maze; Vascular dementia; iNOS; NADPH oxidase
Dietary unsaponifiable fraction from extra virgin olive oil supplementation attenuates acute ulcerative colitis in mice
Keywords: Unsaponifiable fraction; Extra virgin olive oil; iNOS; COX-2; MAPK; IκBα
Endothelial nitric oxide synthase plays a main role in producing nitric oxide in the superacute phase of hepatic ischemia prior to the upregulation of inducible nitric oxide synthase
Keywords: Nitric oxide; eNOS; iNOS; Ischemia; Reperfusion
Protective effect of Bauhinia tomentosa on acetic acid induced ulcerative colitis by regulating antioxidant and inflammatory mediators
Keywords: Bauhinia tomentosa; Ulcerative colitis; Myeloperoxidase; iNOS; TNF-alpha
Indirubin-3′-(2,3 dihydroxypropyl)-oximether (E804) is a potent modulator of LPS-stimulated macrophage functions
Keywords: Indirubin-3′-(2,3 dihydroxypropyl)-oximether (E804); RAW264.7 macrophages; LPS; IL-6; iNOS; IL-10; COX-2; Phagocytosis and intracellular killing
Striatal TH-immunopositive fibers recover after an intrastriatal injection of 6-hydroxydopamine in golden hamsters treated with prednisolone: Roles of tumor necrosis factor-α and inducible nitric oxide synthase in neurodegeneration
Keywords: Golden hamster; 6-Hydroxydopamine; Striatal Recovery; Activated microglia; Prednisolone; Minocycline; TNF-α; iNOS;
Remote Ischemic Preconditioning for Coronary Artery Bypass Graft Operations
Keywords: 17; AAR; area at risk; ATP; adenosine triphosphate; AUC; area under the curve; BNP; brain natriuretic peptide; CABG; coronary artery bypass graft; CGRP; calcitonin gene-related peptide; CK-MB; creatine kinase-MB; I; induction; I/R; ischemia-reperfusion; i
Regional variations and age-related changes in arginine metabolism in the rat brain stem and spinal cord
Keywords: ADC; arginine decarboxylase; ANOVA; analysis of variance; ASL; argininosuccinate lyase; ASS; argininosuccinate synthetase; eNOS; endothelial nitric oxide synthase; HPLC; high-performance liquid chromatography; iNOS; inducible nitric oxide synthase; LC/MS;
Effects of corticosteroid, montelukast and iNOS inhibition on distal lung with chronic inflammation
Keywords: Asthma; Chronic airway inflammation; Experimental models of asthma; iNOS; Corticosteroids; Leukotriene antagonists
Chronic Cough: An Update
Keywords: ACE; angiotensin-converting enzyme; CRS; chronic rhinosinusitis; CT; computed tomography; GERD; gastroesophageal reflux disease; iNOS; inducible nitric oxide synthase; LPR; laryngopharyngeal reflux; NAEB; nonasthmatic eosinophilic bronchitis; NO; nitric o
Mitochondrial dysfunction in the hippocampus of rats caused by chronic oxidative stress
Keywords: Apaf-1; apoptosis protease-activating factor; Bcl-2; B-cell lymphoma; BSA; bovine serum albumin; DDC; diethyldithiocarbamate; DNPH; 2,4-dinitrophenylhydrazine; EDTA; ethylenediaminetetraacetic acid; EGTA; ethylene glycol tetraacetic acid; eNOS; endothelia
Human T Cell Leukemia Virus Type I Tax-Induced IκB-ζ Modulates Tax-Dependent and Tax-Independent Gene Expression in T Cells
Keywords: Abs; antibodies; AP-1; activator protein 1; ATL; adult T cell leukemia; Bcl3; B cell CLL/lymphoma 3; CBB; Coomassie brilliant blue; CREB; cyclic adenosine 3â²,5â²-monophosphate response element-binding protein; EGFP; enhanced green fluorescent protein;
Hepatoprotective effect and mechanistic insights of deoxyelephantopin, a phyto-sesquiterpene lactone, against fulminant hepatitis
Keywords: ALT; alanine aminotransferase; AST; aspartate aminotransferase; COX-2; cyclooxygenase-2; DAPI; 4,6-diamidino-2-phenylindole; DET; deoxyelephantopin; FHF; fulminant hepatic failure; D-GalN; d-galactosamine; HO-1; heme oxygenase-1; IL-6; interleukin-6; iNOS
IL-4 blocks TH1-polarizing/inflammatory cytokine gene expression during monocyte-derived dendritic cell differentiation through histone hypoacetylation
Keywords: TH2 responses; IL-4; dendritic cells; monocyte-derived dendritic cells; house dust mite-induced allergic reactions; AAMΦ; Alternatively activated macrophage; BMDC; Bone marrow-derived dendritic cell; BMMΦ; Bone marrow macrophage; cDC; Conventional d
DNA damage in peripheral blood mononuclear cells of patients undergoing anti-tuberculosis treatment
Keywords: DNA damage; Tuberculosis; Antioxidants; iNOS;
Comparing the temperature dependence of FMN to heme electron transfer in full length and truncated inducible nitric oxide synthase proteins
Keywords: Heme-FMN electron transfer; Nitric oxide synthase; Intraprotein kinetics; Laser flash photolysis; Temperature dependence; NO; nitric oxide; NOS; nitric oxide synthase; iNOS; inducible NOS; nNOS; neuronal NOS; eNOS; endothelial NOS; CaM; calmodulin; oxyFMN
Design and synthesis of carbamate and thiocarbamate derivatives and their inhibitory activities of NO production in LPS activated macrophages
Keywords: Carbamate; Thiocarbamate; Nitric oxide; iNOS;
Suppression of nitric oxide production on LPS/IFN-γ-stimulated RAW264.7 macrophages by a novel catechin, pilosanol N, from Agrimonia pilosa Ledeb
Keywords: Nitric oxide; iNOS; Nitric oxide scavenger; Catechin; RAW264.7 macrophages; Agrimonia pilosa Ledeb
Carnosic acid, a pro-electrophilic compound, inhibits LPS-induced activation of microglia
Keywords: ARE; antioxidant-response element; CA; carnosic acid; DMSO; dimethyl sulfoxide; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; gclc; glutamate-cysteine ligase, catalytic subunit; gclm; glutamyl cysteine ligase modifier subunit; HO-
Heteroaromatic-aminomethyl quinolones: Potent and selective iNOS inhibitors
Keywords: Quinolone; Nitric oxide synthase; iNOS; nNOS; Inhibitor; SAR studies; Lipopolysaccharide challenge assay;
High expression of human monocyte iNOS mRNA induced by Paracoccidioides brasiliensis is not associated with increase in NO production
Keywords: Human monocytes; Paracoccidioides brasiliensis; Nitric oxide; iNOS; Fungicidal activity; Cytokines;
Anti-inflammatory effects of dichloromethane fraction from Orostachys japonicus in RAW 264.7 cells: Suppression of NF-κB activation and MAPK signaling
Keywords: LPS; lipopolysaccharide; NO; nitric oxide; TLR4; toll like receptor 4; IL-1β; interleukin-1 beta; iNOS; inducible nitric oxide synthase; COX-2; cyclooxygenase-2; NF-κB; nuclear factor-kappa B; IκBα; inhibitory factor kappa α; MAPKs; mitogen-activated
Inhibition of LPS binding to MD-2 co-receptor for suppressing TLR4-mediated expression of inflammatory cytokine by 1-dehydro-10-gingerdione from dietary ginger
Keywords: 1D10G; 1-dehydro-10-gingerdione; AP1; activating protein 1; Bis-ANS; 1,1â²-bis(anilino)-4,4â²-bis(naphthalene)-8,8â²-disulfonate; COX-2; cyclooxygenase 2; IFN; interferon; IκB; inhibitory κB; IL; interleukin; iNOS; inducible nitric oxide synthase; IP
Lipopolysaccharide induces multinuclear cell from RAW264.7 line with increased phagocytosis activity
Keywords: LPS; lipopolysaccharide; iNOS; inducible nitric oxide synthase; TLR4; Toll-like receptor-4; RANKL; receptor activator of nuclear factor κB ligand; M-CSF; macrophage colony-stimulating factor; RANK; receptor activator of nuclear factor κB; FBGC; foreign
Comparative effects of tocotrienol-rich fraction, α-tocopherol and α-tocopheryl acetate on inflammatory mediators and nuclear factor kappa B expression in mouse peritoneal macrophages
Keywords: Tocotrienols; Cytokines; iNOS; COX-2; NF-κB; Macrophages;
The contribution of a murine CNS-TB model for the understanding of the host-pathogen interactions in the formation of granulomas
Keywords: cfu; colony-forming units; CNS; central nervous system; CNS-TB; central nervous system tuberculosis; IL-1α; interleukin-1 alpha; IL-1β; interleukin-1 beta; IL-6; interleukin-6; LPS; lipopolysaccharides; NF-κB; nuclear factor-κB; NO; nitric oxide; iNOS
Lamotrigine monotherapy does not provide protection against the loss of optic nerve axons in a rat model of ocular hypertension
Keywords: glaucoma; retinal ganglion cell; lamotrigine; axonal degeneration; neuroprotection; nitric oxide; IOP; Intraocular pressure; RGC; Retinal ganglion cell; iNOS; Inducible nitric oxide synthase; PBS; Phosphate buffered saline; PFA; Paraformaldehyde; INaF; Fa
Anti-inflammatory effects of sophocarpine in LPS-induced RAW 264.7 cells via NF-κB and MAPKs signaling pathways
Keywords: Cmax; maximum plasma concentration; COX-2; cyclooxygenase-2; Erk1/2; extracellular signal-regulated kinase 1/2; IκB; inhibitor κB; IL-6; interleukin-6; iNOS; inducible nitric oxide synthase; JNK; c-Jun NH2-terminal kinase; LDH; lactate dehydrogenase; LP
Involvement of the l-arginine-nitric oxide pathway in the antinociception caused by fruits of Prosopis strombulifera (Lam.) Benth.
Keywords: CE; chloroform extract; DMSO; dimethylsulfoxide; EE; ethanol extract; EtOAce; ethyl acetate extract; FBS; fetal bovine serum; HRP; horseradish peroxidase; IC50; 50% inhibitory concentration; ID50; 50% inhibitory dose; iNOS; inducible nitric oxide synthase
Effect of Rhizoma Polygonati on 12-O-tetradecanoylphorbol-acetate-induced ear edema in mice
Keywords: NSAIDs; Non-steroidal anti-inflammatory drugs; RP; Rhizoma Polygonati; TPA; 12-O-tetradecanoyl-phorbol-13-acetate; iNOS; inducible nitric oxide synthase; PGE2; prostaglandin E2; COX-2; cyclooxygenase-2; TNF-α; tumor necrosis factor-α; IL-1β; Interleuki
JAK-STAT pathway modulates the roles of iNOS and COX-2 in the cytoprotection of early phase of hydrogen peroxide preconditioning against apoptosis induced by oxidative stress
Keywords: H2O2 preconditioning; Early phase; JAK-STAT; iNOS; COX-2; Cytoprotection
Nitric oxide mediates low magnesium inhibition of osteoblast-like cell proliferation
Keywords: Osteoblast; Nitric oxide; iNOS; Magnesium; Osteoporosis
New Anthranilic Acid Derivative, EAntS-GS, Attenuates Freund’s Complete Adjuvant-Induced Acute Pain in Rats
Keywords: anthranilic acid; Freund’s complete adjuvant (FCA); pain; iNOS; PAR2
Quantitative and qualitative evaluation of iNOS expression in turbot (Psetta maxima) infected with Enteromyxum scophthalmi
Keywords: Psetta maxima; Enteromyxum scophthalmi; iNOS; Intestinal inflammation; ImmunohistochemistryeNOS, endothelial nitric oxide synthase; iNOS, inducible nitric oxide synthase; IT, infected turbot; LP, lamina propria-submucosa; MMC(s), melano-macrophage centre(
Histopathological and immunohistochemical alterations in rat heart after thyroidectomy and the role of hemin and ketoconazole in treatment
Keywords: Thyroidectomy; Heart; Hemin; Ketoconazole; INOS; Immunohistochemistry
Increased expression of VEGF, iNOS, IL-1β, and IL-17 in a rabbit model of gastric content-induced middle ear inflammation
Keywords: VEGF; iNOS; IL-1β; IL-17; Gastric content; Inflamation
In vitro antioxidant and anti-inflammatory activities of 1-dehydro-[6]-gingerdione, 6-shogaol, 6-dehydroshogaol and hexahydrocurcumin
Keywords: Ginger rhizome; Antioxidant; Anti-inflammation; PGE2; iNOS; COX-2
Immunoglobulin G1 immune complex upregulates interferon-γ-induced nitric oxide production via ERK1/2 activation in murine microglia
Keywords: CNS; central nervous system; EAE; experimental autoimmune encephalomyelitis; ERK; extracellular signal-regulated kinase; FcγR; Fcγ receptor; IC; immune complex; IgG; Immunoglobulin G; IL; interleukin; iNOS; inducible nitric oxide synthatase; L-NMMA; NG-
Inhibitory effects of a spinasterol glycoside on lipopolysaccharide-induced production of nitric oxide and proinflammatory cytokines via down-regulating MAP kinase pathways and NF-κB activation in RAW264.7 macrophage cells
Keywords: Inflammation; Nitric oxide; iNOS; Proinflammatory cytokine; NF-κB; Spinasterol
Expression of NOS and VEGF in feline mammary tumours and their correlation with angiogenesis
Keywords: Angiogenesis; Feline mammary tumours; Immunohistochemistry; iNOS; Tumour grade; VEGF;
Anti-inflammatory potential of an ethyl acetate fraction isolated from Justicia gendarussa roots through inhibition of iNOS and COX-2 expression via NF-κB pathway
Keywords: Justicia gendarussa Burm.f; Carrageenan; Cyclooxygenase; NF-κB; iNOS; COX-2